KEGG   PATHWAY: sha03440
Entry
sha03440                    Pathway                                
Name
Homologous recombination - Staphylococcus haemolyticus JCSC1435
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
sha03440  Homologous recombination
sha03440

Other DBs
GO: 0000724
Organism
Staphylococcus haemolyticus JCSC1435 [GN:sha]
Gene
SH1285  unnamed protein product; hypothetical protein, similar to single-strand DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
SH1792  single strand DNA binding protein [KO:K03111]
SH2627  ssb; single-strand DNA-binding protein of phage phi PVL [KO:K03111]
SH0938  unnamed protein product; hypothetical protein, similar to single-strand DNA binding protein [KO:K03111]
SH0004  recF; DNA repair and genetic recombination protein [KO:K03629]
SH1350  unnamed protein product; hypothetical protein, similar to DNA repair protein RecO [KO:K03584]
SH2532  recR; recombination protein [KO:K06187]
SH1628  recA; RecA protein [KO:K03553]
SH1234  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
SH1279  ruvA; holliday junction DNA helicase [KO:K03550]
SH1280  ruvB; holliday junction DNA helicase [KO:K03551] [EC:5.6.2.4]
SH1687  recG; ATP-dependent DNA helicase [KO:K03655] [EC:5.6.2.4]
SH1300  unnamed protein product; hypothetical protein, similar to exodeoxyribonuclease V [KO:K03581] [EC:3.1.11.5]
SH1222  dnaE; DNA polymerase III, alpha chain [KO:K02337] [EC:2.7.7.7]
SH1650  polC; DNA polymerase III alpha chain PolC-type [KO:K03763] [EC:2.7.7.7]
SH0002  dnaN; DNA polymerase III beta chain, sliding clamp subunit [KO:K02338] [EC:2.7.7.7]
SH2534  dnaX; DNA polymerase III gamma and tau subunits [KO:K02343] [EC:2.7.7.7]
SH1328  unnamed protein product; similar to unknown protein [KO:K02340] [EC:2.7.7.7]
SH2527  unnamed protein product; DNA polymerase III delta prime subunit homolog [KO:K02341] [EC:2.7.7.7]
SH1059  unnamed protein product; hypothetical protein, similar to DNA polymerase III, alpha chain PolC type [KO:K02342] [EC:2.7.7.7]
SH1702  priA; primosomal protein [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG GENES (21)   
All databases (22)   

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