Entry
Name
Epstein-Barr virus infection - Rattus norvegicus (rat)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases. EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
BRITE hierarchy
Pathway map
Ortholog table
Organism
Rattus norvegicus (rat) [GN:
rno ]
Gene
289395 Cr2; complement receptor type 2 precursor [KO:K04012 ]
365367 Cd19; B-lymphocyte antigen CD19 precursor [KO:K06465 ]
294274 RT1-DMa; RT1 class II, DM alpha precursor [KO:K06752 ]
24984 RT1-DOa; RT1 class II, locus DOa precursor [KO:K06752 ]
24986 RT1-Ha; RT1 class II, locus Ha precursor [KO:K06752 ]
294270 RT1-Db1; rano class II histocompatibility antigen, D-1 beta chain precursor [KO:K06752 ]
309621 RT1-Ba; rano class II histocompatibility antigen, B alpha chain precursor [KO:K06752 ]
309622 RT1-Bb; rano class II histocompatibility antigen, B-1 beta chain precursor [KO:K06752 ]
24981 RT1-Db2; RT1 class II, locus Db2 precursor [KO:K06752 ]
301059 Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
315139 Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
308267 Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
81736 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580 ]
311430 Mavs; mitochondrial antiviral-signaling protein [KO:K12648 ]
298213 Ifna2; interferon alpha family, gene 2 precursor [KO:K05414 ]
690894 Ifna1; interferon alpha family, gene 5 precursor [KO:K05414 ]
502961 Ifna4l2; similar to Interferon alpha-1 precursor [KO:K05414 ]
500491 Ifna16l1; interferon, alpha 16-like 1 precursor [KO:K05414 ]
502959 Ifna1l1; similar to put. precursor MuIFN-alpha 5 precursor [KO:K05414 ]
288264 Ifnar1; interferon alpha/beta receptor 1 isoform 1 precursor [KO:K05130 ]
686326 Ifnar2; interferon alpha and beta receptor subunit 2 isoform 1 precursor [KO:K05131 ]
25124 Stat1; signal transducer and activator of transcription 1-alpha/beta isoform beta [KO:K11220 ]
288774 Stat2; signal transducer and activator of transcription 2 [KO:K11221 ]
54287 Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195 ] [EC:2.7.11.1 ]
245920 Cxcl10; C-X-C motif chemokine 10 precursor [KO:K12671 ]
246097 Fas; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390 ]
266610 Fadd; FAS-associated death domain protein [KO:K02373 ]
64625 Bid; BH3-interacting domain death agonist [KO:K04726 ]
78963 Apaf1; apoptotic protease-activating factor 1 [KO:K02084 ]
315609 Cd3e; T-cell surface glycoprotein CD3 epsilon chain precursor [KO:K06451 ]
300678 Cd3g; T-cell surface glycoprotein CD3 gamma chain precursor [KO:K06452 ]
25710 Cd3d; T-cell surface glycoprotein CD3 delta chain precursor [KO:K06450 ]
25300 Cd247; T-cell surface glycoprotein CD3 zeta chain isoform 2 precursor [KO:K06453 ]
25581 Psmc2; 26S proteasome regulatory subunit 7 [KO:K03061 ]
117263 Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062 ]
117262 Psmc4; 26S proteasome regulatory subunit 6B [KO:K03063 ]
289990 Psmc6; 26S proteasome regulatory subunit 10B [KO:K03064 ]
29677 Psmc3; 26S proteasome regulatory subunit 6A [KO:K03065 ]
81827 Psmc5; 26S proteasome regulatory subunit 8 [KO:K03066 ]
287984 Psmd2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028 ]
83806 Psmd1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032 ]
287670 Psmd3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033 ]
287772 Psmd12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035 ]
303353 Psmd11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036 ]
289924 Psmd6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037 ]
307821 Psmd7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038 ]
365388 Psmd13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039 ]
83499 Psmd4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029 ]
311078 Psmd14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030 ]
292766 Psmd8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031 ]
65138 Adrm1; proteasomal ubiquitin receptor ADRM1 [KO:K06691 ]
680532 Sem1; 26S proteasome complex subunit SEM1 [KO:K10881 ]
24747 RT1-M3-1; RT1 class Ib, locus M3-1 precursor [KO:K06751 ]
24973 RT1-A1; RT1 class Ia, locus A1 precursor [KO:K06751 ]
24974 RT1-A2; RT1 class Ia, locus A2 precursor [KO:K06751 ]
24988 RT1-M2; RT1 class Ib, locus M2 precursor [KO:K06751 ]
294213 RT1-M1-4; RT1 class I, locus M1, gene 4 precursor [KO:K06751 ]
309600 RT1-CE12; RT1 class I, locus CE12 precursor [KO:K06751 ]
309603 RT1-CE1; RT1 class I, locus CE1 precursor [KO:K06751 ]
309607 RT1-CE5; RT1 class I, locus CE5 isoform 1 precursor [KO:K06751 ]
361787 RT1-T24-1; RT1 class I, locus T24, gene 1 isoform 1 [KO:K06751 ]
365527 RT1-M6-2; RT1 class I, locus M6, gene 2 precursor [KO:K06751 ]
368153 RT1-CE7; RT1 class I, locus CE7 precursor [KO:K06751 ]
414779 RT1-CE2; RT1 class I, locus CE2 precursor [KO:K06751 ]
414783 RT1-CE4; RT1 class I, locus CE4 precursor [KO:K06751 ]
414784 RT1-T24-4; RT1 class I, locus T24, gene 4 [KO:K06751 ]
414785 RT1-M6-1; RT1 class I, locus M6, gene 1 precursor [KO:K06751 ]
414786 RT1-M1-2; RT1 class I, locus M1, gene 2 precursor [KO:K06751 ]
414789 RT1-CE15; RT1 class I, locus CE15 precursor [KO:K06751 ]
414790 RT1-CE13; RT1 class I, locus CE13 precursor [KO:K06751 ]
414791 RT1-CE11; RT1 class I, locus CE11 precursor [KO:K06751 ]
414792 RT1-CE10; RT1 class I, locus CE10 precursor [KO:K06751 ]
414793 RT1-CE3; RT1 class I, locus CE3 precursor [KO:K06751 ]
414819 RT1-CE16; RT1 class I, locus CE16 precursor [KO:K06751 ]
406194 RT1-T18; RT1 class Ib, locus T18 precursor [KO:K06751 ]
414788 RT1-T24-3; RT1 class I, locus T24, gene 3 [KO:K06751 ]
680842 RT1-M1-5; RT1 class I, M1, gene 5 precursor [KO:K06751 ]
102546590 H2-M10.6l; patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751 ]
499400 RT1-M5; RT1 class Ib, locus M5 isoform 2 precursor [KO:K06751 ]
363067 Sin3a; paired amphipathic helix protein Sin3a [KO:K11644 ]
680122 Sap30; histone deacetylase complex subunit SAP30 [KO:K19202 ]
360531 Sap30l; histone deacetylase complex subunit SAP30L [KO:K19202 ]
362149 Cir1; corepressor interacting with RBPJ 1 [KO:K06066 ]
362268 Rbpjl; recombining binding protein suppressor of hairless-like protein [KO:K06053 ]
679028 Rbpj; recombining binding protein suppressor of hairless isoform 1 [KO:K06053 ]
171075 Fcer2; low affinity immunoglobulin epsilon Fc receptor isoform a [KO:K06468 ]
156726 Runx3; runt-related transcription factor 3 isoform 2 [KO:K09279 ]
114851 Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625 ]
25112 Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402 ]
291005 Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
299626 Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
85243 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
170911 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
366508 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
134484121 LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
25513 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
60664 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
29741 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
309452 Nfkb2; nuclear factor NF-kappa-B p100 subunit [KO:K04469 ]
246756 Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
363855 Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform 1 [KO:K04431 ] [EC:2.7.12.2 ]
171369 Cd40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160 ]
25464 Icam1; intercellular adhesion molecule 1 precursor [KO:K06490 ]
25125 Stat3; signal transducer and activator of transcription 3 [KO:K04692 ]
363875 Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
29337 Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859 ] [EC:3.1.4.11 ]
294790 Skp2; S-phase kinase-associated protein 2 [KO:K03875 ]
83571 Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624 ]
24708 Rb1; retinoblastoma-associated protein [KO:K06618 ]
684111 E2f2; transcription factor E2F2 isoform X2 [KO:K09389 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Young LS, Rickinson AB.
Title
Epstein-Barr virus: 40 years on.
Journal
Reference
Authors
Saha A, Robertson ES
Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
Journal
Reference
Authors
Ning S
Title
Innate immune modulation in EBV infection.
Journal
Reference
Authors
Stanfield BA, Luftig MA
Title
Recent advances in understanding Epstein-Barr virus.
Journal
Reference
Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
Journal
Reference
Authors
Rajsbaum R, Garcia-Sastre A
Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
Journal
Reference
Authors
Hoffmann HH, Schneider WM, Rice CM
Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
Journal
Reference
Authors
Spender LC, Inman GJ
Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
Journal
Reference
Authors
Fu Q, He C, Mao ZR
Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
Journal
Reference
Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
Journal
Reference
Authors
Melchjorsen J
Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
Journal
Reference
Authors
Hansen TH, Bouvier M
Title
MHC class I antigen presentation: learning from viral evasion strategies.
Journal
Reference
Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
Journal
Reference
Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
Journal
Reference
Authors
Ghosh Roy S, Robertson ES, Saha A
Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
Journal
Reference
Authors
Dawson CW, Port RJ, Young LS
Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
Journal
Reference
Authors
Cai Q, Chen K, Young KH
Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
Journal
Reference
Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
Authors
Ersing I, Bernhardt K, Gewurz BE
Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
Journal
Reference
Authors
Wang LW, Jiang S, Gewurz BE
Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
Journal
Reference
Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
Journal
Reference
Authors
Edwards RH, Marquitz AR, Raab-Traub N
Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
Journal
Reference
Authors
Thorley-Lawson DA
Title
Epstein-Barr virus: exploiting the immune system.
Journal
Reference
Authors
Eliopoulos AG, Young LS
Title
LMP1 structure and signal transduction.
Journal
Reference
Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
Journal
Reference
Authors
Kang H, Kiess A, Chung CH
Title
Emerging biomarkers in head and neck cancer in the era of genomics.
Journal
Reference
Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
Journal
Reference
Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
Journal
Reference
Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
Journal
Reference
Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
Journal
Reference
Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
Journal
Reference
Authors
Longnecker R
Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
Journal
Reference
Authors
El-Sharkawy A, Al Zaidan L, Malki A
Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
Journal
Reference
Authors
Dolcetti R, Masucci MG
Title
Epstein-Barr virus: induction and control of cell transformation.
Journal
Reference
Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
Journal
Related pathway
rno04612 Antigen processing and presentation
rno04620 Toll-like receptor signaling pathway
rno04622 RIG-I-like receptor signaling pathway
rno04662 B cell receptor signaling pathway
KO pathway