KEGG   PATHWAY: rcu03420
Entry
rcu03420                    Pathway                                
Name
Nucleotide excision repair - Ricinus communis (castor bean)
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
rcu03420  Nucleotide excision repair
rcu03420

Other DBs
GO: 0006289
Organism
Ricinus communis (castor bean) [GN:rcu]
Gene
8260798  DNA polymerase I A, chloroplastic/mitochondrial [KO:K02335] [EC:2.7.7.7]
8259356  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
8281168  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
8264103  cullin-4 isoform X1 [KO:K10609]
8266532  DNA damage-binding protein 1a isoform X1 [KO:K10610]
8286445  protein DAMAGED DNA-BINDING 2 [KO:K10140]
8272178  DNA repair protein RAD4 [KO:K10838]
8280290  ubiquitin receptor RAD23b [KO:K10839]
8261180  ubiquitin receptor RAD23d isoform X2 [KO:K10839]
8260406  ubiquitin receptor RAD23d [KO:K10839]
8265297  WD repeat-containing protein ATCSA-1 isoform X1 [KO:K10570]
8283870  protein CHROMATIN REMODELING 8 [KO:K10841]
8263514  UV-stimulated scaffold protein A homolog isoform X1 [KO:K23720]
8267704  DNA-directed RNA polymerase II subunit RPB1 [KO:K03006] [EC:2.7.7.6]
8279501  DNA-directed RNA polymerase II subunit RPB2 [KO:K03010] [EC:2.7.7.6]
8288139  DNA-directed RNA polymerases II, IV and V subunit 3 [KO:K03011]
8258662  DNA-directed RNA polymerase II subunit 4 [KO:K03012]
8264771  DNA-directed RNA polymerases IV and V subunit 4 isoform X1 [KO:K03012]
8260415  DNA-directed RNA polymerase V subunit 5A [KO:K03013]
8270900  DNA-directed RNA polymerase V subunit 5A isoform X1 [KO:K03013]
8268331  DNA-directed RNA polymerases II and IV subunit 5A [KO:K03013]
8258290  DNA-directed RNA polymerases II, IV and V subunit 6A isoform X1 [KO:K03014]
8284145  DNA-directed RNA polymerase II subunit RPB7 [KO:K03015]
8263166  DNA-directed RNA polymerases II, IV and V subunit 8B [KO:K03016]
107260747  DNA-directed RNA polymerases II, IV and V subunit 9A isoform X2 [KO:K03017]
8258795  DNA-directed RNA polymerases II, IV and V subunit 9A-like [KO:K03017]
8279042  DNA-directed RNA polymerase subunit 10-like protein [KO:K03007]
8272277  DNA-directed RNA polymerases II, IV and V subunit 12 [KO:K03009]
8259315  DNA-directed RNA polymerases II, IV and V subunit 11 [KO:K03008]
8275727  cyclin-dependent kinase D-3 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
8265933  uncharacterized protein LOC8265933 [KO:K10842]
8287059  cyclin-H1-1 isoform X1 [KO:K06634]
8287410  general transcription and DNA repair factor IIH helicase subunit XPB1 isoform X2 [KO:K10843] [EC:5.6.2.4]
8272056  general transcription and DNA repair factor IIH helicase subunit XPD isoform X1 [KO:K10844] [EC:5.6.2.3]
107262487  general transcription and DNA repair factor IIH subunit TFB5 [KO:K10845]
8267682  general transcription and DNA repair factor IIH subunit TFB1-1 [KO:K03141]
8286024  general transcription factor IIH subunit 2 [KO:K03142]
8276554  general transcription and DNA repair factor IIH subunit TFB4 isoform X1 [KO:K03143]
8275581  general transcription and DNA repair factor IIH subunit TFB2 isoform X1 [KO:K03144]
8280552  DNA repair protein UVH3 isoform X1 [KO:K10846]
8280087  replication protein A 70 kDa DNA-binding subunit E [KO:K07466]
8268447  replication protein A 70 kDa DNA-binding subunit A [KO:K07466]
8284426  replication protein A 70 kDa DNA-binding subunit B [KO:K07466]
8260297  replication protein A 32 kDa subunit B isoform X2 [KO:K10739]
8282067  LOW QUALITY PROTEIN: replication protein A 32 kDa subunit A [KO:K10739]
8263182  replication protein A 14 kDa subunit B [KO:K10740]
8269025  DNA repair endonuclease UVH1 isoform X1 [KO:K10848] [EC:3.1.-.-]
8285528  DNA excision repair protein ERCC-1 isoform X1 [KO:K10849]
8277728  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
8267087  DNA polymerase delta small subunit [KO:K02328]
8288260  uncharacterized protein LOC8288260 isoform X1 [KO:K03504]
8284291  DNA polymerase delta subunit 4 [KO:K03505]
8277599  DNA polymerase epsilon catalytic subunit A [KO:K02324] [EC:2.7.7.7]
8260279  DNA polymerase epsilon subunit B isoform X1 [KO:K02325] [EC:2.7.7.7]
8271925  DNA polymerase epsilon subunit 3 [KO:K02326] [EC:2.7.7.7]
8279783  proliferating cell nuclear antigen [KO:K04802]
8281056  replication factor C subunit 1 isoform X3 [KO:K10754]
8265440  replication factor C subunit 2 [KO:K10755]
8271000  replication factor C subunit 2 isoform X2 [KO:K10755]
8277766  replication factor C subunit 3 [KO:K10756]
8286493  replication factor C subunit 3 [KO:K10756]
8277632  replication factor C subunit 5 [KO:K10756]
8273383  uncharacterized protein LOC8273383 isoform X2 [KO:K10756]
8275235  DNA ligase 1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
rcu03020  RNA polymerase
rcu04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (64)   
   KEGG GENES (64)   
All databases (65)   

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