KEGG   PATHWAY: tpi00010Help
Entry
tpi00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis - Treponema primitia
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Glycolysis / Gluconeogenesis
tpi00010

All organismsOrtholog table
Module
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:tpi00010]
Glycolysis, core module involving three-carbon compounds [PATH:tpi00010]
Other DBs
Organism
Treponema primitia [GN:tpi]
Gene
hexokinase; K00844 hexokinase [EC:2.7.1.1] [KO:K00844] [EC:2.7.1.1]
pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
6-phosphofructokinase; K00850 6-phosphofructokinase 1 [EC:2.7.1.11] [KO:K00850] [EC:2.7.1.11]
diphosphate--fructose-6-phosphate 1-phosphotransferase; K00850 6-phosphofructokinase 1 [EC:2.7.1.11] [KO:K00850] [EC:2.7.1.11]
fba; fructose-1,6-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
tpiA; triose-phosphate isomerase [KO:K01803] [EC:5.3.1.1]
gap; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
glyceraldehyde-3-phosphate dehydrogenase; K00150 glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) [EC:1.2.1.59] [KO:K00150] [EC:1.2.1.59]
pgk_1; phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
pgk_2; phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
phosphoglycerate mutase family protein; K15634 probable phosphoglycerate mutase [EC:5.4.2.12] [KO:K15634] [EC:5.4.2.12]
eno; phosphopyruvate hydratase [KO:K01689] [EC:4.2.1.11]
pyk; pyruvate kinase [KO:K00873] [EC:2.7.1.40]
dihydrolipoyl dehydrogenase; K00382 dihydrolipoamide dehydrogenase [EC:1.8.1.4] [KO:K00382] [EC:1.8.1.4]
aldehyde-alcohol dehydrogenase 2; K04072 acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1] [KO:K04072] [EC:1.1.1.1 1.2.1.10]
acyl-coenzyme A synthetase ACSM3; K01895 acetyl-CoA synthetase [EC:6.2.1.1] [KO:K01895] [EC:6.2.1.1]
acyl-coenzyme A synthetase ACSM3; K01895 acetyl-CoA synthetase [EC:6.2.1.1] [KO:K01895] [EC:6.2.1.1]
aldose 1-epimerase; K01785 aldose 1-epimerase [EC:5.1.3.3] [KO:K01785] [EC:5.1.3.3]
putative phosphomannomutase; K01835 phosphoglucomutase [EC:5.4.2.2] [KO:K01835] [EC:5.4.2.2]
phosphoenolpyruvate carboxykinase; K01596 phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32] [KO:K01596] [EC:4.1.1.32]
glycoside hydrolase family protein; K01222 6-phospho-beta-glucosidase [EC:3.2.1.86] [KO:K01222] [EC:3.2.1.86]
beta-glucosidase; K01223 6-phospho-beta-glucosidase [EC:3.2.1.86] [KO:K01223] [EC:3.2.1.86]
beta-glucosidase; K01223 6-phospho-beta-glucosidase [EC:3.2.1.86] [KO:K01223] [EC:3.2.1.86]
Compound
C00022  
Pyruvate
C00024  
Acetyl-CoA
C00031  
D-Glucose
C00033  
Acetate
C00036  
Oxaloacetate
C00068  
Thiamin diphosphate
C00074  
Phosphoenolpyruvate
C00084  
Acetaldehyde
C00103  
D-Glucose 1-phosphate
C00111  
Glycerone phosphate
C00118  
D-Glyceraldehyde 3-phosphate
C00186  
(S)-Lactate
C00197  
3-Phospho-D-glycerate
C00221  
beta-D-Glucose
C00236  
3-Phospho-D-glyceroyl phosphate
C00267  
alpha-D-Glucose
C00469  
Ethanol
C00631  
2-Phospho-D-glycerate
C00668  
alpha-D-Glucose 6-phosphate
C01159  
2,3-Bisphospho-D-glycerate
C01172  
beta-D-Glucose 6-phosphate
C01451  
Salicin
C05125  
2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  
beta-D-Fructose 6-phosphate
C05378  
beta-D-Fructose 1,6-bisphosphate
C06186  
Arbutin
C06187  
Arbutin 6-phosphate
C06188  
Salicin 6-phosphate
C15972  
Enzyme N6-(lipoyl)lysine
C15973  
Enzyme N6-(dihydrolipoyl)lysine
C16255  
[Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
KO pathway
 

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