KEGG   PATHWAY: tve03420
Entry
tve03420                    Pathway                                
Name
Nucleotide excision repair - Trichophyton verrucosum
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
tve03420  Nucleotide excision repair
tve03420

Other DBs
GO: 0006289
Organism
Trichophyton verrucosum [GN:tve]
Gene
TRV_07648  hypothetical protein [KO:K03868] [EC:2.3.2.32]
TRV_08069  hypothetical protein [KO:K10609]
TRV_06556  hypothetical protein [KO:K10610]
TRV_06394  hypothetical protein [KO:K10838]
TRV_07185  DNA repair protein Rad4, putative [KO:K10838]
TRV_00140  hypothetical protein [KO:K10839]
TRV_02968  hypothetical protein [KO:K10570]
TRV_07841  hypothetical protein [KO:K10841]
TRV_02753  hypothetical protein [KO:K03006] [EC:2.7.7.6]
TRV_00102  hypothetical protein [KO:K03010] [EC:2.7.7.6]
TRV_06869  hypothetical protein [KO:K03011]
TRV_01945  hypothetical protein [KO:K03012]
TRV_01312  hypothetical protein [KO:K03013]
TRV_00891  hypothetical protein [KO:K03014]
TRV_04429  DNA-directed RNA polymerase III complex subunit Rpc25 [KO:K03015]
TRV_04927  hypothetical protein [KO:K03016]
TRV_02570  hypothetical protein [KO:K03008]
TRV_00732  hypothetical protein [KO:K02202] [EC:2.7.11.22 2.7.11.23]
TRV_04304  hypothetical protein [KO:K10842]
TRV_01782  hypothetical protein [KO:K06634]
TRV_05968  hypothetical protein [KO:K10843] [EC:5.6.2.4]
TRV_00914  hypothetical protein [KO:K10844] [EC:5.6.2.3]
TRV_04658  hypothetical protein [KO:K03141]
TRV_05937  hypothetical protein [KO:K03142]
TRV_06076  hypothetical protein [KO:K03143]
TRV_00272  hypothetical protein [KO:K03144]
TRV_01672  hypothetical protein [KO:K10846]
TRV_07906  hypothetical protein [KO:K10847]
TRV_00711  hypothetical protein [KO:K07466]
TRV_01408  possible replication factor-a protein [KO:K10739]
TRV_05859  hypothetical protein [KO:K10848] [EC:3.1.-.-]
TRV_05441  hypothetical protein [KO:K10849]
TRV_02480  POL3; Catalytic subunit of DNA polymerase delta [KO:K02327] [EC:2.7.7.7]
TRV_02865  hypothetical protein [KO:K02328]
TRV_02492  hypothetical protein [KO:K03504]
TRV_00602  DNA polymerase delta subunit 4, putative [KO:K03505]
TRV_03251  hypothetical protein [KO:K02324] [EC:2.7.7.7]
TRV_03045  DNA polymerase epsilon subunit B, putative [KO:K02325] [EC:2.7.7.7]
TRV_02962  CBF/NF-Y family transcription factor, putative [KO:K02326] [EC:2.7.7.7]
TRV_03815  hypothetical protein [KO:K04802]
TRV_05323  hypothetical protein [KO:K10754]
TRV_05402  hypothetical protein [KO:K10755]
TRV_01585  replication factor C subunit [KO:K10755]
TRV_07502  hypothetical protein [KO:K10756]
TRV_05324  hypothetical protein [KO:K10756]
TRV_05913  hypothetical protein [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
tve03020  RNA polymerase
tve04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (46)   
   KEGG GENES (46)   
All databases (47)   

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