KEGG   PATHWAY: smt03440
Entry
smt03440                    Pathway                                
Name
Homologous recombination - Stenotrophomonas maltophilia R551-3
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
smt03440  Homologous recombination
smt03440

Other DBs
GO: 0000724
Organism
Stenotrophomonas maltophilia R551-3 [GN:smt]
Gene
Smal_1817  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Smal_1033  single-strand binding protein [KO:K03111]
Smal_0003  DNA replication and repair protein RecF [KO:K03629]
Smal_2973  DNA repair protein RecO [KO:K03584]
Smal_0859  recombination protein RecR [KO:K06187]
Smal_1476  recA protein [KO:K03553]
Smal_3941  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Smal_3126  Holliday junction DNA helicase RuvA [KO:K03550]
Smal_3124  Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
Smal_3127  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
Smal_3256  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
Smal_4014  exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:3.1.11.5]
Smal_4015  exodeoxyribonuclease V, gamma subunit [KO:K03583] [EC:3.1.11.5]
Smal_4013  exodeoxyribonuclease V, alpha subunit [KO:K03581] [EC:3.1.11.5]
Smal_1251  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Smal_0002  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Smal_0857  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
Smal_2910  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Smal_0878  DNA-directed DNA polymerase [KO:K02341] [EC:2.7.7.7]
Smal_0845  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Smal_3952  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Smal_0535  DNA polymerase III chi subunit HolC [KO:K02339] [EC:2.7.7.7]
Smal_3601  primosomal protein N' [KO:K04066] [EC:5.6.2.4]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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