KEGG   PATHWAY: tgu04145Help
Entry
tgu04145                    Pathway                                

Name
Phagosome - Taeniopygia guttata (zebra finch)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Phagosome
tgu04145

All organismsOrtholog table
Module
Sec61 complex [PATH:tgu04145]
Other DBs
BSID: 
GO: 
Organism
Taeniopygia guttata (zebra finch) [GN:tgu]
Gene
VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
STX12; syntaxin 12 [KO:K13813]
STX7; syntaxin 7 [KO:K08488]
actin; K05692 actin beta/gamma 1 [KO:K05692]
751978  
ACT5C; actin, cytoplasmic 1 [KO:K05692]
STX18; syntaxin 18 [KO:K08492]
SEC22B; SEC22 vesicle trafficking protein homolog B (S. cerevisiae) [KO:K08517]
class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
H-2 class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
RAB5C; RAB5C, member RAS oncogene family [KO:K07889]
EEA1; early endosome antigen 1 [KO:K12478]
PIK3C3; phosphatidylinositol 3-kinase, catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
TFRC; transferrin receptor [KO:K06503]
HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
ATP6V1A; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A [KO:K02145] [EC:3.6.3.14]
ATP6V1B2; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 [KO:K02147]
ATP6V1C2; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 [KO:K02148]
ATP6V1C1; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 [KO:K02148]
ATP6V1D; ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D [KO:K02149]
ATP6V1E1; ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 [KO:K02150]
V-type proton ATPase subunit E 1; K02150 V-type H+-transporting ATPase subunit E [KO:K02150]
ATP6V1F; ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F [KO:K02151]
ATP6V1G3; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 [KO:K02152]
ATP6V1G1; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 [KO:K02152]
ATPase H+ transporting V0 subunit-like; K02153 V-type H+-transporting ATPase subunit e [KO:K02153]
ATP6V0A4; ATPase, H+ transporting, lysosomal V0 subunit a4 [KO:K02154]
TCIRG1; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 [KO:K02154]
ATP6V0A1; ATPase, H+ transporting, lysosomal V0 subunit a1 [KO:K02154]
ATP6V0A2; ATPase, H+ transporting, lysosomal V0 subunit a2 [KO:K02154]
ATP6V0D2; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 [KO:K02146]
ATP6V0D1; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 [KO:K02146]
ATP6V1H; ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H [KO:K02144]
ATP6V0C; ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c [KO:K02155]
ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b [KO:K03661]
ATP6AP1; ATPase, H+ transporting, lysosomal accessory protein 1 [KO:K03662]
RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
RAB7B; RAB7B, member RAS oncogene family [KO:K07898]
RILP; Rab interacting lysosomal protein [KO:K13883]
DYNC1H1; dynein, cytoplasmic 1, heavy chain 1 [KO:K10413]
DYNC2H1; dynein, cytoplasmic 2, heavy chain 1 [KO:K10414]
DYNC1I1; dynein, cytoplasmic 1, intermediate chain 1 [KO:K10415]
DYNC1I2; dynein, cytoplasmic 1, intermediate chain 2 [KO:K10415]
DYNC1LI2; dynein, cytoplasmic 1, light intermediate chain 2 [KO:K10416]
DYNC1LI1; dynein, cytoplasmic 1, light intermediate chain 1 [KO:K10416]
TUBA8; tubulin, alpha 8 [KO:K07374]
tubulin alpha-5 chain; K07374 tubulin alpha [KO:K07374]
TUBA1C; tubulin alpha-3 chain [KO:K07374]
TUBA1C; tubulin alpha-8 chain [KO:K07374]
tubulin alpha-3 chain; K07374 tubulin alpha [KO:K07374]
tubulin alpha-1B chain; K07374 tubulin alpha [KO:K07374]
tubulin alpha-2 chain-like; K07374 tubulin alpha [KO:K07374]
TUBB1; tubulin, beta 1 class VI [KO:K07375]
TUBB4B; tubulin, beta 4B class IVb [KO:K07375]
TUBB6; tubulin, beta 6 class V [KO:K07375]
tubulin beta-5 chain-like; K07375 tubulin beta [KO:K07375]
tubulin beta-1 chain; K07375 tubulin beta [KO:K07375]
tubulin beta chain-like; K07375 tubulin beta [KO:K07375]
tubulin beta 2-like; K07375 tubulin beta [KO:K07375]
LAMP1; lysosomal-associated membrane protein 1 [KO:K06528]
LAMP2; lysosomal-associated membrane protein 2 [KO:K06528]
lysosome-associated membrane glycoprotein 2-like; K06528 lysosomal-associated membrane protein 1/2 [KO:K06528]
PIKFYVE; phosphoinositide kinase, FYVE finger containing [KO:K00921] [EC:2.7.1.150]
M6PR; mannose-6-phosphate receptor (cation dependent) [KO:K10089]
NOS1; nitric oxide synthase 1 (neuronal) [KO:K13240] [EC:1.14.13.39]
MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
CTSL; cathepsin L [KO:K01365] [EC:3.4.22.15]
cathepsin L1-like; K01365 cathepsin L [EC:3.4.22.15] [KO:K01365] [EC:3.4.22.15]
SEC61A1; Sec61 alpha 1 subunit (S. cerevisiae) [KO:K10956]
protein transport protein Sec61 subunit alpha isoform 2-like; K10956 protein transport protein SEC61 subunit alpha [KO:K10956]
SEC61A2; Sec61 alpha 2 subunit (S. cerevisiae) [KO:K10956]
SEC61B; Sec61 beta subunit [KO:K09481]
SEC61G; Sec61 gamma subunit [KO:K07342]
calreticulin; K08057 calreticulin [KO:K08057]
CANX; calnexin [KO:K08054]
C1R; complement component 1, r subcomponent [KO:K01330] [EC:3.4.21.41]
ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) [KO:K06464]
COLEC11; collectin sub-family member 11 [KO:K10066]
COLEC12; collectin sub-family member 12 [KO:K10062]
SFTPA; surfactant protein A [KO:K10067]
ITGAV; integrin, alpha V [KO:K06487]
ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) [KO:K06481]
ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [KO:K05719]
ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) [KO:K06493]
ITGB5; integrin, beta 5 [KO:K06588]
THBS1; thrombospondin 1 [KO:K16857]
THBS4; thrombospondin 4 [KO:K04659]
THBS3; thrombospondin 3 [KO:K04659]
THBS2; thrombospondin 2 [KO:K04659]
toll-like receptor 2 type-2; K10159 toll-like receptor 2 [KO:K10159]
toll-like receptor 2 type-1; K10159 toll-like receptor 2 [KO:K10159]
TLR6; toll-like receptor 1 [KO:K10169]
TLR4; toll-like receptor 4 [KO:K10160]
MRC1; macrophage mannose receptor 1 [KO:K06560]
PLA2R1; phospholipase A2 receptor 1, 180kDa [KO:K06560]
MRC1; macrophage mannose receptor 1 [KO:K06560]
MRC1; macrophage mannose receptor 1 [KO:K06560]
MRC1; macrophage mannose receptor 1 [KO:K06560]
macrophage mannose receptor 1-like; K06560 mannose receptor, C type [KO:K06560]
MRC2; mannose receptor, C type 2 [KO:K06560]
MARCO; macrophage receptor with collagenous structure [KO:K13884]
SCARB1; scavenger receptor class B, member 1 [KO:K13885]
CD36; CD36 molecule (thrombospondin receptor) [KO:K06259]
cytochrome b-245 light chain; K08009 cytochrome b-245, alpha polypeptide [KO:K08009]
cytochrome b-245 heavy chain; K08008 NADPH oxidase [KO:K08008]
NOX3; NADPH oxidase 3 [KO:K08008]
cytochrome b-245 heavy chain; K08008 NADPH oxidase [KO:K08008]
NOX1; NADPH oxidase 1 [KO:K08008]
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
NCF1; neutrophil cytosolic factor 1 [KO:K08011]
NCF2; neutrophil cytosolic factor 2 [KO:K08010]
NCF4; neutrophil cytosolic factor 4, 40kDa [KO:K08012]
Compound
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
KO pathway
 
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