Entry
Name
GABAergic synapse - Rattus norvegicus (rat)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Rattus norvegicus (rat) [GN:
rno ]
Gene
170567 Slc38a1; sodium-coupled neutral amino acid symporter 1 [KO:K14990 ]
29642 Slc38a2; sodium-coupled neutral amino acid symporter 2 [KO:K14207 ]
83612 Slc32a1; vesicular inhibitory amino acid transporter [KO:K15015 ]
29705 Gabra1; gamma-aminobutyric acid receptor subunit alpha-1 precursor [KO:K05175 ]
289606 Gabra2; gamma-aminobutyric acid receptor subunit alpha-2 precursor [KO:K05175 ]
24947 Gabra3; gamma-aminobutyric acid receptor subunit alpha-3 precursor [KO:K05175 ]
140675 Gabra4; gamma-aminobutyric acid receptor subunit alpha-4 precursor [KO:K05175 ]
29707 Gabra5; gamma-aminobutyric acid receptor subunit alpha-5 precursor [KO:K05175 ]
29708 Gabra6; gamma-aminobutyric acid receptor subunit alpha-6 precursor [KO:K05175 ]
25450 Gabrb1; gamma-aminobutyric acid receptor subunit beta-1 precursor [KO:K05181 ]
24922 Gabrb3; gamma-aminobutyric acid receptor subunit beta-3 precursor [KO:K05181 ]
25451 Gabrb2; gamma-aminobutyric acid receptor subunit beta-2 precursor [KO:K05181 ]
140674 Gabrg1; gamma-aminobutyric acid receptor subunit gamma-1 precursor [KO:K05186 ]
29709 Gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 isoform 2 precursor [KO:K05186 ]
79211 Gabrg3; gamma-aminobutyric acid receptor subunit gamma-3 precursor [KO:K05186 ]
29689 Gabrd; gamma-aminobutyric acid receptor subunit delta precursor [KO:K05184 ]
65191 Gabre; gamma-aminobutyric acid receptor subunit epsilon precursor [KO:K05185 ]
65187 Gabrq; gamma-aminobutyric acid receptor subunit theta precursor [KO:K05192 ]
81658 Gabrp; gamma-aminobutyric acid receptor subunit pi precursor [KO:K05189 ]
29430 Hap1; huntingtin-associated protein 1 isoform B [KO:K04647 ]
58974 Gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341 ]
64670 Gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
689161 Gabarapl1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341 ]
134484162 gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
120098596 Gabarapl4; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
171086 Trak2; trafficking kinesin-binding protein 2 [KO:K15374 ]
84587 Plcl1; inactive phospholipase C-like protein 1 [KO:K15375 ]
171373 Slc12a5; solute carrier family 12 member 5 isoform 2 [KO:K23967 ]
29694 Gabrr1; gamma-aminobutyric acid receptor subunit rho-1 precursor [KO:K05190 ]
29695 Gabrr2; gamma-aminobutyric acid receptor subunit rho-2 precursor [KO:K05190 ]
192258 Gabrr3; gamma-aminobutyric acid receptor subunit rho-3 precursor [KO:K05190 ]
25398 Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344 ]
257648 Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform 1 [KO:K04849 ]
24239 Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850 ]
29716 Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851 ]
114493 Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853 ]
682930 Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857 ]
81657 Gabbr1; gamma-aminobutyric acid type B receptor subunit 1 precursor [KO:K04615 ]
83633 Gabbr2; gamma-aminobutyric acid type B receptor subunit 2 precursor [KO:K04615 ]
25686 Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
25643 Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
81664 Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
50664 Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform B [KO:K04534 ]
24400 Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536 ]
81667 Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
60449 Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825 ]
294962 Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538 ]
83579 Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539 ]
80850 Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826 ]
114117 Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540 ]
114118 Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541 ]
79218 Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
58979 Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543 ]
245986 Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544 ]
114119 Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545 ]
64199 Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
114120 Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
685513 Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347 ]
685451 Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547 ]
680149 Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548 ]
690825 Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549 ]
25743 Kcnj6; G protein-activated inward rectifier potassium channel 2 isoform 1 [KO:K05000 ]
79212 Slc6a1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034 ]
171163 Slc6a13; sodium- and chloride-dependent GABA transporter 2 [KO:K05046 ]
79213 Slc6a11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044 ]
50676 Slc6a12; sodium- and chloride-dependent betaine transporter [KO:K05045 ]
252919 Slc38a3; sodium-coupled neutral amino acid transporter 3 [KO:K13576 ]
192208 Slc38a5; sodium-coupled neutral amino acid transporter 5 [KO:K14992 ]
Compound
Reference
Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
Title
Neuropsychopharmacology: The fifth generation of progress
Journal
Reference
Authors
Farrant M, Kaila K
Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
Journal
Reference
Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
Journal
Reference
Authors
Pinard A, Seddik R, Bettler B
Title
GABAB receptors: physiological functions and mechanisms of diversity.
Journal
Reference
Authors
Chalifoux JR, Carter AG
Title
GABAB receptor modulation of synaptic function.
Journal
Reference
Authors
Padgett CL, Slesinger PA
Title
GABAB receptor coupling to G-proteins and ion channels.
Journal
Reference
Authors
Emson PC
Title
GABA(B) receptors: structure and function.
Journal
Reference
Authors
Kornau HC
Title
GABA(B) receptors and synaptic modulation.
Journal
Reference
Authors
Jacob TC, Moss SJ, Jurd R
Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
Journal
Reference
Authors
Kneussel M
Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
Journal
Reference
Authors
Luscher B, Fuchs T, Kilpatrick CL
Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
Journal
Reference
Authors
Arancibia-Carcamo IL, Kittler JT
Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
Journal
Reference
Authors
Bak LK, Schousboe A, Waagepetersen HS
Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
Journal
Reference
Authors
Conti F, Minelli A, Melone M
Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
Journal
Reference
Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
Title
GABAergic dysfunction in mood disorders.
Journal
Reference
Authors
Chebib M, Johnston GA
Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
Journal
Related pathway
rno00250 Alanine, aspartate and glutamate metabolism
KO pathway