KEGG   PATHWAY: ssc03008Help
Entry
ssc03008                    Pathway                                

Name
Ribosome biogenesis in eukaryotes - Sus scrofa (pig)
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is  assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
Ribosome biogenesis in eukaryotes
ssc03008

All organismsOrtholog table
Module
H/ACA ribonucleoprotein complex [PATH:ssc03008]
Organism
Sus scrofa (pig) [GN:ssc]
Gene
397211  
CSNK2B; casein kinase 2 beta [KO:K03115]
CSNK2A1; casein kinase 2 alpha 1 [KO:K03097] [EC:2.7.11.1]
CSNK2A2; casein kinase 2 alpha 2 [KO:K03097] [EC:2.7.11.1]
NOL6; nucleolar protein 6 [KO:K14544]
RRP7A; ribosomal RNA processing 7 homolog A [KO:K14545]
WDR43; WD repeat domain 43 [KO:K14546]
414432  
UTP4; UTP4, small subunit processome component [KO:K14548]
UTP15; UTP15, small subunit processome component [KO:K14549]
HEATR1; HEAT repeat containing 1 [KO:K14550]
WDR75; WD repeat domain 75 [KO:K14552]
UTP18; UTP18, small subunit processome component [KO:K14553]
WDR36; WD repeat domain 36 [KO:K14554]
TBL3; transducin beta like 3 [KO:K14555]
WDR3; WD repeat domain 3 [KO:K14556]
UTP6; UTP6, small subunit processome component [KO:K14557]
PWP2; PWP2 periodic tryptophan protein homolog (yeast) [KO:K14558]
MPHOSPH10; M-phase phosphoprotein 10 [KO:K14559]
IMP3; IMP3, U3 small nucleolar ribonucleoprotein [KO:K14560]
U3 small nucleolar ribonucleoprotein protein IMP4-like [KO:K14561]
IMP4; U3 small nucleolar ribonucleoprotein protein IMP4 [KO:K14561]
TCOF1; treacle ribosome biogenesis factor 1 [KO:K14562]
rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 [KO:K14563] [EC:2.1.1.-]
FBL; fibrillarin [KO:K14563] [EC:2.1.1.-]
NOP56; NOP56 ribonucleoprotein [KO:K14564]
NOP58; NOP58 ribonucleoprotein [KO:K14565]
SNU13; SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) [KO:K12845]
DKC1; dyskerin pseudouridine synthase 1 [KO:K11131] [EC:5.4.99.-]
NHP2; NHP2 ribonucleoprotein [KO:K11129]
GAR1; GAR1 ribonucleoprotein [KO:K11128]
NOP10; NOP10 ribonucleoprotein [KO:K11130]
FCF1; FCF1 rRNA-processing protein [KO:K14566]
UTP14A; UTP14A small subunit processome component [KO:K14567]
DROSHA; drosha ribonuclease III [KO:K03685] [EC:3.1.26.3]
EMG1; EMG1, N1-specific pseudouridine methyltransferase [KO:K14568] [EC:2.1.1.260]
BMS1; BMS1, ribosome biogenesis factor [KO:K14569]
NAT10; N-acetyltransferase 10 [KO:K14521] [EC:2.3.1.-]
RCL1; RNA terminal phosphate cyclase like 1 [KO:K11108]
POP1; POP1 homolog, ribonuclease P/MRP subunit [KO:K01164] [EC:3.1.26.5]
RPP38; ribonuclease P/MRP subunit p38 [KO:K14523] [EC:3.1.26.5]
POP4; POP4 homolog, ribonuclease P/MRP subunit [KO:K03538] [EC:3.1.26.5]
POP5; POP5 homolog, ribonuclease P/MRP subunit [KO:K03537] [EC:3.1.26.5]
RPP25; ribonuclease P/MRP subunit p25 [KO:K14525] [EC:3.1.26.5]
RPP25L; ribonuclease P/MRP subunit p25 like [KO:K14525] [EC:3.1.26.5]
POP7; POP7 homolog, ribonuclease P/MRP subunit [KO:K14527] [EC:3.1.26.5]
RPP30; ribonuclease P/MRP subunit p30 [KO:K03539] [EC:3.1.26.5]
RPP40; ribonuclease P/MRP subunit p40 [KO:K14530] [EC:3.1.26.5]
RNA exonuclease 1 homolog [KO:K14570] [EC:3.1.-.-]
REXO1; RNA exonuclease 1 homolog [KO:K14570] [EC:3.1.-.-]
putative RNA exonuclease NEF-sp [KO:K14570] [EC:3.1.-.-]
REXO2; RNA exonuclease 2 [KO:K13288] [EC:3.1.-.-]
XRN1; 5'-3' exoribonuclease 1 [KO:K12618] [EC:3.1.13.-]
XRN2; 5'-3' exoribonuclease 2 [KO:K12619] [EC:3.1.13.-]
GTPBP4; nucleolar GTP-binding protein 1 [KO:K06943]
GNL2; G protein nucleolar 2 [KO:K14537]
GNL3; G protein nucleolar 3 [KO:K14538]
GNL3L; G protein nucleolar 3 like [KO:K14538]
MDN1; midasin [KO:K14572]
RBM28; RNA binding motif protein 28 [KO:K14573]
NOB1; NIN1/PSMD8 binding protein 1 homolog [KO:K11883]
397655  
RAN; RAN, member RAS oncogene family [KO:K07936]
397330  
XPO1; exportin 1 [KO:K14290]
NMD3; NMD3 ribosome export adaptor [KO:K07562]
60S ribosomal export protein NMD3 [KO:K07562]
NXF2B; nuclear RNA export factor 2 [KO:K14284]
nuclear RNA export factor 2-like [KO:K14284]
NXF1; nuclear RNA export factor 1 [KO:K14284]
NXF2; nuclear RNA export factor 2 [KO:K14284]
NXT1; nuclear transport factor 2 like export factor 1 [KO:K14285]
NXT2; nuclear transport factor 2 like export factor 2 [KO:K14285]
EIF6; eukaryotic translation initiation factor 6 [KO:K03264]
SBDS; SBDS ribosome assembly guanine nucleotide exchange factor [KO:K14574]
EFL1; elongation factor like GTPase 1 [KO:K14536] [EC:3.6.5.-]
EFTUD1; elongation factor Tu GTP-binding domain-containing protein 1-like [KO:K14536] [EC:3.6.5.-]
LSG1; large 60S subunit nuclear export GTPase 1 [KO:K14539] [EC:3.6.1.-]
SPATA5; spermatogenesis associated 5 [KO:K14575]
adenylate kinase isoenzyme 6-like [KO:K18532] [EC:2.7.4.3]
AK6; adenylate kinase 6 [KO:K18532] [EC:2.7.4.3]
RIOK1; RIO kinase 1 [KO:K07178] [EC:2.7.11.1]
RIOK2; RIO kinase 2 [KO:K07179] [EC:2.7.11.1]
12S ribosomal RNA [KO:K01979]
RN18S; 18S ribosomal RNA [KO:K01979]
RN5-8S; 5.8S ribosomal RNA [KO:K01986]
16S ribosomal RNA [KO:K01982]
Reference
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
Reference
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
Reference
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
Reference
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
Reference
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
KO pathway
 

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