KEGG   PATHWAY: sbh00010Help
Entry
sbh00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis - Streptomyces bingchenggensis
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Glycolysis / Gluconeogenesis
sbh00010

All organismsOrtholog table
Module
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:sbh00010]
Glycolysis, core module involving three-carbon compounds [PATH:sbh00010]
Gluconeogenesis, oxaloacetate => fructose-6P [PATH:sbh00010]
Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:sbh00010]
Other DBs
Organism
Streptomyces bingchenggensis [GN:sbh]
Gene
sugar kinase; K00845 glucokinase [EC:2.7.1.2] [KO:K00845] [EC:2.7.1.2]
glucokinase; K00845 glucokinase [EC:2.7.1.2] [KO:K00845] [EC:2.7.1.2]
sugar kinase; K00845 glucokinase [EC:2.7.1.2] [KO:K00845] [EC:2.7.1.2]
sugar kinase; K00845 glucokinase [EC:2.7.1.2] [KO:K00845] [EC:2.7.1.2]
sugar kinase; K00845 glucokinase [EC:2.7.1.2] [KO:K00845] [EC:2.7.1.2]
pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
pfkA1; 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
pfkA3; 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
pfkA4; 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
pfkA2; 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
glpX; fructose 1,6-bisphosphatase II [KO:K02446] [EC:3.1.3.11]
putative aldehyde lyase; K11645 fructose-bisphosphate aldolase, class I [EC:4.1.2.13] [KO:K11645] [EC:4.1.2.13]
ketose-bisphosphate aldolase; K01624 fructose-bisphosphate aldolase, class II [EC:4.1.2.13] [KO:K01624] [EC:4.1.2.13]
fbaA; fructose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
triosephosphate isomerase; K01803 triosephosphate isomerase (TIM) [EC:5.3.1.1] [KO:K01803] [EC:5.3.1.1]
tpiA; triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
gap2; glyceraldehyde-3-phosphate dehydrogenase, type I [KO:K00134] [EC:1.2.1.12]
gap3; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
gap4; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
gap1; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
pgk; phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
mutase; K15634 probable phosphoglycerate mutase [EC:5.4.2.12] [KO:K15634] [EC:5.4.2.12]
putative phosphatase; K15634 probable phosphoglycerate mutase [EC:5.4.2.12] [KO:K15634] [EC:5.4.2.12]
gpm4; putative phosphoglycerate mutase [KO:K15634] [EC:5.4.2.12]
bifunctional RNase H/acid phosphatase; K15634 probable phosphoglycerate mutase [EC:5.4.2.12] [KO:K15634] [EC:5.4.2.12]
gpm3; phosphoglycerate mutase [KO:K15634] [EC:5.4.2.12]
phosphoglycerate mutase family member 5; K15634 probable phosphoglycerate mutase [EC:5.4.2.12] [KO:K15634] [EC:5.4.2.12]
gpm1; putative phosphoglycerate mutase [KO:K15634] [EC:5.4.2.12]
eno; phosphopyruvate hydratase [KO:K01689] [EC:4.2.1.11]
pykA1; pyruvate kinase [KO:K00873] [EC:2.7.1.40]
pykA2; putative pyruvate kinase [KO:K00873] [EC:2.7.1.40]
aceE; pyruvate dehydrogenase subunit E1 [KO:K00163] [EC:1.2.4.1]
aceE1; 2-oxoacid dehydrogenase subunit E1 [KO:K00163] [EC:1.2.4.1]
3-methyl-2-oxobutanoate dehydrogenase E1-alpha chain; K00161 pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1] [KO:K00161] [EC:1.2.4.1]
putative branched-chain alpha keto acid dehydrogenase E1 alpha subunit; K00161 pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1] [KO:K00161] [EC:1.2.4.1]
branched-chain alpha keto acid dehydrogenase E1 beta subunit; K00162 pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1] [KO:K00162] [EC:1.2.4.1]
branched-chain alpha keto acid dehydrogenase E1 beta subunit; K00162 pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1] [KO:K00162] [EC:1.2.4.1]
branched-chain alpha-keto acid dehydrogenase subunit E2; K00627 pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [EC:2.3.1.12] [KO:K00627] [EC:2.3.1.12]
branched-chain alpha-keto acid dehydrogenase subunit E2; K00627 pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [EC:2.3.1.12] [KO:K00627] [EC:2.3.1.12]
putative oxidoreductase; K00382 dihydrolipoamide dehydrogenase [EC:1.8.1.4] [KO:K00382] [EC:1.8.1.4]
flavoprotein disulfide reductase; K00382 dihydrolipoamide dehydrogenase [EC:1.8.1.4] [KO:K00382] [EC:1.8.1.4]
lpdA2; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
lpdA3; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
lpdA1; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
alcohol dehydrogenase; K00121 S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1] [KO:K00121] [EC:1.1.1.1 1.1.1.284]
putative zinc-binding dehydrogenase; K00121 S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1] [KO:K00121] [EC:1.1.1.1 1.1.1.284]
alcohol dehydrogenase GroES-like protein; K13953 alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] [KO:K13953] [EC:1.1.1.1]
alcohol dehydrogenase GroES-like protein; K13953 alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] [KO:K13953] [EC:1.1.1.1]
aldehyde dehydrogenase; K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [KO:K00128] [EC:1.2.1.3]
aldehyde dehydrogenase; K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [KO:K00128] [EC:1.2.1.3]
aldehyde dehydrogenase; K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [KO:K00128] [EC:1.2.1.3]
aldehyde dehydrogenase; K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [KO:K00128] [EC:1.2.1.3]
putative acyl-CoA synthetase; K01895 acetyl-CoA synthetase [EC:6.2.1.1] [KO:K01895] [EC:6.2.1.1]
putative acetyl-coprotein A synthetase; K01895 acetyl-CoA synthetase [EC:6.2.1.1] [KO:K01895] [EC:6.2.1.1]
acetyl-CoA synthetase; K01895 acetyl-CoA synthetase [EC:6.2.1.1] [KO:K01895] [EC:6.2.1.1]
aldose 1-epimerase; K01785 aldose 1-epimerase [EC:5.1.3.3] [KO:K01785] [EC:5.1.3.3]
ppgK; putative polyphosphate glucokinase [KO:K00886] [EC:2.7.1.63]
phosphoenolpyruvate carboxykinase; K01596 phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32] [KO:K01596] [EC:4.1.1.32]
glucosidase; K01222 6-phospho-beta-glucosidase [EC:3.2.1.86] [KO:K01222] [EC:3.2.1.86]
putative sugar hydrolase; K01222 6-phospho-beta-glucosidase [EC:3.2.1.86] [KO:K01222] [EC:3.2.1.86]
6-phospho-beta-glucosidase; K01222 6-phospho-beta-glucosidase [EC:3.2.1.86] [KO:K01222] [EC:3.2.1.86]
phosphoenolpyruvate-dependent sugar phosphotransferase; K02777 PTS system, glucose-specific IIA component [EC:2.7.1.69] [KO:K02777] [EC:2.7.1.69]
Compound
C00022  
Pyruvate
C00024  
Acetyl-CoA
C00031  
D-Glucose
C00033  
Acetate
C00036  
Oxaloacetate
C00068  
Thiamin diphosphate
C00074  
Phosphoenolpyruvate
C00084  
Acetaldehyde
C00103  
D-Glucose 1-phosphate
C00111  
Glycerone phosphate
C00118  
D-Glyceraldehyde 3-phosphate
C00186  
(S)-Lactate
C00197  
3-Phospho-D-glycerate
C00221  
beta-D-Glucose
C00236  
3-Phospho-D-glyceroyl phosphate
C00267  
alpha-D-Glucose
C00469  
Ethanol
C00631  
2-Phospho-D-glycerate
C00668  
alpha-D-Glucose 6-phosphate
C01159  
2,3-Bisphospho-D-glycerate
C01172  
beta-D-Glucose 6-phosphate
C01451  
Salicin
C05125  
2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  
beta-D-Fructose 6-phosphate
C05378  
beta-D-Fructose 1,6-bisphosphate
C06186  
Arbutin
C06187  
Arbutin 6-phosphate
C06188  
Salicin 6-phosphate
C15972  
Enzyme N6-(lipoyl)lysine
C15973  
Enzyme N6-(dihydrolipoyl)lysine
C16255  
[Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
KO pathway
 

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