KEGG PATHWAY: tgu04145

PATHWAY: tgu04145

Entry

tgu04145 Pathway

Name

Phagosome - Taeniopygia guttata (zebra finch)

Description

Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.

Class

Cellular Processes; Transport and catabolism

Pathway map

tgu04145

Phagosome

Module

tgu_M00401

Sec61 complex [PATH:tgu04145]

Other DBs

BSID:

153964

GO:

0045335

Organism

Taeniopygia guttata (zebra finch) [GN:tgu]

Gene

100227418	VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
100223777	syntaxin-12-like; K13813 syntaxin 12/13 [KO:K13813]
100227604	STX7; syntaxin 7 [KO:K08488]
100229883	actin; K05692 actin beta/gamma 1 [KO:K05692]
100224720	STX18; syntaxin 18 [KO:K08492]
100220898	vesicle-trafficking protein SEC22b-like; K08517 vesicle transport protein SEC22 [KO:K08517]
100231469	class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
100229282	class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
100230163	RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
100190713	RAB5C member RAS oncogene family-like; K07889 Ras-related protein Rab-5C [KO:K07889]
100226301	EEA1; early endosome antigen 1 [KO:K12478]
100221298	PIK3C3; phosphatidylinositol 3-kinase, catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
100219280	TFRC; transferrin receptor (p90, CD71) [KO:K06503]
100230661	HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
100229321	ATP6V1A; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A [KO:K02145] [EC:3.6.3.14]
100219912	ATP6V1B2; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 [KO:K02147]
100232700	ATP6V1C2; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 [KO:K02148]
100218219	ATP6V1C1; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 [KO:K02148]
100218128	ATP6V1D; ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D [KO:K02149]
100190066	ATPase H+ transporting lysosomal 31 kDa V1 subunit E-like; K02150 V-type H+-transporting ATPase subunit E [KO:K02150]
100190522	Vacuolar ATP synthase subunit F-like; K02151 V-type H+-transporting ATPase subunit F [KO:K02151]
100231544	ATP6V1G3; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 [KO:K02152]
100190539	ATPase H+ transporting V1 subunit G-like; K02152 V-type H+-transporting ATPase subunit G [KO:K02152]
100190507	ATPase H+ transporting V0 subunit-like; K02153 V-type H+-transporting ATPase subunit e [KO:K02153]
100221499	ATP6V0A4; ATPase, H+ transporting, lysosomal V0 subunit a4 [KO:K02154]
100231607	TCIRG1; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 [KO:K02154]
100229310	ATP6V0A1; ATPase, H+ transporting, lysosomal V0 subunit a1 [KO:K02154]
100218036	ATP6V0A2; ATPase, H+ transporting, lysosomal V0 subunit a2 [KO:K02154]
100222039	ATP6V0D2; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 [KO:K02146]
100227657	ATP6V0D1; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 [KO:K02146]
100220186	ATP6V1H; ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H [KO:K02144]
100221539	TBC1 domain family; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
100190528	ATPase H+ transporting lysosomal 21 kDa V0 subunit-like; K03661 V-type H+-transporting ATPase 21kDa proteolipid subunit [KO:K03661]
100225098	V-type proton ATPase subunit S1-like; K03662 V-type H+-transporting ATPase S1 subunit [KO:K03662]
100231734	RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
100231361	ras-related protein Rab-7b-like; K07898 Ras-related protein Rab-7B [KO:K07898]
100220395	RILP; Rab interacting lysosomal protein [KO:K13883]
100230595	DYNC1H1; dynein, cytoplasmic 1, heavy chain 1 [KO:K10413]
100229193	DYNC2H1; dynein, cytoplasmic 2, heavy chain 1 [KO:K10414]
100190676	dynein cytoplasmic intermediate polypeptide 1-like; K10415 dynein intermediate chain, cytosolic [KO:K10415]
100227509	DYNC1I2; dynein, cytoplasmic 1, intermediate chain 2 [KO:K10415]
100220587	DYNC1LI2; dynein, cytoplasmic 1, light intermediate chain 2 [KO:K10416]
100221637	DYNC1LI1; dynein, cytoplasmic 1, light intermediate chain 1 [KO:K10416]
100227941	TUBA8; tubulin, alpha 8 [KO:K07374]
100218848	tubulin alpha-4A chain-like; K07374 tubulin alpha [KO:K07374]
100224687	TUBA1C; tubulin, alpha 1c [KO:K07374]
100223131	TUBA1C; tubulin, alpha 1c [KO:K07374]
100229371	tubulin alpha-3 chain-like; K07374 tubulin alpha [KO:K07374]
100231628	tubulin beta-6 chain-like; K07375 tubulin beta [KO:K07375]
100101449	TUBB2C; tubulin, beta 4B class IVb [KO:K07375]
100227859	tubulin beta-5 chain-like; K07375 tubulin beta [KO:K07375]
100219053	tubulin beta-5 chain-like; K07375 tubulin beta [KO:K07375]
101233611	tubulin beta-2 chain-like; K07375 tubulin beta [KO:K07375]
100219894	LAMP1; lysosomal-associated membrane protein 1 [KO:K06528]
100222683	LAMP2; lysosomal-associated membrane protein 2 [KO:K06528]
100229363	PIKFYVE; phosphoinositide kinase, FYVE finger containing [KO:K00921] [EC:2.7.1.150]
100225036	M6PR; mannose-6-phosphate receptor (cation dependent) [KO:K10089]
100231414	NOS1; nitric oxide synthase 1 (neuronal) [KO:K13240] [EC:1.14.13.39]
100228147	MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
100232421	cathepsin L1-like; K01365 cathepsin L [EC:3.4.22.15] [KO:K01365] [EC:3.4.22.15]
100226165	cathepsin L1-like; K01365 cathepsin L [EC:3.4.22.15] [KO:K01365] [EC:3.4.22.15]
100232642	SEC61A1; Sec61 alpha 1 subunit (S. cerevisiae) [KO:K10956]
100222701	protein transport protein Sec61 subunit alpha isoform 2-like; K10956 protein transport protein SEC61 subunit alpha [KO:K10956]
100230635	SEC61A2; Sec61 alpha 2 subunit (S. cerevisiae) [KO:K10956]
100190240	protein transport protein SEC61 beta subunit-like; K09481 protein transport protein SEC61 subunit beta [KO:K09481]
100220928	SEC61G; Sec61 gamma subunit [KO:K07342]
100221388	CANX; calnexin [KO:K08054]
100224962	C1R; complement component 1, r subcomponent [KO:K01330] [EC:3.4.21.41]
100229042	ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) [KO:K06464]
100223991	COLEC11; collectin sub-family member 11 [KO:K10066]
100225978	COLEC12; collectin sub-family member 12 [KO:K10062]
100227997	pulmonary surfactant-associated protein A-like; K10067 pulmonary surfactant-associated protein A [KO:K10067]
100228982	ITGAV; integrin, alpha V [KO:K06487]
100221336	ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) [KO:K06481]
100230947	ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [KO:K05719]
100226539	integrin beta-3-like; K06493 integrin beta 3 [KO:K06493]
100222654	ITGB5; integrin, beta 5 [KO:K06588]
100230636	THBS1; thrombospondin 1 [KO:K16857]
100223523	THBS4; thrombospondin 4 [KO:K04659]
100217632	thrombospondin-3-like; K04659 thrombospondin 2/3/4/5 [KO:K04659]
100221289	THBS2; thrombospondin 2 [KO:K04659]
100222593	toll-like receptor 2 type-2-like; K10159 toll-like receptor 2 [KO:K10159]
100219691	toll-like receptor 2 type-1-like; K10159 toll-like receptor 2 [KO:K10159]
100216357	TLR4; toll-like receptor 4 [KO:K10160]
100219050	MRC1; mannose receptor, C type 1 [KO:K06560]
100229329	PLA2R1; phospholipase A2 receptor 1, 180kDa [KO:K06560]
100228653	MRC1; mannose receptor, C type 1 [KO:K06560]
100225774	MRC1; mannose receptor, C type 1 [KO:K06560]
100222908	MRC1; mannose receptor, C type 1 [KO:K06560]
100231534	macrophage mannose receptor 1-like; K06560 mannose receptor, C type [KO:K06560]
100227522	MRC2; mannose receptor, C type 2 [KO:K06560]
100229945	MARCO; macrophage receptor with collagenous structure [KO:K13884]
100222818	SCARB1; scavenger receptor class B, member 1 [KO:K13885]
100221639	CD36; CD36 molecule (thrombospondin receptor) [KO:K06259]
100230391	uncharacterized LOC100230391; K08009 cytochrome b-245, alpha polypeptide [KO:K08009]
100225149	cytochrome b-245 heavy chain-like; K08008 NADPH oxidase [KO:K08008]
100228883	NOX3; NADPH oxidase 3 [KO:K08008]
100221287	RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
101234037	NCF1; neutrophil cytosolic factor 1 [KO:K08011]
100223851	NCF2; neutrophil cytosolic factor 2 [KO:K08010]
100224388	NCF4; neutrophil cytosolic factor 4, 40kDa [KO:K08012]

Compound

C04549

1-Phosphatidyl-1D-myo-inositol 3-phosphate

Reference

PMID:15894272

Authors

Stuart LM, Ezekowitz RA

Title

Phagocytosis: elegant complexity.

Journal

Immunity 22:539-50 (2005)

Reference

PMID:10684585

Authors

Tjelle TE, Lovdal T, Berg T

Title

Phagosome dynamics and function.

Journal

Bioessays 22:255-63 (2000)

Reference

PMID:18492791

Authors

Dupuy AG, Caron E

Title

Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.

Journal

J Cell Sci 121:1773-83 (2008)

Reference

PMID:15036145

Authors

Brumell JH, Grinstein S

Title

Salmonella redirects phagosomal maturation.

Journal

Curr Opin Microbiol 7:78-84 (2004)

Reference

PMID:17245426

Authors

Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S

Title

LAMP proteins are required for fusion of lysosomes with phagosomes.

Journal

EMBO J 26:313-24 (2007)

Reference

PMID:17637737

Authors

Luzio JP, Pryor PR, Bright NA

Title

Lysosomes: fusion and function.

Journal

Nat Rev Mol Cell Biol 8:622-32 (2007)

Reference

PMID:18513324

Authors

Sumimoto H

Title

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.

Journal

FEBS J 275:3249-77 (2008)

KO pathway

ko04145

All links

Pathway (2)   
   KEGG MODULE (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (101)   
   KEGG GENES (101)   
All databases (104)   

Download RDF

DBGET integrated database retrieval system