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tgu04145                    Pathway                                

Phagosome - Taeniopygia guttata (zebra finch)
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Cellular Processes; Transport and catabolism
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All organismsOrtholog table
Sec61 complex [PATH:tgu04145]
Other DBs
Taeniopygia guttata (zebra finch) [GN:tgu]
VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
syntaxin-12-like; K13813 syntaxin 12/13 [KO:K13813]
STX7; syntaxin 7 [KO:K08488]
actin; K05692 actin beta/gamma 1 [KO:K05692]
STX18; syntaxin 18 [KO:K08492]
vesicle-trafficking protein SEC22b-like; K08517 vesicle transport protein SEC22 [KO:K08517]
class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
RAB5C member RAS oncogene family-like; K07889 Ras-related protein Rab-5C [KO:K07889]
EEA1; early endosome antigen 1 [KO:K12478]
PIK3C3; phosphatidylinositol 3-kinase, catalytic subunit type 3 [KO:K00914] [EC:]
TFRC; transferrin receptor (p90, CD71) [KO:K06503]
HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
ATP6V1A; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A [KO:K02145] [EC:]
ATP6V1B2; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 [KO:K02147]
ATP6V1C2; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 [KO:K02148]
ATP6V1C1; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 [KO:K02148]
ATP6V1D; ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D [KO:K02149]
ATPase H+ transporting lysosomal 31 kDa V1 subunit E-like; K02150 V-type H+-transporting ATPase subunit E [KO:K02150]
Vacuolar ATP synthase subunit F-like; K02151 V-type H+-transporting ATPase subunit F [KO:K02151]
ATP6V1G3; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 [KO:K02152]
ATPase H+ transporting V1 subunit G-like; K02152 V-type H+-transporting ATPase subunit G [KO:K02152]
ATPase H+ transporting V0 subunit-like; K02153 V-type H+-transporting ATPase subunit e [KO:K02153]
ATP6V0A4; ATPase, H+ transporting, lysosomal V0 subunit a4 [KO:K02154]
TCIRG1; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 [KO:K02154]
ATP6V0A1; ATPase, H+ transporting, lysosomal V0 subunit a1 [KO:K02154]
ATP6V0A2; ATPase, H+ transporting, lysosomal V0 subunit a2 [KO:K02154]
ATP6V0D2; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 [KO:K02146]
ATP6V0D1; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 [KO:K02146]
ATP6V1H; ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H [KO:K02144]
TBC1 domain family; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
ATPase H+ transporting lysosomal 21 kDa V0 subunit-like; K03661 V-type H+-transporting ATPase 21kDa proteolipid subunit [KO:K03661]
V-type proton ATPase subunit S1-like; K03662 V-type H+-transporting ATPase S1 subunit [KO:K03662]
RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
ras-related protein Rab-7b-like; K07898 Ras-related protein Rab-7B [KO:K07898]
RILP; Rab interacting lysosomal protein [KO:K13883]
DYNC1H1; dynein, cytoplasmic 1, heavy chain 1 [KO:K10413]
DYNC2H1; dynein, cytoplasmic 2, heavy chain 1 [KO:K10414]
dynein cytoplasmic intermediate polypeptide 1-like; K10415 dynein intermediate chain, cytosolic [KO:K10415]
DYNC1I2; dynein, cytoplasmic 1, intermediate chain 2 [KO:K10415]
DYNC1LI2; dynein, cytoplasmic 1, light intermediate chain 2 [KO:K10416]
DYNC1LI1; dynein, cytoplasmic 1, light intermediate chain 1 [KO:K10416]
TUBA8; tubulin, alpha 8 [KO:K07374]
tubulin alpha-4A chain-like; K07374 tubulin alpha [KO:K07374]
TUBA1C; tubulin, alpha 1c [KO:K07374]
TUBA1C; tubulin, alpha 1c [KO:K07374]
tubulin alpha-3 chain-like; K07374 tubulin alpha [KO:K07374]
tubulin beta-6 chain-like; K07375 tubulin beta [KO:K07375]
TUBB2C; tubulin, beta 4B class IVb [KO:K07375]
tubulin beta-5 chain-like; K07375 tubulin beta [KO:K07375]
tubulin beta-5 chain-like; K07375 tubulin beta [KO:K07375]
tubulin beta-2 chain-like; K07375 tubulin beta [KO:K07375]
LAMP1; lysosomal-associated membrane protein 1 [KO:K06528]
LAMP2; lysosomal-associated membrane protein 2 [KO:K06528]
PIKFYVE; phosphoinositide kinase, FYVE finger containing [KO:K00921] [EC:]
M6PR; mannose-6-phosphate receptor (cation dependent) [KO:K10089]
NOS1; nitric oxide synthase 1 (neuronal) [KO:K13240] [EC:]
MPO; myeloperoxidase [KO:K10789] [EC:]
cathepsin L1-like; K01365 cathepsin L [EC:] [KO:K01365] [EC:]
cathepsin L1-like; K01365 cathepsin L [EC:] [KO:K01365] [EC:]
SEC61A1; Sec61 alpha 1 subunit (S. cerevisiae) [KO:K10956]
protein transport protein Sec61 subunit alpha isoform 2-like; K10956 protein transport protein SEC61 subunit alpha [KO:K10956]
SEC61A2; Sec61 alpha 2 subunit (S. cerevisiae) [KO:K10956]
protein transport protein SEC61 beta subunit-like; K09481 protein transport protein SEC61 subunit beta [KO:K09481]
SEC61G; Sec61 gamma subunit [KO:K07342]
CANX; calnexin [KO:K08054]
C1R; complement component 1, r subcomponent [KO:K01330] [EC:]
ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) [KO:K06464]
COLEC11; collectin sub-family member 11 [KO:K10066]
COLEC12; collectin sub-family member 12 [KO:K10062]
pulmonary surfactant-associated protein A-like; K10067 pulmonary surfactant-associated protein A [KO:K10067]
ITGAV; integrin, alpha V [KO:K06487]
ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) [KO:K06481]
ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [KO:K05719]
integrin beta-3-like; K06493 integrin beta 3 [KO:K06493]
ITGB5; integrin, beta 5 [KO:K06588]
THBS1; thrombospondin 1 [KO:K16857]
THBS4; thrombospondin 4 [KO:K04659]
thrombospondin-3-like; K04659 thrombospondin 2/3/4/5 [KO:K04659]
THBS2; thrombospondin 2 [KO:K04659]
toll-like receptor 2 type-2-like; K10159 toll-like receptor 2 [KO:K10159]
toll-like receptor 2 type-1-like; K10159 toll-like receptor 2 [KO:K10159]
TLR4; toll-like receptor 4 [KO:K10160]
MRC1; mannose receptor, C type 1 [KO:K06560]
PLA2R1; phospholipase A2 receptor 1, 180kDa [KO:K06560]
MRC1; mannose receptor, C type 1 [KO:K06560]
MRC1; mannose receptor, C type 1 [KO:K06560]
MRC1; mannose receptor, C type 1 [KO:K06560]
macrophage mannose receptor 1-like; K06560 mannose receptor, C type [KO:K06560]
MRC2; mannose receptor, C type 2 [KO:K06560]
MARCO; macrophage receptor with collagenous structure [KO:K13884]
SCARB1; scavenger receptor class B, member 1 [KO:K13885]
CD36; CD36 molecule (thrombospondin receptor) [KO:K06259]
uncharacterized LOC100230391; K08009 cytochrome b-245, alpha polypeptide [KO:K08009]
cytochrome b-245 heavy chain-like; K08008 NADPH oxidase [KO:K08008]
NOX3; NADPH oxidase 3 [KO:K08008]
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
NCF1; neutrophil cytosolic factor 1 [KO:K08011]
NCF2; neutrophil cytosolic factor 2 [KO:K08010]
NCF4; neutrophil cytosolic factor 4, 40kDa [KO:K08012]
1-Phosphatidyl-1D-myo-inositol 3-phosphate
Stuart LM, Ezekowitz RA
Phagocytosis: elegant complexity.
Immunity 22:539-50 (2005)
Tjelle TE, Lovdal T, Berg T
Phagosome dynamics and function.
Bioessays 22:255-63 (2000)
Dupuy AG, Caron E
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
J Cell Sci 121:1773-83 (2008)
Brumell JH, Grinstein S
Salmonella redirects phagosomal maturation.
Curr Opin Microbiol 7:78-84 (2004)
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
LAMP proteins are required for fusion of lysosomes with phagosomes.
EMBO J 26:313-24 (2007)
Luzio JP, Pryor PR, Bright NA
Lysosomes: fusion and function.
Nat Rev Mol Cell Biol 8:622-32 (2007)
Sumimoto H
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
FEBS J 275:3249-77 (2008)
KO pathway

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