KEGG   PATHWAY: sne03030
Entry
sne03030                    Pathway                                
Name
DNA replication - Streptococcus pneumoniae ATCC 700669 (serotype 23F ST81 lineage)
Description
A complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (DnaB or MCM complex) precedes the DNA synthetic machinery and unwinds the duplex parental DNA in cooperation with the SSB or RPA. On the leading strand, replication occurs continuously in a 5 to 3 direction, whereas on the lagging strand, DNA replication occurs discontinuously by synthesis and joining of short Okazaki fragments. In prokaryotes, the leading strand replication apparatus consists of a DNA polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). The DNA primase (DnaG) is needed to form RNA primers. Normally, during replication of the lagging-strand DNA template, an RNA primer is removed either by an RNase H or by the 5 to 3 exonuclease activity of DNA pol I, and the DNA ligase joins the Okazaki fragments. In eukaryotes, three DNA polymerases (alpha, delta, and epsilon) have been identified. DNA primase forms a permanent complex with DNA polymerase alpha. PCNA and RFC function as a clamp and a clamp loader. FEN 1 and RNase H1 remove the RNA from the Okazaki fragments and DNA ligase I joins the DNA.
Class
Genetic Information Processing; Replication and repair
Pathway map
sne03030  DNA replication
sne03030

Organism
Streptococcus pneumoniae ATCC 700669 (serotype 23F ST81 lineage) [GN:sne]
Gene
SPN23F00020  dnaN; DNA polymerase III, beta chain [KO:K02338] [EC:2.7.7.7]
SPN23F00490  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
SPN23F02600  polC; DNA polymerase III PolC-type [KO:K03763] [EC:2.7.7.7]
SPN23F03800  [KO:K03471] [EC:3.1.26.4]
SPN23F06870  [KO:K02340] [EC:2.7.7.7]
SPN23F07880  dnaH; DNA polymerase III subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
SPN23F08170  dnaE; DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
SPN23F08580  holB; putative DNA polymerase III, delta' subunit [KO:K02341] [EC:2.7.7.7]
SPN23F09180  [KO:K02342] [EC:2.7.7.7]
SPN23F09930  dnaG; DNA primase [KO:K02316] [EC:2.7.7.101]
SPN23F10380  lig; DNA ligase [KO:K01972] [EC:6.5.1.2]
SPN23F10610  rnh; ribonuclease HII [KO:K03470] [EC:3.1.26.4]
SPN23F15030  ssb; single strand binding protein (SSB) [KO:K03111]
SPN23F15680  ssb; putative single-strand DNA-binding protein [KO:K03111]
SPN23F19320  [KO:K03111]
SPN23F22360  dnaC; replicative DNA helicase [KO:K02314] [EC:5.6.2.3]
Reference
PMID:8087839
  Authors
Stillman B.
  Title
Smart machines at the DNA replication fork.
  Journal
Cell 78:725-8 (1994)
DOI:10.1016/S0092-8674(94)90362-X
Reference
PMID:9759502
  Authors
Waga S, Stillman B.
  Title
The DNA replication fork in eukaryotic cells.
  Journal
Annu Rev Biochem 67:721-51 (1998)
DOI:10.1146/annurev.biochem.67.1.721
KO pathway
ko03030   

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