KEGG   PATHWAY: xfn00550
Entry
xfn00550                    Pathway                                
Name
Peptidoglycan biosynthesis - Xylella fastidiosa M23
Description
Peptidoglycan is a macromolecule made of long aminosugar strands cross-linked by short peptides. It forms the cell wall in bacteria surrounding the cytoplasmic membrane. The glycan strands are typically comprised of repeating N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc) disaccharides. Each MurNAc is linked to a peptide of three to five amino acid residues. Disaccharide subunits are first assembled on the cytoplasmic side of the bacterial membrane on a polyisoprenoid anchor (lipid I and II). Polymerization of disaccharide subunits by transglycosylases and cross-linking of glycan strands by transpeptidases occur on the other side of the membrane. Bacterial cell wall biosynthesis inhibitors form a major class of antibiotics.
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
xfn00550  Peptidoglycan biosynthesis
xfn00550

Organism
Xylella fastidiosa M23 [GN:xfn]
Gene
XfasM23_0677  UDP-N-acetylglucosamine 1-carboxyvinyltransferase [KO:K00790] [EC:2.5.1.7]
XfasM23_2059  UDP-N-acetylenolpyruvoylglucosamine reductase [KO:K00075] [EC:1.3.1.98]
XfasM23_1968  UDP-N-acetylmuramate--alanine ligase [KO:K01924] [EC:6.3.2.8]
XfasM23_0404  UDP-N-acetylmuramoylalanine--D-glutamate ligase [KO:K23169] [EC:6.3.2.53]
XfasM23_0403  conserved hypothetical protein [KO:K23170] [EC:5.1.1.23]
XfasM23_1973  UDP-N-acetylmuramyl-tripeptide synthetase [KO:K01928] [EC:6.3.2.13]
XfasM23_1967  D-alanine--D-alanine ligase [KO:K01921] [EC:6.3.2.4]
XfasM23_1972  UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase [KO:K01929] [EC:6.3.2.10]
XfasM23_0326  undecaprenyl diphosphate synthase [KO:K00806] [EC:2.5.1.31]
XfasM23_1091  Undecaprenyl-diphosphatase [KO:K06153] [EC:3.6.1.27]
XfasM23_1971  phospho-N-acetylmuramoyl-pentapeptide-transferase [KO:K01000] [EC:2.7.8.13]
XfasM23_1969  UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [KO:K02563] [EC:2.4.1.227]
XfasM23_1147  monofunctional biosynthetic peptidoglycan transglycosylase [KO:K03814] [EC:2.4.99.28]
XfasM23_1790  penicillin-binding protein, 1A family [KO:K05366] [EC:2.4.99.28 3.4.16.4]
XfasM23_1899  penicillin-binding protein 1B [KO:K05365] [EC:2.4.99.28 3.4.16.4]
XfasM23_1366  penicillin-binding protein 1C [KO:K05367] [EC:2.4.99.28]
XfasM23_0590  penicillin-binding protein 2 [KO:K05515] [EC:3.4.16.4]
XfasM23_1974  Peptidoglycan glycosyltransferase [KO:K03587] [EC:3.4.16.4]
XfasM23_1362  Serine-type D-Ala-D-Ala carboxypeptidase [KO:K07258] [EC:3.4.16.4]
XfasM23_1902  peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin [KO:K07260] [EC:3.4.17.14]
Compound
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00133  D-Alanine
C00448  trans,trans-Farnesyl diphosphate
C00692  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
C00993  D-Alanyl-D-alanine
C01050  UDP-N-acetylmuramate
C01212  UDP-N-acetylmuramoyl-L-alanine
C04574  di-trans,poly-cis-Undecaprenyl diphosphate
C04631  UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
C04702  UDPMurNAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)
C04851  MurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphospho-undecaprenol
C04877  UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate
C04882  UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine
C05892  UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine
C05893  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
C05894  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine
C05895  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)5-D-alanyl-D-alanine
C05896  Crosslinked peptidoglycan
C05897  Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
C05898  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
C17541  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)-D-alanyl-D-alanine
C17542  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)3-D-alanyl-D-alanine
C17549  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl-L-alanyl)-D-alanyl-D-alanine
C17550  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl)-D-alanyl-D-alanine
C17556  di-trans,poly-cis-Undecaprenyl phosphate
C17558  di-trans,poly-cis-Undecaprenol
C22053  UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate
Reference
PMID:18081839
  Authors
Bouhss A, Trunkfield AE, Bugg TD, Mengin-Lecreulx D
  Title
The biosynthesis of peptidoglycan lipid-linked intermediates.
  Journal
FEMS Microbiol Rev 32:208-33 (2008)
DOI:10.1111/j.1574-6976.2007.00089.x
Reference
PMID:18077448
  Authors
Lloyd AJ, Gilbey AM, Blewett AM, De Pascale G, El Zoeiby A, Levesque RC, Catherwood AC, Tomasz A, Bugg TD, Roper DI, Dowson CG
  Title
Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan.
  Journal
J Biol Chem 283:6402-17 (2008)
DOI:10.1074/jbc.M708105200
Reference
PMID:18266853
  Authors
Barreteau H, Kovac A, Boniface A, Sova M, Gobec S, Blanot D
  Title
Cytoplasmic steps of peptidoglycan biosynthesis.
  Journal
FEMS Microbiol Rev 32:168-207 (2008)
DOI:10.1111/j.1574-6976.2008.00104.x
Reference
PMID:11699883
  Authors
van Heijenoort J
  Title
Recent advances in the formation of the bacterial peptidoglycan monomer unit.
  Journal
Nat Prod Rep 18:503-19 (2001)
DOI:10.1039/a804532a
Reference
PMID:11320055
  Authors
van Heijenoort  J
  Title
Formation of the glycan chains in the synthesis of bacterial peptidoglycan.
  Journal
Glycobiology 11:25R-36R (2001)
DOI:10.1093/glycob/11.3.25R
Related
pathway
xfn00470  D-Amino acid metabolism
xfn00520  Amino sugar and nucleotide sugar metabolism
xfn00900  Terpenoid backbone biosynthesis
KO pathway
ko00550   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG GENES (20)   
All databases (21)   

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