KEGG   PATHWAY: scm04146
Entry
scm04146                    Pathway                                
Name
Peroxisome - Schizophyllum commune
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
scm04146  Peroxisome
scm04146

Other DBs
GO: 0005777
Organism
Schizophyllum commune [GN:scm]
Gene
SCHCO_02612428  SCHCODRAFT_02612428; peroxisome membrane protein [KO:K13335]
SCHCO_02643675  SCHCODRAFT_02643675; Pex19-domain-containing protein [KO:K13337]
SCHCO_02702947  SCHCODRAFT_02702947; AAA-domain-containing protein [KO:K13338]
SCHCO_02695288  SCHCODRAFT_02695288; AAA-domain-containing protein [KO:K13339]
SCHCO_02619568  SCHCODRAFT_02619568; WD40 repeat-like protein [KO:K13341]
SCHCO_02507610  SCHCODRAFT_02507610; TPR-like protein [KO:K13342]
SCHCO_02611097  SCHCODRAFT_02611097; uncharacterized protein [KO:K13343]
SCHCO_02624182  SCHCODRAFT_02624182; uncharacterized protein [KO:K13345]
SCHCO_02609602  SCHCODRAFT_02609602; uncharacterized protein [KO:K13346]
SCHCO_02747415  SCHCODRAFT_02747415; uncharacterized protein [KO:K06664]
SCHCO_02566574  SCHCODRAFT_02566574; uncharacterized protein [KO:K13347]
SCHCO_02604210  SCHCODRAFT_02604210; uncharacterized protein [KO:K13348]
SCHCO_02567275  SCHCODRAFT_02567275; uncharacterized protein [KO:K13348]
SCHCO_02624514  SCHCODRAFT_02624514; uncharacterized protein [KO:K13348]
SCHCO_02612640  SCHCODRAFT_02612640; peroxisomal membrane protein 4 [KO:K13350]
SCHCO_02530642  SCHCODRAFT_02530642; peroxisomal membrane protein 4 [KO:K13350]
SCHCO_02749926  SCHCODRAFT_02749926; mitochondrial carrier [KO:K13354]
SCHCO_02500682  SCHCODRAFT_02500682; mitochondrial carrier [KO:K13354]
SCHCO_02627417  SCHCODRAFT_02627417; mitochondrial carrier [KO:K13354]
SCHCO_01200798  SCHCODRAFT_01200798; CoA-transferase family III [KO:K01796] [EC:5.1.99.4]
SCHCO_02631857  SCHCODRAFT_02631857; phytanoyl-CoA dioxygenase [KO:K00477] [EC:1.14.11.18]
SCHCO_02639639  SCHCODRAFT_02639639; acyl-CoA oxidase [KO:K00232] [EC:1.3.3.6]
SCHCO_02617832  SCHCODRAFT_02617832; thiolase-like protein [KO:K08764] [EC:2.3.1.176]
SCHCO_02510085  SCHCODRAFT_02510085; thiolase [KO:K07513] [EC:2.3.1.16]
SCHCO_02617245  SCHCODRAFT_02617245; thiolase [KO:K07513] [EC:2.3.1.16]
SCHCO_02611836  SCHCODRAFT_02611836; thiolase [KO:K07513] [EC:2.3.1.16]
SCHCO_02641597  SCHCODRAFT_02641597; NAD(P)-binding protein [KO:K13237] [EC:1.3.1.124]
SCHCO_02633256  SCHCODRAFT_02633256; ClpP/crotonase [KO:K12663] [EC:5.3.3.21]
SCHCO_02621533  SCHCODRAFT_02621533; uncharacterized protein [KO:K15628] [EC:7.6.2.4]
SCHCO_02565471  SCHCODRAFT_02565471; uncharacterized protein [KO:K15628] [EC:7.6.2.4]
SCHCO_02607348  SCHCODRAFT_02607348; acetyl-CoA synthetase-like protein [KO:K01897] [EC:6.2.1.3]
SCHCO_02606345  SCHCODRAFT_02606345; uncharacterized protein [KO:K01897] [EC:6.2.1.3]
SCHCO_02752336  SCHCODRAFT_02752336; acetyl-CoA synthetase-like protein [KO:K01897] [EC:6.2.1.3]
SCHCO_02607760  SCHCODRAFT_02607760; ClpP/crotonase [KO:K13239] [EC:5.3.3.8]
SCHCO_02538699  SCHCODRAFT_02538699; uncharacterized protein [KO:K17879] [EC:3.6.1.-]
SCHCO_02521520  SCHCODRAFT_02521520; uncharacterized protein [KO:K03426] [EC:3.6.1.22]
SCHCO_01101178  SCHCODRAFT_01101178; acyltransferase ChoActase/COT/CPT [KO:K00624] [EC:2.3.1.7]
SCHCO_01170927  SCHCODRAFT_01170927; acyltransferase ChoActase/COT/CPT [KO:K00624] [EC:2.3.1.7]
SCHCO_02559216  SCHCODRAFT_02559216; acyltransferase ChoActase/COT/CPT [KO:K00624] [EC:2.3.1.7]
SCHCO_02617999  SCHCODRAFT_02617999; PLP-dependent transferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
SCHCO_02633490  SCHCODRAFT_02633490; nucleotide-binding domain-containing protein [KO:K00273] [EC:1.4.3.3]
SCHCO_01171504  SCHCODRAFT_01171504; DAO-domain-containing protein [KO:K00273] [EC:1.4.3.3]
SCHCO_02611538  SCHCODRAFT_02611538; nucleotide-binding domain-containing protein [KO:K00273] [EC:1.4.3.3]
SCHCO_02624620  SCHCODRAFT_02624620; nucleotide-binding domain-containing protein [KO:K00273] [EC:1.4.3.3]
SCHCO_02637823  SCHCODRAFT_02637823; nucleotide-binding domain-containing protein [KO:K00273] [EC:1.4.3.3]
SCHCO_02637221  SCHCODRAFT_02637221; isocitrate dehydrogenase NADP-dependent [KO:K00031] [EC:1.1.1.42]
SCHCO_02631391  SCHCODRAFT_02631391; FAD dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
SCHCO_02515964  SCHCODRAFT_02515964; FAD dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
SCHCO_02689521  SCHCODRAFT_02689521; aldolase [KO:K01640] [EC:4.1.3.4]
SCHCO_02604628  SCHCODRAFT_02604628; catalase-domain-containing protein [KO:K03781] [EC:1.11.1.6]
SCHCO_02620726  SCHCODRAFT_02620726; catalase-domain-containing protein [KO:K03781] [EC:1.11.1.6]
SCHCO_02605124  SCHCODRAFT_02605124; manganese superoxide dismutase [KO:K04564] [EC:1.15.1.1]
SCHCO_02500694  SCHCODRAFT_02500694; manganese and iron superoxide dismutase [KO:K04564] [EC:1.15.1.1]
SCHCO_02628772  SCHCODRAFT_02628772; manganese and iron superoxide dismutase [KO:K04564] [EC:1.15.1.1]
SCHCO_02625205  SCHCODRAFT_02625205; alpha/beta-hydrolase [KO:K08726] [EC:3.3.2.10 3.1.3.76]
SCHCO_02666784  SCHCODRAFT_02666784; alpha/beta-hydrolase [KO:K08726] [EC:3.3.2.10 3.1.3.76]
SCHCO_02645722  SCHCODRAFT_02645722; alpha/beta-hydrolase [KO:K08726] [EC:3.3.2.10 3.1.3.76]
SCHCO_01159789  SCHCODRAFT_01159789; alpha/beta-hydrolase [KO:K08726] [EC:3.3.2.10 3.1.3.76]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
scm00071  Fatty acid degradation
scm00230  Purine metabolism
scm00564  Glycerophospholipid metabolism
scm00565  Ether lipid metabolism
scm00900  Terpenoid backbone biosynthesis
KO pathway
ko04146   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (58)   
   KEGG GENES (58)   
All databases (59)   

Download RDF
DBGET integrated database retrieval system