KEGG   PATHWAY: sbh00010Help
Entry
sbh00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis - Streptomyces bingchenggensis
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
sbh00010  Glycolysis / Gluconeogenesis
sbh00010

Ortholog table
Module
sbh_M00002  Glycolysis, core module involving three-carbon compounds [PATH:sbh00010]
sbh_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:sbh00010]
sbh_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:sbh00010]
Other DBs
BSID: 548382
GO: 0006096 0006094
Organism
Streptomyces bingchenggensis [GN:sbh]
Gene
SBI_04955  sugar kinase [KO:K00845] [EC:2.7.1.2]
SBI_07836  glucokinase [KO:K00845] [EC:2.7.1.2]
SBI_09537  sugar kinase [KO:K00845] [EC:2.7.1.2]
SBI_02021  sugar kinase [KO:K00845] [EC:2.7.1.2]
SBI_02907  sugar kinase [KO:K00845] [EC:2.7.1.2]
SBI_00351  pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
SBI_08035  pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
SBI_00874  pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
SBI_08890  pfkA4; 6-phosphofructokinase [KO:K21071] [EC:2.7.1.90 2.7.1.11]
SBI_05228  pfkA2; 6-phosphofructokinase [KO:K21071] [EC:2.7.1.90 2.7.1.11]
SBI_07843  pfkA3; 6-phosphofructokinase [KO:K21071] [EC:2.7.1.90 2.7.1.11]
SBI_03731  pfkA1; 6-phosphofructokinase [KO:K21071] [EC:2.7.1.90 2.7.1.11]
SBI_04163  glpX; fructose 1,6-bisphosphatase II [KO:K02446] [EC:3.1.3.11]
SBI_00963  ketose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
SBI_05675  fbaA; fructose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
SBI_04328  triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
SBI_08031  tpiA; triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
SBI_00942  gap2; glyceraldehyde-3-phosphate dehydrogenase, type I [KO:K00134] [EC:1.2.1.12]
SBI_08029  gap3; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
SBI_09132  gap4; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
SBI_00042  gap1; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
SBI_08030  pgk; phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
SBI_05003  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
SBI_04562  eno; phosphopyruvate hydratase [KO:K01689] [EC:4.2.1.11]
SBI_03734  pykA1; pyruvate kinase [KO:K00873] [EC:2.7.1.40]
SBI_07970  pykA2; putative pyruvate kinase [KO:K00873] [EC:2.7.1.40]
SBI_07474  aceE; pyruvate dehydrogenase subunit E1 [KO:K00163] [EC:1.2.4.1]
SBI_07787  aceE1; 2-oxoacid dehydrogenase subunit E1 [KO:K00163] [EC:1.2.4.1]
SBI_05430  3-methyl-2-oxobutanoate dehydrogenase E1-alpha chain [KO:K00161] [EC:1.2.4.1]
SBI_05443  putative branched-chain alpha keto acid dehydrogenase E1 alpha subunit [KO:K00161] [EC:1.2.4.1]
SBI_05431  branched-chain alpha keto acid dehydrogenase E1 beta subunit [KO:K00162] [EC:1.2.4.1]
SBI_05444  branched-chain alpha keto acid dehydrogenase E1 beta subunit [KO:K00162] [EC:1.2.4.1]
SBI_05432  branched-chain alpha-keto acid dehydrogenase subunit E2 [KO:K00627] [EC:2.3.1.12]
SBI_05445  branched-chain alpha-keto acid dehydrogenase subunit E2 [KO:K00627] [EC:2.3.1.12]
SBI_02985  putative oxidoreductase [KO:K00382] [EC:1.8.1.4]
SBI_04616  flavoprotein disulfide reductase [KO:K00382] [EC:1.8.1.4]
SBI_07790  lpdA2; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SBI_09038  lpdA3; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SBI_03053  lpdA1; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SBI_06127  putative ferrodoxin oxidoreductase alpha subunit [KO:K00174] [EC:1.2.7.11 1.2.7.3]
SBI_06126  2-oxoglutarate ferredoxin oxidoreductase subunit beta [KO:K00175] [EC:1.2.7.11 1.2.7.3]
SBI_06288  alcohol dehydrogenase [KO:K00121] [EC:1.1.1.1 1.1.1.284]
SBI_07618  putative zinc-binding dehydrogenase [KO:K00121] [EC:1.1.1.1 1.1.1.284]
SBI_07046  alcohol dehydrogenase GroES-like protein [KO:K13953] [EC:1.1.1.1]
SBI_09850  alcohol dehydrogenase GroES-like protein [KO:K13953] [EC:1.1.1.1]
SBI_05901  aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SBI_00463  aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SBI_04639  aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SBI_02310  aldehyde dehydrogenase [KO:K00138] [EC:1.2.1.-]
SBI_00994  putative acyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
SBI_02959  putative acetyl-coprotein A synthetase [KO:K01895] [EC:6.2.1.1]
SBI_05828  acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
SBI_06477  acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
SBI_07430  aldose 1-epimerase [KO:K01785] [EC:5.1.3.3]
SBI_05673  hypothetical protein [KO:K01785] [EC:5.1.3.3]
SBI_04157  ppgK; putative polyphosphate glucokinase [KO:K00886] [EC:2.7.1.63]
SBI_04261  phosphoenolpyruvate carboxykinase [KO:K01596] [EC:4.1.1.32]
SBI_07013  glucosidase [KO:K01222] [EC:3.2.1.86]
SBI_07071  putative sugar hydrolase [KO:K01222] [EC:3.2.1.86]
SBI_02139  6-phospho-beta-glucosidase [KO:K01222] [EC:3.2.1.86]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
KO pathway
ko00010   

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