KEGG   PATHWAY: sma00740
Entry
sma00740                    Pathway                                
Name
Riboflavin metabolism - Streptomyces avermitilis
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
sma00740  Riboflavin metabolism
sma00740

Other DBs
GO: 0006771
Organism
Streptomyces avermitilis [GN:sma]
Gene
SAVERM_4121  ribA3; putative GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]
SAVERM_1791  ribA2; putative GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]
SAVERM_545  ribA4; putative GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]
SAVERM_6904  ribA1; putative GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase (dhbp synthase) [KO:K14652] [EC:4.1.99.12 3.5.4.25]
SAVERM_6905  ribH; putative 6,7-dimethyl-8-ribityllumazine synthase [KO:K00794] [EC:2.5.1.78]
SAVERM_6902  ribC; putative riboflavin synthase alpha subunit [KO:K00793] [EC:2.5.1.9]
SAVERM_2546  ribF; putative riboflavin kinase [KO:K11753] [EC:2.7.1.26 2.7.7.2]
SAVERM_1207  putative NAD(P)H-dependent FMN reductase [KO:K00299] [EC:1.5.1.38]
SAVERM_4764  putative NAD(P)H-dependent FMN reductase [KO:K00299] [EC:1.5.1.38]
SAVERM_3813  putative NADPH-dependent FMN reductase [KO:K00299] [EC:1.5.1.38]
SAVERM_4811  ubiD; putative 3-octaprenyl-4-hydroxybenzoate carboxy-lyase [KO:K03186] [EC:2.5.1.129]
Compound
C00016  FAD
C00044  GTP
C00061  FMN
C00199  D-Ribulose 5-phosphate
C00235  Dimethylallyl diphosphate
C00255  Riboflavin
C00474  Ribitol
C01007  Reduced riboflavin
C01268  5-Amino-6-(5'-phosphoribosylamino)uracil
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C01352  FADH2
C01390  Prenol
C01727  Lumichrome
C01847  Reduced FMN
C03114  Dimethylbenzimidazole
C04332  6,7-Dimethyl-8-(D-ribityl)lumazine
C04454  5-Amino-6-(5'-phospho-D-ribitylamino)uracil
C04732  5-Amino-6-(1-D-ribitylamino)uracil
C05995  7-Hydroxy-6-methyl-8-ribityllumazine
C15556  L-3,4-Dihydroxybutan-2-one 4-phosphate
C15563  2-Amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C18910  2,5-Diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one
C21214  Dimethylallyl phosphate
C21215  Prenylated FMNH2
Reference
PMID:12136096
  Authors
Vitreschak AG, Rodionov DA, Mironov AA, Gelfand MS.
  Title
Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation.
  Journal
Nucleic Acids Res 30:3141-51 (2002)
DOI:10.1093/nar/30.14.3141
Reference
PMID:11856310
  Authors
Fischer M, Haase I, Feicht R, Richter G, Gerhardt S, Changeux JP, Huber R, Bacher A.
  Title
Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe.
  Journal
Eur J Biochem 269:519-26 (2002)
DOI:10.1046/j.0014-2956.2001.02674.x
Reference
PMID:12867427
  Authors
Haase I, Fischer M, Bacher A, Schramek N.
  Title
Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus.
  Journal
J Biol Chem 278:37909-15 (2003)
DOI:10.1074/jbc.M303090200
Reference
PMID:16042598
  Authors
Fischer M, Romisch W, Illarionov B, Eisenreich W, Bacher A.
  Title
Structures and reaction mechanisms of riboflavin synthases of eubacterial and archaeal origin.
  Journal
Biochem Soc Trans 33:780-4 (2005)
DOI:10.1042/BST0330780
Related
pathway
sma00030  Pentose phosphate pathway
sma00040  Pentose and glucuronate interconversions
sma00230  Purine metabolism
sma00860  Porphyrin metabolism
sma00900  Terpenoid backbone biosynthesis
KO pathway
ko00740   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG GENES (11)   
All databases (12)   

Download RDF
DBGET integrated database retrieval system