KEGG   PATHWAY: ssc03008
Entry
ssc03008                    Pathway                                
Name
Ribosome biogenesis in eukaryotes - Sus scrofa (pig)
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
Pathway map
ssc03008  Ribosome biogenesis in eukaryotes
ssc03008

Organism
Sus scrofa (pig) [GN:ssc]
Gene
100151786  POP5; ribonuclease P/MRP protein subunit POP5 [KO:K03537] [EC:3.1.26.5]
100151831  IMP3; U3 small nucleolar ribonucleoprotein protein IMP3 [KO:K14560]
100153087  [KO:K14284]
100153310  MPHOSPH10; U3 small nucleolar ribonucleoprotein protein MPP10 [KO:K14559]
100154484  RCL1; RNA 3'-terminal phosphate cyclase-like protein isoform X1 [KO:K11108]
100154556  WDR3; WD repeat-containing protein 3 [KO:K14556]
100154560  HEATR1; LOW QUALITY PROTEIN: HEAT repeat-containing protein 1 [KO:K14550]
100155235  GNL3; guanine nucleotide-binding protein-like 3 isoform X2 [KO:K14538]
100155420  SNU13; NHP2-like protein 1 [KO:K12845]
100155652  EFL1; elongation factor-like GTPase 1 [KO:K14536] [EC:3.6.5.-]
100155750  LSG1; LOW QUALITY PROTEIN: large subunit GTPase 1 homolog [KO:K14539] [EC:3.6.1.-]
100156132  NOP58; nucleolar protein 58 isoform X1 [KO:K14565]
100156164  NOP10; H/ACA ribonucleoprotein complex subunit 3 [KO:K11130]
100156540  RPP30; ribonuclease P protein subunit p30 [KO:K03539] [EC:3.1.26.5]
100157338  RPP25; ribonuclease P protein subunit p25 [KO:K14525] [EC:3.1.26.5]
100157879  BMS1; ribosome biogenesis protein BMS1 homolog [KO:K14569]
100157926  RIOK1; serine/threonine-protein kinase RIO1 [KO:K07178] [EC:2.7.11.1]
100216430  DKC1; H/ACA ribonucleoprotein complex subunit 4 [KO:K11131] [EC:5.4.99.-]
100415805  SPATA5; spermatogenesis-associated protein 5 [KO:K14575]
100511276  NOL6; nucleolar protein 6 [KO:K14544]
100511365  NAT10; RNA cytidine acetyltransferase [KO:K14521] [EC:2.3.1.-]
100511538  WDR75; WD repeat-containing protein 75 isoform X2 [KO:K14552]
100511553  RIOK2; LOW QUALITY PROTEIN: serine/threonine-protein kinase RIO2 [KO:K07179] [EC:2.7.11.1]
100512042  REXO5; putative RNA exonuclease NEF-sp isoform X1 [KO:K14570] [EC:3.1.-.-]
100512446  NOP56; nucleolar protein 56 [KO:K14564]
100512568  [KO:K14563] [EC:2.1.1.-]
100514739  NXT1; NTF2-related export protein 1 [KO:K14285]
100515474  UTP15; U3 small nucleolar RNA-associated protein 15 homolog [KO:K14549]
100515927  XRN1; LOW QUALITY PROTEIN: 5'-3' exoribonuclease 1 [KO:K12618] [EC:3.1.13.-]
100516003  SBDS; ribosome maturation protein SBDS [KO:K14574]
100516270  NOB1; RNA-binding protein NOB1 isoform X1 [KO:K11883]
100516425  TCOF1; treacle protein [KO:K14562]
100516629  GAR1; H/ACA ribonucleoprotein complex subunit 1 [KO:K11128]
100517201  XRN2; LOW QUALITY PROTEIN: 5'-3' exoribonuclease 2 [KO:K12619] [EC:3.1.13.-]
100517435  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
100517967  UTP18; U3 small nucleolar RNA-associated protein 18 homolog [KO:K14553]
100519832  WDR43; WD repeat-containing protein 43 [KO:K14546]
100521120  GNL3L; guanine nucleotide-binding protein-like 3-like protein [KO:K14538]
100521422  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
100522095  RPP25L; ribonuclease P protein subunit p25-like protein [KO:K14525] [EC:3.1.26.5]
100522629  REXO2; oligoribonuclease, mitochondrial [KO:K13288] [EC:3.1.-.-]
100523065  POP4; ribonuclease P protein subunit p29 [KO:K03538] [EC:3.1.26.5]
100523416  UTP14A; U3 small nucleolar RNA-associated protein 14 homolog A isoform X1 [KO:K14567]
100524172  UTP6; U3 small nucleolar RNA-associated protein 6 homolog [KO:K14557]
100524688  FCF1; rRNA-processing protein FCF1 homolog isoform X2 [KO:K14566]
100524961  DROSHA; LOW QUALITY PROTEIN: ribonuclease 3 [KO:K03685] [EC:3.1.26.3]
100525449  REXO1; RNA exonuclease 1 homolog isoform X3 [KO:K14570] [EC:3.1.-.-]
100525725  MDN1; LOW QUALITY PROTEIN: midasin [KO:K14572]
100526157  NHP2; H/ACA ribonucleoprotein complex subunit 2 [KO:K11129]
100621511  IMP4; U3 small nucleolar ribonucleoprotein protein IMP4 isoform X1 [KO:K14561]
100623150  GNL2; nucleolar GTP-binding protein 2 isoform X1 [KO:K14537]
100623705  PWP2; periodic tryptophan protein 2 homolog isoform X1 [KO:K14558]
100623969  TBL3; transducin beta-like protein 3 isoform X1 [KO:K14555]
100624357  NVL; nuclear valosin-containing protein-like isoform X1 [KO:K14571]
100625121  RRP7A; ribosomal RNA-processing protein 7 homolog A isoform X1 [KO:K14545]
100625226  GTPBP4; nucleolar GTP-binding protein 1 [KO:K06943]
100626002  FBL; rRNA 2'-O-methyltransferase fibrillarin [KO:K14563] [EC:2.1.1.-]
100626611  RPP38; ribonuclease P protein subunit p38 [KO:K14523] [EC:3.1.26.5]
100627239  POP7; ribonuclease P protein subunit p20 [KO:K14527] [EC:3.1.26.5]
100627271  WDR36; WD repeat-containing protein 36 [KO:K14554]
100627301  EIF6; eukaryotic translation initiation factor 6 [KO:K03264]
100627558  EMG1; ribosomal RNA small subunit methyltransferase NEP1 [KO:K14568] [EC:2.1.1.260]
100628057  RBM28; RNA-binding protein 28 [KO:K14573]
100628213  NXF1; nuclear RNA export factor 1 [KO:K14284]
100737256  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
100738482  NMD3; 60S ribosomal export protein NMD3 isoform X1 [KO:K07562]
100739449  POP1; ribonucleases P/MRP protein subunit POP1 [KO:K01164] [EC:3.1.26.5]
100861536  RN5-8S; 5.8S ribosomal RNA [KO:K01986]
100861538  RN18S; 18S ribosomal RNA [KO:K01979]
102164431  [KO:K14284]
106504175  AK6; adenylate kinase isoenzyme 6 isoform X2 [KO:K18532] [EC:2.7.4.3]
110255215  RPP40; ribonuclease P protein subunit p40 isoform X1 [KO:K14530] [EC:3.1.26.5]
110257687  [KO:K14284]
397211  CSNK2B; casein kinase II subunit beta [KO:K03115]
397330  XPO1; exportin-1 isoform X3 [KO:K14290]
397655  RAN; GTP-binding nuclear protein Ran [KO:K07936]
414432  UTP4; U3 small nucleolar RNA-associated protein 4 homolog [KO:K14548]
Reference
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
DOI:10.1039/b919670f
Reference
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
DOI:10.1128/MCB.00380-07
Reference
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
DOI:10.1261/rna.1792109
Reference
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
DOI:10.1016/j.yexcr.2004.03.016
Reference
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
DOI:10.1016/j.bbamcr.2009.10.009
Related
pathway
ssc03010  Ribosome
KO pathway
ko03008   

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