KEGG   PATHWAY: rno04727Help
Entry
rno04727                    Pathway                                
Name
GABAergic synapse - Rattus norvegicus (rat)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
BRITE hierarchy
Pathway map
GABAergic synapse
rno04727

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BSID: 
GO: 
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
170567  
Slc38a1; solute carrier family 38, member 1 [KO:K14990]
29642  
Slc38a2; solute carrier family 38, member 2 [KO:K14207]
24398  
Gls; glutaminase [KO:K01425] [EC:3.5.1.2]
192268  
Gls2; glutaminase 2 (liver, mitochondrial) [KO:K01425] [EC:3.5.1.2]
24379  
Gad1; glutamate decarboxylase 1 [KO:K01580] [EC:4.1.1.15]
24380  
Gad2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
83612  
Slc32a1; solute carrier family 32 (GABA vesicular transporter), member 1 [KO:K15015]
81632  
Abat; 4-aminobutyrate aminotransferase [KO:K13524] [EC:2.6.1.22 2.6.1.19]
29705  
Gabra1; gamma-aminobutyric acid (GABA) A receptor, alpha 1 [KO:K05175]
289606  
Gabra2; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2 [KO:K05175]
24947  
Gabra3; gamma-aminobutyric acid (GABA) A receptor, alpha 3 [KO:K05175]
140675  
Gabra4; gamma-aminobutyric acid (GABA) A receptor, alpha 4 [KO:K05175]
29707  
Gabra5; gamma-aminobutyric acid (GABA) A receptor, alpha 5 [KO:K05175]
29708  
Gabra6; gamma-aminobutyric acid (GABA) A receptor, alpha 6 [KO:K05175]
25450  
Gabrb1; gamma-aminobutyric acid (GABA) A receptor, beta 1 [KO:K05181]
24922  
Gabrb3; gamma-aminobutyric acid (GABA) A receptor, beta 3 [KO:K05181]
25451  
Gabrb2; gamma-aminobutyric acid (GABA) A receptor, beta 2 [KO:K05181]
140674  
Gabrg1; gamma-aminobutyric acid (GABA) A receptor, gamma 1 [KO:K05186]
29709  
Gabrg2; gamma-aminobutyric acid (GABA) A receptor, gamma 2 [KO:K05186]
79211  
Gabrg3; gamma-aminobutyric acid (GABA) A receptor, gamma 3 [KO:K05186]
29689  
Gabrd; gamma-aminobutyric acid (GABA) A receptor, delta [KO:K05184]
65191  
Gabre; gamma-aminobutyric acid (GABA) A receptor, epsilon [KO:K05185]
65187  
Gabrq; gamma-aminobutyric acid (GABA) A receptor, theta [KO:K05192]
81658  
Gabrp; gamma-aminobutyric acid (GABA-A) receptor, pi [KO:K05189]
25636  
Prkaca; protein kinase, cAMP-dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
293508  
Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
501563  
Prkx; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
83805  
Src; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [KO:K05704] [EC:2.7.10.2]
24680  
Prkca; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
24681  
Prkcg; protein kinase C, gamma [KO:K02677] [EC:2.7.11.13]
25023  
Prkcb; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
29430  
Hap1; huntingtin-associated protein 1 [KO:K04647]
58974  
Gabarap; GABA(A) receptor-associated protein [KO:K08341]
64670  
Gabarapl2; GABA(A) receptor-associated protein like 2 [KO:K08341]
GABA(A) receptor-associated protein-like 2-like; K08341 GABA(A) receptor-associated protein (autophagy-related protein 8) [KO:K08341]
689161  
Gabarapl1; GABA(A) receptor-associated protein like 1 [KO:K08341]
60355  
Nsf; N-ethylmaleimide-sensitive factor [KO:K06027] [EC:3.6.4.6]
171086  
Trak2; trafficking protein, kinesin binding 2 [KO:K15374]
84587  
Plcl1; phospholipase C-like 1 [KO:K15375]
64845  
Gphn; gephyrin [KO:K15376] [EC:2.7.7.75 2.10.1.1]
29694  
Gabrr1; gamma-aminobutyric acid (GABA) A receptor, rho 1 [KO:K05190]
29695  
Gabrr2; gamma-aminobutyric acid (GABA) A receptor, rho 2 [KO:K05190]
192258  
Gabrr3; gamma-aminobutyric acid (GABA) A receptor, rho 3 [KO:K05190]
25398  
Cacna1a; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit [KO:K04344]
257648  
Cacna1b; calcium channel, voltage-dependent, N type, alpha 1B subunit [KO:K04849]
24239  
Cacna1c; calcium channel, voltage-dependent, L type, alpha 1C subunit [KO:K04850]
29716  
Cacna1d; calcium channel, voltage-dependent, L type, alpha 1D subunit [KO:K04851]
114493  
Cacna1f; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
682930  
Cacna1s; calcium channel, voltage-dependent, L type, alpha 1S subunit [KO:K04857]
81657  
Gabbr1; gamma-aminobutyric acid (GABA) B receptor 1 [KO:K04615]
83633  
Gabbr2; gamma-aminobutyric acid (GABA) B receptor 2 [KO:K04615]
25686  
Gnai1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 [KO:K04630]
25643  
Gnai3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 [KO:K04630]
81664  
Gnai2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 [KO:K04630]
50664  
Gnao1; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O [KO:K04534]
24400  
Gnb1; guanine nucleotide binding protein (G protein), beta polypeptide 1 [KO:K04536]
81667  
Gnb2; guanine nucleotide binding protein (G protein), beta polypeptide 2 [KO:K04537]
60449  
Gnb3; guanine nucleotide binding protein (G protein), beta polypeptide 3 [KO:K07825]
294962  
Gnb4; guanine nucleotide binding protein (G protein), beta polypeptide 4 [KO:K04538]
83579  
Gnb5; guanine nucleotide binding protein (G protein), beta 5 [KO:K04539]
80850  
Gng2; guanine nucleotide binding protein (G protein), gamma 2 [KO:K07826]
114117  
Gng3; guanine nucleotide binding protein (G protein), gamma 3 [KO:K04540]
114118  
Gng4; guanine nucleotide binding protein (G protein), gamma 4 subunit [KO:K04541]
79218  
Gng5; guanine nucleotide binding protein (G protein), gamma 5 [KO:K04542]
guanine nucleotide binding protein (G protein); K04542 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
58979  
Gng7; guanine nucleotide binding protein (G protein), gamma 7 [KO:K04543]
245986  
Gng8; guanine nucleotide binding protein (G protein), gamma 8 [KO:K04544]
114119  
Gng10; guanine nucleotide binding protein (G protein), gamma 10 [KO:K04545]
64199  
Gng11; guanine nucleotide binding protein (G protein), gamma 11 [KO:K04546]
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11-like; K04546 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
114120  
Gng12; guanine nucleotide binding protein (G protein), gamma 12 [KO:K04347]
685513  
similar to Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-12 subunit precursor; K04347 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
685451  
Gng13; guanine nucleotide binding protein (G protein), gamma 13 [KO:K04547]
680149  
Gngt1; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 [KO:K04548]
690825  
Gngt2; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 [KO:K04549]
305509  
Adcy1; adenylate cyclase 1 (brain) [KO:K08041] [EC:4.6.1.1]
81636  
Adcy2; adenylate cyclase 2 (brain) [KO:K08042] [EC:4.6.1.1]
64508  
Adcy3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
54223  
Adcy4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
64532  
Adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
25289  
Adcy6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
84420  
Adcy7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
29241  
Adcy8; adenylate cyclase 8 (brain) [KO:K08048] [EC:4.6.1.1]
302950  
Adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
25743  
Kcnj6; potassium inwardly-rectifying channel, subfamily J, member 6 [KO:K05000]
79212  
Slc6a1; solute carrier family 6 (neurotransmitter transporter, GABA), member 1 [KO:K05034]
24957  
Glul; glutamate-ammonia ligase [KO:K01915] [EC:6.3.1.2]
252919  
Slc38a3; solute carrier family 38, member 3 [KO:K13576]
192208  
Slc38a5; solute carrier family 38, member 5 [KO:K14992]
171163  
Slc6a13; solute carrier family 6 (neurotransmitter transporter, GABA), member 13 [KO:K05039]
171373  
Slc12a5; solute carrier family 12 (potassium-chloride transporter), member 5 [KO:K14427]
79213  
Slc6a11; solute carrier family 6 (neurotransmitter transporter, GABA), member 11 [KO:K05039]
Compound
C00025  
L-Glutamate
C00026  
2-Oxoglutarate
C00042  
Succinate
C00064  
L-Glutamine
C00076  
Calcium cation
C00238  
Potassium cation
C00334  
4-Aminobutanoate
C00575  
3',5'-Cyclic AMP
C00698  
Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
Reference
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
Reference
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
Reference
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
Reference
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
Reference
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
Reference
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
Reference
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
Reference
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
Reference
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
Reference
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
Reference
(Japanese)
  Authors
Kanematsu T, Terunuma M, Goto H, Kuratani A, Hirata M.
  Title
[The life cycle of the GABAA receptor and its regulating molecules] (In Japanese)
  Journal
Folia Pharmacol. Jpn. (Nippon Yakurigaku Sasshi) (2004)
Reference
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
Reference
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
Reference
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
Reference
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
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