KEGG   PATHWAY: ssc03008Help
Entry
ssc03008                    Pathway                                

Name
Ribosome biogenesis in eukaryotes - Sus scrofa (pig)
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is  assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
Ribosome biogenesis in eukaryotes
ssc03008

All organismsOrtholog table
Module
H/ACA ribonucleoprotein complex [PATH:ssc03008]
Organism
Sus scrofa (pig) [GN:ssc]
Gene
397211  
CSNK2B; casein kinase 2, beta polypeptide [KO:K03115]
CSNK2A1; casein kinase 2, alpha 1 polypeptide [KO:K03097] [EC:2.7.11.1]
CSNK2A2; casein kinase 2, alpha prime polypeptide [KO:K03097] [EC:2.7.11.1]
NOL6; nucleolar protein 6 (RNA-associated) [KO:K14544]
RRP7A; ribosomal RNA processing 7 homolog A [KO:K14545]
WDR43; WD repeat domain 43 [KO:K14546]
414432  
CIRH1A; cirrhosis, autosomal recessive 1A (cirhin) [KO:K14548]
UTP15; UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae) [KO:K14549]
HEATR1; HEAT repeat containing 1 [KO:K14550]
WDR75; WD repeat domain 75 [KO:K14552]
UTP18; UTP18 small subunit (SSU) processome component homolog (yeast) [KO:K14553]
WDR36; WD repeat domain 36 [KO:K14554]
TBL3; transducin (beta)-like 3 [KO:K14555]
WDR3; WD repeat domain 3 [KO:K14556]
UTP6; UTP6, small subunit (SSU) processome component, homolog (yeast) [KO:K14557]
PWP2; PWP2 periodic tryptophan protein homolog (yeast) [KO:K14558]
MPHOSPH10; M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) [KO:K14559]
IMP3; IMP3, U3 small nucleolar ribonucleoprotein [KO:K14560]
U3 small nucleolar ribonucleoprotein protein IMP4-like; K14561 U3 small nucleolar ribonucleoprotein protein IMP4 [KO:K14561]
IMP4; U3 small nucleolar ribonucleoprotein protein IMP4 [KO:K14561]
TCOF1; Treacher Collins-Franceschetti syndrome 1 [KO:K14562]
rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1; K14563 rRNA 2'-O-methyltransferase fibrillarin [EC:2.1.1.-] [KO:K14563] [EC:2.1.1.-]
FBL; fibrillarin [KO:K14563] [EC:2.1.1.-]
NOP56; NOP56 ribonucleoprotein [KO:K14564]
NOP58; NOP58 ribonucleoprotein [KO:K14565]
SNU13; SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) [KO:K12845]
DKC1; dyskeratosis congenita 1, dyskerin [KO:K11131] [EC:5.4.99.-]
NHP2; NHP2 ribonucleoprotein [KO:K11129]
GAR1; GAR1 homolog, ribonucleoprotein [KO:K11128]
NOP10; NOP10 ribonucleoprotein [KO:K11130]
FCF1; FCF1 rRNA-processing protein [KO:K14566]
UTP14A; UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) [KO:K14567]
DROSHA; drosha, ribonuclease type III [KO:K03685] [EC:3.1.26.3]
EMG1; EMG1 N1-specific pseudouridine methyltransferase [KO:K14568] [EC:2.1.1.260]
BMS1; BMS1 ribosome biogenesis factor [KO:K14569]
NAT10; N-acetyltransferase 10 (GCN5-related) [KO:K14521] [EC:2.3.1.-]
RCL1; RNA terminal phosphate cyclase-like 1 [KO:K11108]
POP1; POP1 homolog, ribonuclease P/MRP subunit [KO:K01164] [EC:3.1.26.5]
RPP38; ribonuclease P/MRP 38kDa subunit [KO:K14523] [EC:3.1.26.5]
POP4; POP4 homolog, ribonuclease P/MRP subunit [KO:K03538] [EC:3.1.26.5]
POP5; POP5 homolog, ribonuclease P/MRP subunit [KO:K03537] [EC:3.1.26.5]
RPP25; ribonuclease P/MRP 25kDa subunit [KO:K14525] [EC:3.1.26.5]
RPP25L; ribonuclease P/MRP 25kDa subunit-like [KO:K14525] [EC:3.1.26.5]
POP7; POP7 homolog, ribonuclease P/MRP subunit [KO:K14527] [EC:3.1.26.5]
RPP30; ribonuclease P/MRP 30kDa subunit [KO:K03539] [EC:3.1.26.5]
RPP40; ribonuclease P/MRP 40kDa subunit [KO:K14530] [EC:3.1.26.5]
RNA exonuclease 1 homolog; K14570 RNA exonuclease 1 [EC:3.1.-.-] [KO:K14570] [EC:3.1.-.-]
REXO1; RNA exonuclease 1 homolog [KO:K14570] [EC:3.1.-.-]
putative RNA exonuclease NEF-sp; K14570 RNA exonuclease 1 [EC:3.1.-.-] [KO:K14570] [EC:3.1.-.-]
REXO2; RNA exonuclease 2 [KO:K13288] [EC:3.1.-.-]
XRN1; 5'-3' exoribonuclease 1 [KO:K12618] [EC:3.1.13.-]
XRN2; 5'-3' exoribonuclease 2 [KO:K12619] [EC:3.1.13.-]
GTPBP4; nucleolar GTP-binding protein 1 [KO:K06943]
GNL2; guanine nucleotide binding protein-like 2 (nucleolar) [KO:K14537]
GNL3; guanine nucleotide binding protein-like 3 (nucleolar) [KO:K14538]
GNL3L; guanine nucleotide binding protein-like 3 (nucleolar)-like [KO:K14538]
MDN1; midasin [KO:K14572]
RBM28; RNA binding motif protein 28 [KO:K14573]
NOB1; NIN1/RPN12 binding protein 1 homolog [KO:K11883]
397655  
RAN; RAN, member RAS oncogene family [KO:K07936]
397330  
XPO1; exportin 1 [KO:K14290]
NMD3; NMD3 ribosome export adaptor [KO:K07562]
NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
NXF2B; nuclear RNA export factor 2 [KO:K14284]
nuclear RNA export factor 2-like; K14284 nuclear RNA export factor [KO:K14284]
NXF1; nuclear RNA export factor 1 [KO:K14284]
NXF2; nuclear RNA export factor 2 [KO:K14284]
NXT1; nuclear transport factor 2-like export factor 1 [KO:K14285]
NXT2; nuclear transport factor 2-like export factor 2 [KO:K14285]
EIF6; eukaryotic translation initiation factor 6 [KO:K03264]
SBDS; Shwachman-Bodian-Diamond syndrome [KO:K14574]
EFTUD1; elongation factor Tu GTP binding domain containing 1 [KO:K14536] [EC:3.6.5.-]
EFTUD1; elongation factor Tu GTP-binding domain-containing protein 1-like [KO:K14536] [EC:3.6.5.-]
LSG1; large 60S subunit nuclear export GTPase 1 [KO:K14539] [EC:3.6.1.-]
SPATA5; spermatogenesis associated 5 [KO:K14575]
adenylate kinase isoenzyme 6-like; K18532 adenylate kinase [EC:2.7.4.3] [KO:K18532] [EC:2.7.4.3]
AK6; adenylate kinase 6 [KO:K18532] [EC:2.7.4.3]
RIOK1; RIO kinase 1 [KO:K07178] [EC:2.7.11.1]
RIOK2; RIO kinase 2 [KO:K07179] [EC:2.7.11.1]
12S ribosomal RNA; K01979 small subunit ribosomal RNA [KO:K01979]
RN18S; 18S ribosomal RNA [KO:K01979]
16S ribosomal RNA; K01982 large subunit ribosomal RNA [KO:K01982]
Reference
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
Reference
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
Reference
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
Reference
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
Reference
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
KO pathway
 

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