KEGG   PATHWAY: ssr03440Help
Entry
ssr03440                    Pathway                                

Name
Homologous recombination - Streptococcus salivarius CCHSS3
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
ssr03440  Homologous recombination
ssr03440

Ortholog table
Module
ssr_M00260  DNA polymerase III complex, bacteria [PATH:ssr03440]
Other DBs
BSID: 377651
GO: 0000724
Organism
Streptococcus salivarius CCHSS3 [GN:ssr]
Gene
SALIVB_1217  recJ; putative single-strand DNA-specific exonuclease (Single-stranded-DNA-specific exonuclease) [KO:K07462] [EC:3.1.-.-]
SALIVB_1880  single-stranded DNA-binding protein [KO:K03111]
SALIVB_1981  single-stranded DNA-binding protein [KO:K03111]
SALIVB_2143  recF; DNA replication and repair protein recF [KO:K03629]
SALIVB_0039  recO; DNA repair protein recO (Recombination protein O) [KO:K03584]
SALIVB_1457  recR; recombination protein recR [KO:K06187]
SALIVB_0078  recA; protein recA (recombinase A) [KO:K03553]
SALIVB_1890  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
SALIVB_0075  ruvA; holliday junction ATP-dependent DNA helicase ruvA [KO:K03550] [EC:3.6.4.12]
SALIVB_2063  ruvB; holliday junction ATP-dependent DNA helicase ruvB [KO:K03551] [EC:3.6.4.12]
SALIVB_1850  recG; ATP-dependent DNA helicase recG [KO:K03655] [EC:3.6.4.12]
SALIVB_1902  recD; putative exodeoxyribonuclease V (Alpha subunit) (Exodeoxyribonuclease V alpha chain) [KO:K03581] [EC:3.1.11.5]
SALIVB_1193  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
SALIVB_0093  polC; DNA polymerase III polC-type (PolIII) [KO:K03763] [EC:2.7.7.7]
SALIVB_0002  dnaN; beta subunit of DNA polymerase III [KO:K02338] [EC:2.7.7.7]
SALIVB_1165  dnaX; DNA polymerase III subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
SALIVB_1312  holA; DNA polymerase III delta subunit [KO:K02340] [EC:2.7.7.7]
SALIVB_1597  holB; DNA polymerase III subunit delta [KO:K02341] [EC:2.7.7.7]
SALIVB_1706  dnaQ; DNA polymerase III, epsilon chain [KO:K02342] [EC:2.7.7.7]
SALIVB_0580  priA; primosomal protein N (ATP-dependent helicase priA) (Replication factor Y) [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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