KEGG   PATHWAY: ssc03008Help
Entry
ssc03008                    Pathway                                

Name
Ribosome biogenesis in eukaryotes - Sus scrofa (pig)
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is  assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
Ribosome biogenesis in eukaryotes
ssc03008

All organismsOrtholog table
Module
H/ACA ribonucleoprotein complex [PATH:ssc03008]
Organism
Sus scrofa (pig) [GN:ssc]
Gene
397211  
CSNK2B; casein kinase II subunit beta [KO:K03115]
CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
NOL6; nucleolar protein 6 [KO:K14544]
RRP7A; ribosomal RNA-processing protein 7 homolog A isoform X1 [KO:K14545]
WDR43; WD repeat-containing protein 43 [KO:K14546]
414432  
UTP4; U3 small nucleolar RNA-associated protein 4 homolog [KO:K14548]
UTP15; U3 small nucleolar RNA-associated protein 15 homolog [KO:K14549]
HEATR1; LOW QUALITY PROTEIN: HEAT repeat-containing protein 1 [KO:K14550]
WDR75; WD repeat-containing protein 75 isoform X2 [KO:K14552]
UTP18; U3 small nucleolar RNA-associated protein 18 homolog [KO:K14553]
WDR36; WD repeat-containing protein 36 [KO:K14554]
TBL3; transducin beta-like protein 3 isoform X1 [KO:K14555]
WDR3; WD repeat-containing protein 3 [KO:K14556]
UTP6; U3 small nucleolar RNA-associated protein 6 homolog [KO:K14557]
PWP2; periodic tryptophan protein 2 homolog isoform X1 [KO:K14558]
MPHOSPH10; U3 small nucleolar ribonucleoprotein protein MPP10 [KO:K14559]
IMP3; U3 small nucleolar ribonucleoprotein protein IMP3 [KO:K14560]
IMP4; U3 small nucleolar ribonucleoprotein protein IMP4 isoform X1 [KO:K14561]
TCOF1; treacle protein [KO:K14562]
rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 [KO:K14563] [EC:2.1.1.-]
FBL; rRNA 2'-O-methyltransferase fibrillarin [KO:K14563] [EC:2.1.1.-]
NOP56; nucleolar protein 56 [KO:K14564]
NOP58; nucleolar protein 58 isoform X1 [KO:K14565]
SNU13; NHP2-like protein 1 [KO:K12845]
DKC1; H/ACA ribonucleoprotein complex subunit 4 [KO:K11131] [EC:5.4.99.-]
NHP2; H/ACA ribonucleoprotein complex subunit 2 [KO:K11129]
GAR1; H/ACA ribonucleoprotein complex subunit 1 [KO:K11128]
NOP10; H/ACA ribonucleoprotein complex subunit 3 [KO:K11130]
FCF1; rRNA-processing protein FCF1 homolog isoform X2 [KO:K14566]
UTP14A; U3 small nucleolar RNA-associated protein 14 homolog A isoform X1 [KO:K14567]
DROSHA; LOW QUALITY PROTEIN: ribonuclease 3 [KO:K03685] [EC:3.1.26.3]
EMG1; ribosomal RNA small subunit methyltransferase NEP1 [KO:K14568] [EC:2.1.1.260]
BMS1; ribosome biogenesis protein BMS1 homolog [KO:K14569]
NAT10; RNA cytidine acetyltransferase [KO:K14521] [EC:2.3.1.-]
RCL1; RNA 3'-terminal phosphate cyclase-like protein isoform X1 [KO:K11108]
POP1; ribonucleases P/MRP protein subunit POP1 [KO:K01164] [EC:3.1.26.5]
RPP38; ribonuclease P protein subunit p38 [KO:K14523] [EC:3.1.26.5]
POP4; ribonuclease P protein subunit p29 [KO:K03538] [EC:3.1.26.5]
POP5; ribonuclease P/MRP protein subunit POP5 [KO:K03537] [EC:3.1.26.5]
RPP25; ribonuclease P protein subunit p25 [KO:K14525] [EC:3.1.26.5]
RPP25L; ribonuclease P protein subunit p25-like protein [KO:K14525] [EC:3.1.26.5]
POP7; ribonuclease P protein subunit p20 [KO:K14527] [EC:3.1.26.5]
RPP30; ribonuclease P protein subunit p30 [KO:K03539] [EC:3.1.26.5]
REXO1; RNA exonuclease 1 homolog isoform X3 [KO:K14570] [EC:3.1.-.-]
REXO5; putative RNA exonuclease NEF-sp isoform X1 [KO:K14570] [EC:3.1.-.-]
REXO2; oligoribonuclease, mitochondrial [KO:K13288] [EC:3.1.-.-]
XRN1; LOW QUALITY PROTEIN: 5'-3' exoribonuclease 1 [KO:K12618] [EC:3.1.13.-]
XRN2; LOW QUALITY PROTEIN: 5'-3' exoribonuclease 2 [KO:K12619] [EC:3.1.13.-]
GTPBP4; nucleolar GTP-binding protein 1 [KO:K06943]
GNL2; nucleolar GTP-binding protein 2 isoform X1 [KO:K14537]
GNL3; guanine nucleotide-binding protein-like 3 isoform X2 [KO:K14538]
GNL3L; guanine nucleotide-binding protein-like 3-like protein [KO:K14538]
NVL; nuclear valosin-containing protein-like isoform X1 [KO:K14571]
MDN1; LOW QUALITY PROTEIN: midasin [KO:K14572]
RBM28; RNA-binding protein 28 [KO:K14573]
NOB1; RNA-binding protein NOB1 isoform X1 [KO:K11883]
397655  
RAN; GTP-binding nuclear protein Ran [KO:K07936]
397330  
XPO1; exportin-1 isoform X3 [KO:K14290]
NMD3; 60S ribosomal export protein NMD3 isoform X1 [KO:K07562]
nuclear RNA export factor 2 [KO:K14284]
NXF1; nuclear RNA export factor 1 [KO:K14284]
nuclear RNA export factor 3-like [KO:K14284]
NXT1; NTF2-related export protein 1 [KO:K14285]
NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
EIF6; eukaryotic translation initiation factor 6 [KO:K03264]
SBDS; ribosome maturation protein SBDS [KO:K14574]
EFL1; elongation factor-like GTPase 1 [KO:K14536] [EC:3.6.5.-]
LSG1; LOW QUALITY PROTEIN: large subunit GTPase 1 homolog [KO:K14539] [EC:3.6.1.-]
SPATA5; spermatogenesis-associated protein 5 [KO:K14575]
AK6; adenylate kinase isoenzyme 6 isoform X2 [KO:K18532] [EC:2.7.4.3]
RIOK1; serine/threonine-protein kinase RIO1 [KO:K07178] [EC:2.7.11.1]
RIOK2; LOW QUALITY PROTEIN: serine/threonine-protein kinase RIO2 [KO:K07179] [EC:2.7.11.1]
12S ribosomal RNA [KO:K01979]
RN18S; 18S ribosomal RNA [KO:K01979]
RN5-8S; 5.8S ribosomal RNA [KO:K01986]
16S ribosomal RNA [KO:K01982]
Reference
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
DOI:10.1039/b919670f
Reference
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
DOI:10.1128/MCB.00380-07
Reference
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
DOI:10.1261/rna.1792109
Reference
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
DOI:10.1016/j.yexcr.2004.03.016
Reference
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
DOI:10.1016/j.bbamcr.2009.10.009
KO pathway
 

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