KEGG PATHWAY: ssc03008

PATHWAY: ssc03008

Entry

ssc03008 Pathway

Name

Ribosome biogenesis in eukaryotes - Sus scrofa (pig)

Description

Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.

Class

Genetic Information Processing; Translation

Pathway map

ssc03008

Ribosome biogenesis in eukaryotes

Module

ssc_M00425

H/ACA ribonucleoprotein complex [PATH:ssc03008]

Organism

Sus scrofa (pig) [GN:ssc]

Gene

397211	CSNK2B; casein kinase 2, beta polypeptide [KO:K03115]
100517435	CSNK2A1; casein kinase 2, alpha 1 polypeptide [KO:K03097] [EC:2.7.11.1]
100737256	CSNK2A2; casein kinase 2, alpha prime polypeptide [KO:K03097] [EC:2.7.11.1]
100511276	NOL6; nucleolar protein 6 (RNA-associated) [KO:K14544]
100625121	RRP7A; ribosomal RNA processing 7 homolog A [KO:K14545]
100519832	WDR43; WD repeat domain 43 [KO:K14546]
414432	CIRH1A; cirrhosis, autosomal recessive 1A (cirhin) [KO:K14548]
100515474	UTP15; UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae) [KO:K14549]
100154560	HEATR1; HEAT repeat containing 1 [KO:K14550]
100511538	WDR75; WD repeat domain 75 [KO:K14552]
100517967	UTP18; UTP18 small subunit (SSU) processome component homolog (yeast) [KO:K14553]
100627271	WDR36; WD repeat domain 36 [KO:K14554]
100623969	TBL3; transducin (beta)-like 3 [KO:K14555]
100154556	WDR3; WD repeat domain 3 [KO:K14556]
100524172	UTP6; UTP6, small subunit (SSU) processome component, homolog (yeast) [KO:K14557]
100623705	PWP2; PWP2 periodic tryptophan protein homolog (yeast) [KO:K14558]
100153310	MPHOSPH10; M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) [KO:K14559]
100151831	IMP3; IMP3, U3 small nucleolar ribonucleoprotein [KO:K14560]
100522523	U3 small nucleolar ribonucleoprotein protein IMP4-like; K14561 U3 small nucleolar ribonucleoprotein protein IMP4 [KO:K14561]
100621511	IMP4; U3 small nucleolar ribonucleoprotein protein IMP4 [KO:K14561]
100516425	TCOF1; Treacher Collins-Franceschetti syndrome 1 [KO:K14562]
100512568	rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1; K14563 rRNA 2'-O-methyltransferase fibrillarin [EC:2.1.1.-] [KO:K14563] [EC:2.1.1.-]
100626002	FBL; fibrillarin [KO:K14563] [EC:2.1.1.-]
100512446	NOP56; NOP56 ribonucleoprotein [KO:K14564]
100156132	NOP58; NOP58 ribonucleoprotein [KO:K14565]
100155420	SNU13; SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) [KO:K12845]
100216430	DKC1; dyskeratosis congenita 1, dyskerin [KO:K11131] [EC:5.4.99.-]
100526157	NHP2; NHP2 ribonucleoprotein [KO:K11129]
100516629	GAR1; GAR1 homolog, ribonucleoprotein [KO:K11128]
100156164	NOP10; NOP10 ribonucleoprotein [KO:K11130]
100524688	FCF1; FCF1 rRNA-processing protein [KO:K14566]
100523416	UTP14A; UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) [KO:K14567]
100524961	DROSHA; drosha, ribonuclease type III [KO:K03685] [EC:3.1.26.3]
100627558	EMG1; EMG1 N1-specific pseudouridine methyltransferase [KO:K14568] [EC:2.1.1.260]
100157879	BMS1; BMS1 ribosome biogenesis factor [KO:K14569]
100511365	NAT10; N-acetyltransferase 10 (GCN5-related) [KO:K14521] [EC:2.3.1.-]
100154484	RCL1; RNA terminal phosphate cyclase-like 1 [KO:K11108]
100739449	POP1; POP1 homolog, ribonuclease P/MRP subunit [KO:K01164] [EC:3.1.26.5]
100626611	RPP38; ribonuclease P/MRP 38kDa subunit [KO:K14523] [EC:3.1.26.5]
100523065	POP4; POP4 homolog, ribonuclease P/MRP subunit [KO:K03538] [EC:3.1.26.5]
100151786	POP5; POP5 homolog, ribonuclease P/MRP subunit [KO:K03537] [EC:3.1.26.5]
100157338	RPP25; ribonuclease P/MRP 25kDa subunit [KO:K14525] [EC:3.1.26.5]
100522095	RPP25L; ribonuclease P/MRP 25kDa subunit-like [KO:K14525] [EC:3.1.26.5]
100627239	POP7; POP7 homolog, ribonuclease P/MRP subunit [KO:K14527] [EC:3.1.26.5]
100156540	RPP30; ribonuclease P/MRP 30kDa subunit [KO:K03539] [EC:3.1.26.5]
100522444	RPP40; ribonuclease P/MRP 40kDa subunit [KO:K14530] [EC:3.1.26.5]
100513338	RNA exonuclease 1 homolog; K14570 RNA exonuclease 1 [EC:3.1.-.-] [KO:K14570] [EC:3.1.-.-]
100525449	REXO1; RNA exonuclease 1 homolog [KO:K14570] [EC:3.1.-.-]
100512042	putative RNA exonuclease NEF-sp; K14570 RNA exonuclease 1 [EC:3.1.-.-] [KO:K14570] [EC:3.1.-.-]
100522629	REXO2; RNA exonuclease 2 [KO:K13288] [EC:3.1.-.-]
100515927	XRN1; 5'-3' exoribonuclease 1 [KO:K12618] [EC:3.1.13.-]
100517201	XRN2; 5'-3' exoribonuclease 2 [KO:K12619] [EC:3.1.13.-]
100625226	GTPBP4; nucleolar GTP-binding protein 1 [KO:K06943]
100623150	GNL2; guanine nucleotide binding protein-like 2 (nucleolar) [KO:K14537]
100155235	GNL3; guanine nucleotide binding protein-like 3 (nucleolar) [KO:K14538]
100521120	GNL3L; guanine nucleotide binding protein-like 3 (nucleolar)-like [KO:K14538]
100525725	MDN1; midasin [KO:K14572]
100628057	RBM28; RNA binding motif protein 28 [KO:K14573]
100516270	NOB1; NIN1/RPN12 binding protein 1 homolog [KO:K11883]
397655	RAN; RAN, member RAS oncogene family [KO:K07936]
397330	XPO1; exportin 1 [KO:K14290]
100738482	NMD3; NMD3 ribosome export adaptor [KO:K07562]
100738553	NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
100153087	NXF2B; nuclear RNA export factor 2 [KO:K14284]
100511855	nuclear RNA export factor 2-like; K14284 nuclear RNA export factor [KO:K14284]
100628213	NXF1; nuclear RNA export factor 1 [KO:K14284]
100622292	NXF2; nuclear RNA export factor 2 [KO:K14284]
100514739	NXT1; nuclear transport factor 2-like export factor 1 [KO:K14285]
100521422	NXT2; nuclear transport factor 2-like export factor 2 [KO:K14285]
100627301	EIF6; eukaryotic translation initiation factor 6 [KO:K03264]
100516003	SBDS; Shwachman-Bodian-Diamond syndrome [KO:K14574]
100155652	EFTUD1; elongation factor Tu GTP binding domain containing 1 [KO:K14536] [EC:3.6.5.-]
102165816	EFTUD1; elongation factor Tu GTP-binding domain-containing protein 1-like [KO:K14536] [EC:3.6.5.-]
100155750	LSG1; large 60S subunit nuclear export GTPase 1 [KO:K14539] [EC:3.6.1.-]
100415805	SPATA5; spermatogenesis associated 5 [KO:K14575]
102160117	adenylate kinase isoenzyme 6-like; K18532 adenylate kinase [EC:2.7.4.3] [KO:K18532] [EC:2.7.4.3]
106504175	AK6; adenylate kinase 6 [KO:K18532] [EC:2.7.4.3]
100157926	RIOK1; RIO kinase 1 [KO:K07178] [EC:2.7.11.1]
100511553	RIOK2; RIO kinase 2 [KO:K07179] [EC:2.7.11.1]
12S_rRNA	12S ribosomal RNA; K01979 small subunit ribosomal RNA [KO:K01979]
100861538	RN18S; 18S ribosomal RNA [KO:K01979]
100861536	RN5-8S; 5.8S ribosomal RNA [KO:K01986]
16S_rRNA	16S ribosomal RNA; K01982 large subunit ribosomal RNA [KO:K01982]

Reference

PMID:20174677

Authors

Freed EF, Bleichert F, Dutca LM, Baserga SJ

Title

When ribosomes go bad: diseases of ribosome biogenesis.

Journal

Mol Biosyst 6:481-93 (2010)

Reference

PMID:17515605

Authors

Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M

Title

The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.

Journal

Mol Cell Biol 27:5414-29 (2007)

Reference

PMID:19850913

Authors

Strunk BS, Karbstein K

Title

Powering through ribosome assembly.

Journal

RNA 15:2083-104 (2009)

Reference

PMID:15120992

Authors

Granneman S, Baserga SJ

Title

Ribosome biogenesis: of knobs and RNA processing.

Journal

Exp Cell Res 296:43-50 (2004)

Reference

PMID:19879902

Authors

Kressler D, Hurt E, Bassler J

Title

Driving ribosome assembly.

Journal

Biochim Biophys Acta 1803:673-83 (2010)

KO pathway

ko03008

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (83)   
   KEGG GENES (83)   
All databases (85)   

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