KEGG   PATHWAY: pva00920Help
Entry
pva00920                    Pathway                                

Name
Sulfur metabolism - Pantoea vagans C9-1
Description
Sulfur is an essential element for life and the metabolism of organic sulfur compounds plays an important role in the global sulfur cycle. Sulfur occurs in various oxidation states ranging from +6 in sulfate to -2 in sulfide (H2S). Sulfate reduction can occur in both an energy consuming assimilatory pathway and an energy producing dissimilatory pathway. The assimilatory pathway, which is found in a wide range of organisms, produces reduced sulfur compounds for the biosynthesis of S-containing amino acids and does not lead to direct excretion of sulfide. In the dissimilatory pathway, which is restricted to obligatory anaerobic bacterial and archaeal lineages, sulfate (or sulfur) is the terminal electron acceptor of the respiratory chain producing large quantities of inorganic sulfide. Both pathways start from the activation of sulfate by reaction with ATP to form adenylyl sulfate (APS). In the assimilatory pathway [MD:M00176] APS is converted to 3'-phosphoadenylyl sulfate (PAPS) and then reduced to sulfite, and sulfite is further reduced to sulfide by the assimilatory sulfite reductase. In the dissimilatory pathway [MD:M00596] APS is directly reduced to sulfite, and sulfite is further reduced to sulfide by the dissimilatory sulfite reductase. The capacity for oxidation of sulfur is quite widespread among bacteria and archaea, comprising phototrophs and chemolithoautotrophs. The SOX (sulfur-oxidation) system [MD:M00595] is a well-known sulfur oxidation pathway and is found in both photosynthetic and non-photosynthetic sulfur-oxidizing bacteria. Green sulfur bacteria and purple sulfur bacteria carry out anoxygenic photosynthesis with reduced sulfur compounds such as sulfide and elemental sulfur, as well as thiosulfate (in some species with the SOX system), as the electron donor for photoautotrophic growth. In some chemolithoautotrophic sulfur oxidizers (such as Thiobacillus denitrificans), it has been suggested that dissimilatory sulfur reduction enzymes operate in the reverse direction, forming a sulfur oxidation pathway from sulfite to APS and then to sulfate.
Class
Metabolism; Energy metabolism
BRITE hierarchy
Pathway map
pva00920  Sulfur metabolism
pva00920

Ortholog table
Module
pva_M00176  Assimilatory sulfate reduction, sulfate => H2S [PATH:pva00920]
Other DBs
BSID: 171843
GO: 0006790
Organism
Pantoea vagans C9-1 [GN:pva]
Gene
Pvag_2212  cysP; Thiosulfate-binding protein precursor [KO:K02048]
Pvag_3161  sbp; Sulfate-binding protein precursor [KO:K02048]
Pvag_2211  cysT; Probable sulfate transport system permease protein cysT [KO:K02046]
Pvag_2210  cysW; Sulfate transport system permease protein cysW [KO:K02047]
Pvag_2209  cysA; ATP-binding component of sulfate permease A protein [KO:K02045] [EC:3.6.3.25]
Pvag_2913  tauA; Taurine-binding periplasmic protein precursor [KO:K15551]
Pvag_2911  tauC; Taurine transport permease protein tauC [KO:K15552]
Pvag_2912  tauB; taurine ATP-binding component of a transport system [KO:K10831] [EC:3.6.3.36]
Pvag_2910  tauD; taurine dioxygenase, 2-oxoglutarate-dependent [KO:K03119] [EC:1.14.11.17]
Pvag_0762  ssuA; Putative aliphatic sulfonates-binding protein precursor [KO:K15553]
Pvag_pPag10060  ssuA1; Putative aliphatic sulfonates-binding protein precursor [KO:K15553]
Pvag_pPag10061  ssuA3; Putative aliphatic sulfonates-binding protein precursor [KO:K15553]
Pvag_0760  ssuC; Sulfonate transport permease protein ssuC [KO:K15554]
Pvag_0759  ssuB; Sulfonate import ATP-binding protein ssuB [KO:K15555] [EC:3.6.3.-]
Pvag_0761  ssuD; alkanesulfonate monooxygenase [KO:K04091] [EC:1.14.14.5]
Pvag_pPag10058  msuD; alkanesulfonate monooxygenase [KO:K04091] [EC:1.14.14.5]
Pvag_0763  ssuE; putative NAD(P)H-dependent FMN reductase [KO:K00299] [EC:1.5.1.38]
Pvag_2448  cysN; ATP-sulfurylase, subunit 1 (ATP:sulfate adenylyltransferase) [KO:K00956] [EC:2.7.7.4]
Pvag_2449  cysD; ATP-sulfurylase, subunit 1 (ATP:sulfate adenylyltransferase) [KO:K00957] [EC:2.7.7.4]
Pvag_2447  cysC; adenosine 5'-phosphosulfate kinase [KO:K00860] [EC:2.7.1.25]
Pvag_2771  cysQ; PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase [KO:K01082] [EC:3.1.3.7]
Pvag_2453  cysH; 3'-phosphoadenosine 5'-phosphosulfate (PAPS) reductase [KO:K00390] [EC:1.8.4.10 1.8.4.8]
Pvag_2455  cysJ; sulfite reductase [KO:K00380] [EC:1.8.1.2]
Pvag_3626  yvgR; sulfite reductase (NADPH) flavoprotein alpha-component [KO:K00380] [EC:1.8.1.2]
Pvag_2454  cysI; sulfite reductase (NADPH) hemoprotein beta-component [KO:K00381] [EC:1.8.1.2]
Pvag_2286  sseA; putative thiosulfate sulfurtransferase [KO:K01011] [EC:2.8.1.2 2.8.1.1]
Pvag_2965  glpE; Putative thiosulfate sulfurtransferase [KO:K02439] [EC:2.8.1.1]
Pvag_3170  cysE; serine O-acetyltransferase [KO:K00640] [EC:2.3.1.30]
Pvag_0387  cbs; putative lyase [KO:K01738] [EC:2.5.1.47]
Pvag_2201  cysK; cysteine synthase A [KO:K01738] [EC:2.5.1.47]
Pvag_2208  cysM; cysteine synthase B [KO:K12339] [EC:2.5.1.47]
Pvag_3487  metA; homoserine transsuccinylase [KO:K00651] [EC:2.3.1.46]
Pvag_3139  metB; cystathionine gamma-synthase [KO:K01739] [EC:2.5.1.48]
Pvag_pPag30468  sfnG; putative FMNH2-dependent dimethyl sulfone monooxygenase [KO:K17228] [EC:1.14.14.35]
Compound
C00033  Acetate
C00042  Succinate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00065  L-Serine
C00084  Acetaldehyde
C00087  Sulfur
C00094  Sulfite
C00097  L-Cysteine
C00155  L-Homocysteine
C00224  Adenylyl sulfate
C00245  Taurine
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00320  Thiosulfate
C00409  Methanethiol
C00580  Dimethyl sulfide
C00979  O-Acetyl-L-serine
C01118  O-Succinyl-L-homoserine
C01861  Trithionate
C02084  Tetrathionate
C03920  2-(Methylthio)ethanesulfonate
C04022  S,S-Dimethyl-beta-propiothetin
C08276  3-(Methylthio)propanoate
C11142  Dimethyl sulfone
C11143  Dimethyl sulfoxide
C11145  Methanesulfonic acid
C15521  Alkanesulfonate
C17267  S-Sulfanylglutathione
C19692  Polysulfide
C20870  3-(Methylthio)propanoyl-CoA
C20955  3-(Methylthio)acryloyl-CoA
Reference
  Authors
Grein F, Ramos AR, Venceslau SS, Pereira IA
  Title
Unifying concepts in anaerobic respiration: Insights from dissimilatory sulfur metabolism.
  Journal
Biochim Biophys Acta 1827:145-60 (2013)
DOI:10.1016/j.bbabio.2012.09.001
Reference
  Authors
Fauque GD, Barton LL
  Title
Hemoproteins in dissimilatory sulfate- and sulfur-reducing prokaryotes.
  Journal
Adv Microb Physiol 60:1-90 (2012)
DOI:10.1016/B978-0-12-398264-3.00001-2
Reference
  Authors
Sakurai H, Ogawa T, Shiga M, Inoue K
  Title
Inorganic sulfur oxidizing system in green sulfur bacteria.
  Journal
Photosynth Res 104:163-76 (2010)
DOI:10.1007/s11120-010-9531-2
Reference
  Authors
Falkenby LG, Szymanska M, Holkenbrink C, Habicht KS, Andersen JS, Miller M, Frigaard NU
  Title
Quantitative proteomics of Chlorobaculum tepidum: insights into the sulfur metabolism of a phototrophic green sulfur bacterium.
  Journal
FEMS Microbiol Lett 323:142-50 (2011)
DOI:10.1111/j.1574-6968.2011.02370.x
Reference
  Authors
Gregersen LH, Bryant DA, Frigaard NU
  Title
Mechanisms and evolution of oxidative sulfur metabolism in green sulfur bacteria.
  Journal
Front Microbiol 2:116 (2011)
DOI:10.3389/fmicb.2011.00116
Reference
  Authors
Beller HR, Chain PS, Letain TE, Chakicherla A, Larimer FW, Richardson PM, Coleman MA, Wood AP, Kelly DP.
  Title
The genome sequence of the obligately chemolithoautotrophic, facultatively anaerobic bacterium Thiobacillus denitrificans.
  Journal
J Bacteriol 188:1473-88 (2006)
DOI:10.1128/JB.188.4.1473-1488.2006
Reference
PMID:9695921
  Authors
Pott AS, Dahl C
  Title
Sirohaem sulfite reductase and other proteins encoded by genes at the dsr locus of Chromatium vinosum are involved in the oxidation of intracellular sulfur.
  Journal
Microbiology 144 ( Pt 7):1881-94 (1998)
DOI:10.1099/00221287-144-7-1881
Reference
  Authors
Frigaard NU, Dahl C
  Title
Sulfur metabolism in phototrophic sulfur bacteria.
  Journal
Adv Microb Physiol 54:103-200 (2009)
DOI:10.1016/S0065-2911(08)00002-7
KO pathway
ko00920   

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