KEGG PATHWAY: tgu04145

PATHWAY: tgu04145

Entry

tgu04145 Pathway

Name

Phagosome - Taeniopygia guttata (zebra finch)

Description

Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.

Class

Cellular Processes; Transport and catabolism

Pathway map

tgu04145

Phagosome

Module

tgu_M00401

Sec61 complex [PATH:tgu04145]

Other DBs

BSID:

153964

GO:

0045335

Organism

Taeniopygia guttata (zebra finch) [GN:tgu]

Gene

100227418	VAMP3; vesicle associated membrane protein 3 [KO:K13505]
100223777	STX12; syntaxin 12 [KO:K13813]
100227604	STX7; syntaxin 7 [KO:K08488]
100229883	actin, cytoplasmic type 5 [KO:K05692]
751978	ACT5C; actin, cytoplasmic 1 [KO:K05692]
100224720	STX18; syntaxin 18 [KO:K08492]
100220898	SEC22B; SEC22 homolog B, vesicle trafficking protein [KO:K08517]
100231469	class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
100229282	class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
100222832	class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
100218309	class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
100225145	H-2 class II histocompatibility antigen, I-E beta chain-like [KO:K06752]
100230163	RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
100190713	RAB5C; RAB5C, member RAS oncogene family [KO:K07889]
100226301	EEA1; early endosome antigen 1 [KO:K12478]
100221298	PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
100219280	TFRC; transferrin receptor [KO:K06503]
100230661	HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
100229321	ATP6V1A; ATPase H+ transporting V1 subunit A [KO:K02145] [EC:3.6.3.14]
100219912	ATP6V1B2; ATPase H+ transporting V1 subunit B2 [KO:K02147]
100232700	ATP6V1C2; ATPase H+ transporting V1 subunit C2 [KO:K02148]
100218219	ATP6V1C1; ATPase H+ transporting V1 subunit C1 [KO:K02148]
100218128	ATP6V1D; ATPase H+ transporting V1 subunit D [KO:K02149]
100190066	ATP6V1E1; ATPase H+ transporting V1 subunit E1 [KO:K02150]
100223433	V-type proton ATPase subunit E 1 [KO:K02150]
100190522	ATP6V1F; ATPase H+ transporting V1 subunit F [KO:K02151]
100231544	ATP6V1G3; ATPase H+ transporting V1 subunit G3 [KO:K02152]
100190539	ATP6V1G1; ATPase H+ transporting V1 subunit G1 [KO:K02152]
100190507	ATPase H+ transporting V0 subunit-like [KO:K02153]
100221499	ATP6V0A4; ATPase H+ transporting V0 subunit a4 [KO:K02154]
100231607	TCIRG1; T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3 [KO:K02154]
100229310	ATP6V0A1; ATPase H+ transporting V0 subunit a1 [KO:K02154]
100218036	ATP6V0A2; ATPase H+ transporting V0 subunit a2 [KO:K02154]
100222039	ATP6V0D2; ATPase H+ transporting V0 subunit d2 [KO:K02146]
100227657	ATP6V0D1; ATPase H+ transporting V0 subunit d1 [KO:K02146]
100220186	ATP6V1H; ATPase H+ transporting V1 subunit H [KO:K02144]
100221539	ATP6V0C; ATPase H+ transporting V0 subunit c [KO:K02155]
100190528	ATP6V0B; ATPase H+ transporting V0 subunit b [KO:K03661]
100225098	ATP6AP1; ATPase H+ transporting accessory protein 1 [KO:K03662]
100231734	RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
100231361	RAB7B; RAB7B, member RAS oncogene family [KO:K07898]
100220395	RILP; Rab interacting lysosomal protein [KO:K13883]
100230595	DYNC1H1; dynein cytoplasmic 1 heavy chain 1 [KO:K10413]
100229193	DYNC2H1; dynein cytoplasmic 2 heavy chain 1 [KO:K10414]
100190676	DYNC1I1; dynein cytoplasmic 1 intermediate chain 1 [KO:K10415]
100227509	DYNC1I2; dynein cytoplasmic 1 intermediate chain 2 [KO:K10415]
100220587	DYNC1LI2; dynein cytoplasmic 1 light intermediate chain 2 [KO:K10416]
100221637	DYNC1LI1; dynein cytoplasmic 1 light intermediate chain 1 [KO:K10416]
100227941	TUBA8; tubulin alpha 8 [KO:K07374]
100218848	tubulin alpha-5 chain [KO:K07374]
100224687	TUBA1C; tubulin alpha-3 chain [KO:K07374]
100223131	TUBA1C; tubulin alpha-8 chain [KO:K07374]
100229371	tubulin alpha-3 chain [KO:K07374]
100229710	tubulin alpha-1B chain [KO:K07374]
100190739	tubulin alpha-2 chain-like [KO:K07374]
100231628	TUBB1; tubulin beta 1 class VI [KO:K07375]
100101449	TUBB4B; tubulin beta 4B class IVb [KO:K07375]
100227859	TUBB6; tubulin beta 6 class V [KO:K07375]
100219053	tubulin beta-5 chain-like [KO:K07375]
101233611	tubulin beta-1 chain [KO:K07375]
100190505	tubulin beta chain-like [KO:K07375]
100190525	tubulin beta 2-like [KO:K07375]
100219894	LAMP1; lysosomal associated membrane protein 1 [KO:K06528]
100222683	LAMP2; lysosomal associated membrane protein 2 [KO:K06528]
100218047	lysosome-associated membrane glycoprotein 2-like [KO:K06528]
100229363	PIKFYVE; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150]
100225036	M6PR; mannose-6-phosphate receptor, cation dependent [KO:K10089]
100231414	NOS1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
100228147	MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
100232421	CTSL; cathepsin L [KO:K01365] [EC:3.4.22.15]
100226165	cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
100232642	SEC61A1; Sec61 translocon alpha 1 subunit [KO:K10956]
100222701	protein transport protein Sec61 subunit alpha isoform 2-like [KO:K10956]
100230635	SEC61A2; Sec61 translocon alpha 2 subunit [KO:K10956]
100190240	SEC61B; Sec61 translocon beta subunit [KO:K09481]
100220928	SEC61G; Sec61 translocon gamma subunit [KO:K07342]
100190479	calreticulin [KO:K08057]
100221388	CANX; calnexin [KO:K08054]
100224962	C1R; complement C1r [KO:K01330] [EC:3.4.21.41]
100229042	ITGB2; integrin subunit beta 2 [KO:K06464]
100223991	COLEC11; collectin subfamily member 11 [KO:K10066]
100225978	COLEC12; collectin subfamily member 12 [KO:K10062]
100227997	SFTPA; surfactant protein A [KO:K10067]
100228982	ITGAV; integrin subunit alpha V [KO:K06487]
100221336	ITGA2; integrin subunit alpha 2 [KO:K06481]
100230947	ITGB1; integrin subunit beta 1 [KO:K05719]
100226539	ITGB3; integrin subunit beta 3 [KO:K06493]
100222654	ITGB5; integrin subunit beta 5 [KO:K06588]
100230636	THBS1; thrombospondin 1 [KO:K16857]
100223523	THBS4; thrombospondin 4 [KO:K04659]
100217632	THBS3; thrombospondin 3 [KO:K04659]
100221289	THBS2; thrombospondin 2 [KO:K04659]
100222593	toll-like receptor 2 type-2 [KO:K10159]
100219691	toll-like receptor 2 type-1 [KO:K10159]
100226645	TLR6; toll-like receptor 1 [KO:K10169]
100216357	TLR4; toll like receptor 4 [KO:K10160]
100219050	MRC1; macrophage mannose receptor 1 [KO:K06560]
100229329	PLA2R1; phospholipase A2 receptor 1 [KO:K06560]
100228653	MRC1; macrophage mannose receptor 1 [KO:K06560]
100225774	MRC1; macrophage mannose receptor 1 [KO:K06560]
100222908	MRC1; macrophage mannose receptor 1 [KO:K06560]
100231534	macrophage mannose receptor 1-like [KO:K06560]
100227522	MRC2; mannose receptor C type 2 [KO:K06560]
100229945	MARCO; macrophage receptor with collagenous structure [KO:K13884]
100222818	SCARB1; scavenger receptor class B member 1 [KO:K13885]
100221639	CD36; CD36 molecule [KO:K06259]
100230391	cytochrome b-245 light chain [KO:K08009]
100225149	cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
100227483	cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
100221287	RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
101234037	NCF1; neutrophil cytosolic factor 1 [KO:K08011]
100223851	NCF2; neutrophil cytosolic factor 2 [KO:K08010]
100224388	NCF4; neutrophil cytosolic factor 4 [KO:K08012]

Compound

C04549

1-Phosphatidyl-1D-myo-inositol 3-phosphate

Reference

PMID:15894272

Authors

Stuart LM, Ezekowitz RA

Title

Phagocytosis: elegant complexity.

Journal

Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002

Reference

PMID:10684585

Authors

Tjelle TE, Lovdal T, Berg T

Title

Phagosome dynamics and function.

Journal

Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R

Reference

PMID:18492791

Authors

Dupuy AG, Caron E

Title

Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.

Journal

J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036

Reference

PMID:15036145

Authors

Brumell JH, Grinstein S

Title

Salmonella redirects phagosomal maturation.

Journal

Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005

Reference

PMID:17245426

Authors

Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S

Title

LAMP proteins are required for fusion of lysosomes with phagosomes.

Journal

EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511

Reference

PMID:17637737

Authors

Luzio JP, Pryor PR, Bright NA

Title

Lysosomes: fusion and function.

Journal

Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217

Reference

PMID:18513324

Authors

Sumimoto H

Title

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.

Journal

FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x

KO pathway

ko04145

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (113)   
   KEGG GENES (113)   
All databases (115)   

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