Entry
Name
Phagosome - Taeniopygia guttata (zebra finch)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Other DBs
Organism
Taeniopygia guttata (zebra finch) [GN:
tgu ]
Gene
100190528 ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661 ]
100190676 DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415 ]
100218047 LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528 ]
100219912 ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147 ]
100220587 DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416 ]
100220928 SEC61G; protein transport protein Sec61 subunit gamma isoform X2 [KO:K07342 ]
100221287 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
100221539 ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155 ]
100221637 DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416 ]
100222818 SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885 ]
100227509 DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415 ]
100227997 SFTPA; pulmonary surfactant-associated protein A isoform X1 [KO:K10067 ]
100229193 DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414 ]
100229310 ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X6 [KO:K02154 ]
100230635 SEC61A2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956 ]
100230661 HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182 ]
100231607 TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154 ]
100232642 SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956 ]
100232700 ATP6V1C2; V-type proton ATPase subunit C 2 isoform X2 [KO:K02148 ]
115494843 ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147 ]
Compound
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
Authors
Stuart LM, Ezekowitz RA
Title
Phagocytosis: elegant complexity.
Journal
Reference
Authors
Tjelle TE, Lovdal T, Berg T
Title
Phagosome dynamics and function.
Journal
Reference
Authors
Dupuy AG, Caron E
Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
Journal
Reference
Authors
Brumell JH, Grinstein S
Title
Salmonella redirects phagosomal maturation.
Journal
Reference
Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
Journal
Reference
Authors
Luzio JP, Pryor PR, Bright NA
Title
Lysosomes: fusion and function.
Journal
Reference
Authors
Sumimoto H
Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
Journal
Related pathway
tgu04620 Toll-like receptor signaling pathway
KO pathway