KEGG PATHWAY: sbh00010

PATHWAY: sbh00010

Entry

sbh00010 Pathway

Name

Glycolysis / Gluconeogenesis - Streptomyces bingchenggensis

Description

Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].

Class

Metabolism; Carbohydrate metabolism

Pathway map

sbh00010

Glycolysis / Gluconeogenesis

Module

sbh_M00001	Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:sbh00010]
sbh_M00002	Glycolysis, core module involving three-carbon compounds [PATH:sbh00010]
sbh_M00003	Gluconeogenesis, oxaloacetate => fructose-6P [PATH:sbh00010]
sbh_M00307	Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:sbh00010]

Other DBs

BSID:

548382

GO:

0006096 0006094

Organism

Streptomyces bingchenggensis [GN:sbh]

Gene

SBI_04955	sugar kinase; K00845 glucokinase [EC:2.7.1.2] [KO:K00845] [EC:2.7.1.2]
SBI_07836	glucokinase; K00845 glucokinase [EC:2.7.1.2] [KO:K00845] [EC:2.7.1.2]
SBI_09537	sugar kinase; K00845 glucokinase [EC:2.7.1.2] [KO:K00845] [EC:2.7.1.2]
SBI_02021	sugar kinase; K00845 glucokinase [EC:2.7.1.2] [KO:K00845] [EC:2.7.1.2]
SBI_02907	sugar kinase; K00845 glucokinase [EC:2.7.1.2] [KO:K00845] [EC:2.7.1.2]
SBI_00351	pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
SBI_08035	pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
SBI_00874	pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
SBI_03731	pfkA1; 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
SBI_07843	pfkA3; 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
SBI_08890	pfkA4; 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
SBI_05228	pfkA2; 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
SBI_04163	glpX; fructose 1,6-bisphosphatase II [KO:K02446] [EC:3.1.3.11]
SBI_00963	ketose-bisphosphate aldolase; K01624 fructose-bisphosphate aldolase, class II [EC:4.1.2.13] [KO:K01624] [EC:4.1.2.13]
SBI_05675	fbaA; fructose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
SBI_04328	triosephosphate isomerase; K01803 triosephosphate isomerase (TIM) [EC:5.3.1.1] [KO:K01803] [EC:5.3.1.1]
SBI_08031	tpiA; triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
SBI_00942	gap2; glyceraldehyde-3-phosphate dehydrogenase, type I [KO:K00134] [EC:1.2.1.12]
SBI_08029	gap3; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
SBI_09132	gap4; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
SBI_00042	gap1; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
SBI_08030	pgk; phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
SBI_05003	gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
SBI_06882	mutase; K15634 probable phosphoglycerate mutase [EC:5.4.2.12] [KO:K15634] [EC:5.4.2.12]
SBI_07389	putative phosphatase; K15634 probable phosphoglycerate mutase [EC:5.4.2.12] [KO:K15634] [EC:5.4.2.12]
SBI_07508	gpm4; putative phosphoglycerate mutase [KO:K15634] [EC:5.4.2.12]
SBI_07624	bifunctional RNase H/acid phosphatase; K15634 probable phosphoglycerate mutase [EC:5.4.2.12] [KO:K15634] [EC:5.4.2.12]
SBI_07140	gpm3; phosphoglycerate mutase [KO:K15634] [EC:5.4.2.12]
SBI_00078	phosphoglycerate mutase family member 5; K15634 probable phosphoglycerate mutase [EC:5.4.2.12] [KO:K15634] [EC:5.4.2.12]
SBI_03998	gpm1; putative phosphoglycerate mutase [KO:K15634] [EC:5.4.2.12]
SBI_04562	eno; phosphopyruvate hydratase [KO:K01689] [EC:4.2.1.11]
SBI_03734	pykA1; pyruvate kinase [KO:K00873] [EC:2.7.1.40]
SBI_07970	pykA2; putative pyruvate kinase [KO:K00873] [EC:2.7.1.40]
SBI_07474	aceE; pyruvate dehydrogenase subunit E1 [KO:K00163] [EC:1.2.4.1]
SBI_07787	aceE1; 2-oxoacid dehydrogenase subunit E1 [KO:K00163] [EC:1.2.4.1]
SBI_05430	3-methyl-2-oxobutanoate dehydrogenase E1-alpha chain; K00161 pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1] [KO:K00161] [EC:1.2.4.1]
SBI_05443	putative branched-chain alpha keto acid dehydrogenase E1 alpha subunit; K00161 pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1] [KO:K00161] [EC:1.2.4.1]
SBI_05431	branched-chain alpha keto acid dehydrogenase E1 beta subunit; K00162 pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1] [KO:K00162] [EC:1.2.4.1]
SBI_05444	branched-chain alpha keto acid dehydrogenase E1 beta subunit; K00162 pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1] [KO:K00162] [EC:1.2.4.1]
SBI_05432	branched-chain alpha-keto acid dehydrogenase subunit E2; K00627 pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [EC:2.3.1.12] [KO:K00627] [EC:2.3.1.12]
SBI_05445	branched-chain alpha-keto acid dehydrogenase subunit E2; K00627 pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [EC:2.3.1.12] [KO:K00627] [EC:2.3.1.12]
SBI_02985	putative oxidoreductase; K00382 dihydrolipoamide dehydrogenase [EC:1.8.1.4] [KO:K00382] [EC:1.8.1.4]
SBI_04616	flavoprotein disulfide reductase; K00382 dihydrolipoamide dehydrogenase [EC:1.8.1.4] [KO:K00382] [EC:1.8.1.4]
SBI_07790	lpdA2; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SBI_09038	lpdA3; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SBI_03053	lpdA1; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SBI_06288	alcohol dehydrogenase; K00121 S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1] [KO:K00121] [EC:1.1.1.1 1.1.1.284]
SBI_07618	putative zinc-binding dehydrogenase; K00121 S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1] [KO:K00121] [EC:1.1.1.1 1.1.1.284]
SBI_07046	alcohol dehydrogenase GroES-like protein; K13953 alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] [KO:K13953] [EC:1.1.1.1]
SBI_09850	alcohol dehydrogenase GroES-like protein; K13953 alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] [KO:K13953] [EC:1.1.1.1]
SBI_05901	aldehyde dehydrogenase; K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [KO:K00128] [EC:1.2.1.3]
SBI_00463	aldehyde dehydrogenase; K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [KO:K00128] [EC:1.2.1.3]
SBI_04639	aldehyde dehydrogenase; K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [KO:K00128] [EC:1.2.1.3]
SBI_02310	aldehyde dehydrogenase; K00138 aldehyde dehydrogenase [EC:1.2.1.-] [KO:K00138] [EC:1.2.1.-]
SBI_00994	putative acyl-CoA synthetase; K01895 acetyl-CoA synthetase [EC:6.2.1.1] [KO:K01895] [EC:6.2.1.1]
SBI_02959	putative acetyl-coprotein A synthetase; K01895 acetyl-CoA synthetase [EC:6.2.1.1] [KO:K01895] [EC:6.2.1.1]
SBI_05828	acetyl-CoA synthetase; K01895 acetyl-CoA synthetase [EC:6.2.1.1] [KO:K01895] [EC:6.2.1.1]
SBI_06477	acetyl-CoA synthetase; K01895 acetyl-CoA synthetase [EC:6.2.1.1] [KO:K01895] [EC:6.2.1.1]
SBI_07430	aldose 1-epimerase; K01785 aldose 1-epimerase [EC:5.1.3.3] [KO:K01785] [EC:5.1.3.3]
SBI_04157	ppgK; putative polyphosphate glucokinase [KO:K00886] [EC:2.7.1.63]
SBI_04261	phosphoenolpyruvate carboxykinase; K01596 phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32] [KO:K01596] [EC:4.1.1.32]
SBI_07013	glucosidase; K01222 6-phospho-beta-glucosidase [EC:3.2.1.86] [KO:K01222] [EC:3.2.1.86]
SBI_07071	putative sugar hydrolase; K01222 6-phospho-beta-glucosidase [EC:3.2.1.86] [KO:K01222] [EC:3.2.1.86]
SBI_02139	6-phospho-beta-glucosidase; K01222 6-phospho-beta-glucosidase [EC:3.2.1.86] [KO:K01222] [EC:3.2.1.86]
SBI_01986	phosphoenolpyruvate-dependent sugar phosphotransferase; K02777 PTS system, glucose-specific IIA component [EC:2.7.1.69] [KO:K02777] [EC:2.7.1.69]

Compound

C00022	Pyruvate
C00024	Acetyl-CoA
C00031	D-Glucose
C00033	Acetate
C00036	Oxaloacetate
C00068	Thiamin diphosphate
C00074	Phosphoenolpyruvate
C00084	Acetaldehyde
C00103	D-Glucose 1-phosphate
C00111	Glycerone phosphate
C00118	D-Glyceraldehyde 3-phosphate
C00186	(S)-Lactate
C00197	3-Phospho-D-glycerate
C00221	beta-D-Glucose
C00236	3-Phospho-D-glyceroyl phosphate
C00267	alpha-D-Glucose
C00469	Ethanol
C00631	2-Phospho-D-glycerate
C00668	alpha-D-Glucose 6-phosphate
C01159	2,3-Bisphospho-D-glycerate
C01172	beta-D-Glucose 6-phosphate
C01451	Salicin
C05125	2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345	beta-D-Fructose 6-phosphate
C05378	beta-D-Fructose 1,6-bisphosphate
C06186	Arbutin
C06187	Arbutin 6-phosphate
C06188	Salicin 6-phosphate
C15972	Enzyme N6-(lipoyl)lysine
C15973	Enzyme N6-(dihydrolipoyl)lysine
C16255	[Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine

Reference

(map 1)

Authors

Nishizuka Y (ed).

Title

[Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1980)

Reference

(map 1)

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

Authors

Michal G.

Title

Biochemical Pathways

Journal

Wiley (1999)

KO pathway

ko00010

All links

Pathway (5)   
   KEGG MODULE (4)   
   BioSystems (1)   
Gene (65)   
   KEGG GENES (65)   
All databases (70)   

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