KEGG   PATHWAY: xac03440
Entry
xac03440                    Pathway                                
Name
Homologous recombination - Xanthomonas citri pv. citri 306
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
xac03440  Homologous recombination
xac03440

Other DBs
GO: 0000724
Organism
Xanthomonas citri pv. citri 306 [GN:xac]
Gene
XAC1865  recJ; single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
XAC2905  ssb; single-stranded DNA binding protein [KO:K03111]
XAC2211  ssb; single-stranded DNA binding protein [KO:K03111]
XAC0003  recF; DNA replication and repair RecF protein [KO:K03629]
XAC1327  recO; DNA repair protein [KO:K03584]
XAC1111  recR; recombination protein RecR [KO:K06187]
XAC1740  recA; RecA protein [KO:K03553]
XAC4110  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
XAC3149  ruvA; holliday junction binding protein DNA helicase [KO:K03550]
XAC3147  ruvB; holliday junction binding protein DNA helicase [KO:K03551] [EC:5.6.2.4]
XAC3150  ruvC; holliday junction resolvase [KO:K01159] [EC:3.1.21.10]
XAC3391  recG; ATP-dependent DNA helicase [KO:K03655] [EC:5.6.2.4]
XAC4336  recB; exodeoxyribonuclease V beta chain [KO:K03582] [EC:3.1.11.5]
XAC4337  recC; exodeoxyribonuclease V gamma chain [KO:K03583] [EC:3.1.11.5]
XAC4335  recD; exodeoxyribonuclease V alpha chain [KO:K03581] [EC:3.1.11.5]
XAC1406  dnaE1; DNA polymerase III alpha chain [KO:K02337] [EC:2.7.7.7]
XAC0002  dnaN; DNA polymerase III beta chain [KO:K02338] [EC:2.7.7.7]
XAC1109  dnaX; DNA polymerase III tau and gamma subunits [KO:K02343] [EC:2.7.7.7]
XAC2779  holA; DNA polymerase III delta subunit [KO:K02340] [EC:2.7.7.7]
XAC1132  holB; DNA polymerase III delta' subunit [KO:K02341] [EC:2.7.7.7]
XAC1090  dnaQ; DNA polymerase III epsilon chain [KO:K02342] [EC:2.7.7.7]
XAC3558  holC; DNA polymerase III holoenzyme chi subunit [KO:K02339] [EC:2.7.7.7]
XAC3818  priA; primosomal protein N' [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG GENES (23)   
All databases (24)   

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