KEGG   PATHWAY: tpi00010Help
Entry
tpi00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis - Treponema primitia
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
tpi00010  Glycolysis / Gluconeogenesis
tpi00010

Ortholog table
Module
tpi_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:tpi00010]
tpi_M00002  Glycolysis, core module involving three-carbon compounds [PATH:tpi00010]
tpi_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:tpi00010]
Other DBs
BSID: 219599
GO: 0006096 0006094
Organism
Treponema primitia [GN:tpi]
Gene
TREPR_1339  hexokinase [KO:K00844] [EC:2.7.1.1]
TREPR_2249  pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
TREPR_0608  diphosphate--fructose-6-phosphate 1-phosphotransferase [KO:K00850] [EC:2.7.1.11]
TREPR_3551  6-phosphofructokinase [KO:K21071] [EC:2.7.1.90 2.7.1.11]
TREPR_1621  diphosphate--fructose-6-phosphate 1-phosphotransferase [KO:K00895] [EC:2.7.1.90]
TREPR_1085  fba; fructose-1,6-bisphosphate aldolase, class II [KO:K01624] [EC:4.1.2.13]
TREPR_2452  tpiA; triose-phosphate isomerase [KO:K01803] [EC:5.3.1.1]
TREPR_2454  gap; glyceraldehyde-3-phosphate dehydrogenase, type I [KO:K00134] [EC:1.2.1.12]
TREPR_0394  glyceraldehyde-3-phosphate dehydrogenase, type II [KO:K00150] [EC:1.2.1.59]
TREPR_2453  pgk_1; phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
TREPR_0395  pgk_2; phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
TREPR_2434  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
TREPR_0776  eno; phosphopyruvate hydratase [KO:K01689] [EC:4.2.1.11]
TREPR_0649  pyk; pyruvate kinase [KO:K00873] [EC:2.7.1.40]
TREPR_3835  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
TREPR_1990  nifJ; pyruvate:ferredoxin (flavodoxin) oxidoreductase [KO:K03737] [EC:1.2.7.- 1.2.7.1]
TREPR_3421  vorB; 2-oxoglutarate oxidoreductase, alpha subunit [KO:K00174] [EC:1.2.7.11 1.2.7.3]
TREPR_3420  2-oxoglutarate oxidoreductase, beta subunit [KO:K00175] [EC:1.2.7.11 1.2.7.3]
TREPR_3297  aldehyde-alcohol dehydrogenase 2 [KO:K04072] [EC:1.1.1.1 1.2.1.10]
TREPR_0157  acyl-coenzyme A synthetase ACSM3 [KO:K01895] [EC:6.2.1.1]
TREPR_1800  acyl-coenzyme A synthetase ACSM3 [KO:K01895] [EC:6.2.1.1]
TREPR_2660  aldose 1-epimerase (Mutarotase) [KO:K01785] [EC:5.1.3.3]
TREPR_1681  putative phosphomannomutase [KO:K01835] [EC:5.4.2.2]
TREPR_3050  phosphoenolpyruvate carboxykinase (ATP) [KO:K01596] [EC:4.1.1.32]
TREPR_1512  glycoside hydrolase family 4 [KO:K01222] [EC:3.2.1.86]
TREPR_0470  beta-glucosidase (Gentiobiase) (Cellobiase) (Beta-D-glucoside glucohydrolase) (Amygdalase) [KO:K01223] [EC:3.2.1.86]
TREPR_2952  beta-glucosidase (Gentiobiase) (Cellobiase) (Beta-D-glucoside glucohydrolase) (Amygdalase) [KO:K01223] [EC:3.2.1.86]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
KO pathway
ko00010   

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