KEGG   PATHWAY: ssr00290
Entry
ssr00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Streptococcus salivarius CCHSS3
Class
Metabolism; Amino acid metabolism
Pathway map
ssr00290  Valine, leucine and isoleucine biosynthesis
ssr00290

Module
ssr_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:ssr00290]
ssr_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:ssr00290]
ssr_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:ssr00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Streptococcus salivarius CCHSS3 [GN:ssr]
Gene
SALIVB_0183  ilvA; threonine dehydratase biosynthetic (Threonine deaminase) [KO:K01754] [EC:4.3.1.19]
SALIVB_1195  leuC; 3-isopropylmalate dehydratase large subunit (isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) [KO:K01703] [EC:4.2.1.33 4.2.1.35]
SALIVB_1194  leuD; 3-isopropylmalate dehydratase small subunit (isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) [KO:K01704] [EC:4.2.1.33 4.2.1.35]
SALIVB_1197  leuB; 3-isopropylmalate dehydrogenase (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) [KO:K00052] [EC:1.1.1.85]
SALIVB_2011  ilvB; acetolactate synthase [KO:K01652] [EC:2.2.1.6]
SALIVB_0952  alsS; acetolactate synthase (Acetohydroxy-acid synthase) (ALS) [KO:K01652] [EC:2.2.1.6]
SALIVB_2010  ilvH; acetolactate synthase small subunit (AHAS) (Acetohydroxy-acid synthase small subunit) (ALS) [KO:K01653] [EC:2.2.1.6]
SALIVB_2009  ilvC; Ketol-acid reductoisomerase (Acetohydroxy-acid isomeroreductase) (Alpha-keto-beta-hydroxylacil reductoisomerase) [KO:K00053] [EC:1.1.1.86]
SALIVB_2012  dihydroxy-acid dehydratase (DAD) [KO:K01687] [EC:4.2.1.9]
SALIVB_1710  ilvD; dihydroxy-acid dehydratase (DAD) [KO:K01687] [EC:4.2.1.9]
SALIVB_1494  ilvE; branched-chain-amino-acid aminotransferase (BCAT) [KO:K00826] [EC:2.6.1.42]
SALIVB_1752  yfbQ; uncharacterized aminotransferase yfbQ [KO:K14260] [EC:2.6.1.66 2.6.1.2]
SALIVB_1198  leuA; 2-isopropylmalate synthase (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase) [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
ssr00260  Glycine, serine and threonine metabolism
ssr00280  Valine, leucine and isoleucine degradation
ssr00620  Pyruvate metabolism
KO pathway
ko00290   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG GENES (13)   
All databases (14)   

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