KEGG   PATHWAY: tgu04145Help
Entry
tgu04145                    Pathway                                

Name
Phagosome - Taeniopygia guttata (zebra finch)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Phagosome
tgu04145

All organismsOrtholog table
Module
Sec61 complex [PATH:tgu04145]
Other DBs
BSID: 
GO: 
Organism
Taeniopygia guttata (zebra finch) [GN:tgu]
Gene
VAMP3; vesicle associated membrane protein 3 [KO:K13505]
STX12; syntaxin 12 [KO:K13813]
STX7; syntaxin 7 [KO:K08488]
actin, cytoplasmic type 5 [KO:K05692]
751978  
ACT5C; actin, cytoplasmic 1 [KO:K05692]
STX18; syntaxin 18 [KO:K08492]
SEC22B; SEC22 homolog B, vesicle trafficking protein [KO:K08517]
class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
H-2 class II histocompatibility antigen, I-E beta chain-like [KO:K06752]
RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
RAB5C; RAB5C, member RAS oncogene family [KO:K07889]
EEA1; early endosome antigen 1 [KO:K12478]
PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
TFRC; transferrin receptor [KO:K06503]
HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
ATP6V1A; ATPase H+ transporting V1 subunit A [KO:K02145] [EC:3.6.3.14]
ATP6V1B2; ATPase H+ transporting V1 subunit B2 [KO:K02147]
ATP6V1C2; ATPase H+ transporting V1 subunit C2 [KO:K02148]
ATP6V1C1; ATPase H+ transporting V1 subunit C1 [KO:K02148]
ATP6V1D; ATPase H+ transporting V1 subunit D [KO:K02149]
ATP6V1E1; ATPase H+ transporting V1 subunit E1 [KO:K02150]
V-type proton ATPase subunit E 1 [KO:K02150]
ATP6V1F; ATPase H+ transporting V1 subunit F [KO:K02151]
ATP6V1G3; ATPase H+ transporting V1 subunit G3 [KO:K02152]
ATP6V1G1; ATPase H+ transporting V1 subunit G1 [KO:K02152]
ATPase H+ transporting V0 subunit-like [KO:K02153]
ATP6V0A4; ATPase H+ transporting V0 subunit a4 [KO:K02154]
TCIRG1; T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3 [KO:K02154]
ATP6V0A1; ATPase H+ transporting V0 subunit a1 [KO:K02154]
ATP6V0A2; ATPase H+ transporting V0 subunit a2 [KO:K02154]
ATP6V0D2; ATPase H+ transporting V0 subunit d2 [KO:K02146]
ATP6V0D1; ATPase H+ transporting V0 subunit d1 [KO:K02146]
ATP6V1H; ATPase H+ transporting V1 subunit H [KO:K02144]
ATP6V0C; ATPase H+ transporting V0 subunit c [KO:K02155]
ATP6V0B; ATPase H+ transporting V0 subunit b [KO:K03661]
ATP6AP1; ATPase H+ transporting accessory protein 1 [KO:K03662]
RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
RAB7B; RAB7B, member RAS oncogene family [KO:K07898]
RILP; Rab interacting lysosomal protein [KO:K13883]
DYNC1H1; dynein cytoplasmic 1 heavy chain 1 [KO:K10413]
DYNC2H1; dynein cytoplasmic 2 heavy chain 1 [KO:K10414]
DYNC1I1; dynein cytoplasmic 1 intermediate chain 1 [KO:K10415]
DYNC1I2; dynein cytoplasmic 1 intermediate chain 2 [KO:K10415]
DYNC1LI2; dynein cytoplasmic 1 light intermediate chain 2 [KO:K10416]
DYNC1LI1; dynein cytoplasmic 1 light intermediate chain 1 [KO:K10416]
TUBA8; tubulin alpha 8 [KO:K07374]
tubulin alpha-5 chain [KO:K07374]
TUBA1C; tubulin alpha-3 chain [KO:K07374]
TUBA1C; tubulin alpha-8 chain [KO:K07374]
tubulin alpha-3 chain [KO:K07374]
tubulin alpha-1B chain [KO:K07374]
tubulin alpha-2 chain-like [KO:K07374]
TUBB1; tubulin beta 1 class VI [KO:K07375]
TUBB4B; tubulin beta 4B class IVb [KO:K07375]
TUBB6; tubulin beta 6 class V [KO:K07375]
tubulin beta-5 chain-like [KO:K07375]
tubulin beta-1 chain [KO:K07375]
tubulin beta chain-like [KO:K07375]
tubulin beta 2-like [KO:K07375]
LAMP1; lysosomal associated membrane protein 1 [KO:K06528]
LAMP2; lysosomal associated membrane protein 2 [KO:K06528]
lysosome-associated membrane glycoprotein 2-like [KO:K06528]
PIKFYVE; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150]
M6PR; mannose-6-phosphate receptor, cation dependent [KO:K10089]
NOS1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
CTSL; cathepsin L [KO:K01365] [EC:3.4.22.15]
cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
SEC61A1; Sec61 translocon alpha 1 subunit [KO:K10956]
protein transport protein Sec61 subunit alpha isoform 2-like [KO:K10956]
SEC61A2; Sec61 translocon alpha 2 subunit [KO:K10956]
SEC61B; Sec61 translocon beta subunit [KO:K09481]
SEC61G; Sec61 translocon gamma subunit [KO:K07342]
calreticulin [KO:K08057]
CANX; calnexin [KO:K08054]
C1R; complement C1r [KO:K01330] [EC:3.4.21.41]
ITGB2; integrin subunit beta 2 [KO:K06464]
COLEC11; collectin subfamily member 11 [KO:K10066]
COLEC12; collectin subfamily member 12 [KO:K10062]
SFTPA; surfactant protein A [KO:K10067]
ITGAV; integrin subunit alpha V [KO:K06487]
ITGA2; integrin subunit alpha 2 [KO:K06481]
ITGB1; integrin subunit beta 1 [KO:K05719]
ITGB3; integrin subunit beta 3 [KO:K06493]
ITGB5; integrin subunit beta 5 [KO:K06588]
THBS1; thrombospondin 1 [KO:K16857]
THBS4; thrombospondin 4 [KO:K04659]
THBS3; thrombospondin 3 [KO:K04659]
THBS2; thrombospondin 2 [KO:K04659]
toll-like receptor 2 type-2 [KO:K10159]
toll-like receptor 2 type-1 [KO:K10159]
TLR6; toll-like receptor 1 [KO:K10169]
TLR4; toll like receptor 4 [KO:K10160]
MRC1; macrophage mannose receptor 1 [KO:K06560]
PLA2R1; phospholipase A2 receptor 1 [KO:K06560]
MRC1; macrophage mannose receptor 1 [KO:K06560]
MRC1; macrophage mannose receptor 1 [KO:K06560]
MRC1; macrophage mannose receptor 1 [KO:K06560]
macrophage mannose receptor 1-like [KO:K06560]
MRC2; mannose receptor C type 2 [KO:K06560]
MARCO; macrophage receptor with collagenous structure [KO:K13884]
SCARB1; scavenger receptor class B member 1 [KO:K13885]
CD36; CD36 molecule [KO:K06259]
cytochrome b-245 light chain [KO:K08009]
cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
NCF1; neutrophil cytosolic factor 1 [KO:K08011]
NCF2; neutrophil cytosolic factor 2 [KO:K08010]
NCF4; neutrophil cytosolic factor 4 [KO:K08012]
Compound
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
KO pathway
 

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