KEGG   PATHWAY: rno04662
Entry
rno04662                    Pathway                                
Name
B cell receptor signaling pathway - Rattus norvegicus (rat)
Description
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class
Organismal Systems; Immune system
Pathway map
rno04662  B cell receptor signaling pathway
rno04662

Other DBs
GO: 0050853
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100913063  Cd79a; B-cell antigen receptor complex-associated protein alpha chain precursor [KO:K06506]
171055  Cd79b; B-cell antigen receptor complex-associated protein beta chain precursor [KO:K06507]
81515  Lyn; tyrosine-protein kinase Lyn isoform A [KO:K05854] [EC:2.7.10.2]
25155  Syk; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
367901  Btk; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
362046  Dapp1; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide [KO:K12229]
499356  Blnk; B-cell linker protein [KO:K07371]
25156  Vav1; proto-oncogene vav [KO:K05730]
295378  Vav3; guanine nucleotide exchange factor VAV3 [KO:K05730]
296603  Vav2; guanine nucleotide exchange factor VAV2 [KO:K05730]
363875  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
366957  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
688319  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
365948  Bank1; B-cell scaffold protein with ankyrin repeats [KO:K26239]
364403  Blk; tyrosine-protein kinase Blk [KO:K08890] [EC:2.7.10.2]
29337  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
24674  Ppp3ca; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
24675  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
171378  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
29748  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
29749  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
100361818  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 [KO:K04446]
311658  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
361400  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
81504  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
85384  Sos2; son of sevenless homolog 2 [KO:K03099]
313845  Sos1; son of sevenless homolog 1 [KO:K03099]
313874  Rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
293621  Hras; GTPase HRas [KO:K02833]
367858  Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833]
24525  Kras; GTPase KRas [KO:K07827]
24605  Nras; GTPase NRas [KO:K07828]
24703  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
170851  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
58960  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
314322  Fos; protein c-Fos [KO:K04379]
24516  Jun; transcription factor Jun [KO:K04448]
25023  Prkcb; protein kinase C beta type isoform 2 [KO:K19662] [EC:2.7.11.13]
100363332  Card11; caspase recruitment domain-containing protein 11 [KO:K07367]
83477  Bcl10; B-cell lymphoma/leukemia 10 [KO:K07368]
307366  Malt1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform 1 [KO:K07369] [EC:3.4.22.-]
309361  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
84351  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
309295  Ikbkg; NF-kappa-B essential modulator [KO:K07210]
81736  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580]
309165  Rela; transcription factor p65 [KO:K04735]
25493  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
81525  Nfkbib; NF-kappa-B inhibitor beta [KO:K02581]
316241  Nfkbie; NF-kappa-B inhibitor epsilon [KO:K05872]
293618  Ifitm1; interferon-induced transmembrane protein 1 [KO:K19831]
25621  Cd81; CD81 antigen [KO:K06508]
365367  Cd19; B-lymphocyte antigen CD19 precursor [KO:K06465]
289395  Cr2; complement receptor type 2 precursor [KO:K04012]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
134484121  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
24185  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
25233  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
29414  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
84027  Gsk3b; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
289211  Fcgr2b; low affinity immunoglobulin gamma Fc region receptor II [KO:K12560]
54259  Inpp5d; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
65038  Inppl1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform 1 [KO:K15909] [EC:3.1.3.86]
308350  Lilrb3; leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X6 [KO:K06512]
361493  Pira2; paired-Ig-like receptor A2 precursor [KO:K06512]
683463  Pirb; leukocyte immunoglobulin-like receptor subfamily B member 3A precursor [KO:K06512]
691533  Lilra5; leukocyte immunoglobulin-like receptor subfamily A member 5 precursor [KO:K06512]
690906  Lilrc2; leukocyte immunoglobulin-like receptor, subfamily C, member 2 [KO:K06512]
292594  Lilrb4; leukocyte immunoglobulin like receptor B4 isoform 3 precursor [KO:K06512]
65146  Lilrb2; neutrophil immunoglobulin-like receptor 1 [KO:K06512]
100912456  Lilrb1; leukocyte immunoglobulin-like receptor subfamily B member 3-like isoform X1 [KO:K06512]
134485274  LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 3-like [KO:K06512]
308501  Cd22; B-cell receptor CD22 precursor [KO:K06467]
313498  Cd72; B-cell differentiation antigen CD72 [KO:K06504]
116689  Ptpn6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
294048  Pik3ap1; phosphoinositide 3-kinase adapter protein 1 isoform 2 [KO:K12230]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12461567
  Authors
Niiro H, Clark EA.
  Title
Regulation of B-cell fate by antigen-receptor signals.
  Journal
Nat Rev Immunol 2:945-56 (2002)
DOI:10.1038/nri955
Reference
PMID:10358768
  Authors
Kurosaki T.
  Title
Genetic analysis of B cell antigen receptor signaling.
  Journal
Annu Rev Immunol 17:555-92 (1999)
DOI:10.1146/annurev.immunol.17.1.555
Reference
PMID:15886119
  Authors
Nitschke L.
  Title
The role of CD22 and other inhibitory co-receptors in B-cell activation.
  Journal
Curr Opin Immunol 17:290-7 (2005)
DOI:10.1016/j.coi.2005.03.005
Reference
PMID:15752555
  Authors
Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
  Title
Complement: central to innate immunity and bridging to adaptive responses.
  Journal
Immunol Lett 97:171-9 (2005)
DOI:10.1016/j.imlet.2004.11.010
Reference
PMID:12033741
  Authors
Kurosaki T.
  Title
Regulation of B-cell signal transduction by adaptor proteins.
  Journal
Nat Rev Immunol 2:354-63 (2002)
DOI:10.1038/nri801
Reference
PMID:15364057
  Authors
Nitschke L, Tsubata T.
  Title
Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
  Journal
Trends Immunol 25:543-50 (2004)
DOI:10.1016/j.it.2004.08.002
Reference
PMID:15771577
  Authors
Jumaa H, Hendriks RW, Reth M.
  Title
B cell signaling and tumorigenesis.
  Journal
Annu Rev Immunol 23:415-45 (2005)
DOI:10.1146/annurev.immunol.23.021704.115606
Reference
PMID:15886112
  Authors
Rickert RC.
  Title
Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
  Journal
Curr Opin Immunol 17:237-43 (2005)
DOI:10.1016/j.coi.2005.03.001
Reference
PMID:15457440
  Authors
Zouali M, Sarmay G
  Title
B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
  Journal
Arthritis Rheum 50:2730-41 (2004)
DOI:10.1002/art.20487
Reference
PMID:15322145
  Authors
Chiles TC.
  Title
Regulation and function of cyclin D2 in B lymphocyte subsets.
  Journal
J Immunol 173:2901-7 (2004)
DOI:10.4049/jimmunol.173.5.2901
Reference
PMID:15626471
  Authors
Allam A, Marshall AJ
  Title
Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
  Journal
Immunol Lett 97:7-17 (2005)
DOI:10.1016/j.imlet.2004.09.019
Reference
PMID:12119152
  Authors
Gold MR
  Title
To make antibodies or not: signaling by the B-cell antigen receptor.
  Journal
Trends Pharmacol Sci 23:316-24 (2002)
DOI:10.1016/S0165-6147(02)02045-X
Reference
PMID:9697839
  Authors
Fu C, Turck CW, Kurosaki T, Chan AC
  Title
BLNK: a central linker protein in B cell activation.
  Journal
Immunity 9:93-103 (1998)
DOI:10.1016/S1074-7613(00)80591-9
Reference
PMID:11163197
  Authors
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
  Title
BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
  Journal
Immunity 13:817-27 (2000)
DOI:10.1016/S1074-7613(00)00079-0
Reference
PMID:18086859
  Authors
Shinohara H, Maeda S, Watarai H, Kurosaki T
  Title
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
  Journal
J Exp Med 204:3285-93 (2007)
DOI:10.1084/jem.20070379
Related
pathway
rno04010  MAPK signaling pathway
rno04020  Calcium signaling pathway
rno04064  NF-kappa B signaling pathway
rno04120  Ubiquitin mediated proteolysis
rno04151  PI3K-Akt signaling pathway
rno04610  Complement and coagulation cascades
rno04810  Regulation of actin cytoskeleton
KO pathway
ko04662   

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Genome (1)   
   KEGG GENOME (1)   
Gene (82)   
   KEGG GENES (82)   
All databases (83)   

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