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ssc03008                    Pathway                                

Ribosome biogenesis in eukaryotes - Sus scrofa (pig)
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is  assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Genetic Information Processing; Translation
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Pathway map
Ribosome biogenesis in eukaryotes

All organismsOrtholog table
H/ACA ribonucleoprotein complex [PATH:ssc03008]
Sus scrofa (pig) [GN:ssc]
CSNK2B; casein kinase II subunit beta [KO:K03115]
CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:]
CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:]
NOL6; nucleolar protein 6 [KO:K14544]
RRP7A; ribosomal RNA-processing protein 7 homolog A isoform X1 [KO:K14545]
WDR43; WD repeat-containing protein 43 [KO:K14546]
UTP4; U3 small nucleolar RNA-associated protein 4 homolog [KO:K14548]
UTP15; U3 small nucleolar RNA-associated protein 15 homolog [KO:K14549]
HEATR1; LOW QUALITY PROTEIN: HEAT repeat-containing protein 1 [KO:K14550]
WDR75; WD repeat-containing protein 75 isoform X2 [KO:K14552]
UTP18; U3 small nucleolar RNA-associated protein 18 homolog [KO:K14553]
WDR36; WD repeat-containing protein 36 [KO:K14554]
TBL3; transducin beta-like protein 3 isoform X1 [KO:K14555]
WDR3; WD repeat-containing protein 3 [KO:K14556]
UTP6; U3 small nucleolar RNA-associated protein 6 homolog [KO:K14557]
PWP2; periodic tryptophan protein 2 homolog isoform X1 [KO:K14558]
MPHOSPH10; U3 small nucleolar ribonucleoprotein protein MPP10 [KO:K14559]
IMP3; U3 small nucleolar ribonucleoprotein protein IMP3 [KO:K14560]
IMP4; U3 small nucleolar ribonucleoprotein protein IMP4 isoform X1 [KO:K14561]
TCOF1; treacle protein [KO:K14562]
rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 [KO:K14563] [EC:2.1.1.-]
FBL; rRNA 2'-O-methyltransferase fibrillarin [KO:K14563] [EC:2.1.1.-]
NOP56; nucleolar protein 56 [KO:K14564]
NOP58; nucleolar protein 58 isoform X1 [KO:K14565]
SNU13; NHP2-like protein 1 [KO:K12845]
DKC1; H/ACA ribonucleoprotein complex subunit 4 [KO:K11131] [EC:5.4.99.-]
NHP2; H/ACA ribonucleoprotein complex subunit 2 [KO:K11129]
GAR1; H/ACA ribonucleoprotein complex subunit 1 [KO:K11128]
NOP10; H/ACA ribonucleoprotein complex subunit 3 [KO:K11130]
FCF1; rRNA-processing protein FCF1 homolog isoform X2 [KO:K14566]
UTP14A; U3 small nucleolar RNA-associated protein 14 homolog A isoform X1 [KO:K14567]
DROSHA; LOW QUALITY PROTEIN: ribonuclease 3 [KO:K03685] [EC:]
EMG1; ribosomal RNA small subunit methyltransferase NEP1 [KO:K14568] [EC:]
BMS1; ribosome biogenesis protein BMS1 homolog [KO:K14569]
NAT10; RNA cytidine acetyltransferase [KO:K14521] [EC:2.3.1.-]
RCL1; RNA 3'-terminal phosphate cyclase-like protein isoform X1 [KO:K11108]
POP1; ribonucleases P/MRP protein subunit POP1 [KO:K01164] [EC:]
RPP38; ribonuclease P protein subunit p38 [KO:K14523] [EC:]
POP4; ribonuclease P protein subunit p29 [KO:K03538] [EC:]
POP5; ribonuclease P/MRP protein subunit POP5 [KO:K03537] [EC:]
RPP25; ribonuclease P protein subunit p25 [KO:K14525] [EC:]
RPP25L; ribonuclease P protein subunit p25-like protein [KO:K14525] [EC:]
POP7; ribonuclease P protein subunit p20 [KO:K14527] [EC:]
RPP30; ribonuclease P protein subunit p30 [KO:K03539] [EC:]
REXO1; RNA exonuclease 1 homolog isoform X3 [KO:K14570] [EC:3.1.-.-]
REXO5; putative RNA exonuclease NEF-sp isoform X1 [KO:K14570] [EC:3.1.-.-]
REXO2; oligoribonuclease, mitochondrial [KO:K13288] [EC:3.1.-.-]
XRN1; LOW QUALITY PROTEIN: 5'-3' exoribonuclease 1 [KO:K12618] [EC:3.1.13.-]
XRN2; LOW QUALITY PROTEIN: 5'-3' exoribonuclease 2 [KO:K12619] [EC:3.1.13.-]
GTPBP4; nucleolar GTP-binding protein 1 [KO:K06943]
GNL2; nucleolar GTP-binding protein 2 isoform X1 [KO:K14537]
GNL3; guanine nucleotide-binding protein-like 3 isoform X2 [KO:K14538]
GNL3L; guanine nucleotide-binding protein-like 3-like protein [KO:K14538]
NVL; nuclear valosin-containing protein-like isoform X1 [KO:K14571]
MDN1; LOW QUALITY PROTEIN: midasin [KO:K14572]
RBM28; RNA-binding protein 28 [KO:K14573]
NOB1; RNA-binding protein NOB1 isoform X1 [KO:K11883]
RAN; GTP-binding nuclear protein Ran [KO:K07936]
XPO1; exportin-1 isoform X3 [KO:K14290]
NMD3; 60S ribosomal export protein NMD3 isoform X1 [KO:K07562]
nuclear RNA export factor 2 [KO:K14284]
NXF1; nuclear RNA export factor 1 [KO:K14284]
nuclear RNA export factor 3-like [KO:K14284]
NXT1; NTF2-related export protein 1 [KO:K14285]
NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
EIF6; eukaryotic translation initiation factor 6 [KO:K03264]
SBDS; ribosome maturation protein SBDS [KO:K14574]
EFL1; elongation factor-like GTPase 1 [KO:K14536] [EC:3.6.5.-]
LSG1; LOW QUALITY PROTEIN: large subunit GTPase 1 homolog [KO:K14539] [EC:3.6.1.-]
SPATA5; spermatogenesis-associated protein 5 [KO:K14575]
AK6; adenylate kinase isoenzyme 6 isoform X2 [KO:K18532] [EC:]
RIOK1; serine/threonine-protein kinase RIO1 [KO:K07178] [EC:]
RIOK2; LOW QUALITY PROTEIN: serine/threonine-protein kinase RIO2 [KO:K07179] [EC:]
12S ribosomal RNA [KO:K01979]
RN18S; 18S ribosomal RNA [KO:K01979]
RN5-8S; 5.8S ribosomal RNA [KO:K01986]
16S ribosomal RNA [KO:K01982]
Freed EF, Bleichert F, Dutca LM, Baserga SJ
When ribosomes go bad: diseases of ribosome biogenesis.
Mol Biosyst 6:481-93 (2010)
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
Mol Cell Biol 27:5414-29 (2007)
Strunk BS, Karbstein K
Powering through ribosome assembly.
RNA 15:2083-104 (2009)
Granneman S, Baserga SJ
Ribosome biogenesis: of knobs and RNA processing.
Exp Cell Res 296:43-50 (2004)
Kressler D, Hurt E, Bassler J
Driving ribosome assembly.
Biochim Biophys Acta 1803:673-83 (2010)
KO pathway

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