KEGG   PATHWAY: shb03440
Entry
shb03440                    Pathway                                
Name
Homologous recombination - Salmonella enterica subsp. enterica serovar Heidelberg B182
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
shb03440  Homologous recombination
shb03440

Other DBs
GO: 0000724
Organism
Salmonella enterica subsp. enterica serovar Heidelberg B182 [GN:shb]
Gene
SU5_03543  Single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
SU5_0330  Single-stranded DNA-binding protein [KO:K03111]
SU5_04314  DNA recombination and repair protein RecF [KO:K03629]
SU5_03175  DNA recombination and repair protein RecO [KO:K03584]
SU5_01178  Recombination protein RecR [KO:K06187]
SU5_03310  RecA protein [KO:K03553]
SU5_0102  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
SU5_02506  Holliday junction DNA helicase RuvA [KO:K03550]
SU5_02505  Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
SU5_02509  Crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
SU5_04221  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
SU5_03482  Exodeoxyribonuclease V beta chain [KO:K03582] [EC:3.1.11.5]
SU5_03484  Exodeoxyribonuclease V gamma chain [KO:K03583] [EC:3.1.11.5]
SU5_03481  Exodeoxyribonuclease V alpha chain [KO:K03581] [EC:3.1.11.5]
SU5_0880  DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
SU5_04315  DNA polymerase III beta subunit [KO:K02338] [EC:2.7.7.7]
SU5_01176  DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
SU5_01337  DNA polymerase III delta subunit [KO:K02340] [EC:2.7.7.7]
SU5_01827  DNA polymerase III delta prime subunit [KO:K02341] [EC:2.7.7.7]
SU5_0907  DNA polymerase III epsilon subunit [KO:K02342] [EC:2.7.7.7]
SU5_02487  DNA polymerase III theta subunit [KO:K02345] [EC:2.7.7.7]
SU5_0525  DNA polymerase III chi subunit [KO:K02339] [EC:2.7.7.7]
SU5_0596  DNA polymerase III psi subunit [KO:K02344] [EC:2.7.7.7]
SU5_0193  Helicase PriA essential for DNA replication [KO:K04066] [EC:5.6.2.4]
SU5_0461  Primosomal replication protein N [KO:K02686]
SU5_01173  Primosomal replication protein N prime prime [KO:K04067]
SU5_0586  Primosomal protein I [KO:K02317]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG GENES (27)   
All databases (28)   

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