KEGG   PATHWAY: tgu04145
Entry
tgu04145                    Pathway                                
Name
Phagosome - Taeniopygia guttata (zebra finch)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
tgu04145  Phagosome
tgu04145

Other DBs
GO: 0045335
Organism
Taeniopygia guttata (zebra finch) [GN:tgu]
Gene
100101449  TUBB4B; tubulin beta-4B chain [KO:K07375]
100190066  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
100190114  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
100190240  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
100190479  CALR; calreticulin [KO:K08057]
100190505  [KO:K07375]
100190507  [KO:K02153]
100190522  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
100190528  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
100190539  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
100190676  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
100190713  RAB5C; ras-related protein Rab-5C [KO:K07889]
100216357  TLR4; toll-like receptor 4 precursor [KO:K10160]
100217632  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
100218036  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
100218047  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
100218128  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
100218219  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
100218446  COMP; cartilage oligomeric matrix protein isoform X4 [KO:K04659]
100218848  [KO:K07374]
100219050  [KO:K06560]
100219280  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
100219691  TLR2; toll-like receptor 2 isoform X2 [KO:K10159]
100219894  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
100219912  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
100220186  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
100220395  RILP; rab-interacting lysosomal protein isoform X1 [KO:K13883]
100220587  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
100220898  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
100220928  SEC61G; protein transport protein Sec61 subunit gamma isoform X2 [KO:K07342]
100221287  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100221289  THBS2; thrombospondin-2 isoform X2 [KO:K04659]
100221298  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
100221336  ITGA2; integrin alpha-2 isoform X2 [KO:K06481]
100221388  CANX; calnexin [KO:K08054]
100221499  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
100221539  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
100221637  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
100221639  CD36; platelet glycoprotein 4 [KO:K06259]
100222039  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
100222654  ITGB5; integrin beta-5 [KO:K06588]
100222818  SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
100222821  C3; complement C3 isoform X1 [KO:K03990]
100222908  [KO:K06560]
100223082  CTSS; cathepsin S isoform X2 [KO:K01368] [EC:3.4.22.27]
100223131  [KO:K07374]
100223523  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
100223777  STX12; syntaxin-12 [KO:K13813]
100223851  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
100223991  COLEC11; collectin-11 isoform X2 [KO:K10066]
100224388  NCF4; neutrophil cytosol factor 4 isoform X2 [KO:K08012]
100224687  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
100224720  STX18; syntaxin-18 [KO:K08492]
100224962  C1R; complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
100225036  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
100225098  ATP6AP1; V-type proton ATPase subunit S1 isoform X1 [KO:K03662]
100225145  [KO:K06752]
100225149  [KO:K21421] [EC:1.-.-.-]
100225774  [KO:K06560]
100225978  COLEC12; collectin-12 [KO:K10062]
100226165  [KO:K01365] [EC:3.4.22.15]
100226301  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
100226539  ITGB3; integrin beta-3 [KO:K06493]
100226645  [KO:K10169]
100227418  VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
100227509  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
100227522  MRC2; C-type mannose receptor 2 [KO:K06560]
100227604  STX7; syntaxin-7 isoform X1 [KO:K08488]
100227657  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
100227859  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
100227941  TUBA8; tubulin alpha-8 chain [KO:K07374]
100227997  SFTPA; pulmonary surfactant-associated protein A isoform X1 [KO:K10067]
100228653  [KO:K06560]
100228982  ITGAV; integrin alpha-V [KO:K06487]
100229042  ITGB2; integrin beta-2 [KO:K06464]
100229193  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
100229310  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X6 [KO:K02154]
100229321  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
100229329  ITGB6; integrin beta-6 isoform X1 [KO:K06560]
100229363  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
100229371  [KO:K07374]
100229447  [KO:K10067]
100229710  [KO:K07374]
100230163  RAB5A; ras-related protein Rab-5A [KO:K07887]
100230391  [KO:K08009]
100230595  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
100230635  SEC61A2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
100230636  THBS1; thrombospondin-1 [KO:K16857]
100230661  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
100230947  ITGB1; integrin beta-1 isoform X4 [KO:K05719]
100231361  RAB7B; ras-related protein Rab-7b isoform X2 [KO:K07898]
100231414  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
100231469  [KO:K06751]
100231534  [KO:K06560]
100231544  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
100231607  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
100231628  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
100231734  RAB7A; ras-related protein Rab-7a [KO:K07897]
100232421  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
100232642  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
100232700  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X2 [KO:K02148]
101234037  NCF1; neutrophil cytosol factor 1 [KO:K08011]
105760000  MARCO; macrophage receptor MARCO isoform X1 [KO:K13884]
115490530  [KO:K07374]
115491411  TUBA1A; tubulin alpha-1A chain [KO:K07374]
115491460  RAB5B; ras-related protein Rab-5B [KO:K07888]
115491489  [KO:K06484]
115492234  [KO:K06752]
115492664  [KO:K05654] [EC:7.4.2.14]
115493080  TUBB; tubulin beta chain [KO:K07375]
115493243  [KO:K06752]
115493246  [KO:K06752]
115493254  [KO:K06752]
115493267  [KO:K06752]
115493268  [KO:K06752]
115493286  [KO:K06752]
115494843  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
115496608  [KO:K05692]
115496848  TUBB3; tubulin beta-3 chain [KO:K07375]
115497627  ACTG1; actin, cytoplasmic 2 [KO:K05692]
115498404  [KO:K02145] [EC:7.1.2.2]
116807070  [KO:K06856]
116807264  [KO:K13240] [EC:1.14.13.39]
116807535  [KO:K06752]
116807540  [KO:K06752]
116809116  [KO:K10789] [EC:1.11.2.2]
116809130  [KO:K10789] [EC:1.11.2.2]
751978  ACTB; actin, cytoplasmic 1 [KO:K05692]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
tgu04142  Lysosome
tgu04144  Endocytosis
tgu04620  Toll-like receptor signaling pathway
KO pathway
ko04145   

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