KEGG   PATHWAY: xla04510
Entry
xla04510                    Pathway                                
Name
Focal adhesion - Xenopus laevis (African clawed frog)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
xla04510  Focal adhesion
xla04510

Other DBs
GO: 0005925
Organism
Xenopus laevis (African clawed frog) [GN:xla]
Gene
380419  col1a2.L; collagen type I alpha 2 L homeolog precursor [KO:K06236]
380515  col1a1.S; collagen, type I, alpha 1 S homeolog precursor [KO:K06236]
108700840  col1a1.L; collagen alpha-1(I) chain [KO:K06236]
108719903  col1a2.S; collagen alpha-2(I) chain [KO:K06236]
397739  col2a1.S; collagen, type II, alpha 1 S homeolog precursor [KO:K19719]
397738  col2a1.L; collagen alpha-1(II) chain precursor [KO:K19719]
108700099  collagen alpha-6(IV) chain isoform X3 [KO:K06237]
373763  col4a2.L; collagen alpha-2(IV) chain [KO:K06237]
108709739  collagen alpha-1(IV) chain-like [KO:K06237]
108698394  col4a6.L; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
108700098  col4a5.S; collagen alpha-5(IV) chain isoform X2 [KO:K06237]
108709738  col4a2.S; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
373764  col4a1.L; collagen alpha-1(IV) chain [KO:K06237]
108698395  col4a5.L; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
380129  col6a1.L; collagen alpha-1(VI) chain [KO:K06238]
734275  col6a2.L; uncharacterized protein LOC734275 precursor [KO:K06238]
108703023  col6a1.S; collagen alpha-1(VI) chain-like [KO:K06238]
108703024  col6a2.S; collagen alpha-2(VI) chain [KO:K06238]
108718494  col6a5.L; collagen alpha-6(VI) chain [KO:K06238]
108702277  collagen alpha-3(VI) chain [KO:K06238]
108702278  collagen alpha-3(VI) chain isoform X1 [KO:K06238]
108719692  col6a6.S; collagen alpha-6(VI) chain [KO:K06238]
108718495  col6a6.L; collagen alpha-6(VI) chain [KO:K06238]
398368  collagen alpha-3(VI) chain isoform X3 [KO:K06238]
446508  col9a3.L; collagen, type IX, alpha 3 L homeolog precursor [KO:K08131]
446631  col9a1.L; collagen, type IX, alpha 1 L homeolog precursor [KO:K08131]
734362  col9a2.L; collagen, type IX, alpha 2 L homeolog precursor [KO:K08131]
108702653  col9a3.S; collagen alpha-3(IX) chain [KO:K08131]
398560  col9a1-b; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
108709589  col9a2.S; collagen alpha-2(IX) chain [KO:K08131]
108718546  laminin subunit alpha-1 [KO:K05637]
108716137  laminin subunit alpha-2-like [KO:K05637]
108702189  laminin subunit alpha-5 isoform X1 [KO:K06240]
108718553  lama3.L; laminin subunit alpha-3 [KO:K06240]
108700926  lama5.L; laminin subunit alpha-5 isoform X1 [KO:K06240]
108717424  LOW QUALITY PROTEIN: laminin subunit alpha-4-like [KO:K06241]
108716825  lama4.L; laminin subunit alpha-4 isoform X1 [KO:K06241]
108713081  lamb1.S; laminin subunit beta-1 [KO:K05636]
108711179  lamb1.L; laminin subunit beta-1 [KO:K05636]
494988  lamb2.L; laminin subunit beta 2 L homeolog precursor [KO:K06243]
108715891  lamb2.S; laminin subunit beta-2 isoform X2 [KO:K06243]
108715892  XB5969698.S; laminin subunit beta-4 [KO:K06243]
108714682  XB5969698.L; laminin subunit beta-4 [KO:K06243]
108709379  lamb3.S; laminin subunit beta-3 [KO:K06244]
108711178  lamb4.L; laminin subunit beta-4 isoform X1 [KO:K06245]
108714357  lamc1.L; laminin subunit gamma-1 isoform X1 [KO:K05635]
108715634  lamc1.S; laminin subunit gamma-1 [KO:K05635]
108714355  lamc2.L; laminin subunit gamma-2 [KO:K06246]
108702793  chad.S; chondroadherin [KO:K06248]
108701097  chad.L; chondroadherin [KO:K06248]
398547  reln.L; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
379508  thbs1.L; thrombospondin 1 L homeolog precursor [KO:K16857]
779026  thbs1.S; thrombospondin-1 [KO:K16857]
380339  thbs3.L; thrombospondin 3 L homeolog precursor [KO:K04659]
446985  thbs4.S; thrombospondin 4 S homeolog precursor [KO:K04659]
397943  thbs4.L; thrombospondin-4 precursor [KO:K04659]
108700446  thbs3.S; thrombospondin-3 isoform X1 [KO:K04659]
108716699  thbs2.L; thrombospondin-2 [KO:K04659]
108706910  comp.S; cartilage oligomeric matrix protein [KO:K04659]
108695262  comp.L; cartilage oligomeric matrix protein [KO:K04659]
108717845  thbs2.S; thrombospondin-2 [KO:K04659]
397744  fn1.S; fibronectin precursor [KO:K05717]
445877  vtn.L; vitronectin L homeolog precursor [KO:K06251]
108714346  tnn.L; tenascin-N [KO:K06252]
108713537  tenascin-R [KO:K06252]
108700569  tnxb.S; tenascin-X isoform X1 [KO:K06252]
108700035  tenascin isoform X1 [KO:K06252]
108698936  tnxb.L; tenascin-X isoform X1 [KO:K06252]
108715624  tenascin-R [KO:K06252]
398332  tnc.L; tenascin isoform X1 [KO:K06252]
108710813  vwf.L; von Willebrand factor [KO:K03900]
100192353  ibsp.L; integrin-binding sialoprotein L homeolog precursor [KO:K06253]
100192352  ibsp.S; bone sialoprotein 2 [KO:K06253]
108705398  itga1.S; integrin alpha-1 [KO:K06480]
108718392  LOW QUALITY PROTEIN: integrin alpha-1-like [KO:K06480]
373743  itga2.L; integrin alpha-2 [KO:K06481]
495051  itga2b.2.L; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), gene 2 L homeolog precursor [KO:K06476]
100191022  itga2b.1.S; integrin subunit alpha 2b S homeolog precursor [KO:K06476]
373657  itga3.L; integrin alpha-3 [KO:K06482]
108702534  itga3.S; integrin alpha-3 isoform X2 [KO:K06482]
397839  itga4.S; integrin alpha-4 precursor [KO:K06483]
108701397  itga4.L; integrin alpha-4-like [KO:K06483]
394366  itga5.L; integrin alpha-5 precursor [KO:K06484]
397842  itga5.S; integrin alpha-5-like isoform X1 [KO:K06484]
108702994  itga6.S; integrin alpha-6 isoform X1 [KO:K06485]
397985  itga6.L; integrin alpha-6 isoform X1 [KO:K06485]
108708991  itga7.S; integrin alpha-7 isoform X1 [KO:K06583]
108708560  itga7.L; integrin alpha-7 isoform X2 [KO:K06583]
108719885  itga8.S; integrin alpha-8 [KO:K06584]
108718824  itga8.L; integrin alpha-8 [KO:K06584]
108719000  itga9.L; integrin alpha-9 [KO:K06585]
108699602  itga10.L; integrin alpha-10 [KO:K06586]
378559  itga11.S; integrin alpha-11 [KO:K06587]
108711510  itga11.L; integrin alpha-11 [KO:K06587]
397997  itgav.L; integrin subunit alpha V L homeolog precursor [KO:K06487]
397755  itgb1.L; integrin beta-1-A precursor [KO:K05719]
399443  itgb1.S; integrin beta-1-B precursor [KO:K05719]
397699  itgb3.L; integrin beta-3 isoform X1 [KO:K06493]
108701118  itgb4.L; integrin beta-4 isoform X1 [KO:K06525]
108702819  itgb4.S; integrin beta-4 isoform X2 [KO:K06525]
446423  itgb5.L; integrin subunit beta 5 L homeolog precursor [KO:K06588]
108702890  itgb5.S; integrin beta-5 isoform X1 [KO:K06588]
378686  itgb6.L; integrin beta-6 isoform X1 [KO:K06589]
108708650  itgb7.L; integrin beta-7 [KO:K06590]
108719918  itgb8.S; integrin beta-8 [KO:K06591]
108718868  itgb8.L; integrin beta-8 [KO:K06591]
379268  emp2.L; epithelial membrane protein 2 L homeolog [KO:K26256]
108703103  emp2.S; epithelial membrane protein 2 [KO:K26256]
397765  pdgfa.S; platelet-derived growth factor subunit A precursor [KO:K04359]
108701573  pdgfa.L; platelet-derived growth factor subunit A-like isoform X2 [KO:K04359]
493575  pdgfb.S; platelet-derived growth factor subunit B [KO:K17386]
108714525  pdgfb.L; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
108699243  pdgfc.L; platelet-derived growth factor C [KO:K05450]
108706647  pdgfc.S; platelet-derived growth factor C [KO:K05450]
108707572  platelet-derived growth factor D-like [KO:K05450]
108709984  pdgfd.S; platelet-derived growth factor D [KO:K05450]
108710179  egf.L; pro-epidermal growth factor [KO:K04357]
108712492  insulin-like growth factor I-A [KO:K05459]
108711020  igf1.S; insulin-like growth factor I-A [KO:K05459]
373589  vegfa.L; vascular endothelial growth factor A L homeolog precursor [KO:K05448]
100037058  vegfa.S; vascular endothelial growth factor A S homeolog precursor [KO:K05448]
100158352  vegfd.L; vascular endothelial growth factor D [KO:K05449]
734331  vegfc.S; vascular endothelial growth factor C S homeolog precursor [KO:K05449]
108698878  vegfc.L; vascular endothelial growth factor C [KO:K05449]
108713062  hgf.S; hepatocyte growth factor [KO:K05460]
108711206  hgf.L; hepatocyte growth factor [KO:K05460]
380245  pdgfra.L; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
108706592  pdgfra.S; platelet-derived growth factor receptor alpha-like [KO:K04363] [EC:2.7.10.1]
108712643  pdgfrb.S; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
398022  igf1r.S; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
108711478  igf1r.L; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
108706593  kdr.S; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
108698463  vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
108719997  egfr.S; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
724072  egfr.L; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
379546  flt1.S; uncharacterized protein LOC379546 precursor [KO:K05096] [EC:2.7.10.1]
373789  flt1.L; fms-related tyrosine kinase 1 L homeolog precursor [KO:K05096] [EC:2.7.10.1]
108698372  kdrl.L; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
108700541  kdrl.S; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
108710830  vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
108712628  vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
373551  met.L; MET proto-oncogene, receptor tyrosine kinase L homeolog precursor [KO:K05099] [EC:2.7.10.1]
108712362  met.S; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
108702492  receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
108700774  erbb2.L; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
444747  emp1.L; epithelial membrane protein 1 L homeolog [KO:K26255]
108715715  emp1.S; epithelial membrane protein 1 [KO:K26255]
380430  src.L; tyrosine-protein kinase Src-2 [KO:K05704] [EC:2.7.10.2]
373647  src.S; tyrosine-protein kinase Src-1 [KO:K05704] [EC:2.7.10.2]
414634  arhgap35.L; rho GTPase-activating protein 35 [KO:K05732]
108700189  arhgap35.S; rho GTPase-activating protein 35-like isoform X1 [KO:K05732]
100381143  arhgap5.S; Rho GTPase activating protein 5 isoform 1 [KO:K13709]
108699237  arhgap5.L; rho GTPase-activating protein 5 [KO:K13709]
379326  rhoc.L; ras homolog family member C L homeolog [KO:K04513]
379416  rhoa.L; ras homolog family member A L homeolog [KO:K04513]
380133  rhoa.2.S; ras homolog gene family, member A, gene 2 S homeolog [KO:K04513]
108715815  rhoa.S; transforming protein RhoA [KO:K04513]
108709436  rhoc.S; rho-related GTP-binding protein RhoA-D [KO:K04513]
108713303  diaph1.S; protein diaphanous homolog 1 [KO:K05740]
108710882  diaph1.L; protein diaphanous homolog 1 isoform X3 [KO:K05740]
108719215  rock1.L; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
108695261  rock1.S; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100301953  rock2.S; uncharacterized protein LOC100301953 [KO:K17388] [EC:2.7.11.1]
394289  rock2.L; Rho-associated, coiled-coil containing protein kinase 2 L homeolog [KO:K17388] [EC:2.7.11.1]
447131  myl2.S; myosin light chain 2 S homeolog [KO:K10351]
108697104  myl2.L; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
380007  mylc2a; myosin light chain, regulatory A [KO:K12754]
108712731  myl7.S; myosin regulatory light chain 2, atrial isoform [KO:K12754]
446851  myl9.L; myosin light chain 9 L homeolog [KO:K12755]
447704  myl9.S; myosin light chain 9 S homeolog [KO:K12755]
108707456  myl10.L; myosin regulatory light chain 2B, cardiac muscle isoform isoform X1 [KO:K12756]
108709092  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K12756]
380472  myl12b.L; myosin light chain 12B L homeolog [KO:K12757]
108695600  myl12b.S; myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
399251  mylpf.L; myosin light chain, phosphorylatable, fast skeletal muscle L homeolog [KO:K12758]
108701718  myosin regulatory light chain 2, skeletal muscle isoform type 2 [KO:K12758]
443852  ppp1cb.L; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
379914  ppp1ca.L; protein phosphatase 1, catalytic subunit, alpha isozyme L homeolog [KO:K06269] [EC:3.1.3.16]
380598  ppp1cc.S; serine/threonine-protein phosphatase PP1-gamma catalytic subunit B [KO:K06269] [EC:3.1.3.16]
397767  ppp1cc.L; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
108717671  ppp1cb.S; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
108704179  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
108713841  protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
733200  ppp1r12a.S; protein phosphatase 1 regulatory subunit 12A isoform X3 [KO:K06270]
108715193  protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
108711109  ppp1r12a.L; protein phosphatase 1 regulatory subunit 12A isoform X3 [KO:K06270]
108708153  ppp1r12b.L; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
108697741  protein phosphatase 1 regulatory subunit 12C isoform X2 [KO:K17457]
108696670  protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
108714133  myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
108701763  mylkl.L; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
108720081  mylk4.S; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
108700969  myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
108702240  mylk.S; LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
108719107  mylk4.L; serine/threonine-protein kinase pakF isoform X1 [KO:K00907] [EC:2.7.11.18]
108715487  myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
108701256  mylk.L; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
444238  pip5k1b.L; phosphatidylinositol-4-phosphate 5-kinase, type I, beta L homeolog [KO:K00889] [EC:2.7.1.68]
398687  pip5k1c.S; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma S homeolog [KO:K00889] [EC:2.7.1.68]
100653493  pip5k1a.S; uncharacterized protein LOC100653493 [KO:K00889] [EC:2.7.1.68]
108699471  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
108712206  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X2 [KO:K00889] [EC:2.7.1.68]
100337595  actg1.S; actin, cytoplasmic type 5 [KO:K05692]
734918  actg1.L; actin, cytoplasmic type 8 [KO:K05692]
108703086  actb.S; actin, cytoplasmic 1 [KO:K05692]
398459  actb.L; actin, cytoplasmic 1 [KO:K05692]
494866  rasgrf1.S; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
108711521  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
399075  capn2.L; calpain 2 L homeolog [KO:K03853] [EC:3.4.22.53]
108717697  capn2.S; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
100127267  XB5844015.L; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
108716477  capn8.5.L; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
446865  actn4.S; actinin alpha 4 S homeolog [KO:K05699]
399422  actn1.L; actinin alpha 1 L homeolog [KO:K05699]
431885  actn1.S; uncharacterized protein LOC431885 [KO:K05699]
734930  actn4.L; uncharacterized protein LOC734930 [KO:K05699]
108712994  talin-2 isoform X2 [KO:K06271]
100037170  tln2.S; talin 2 S homeolog [KO:K06271]
108711290  talin-2 isoform X2 [KO:K06271]
733283  talin-1 isoform X1 [KO:K06271]
108699999  filamin-A isoform X1 [KO:K04437]
108704467  filamin-A isoform X1 [KO:K04437]
108715054  LOW QUALITY PROTEIN: filamin-B-like [KO:K27392]
108705104  flnb.L; filamin-B isoform X1 [KO:K27392]
121393384  filamin-B-like [KO:K27392]
121393385  filamin-B-like [KO:K27392]
121393386  filamin-B-like [KO:K27392]
397826  pxn.S; paxillin S homeolog [KO:K05760]
108716013  pxn.L; paxillin isoform X1 [KO:K05760]
446640  ilk.S; integrin linked kinase S homeolog [KO:K06272] [EC:2.7.11.1]
444414  MGC82989 protein [KO:K06272] [EC:2.7.11.1]
100049724  zyx.S; zyxin [KO:K06273]
108695689  zyxin-like [KO:K06273]
443914  vasp.L; vasodilator stimulated phosphoprotein L homeolog [KO:K06274]
108700560  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
373770  vcl.S; vinculin isoform X2 [KO:K05700]
734573  parvb.S; parvin beta S homeolog [KO:K06275]
100036966  parvg.S; parvin gamma S homeolog [KO:K06275]
108715282  parva.S; alpha-parvin [KO:K06275]
108713738  parva.L; alpha-parvin [KO:K06275]
108710723  parvb.L; beta-parvin isoform X1 [KO:K06275]
444529  pdpk1.L; 3-phosphoinositide dependent protein kinase 1 L homeolog [KO:K06276] [EC:2.7.11.1]
108703133  pdpk1.S; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
432172  akt2.S; RAC-beta serine/threonine-protein kinase B [KO:K04456] [EC:2.7.11.1]
379783  akt2.L; RAC-beta serine/threonine-protein kinase A [KO:K04456] [EC:2.7.11.1]
399170  akt1.S; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108698803  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
399097  gsk3b.L; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
779056  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
399274  ctnnb1.L; catenin beta-1 [KO:K02105]
380441  ctnnb1.S; catenin beta 1 S homeolog [KO:K02105]
447031  prkca.L; protein kinase C, alpha L homeolog [KO:K02677] [EC:2.7.11.13]
108702159  prkca.S; protein kinase C alpha type isoform X3 [KO:K02677] [EC:2.7.11.13]
108701647  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
108703204  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
108697820  protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
108696776  protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
432072  ptk2.S; uncharacterized protein LOC432072 [KO:K05725] [EC:2.7.10.2]
399286  ptk2.L; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
373752  pik3ca.L; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108717120  pik3cb.L; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108718090  pik3ca.S; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108718190  pik3cb.S; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
447594  pik3r3.L; phosphoinositide-3-kinase regulatory subunit 3 L homeolog [KO:K02649]
443964  pik3r1.L; phosphoinositide-3-kinase regulatory subunit 1 L homeolog [KO:K02649]
399202  pik3r1.S; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
446786  pik3r3.S; phosphoinositide-3-kinase regulatory subunit 3 S homeolog [KO:K02649]
108713027  pik3r2.L; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
108706884  pik3r2.S; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
399142  pten.L; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100505440  pten.S; uncharacterized protein LOC100505440 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
446826  vav1.L; vav guanine nucleotide exchange factor 1 L homeolog [KO:K05730]
379646  vav2.S; vav guanine nucleotide exchange factor 2 S homeolog [KO:K05730]
108714432  vav3.L; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
108715695  vav3.S; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
108698197  vav2.L; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
108705008  proto-oncogene vav isoform X1 [KO:K05730]
734382  rac1.L; Rac family small GTPase 1 L homeolog [KO:K04392]
399379  rac3.S; Rac family small GTPase 3 S homeolog [KO:K04392]
444184  rac2.L; Rac family small GTPase 2 L homeolog [KO:K07860]
108715797  ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
108700975  ras-related C3 botulinum toxin substrate 3 isoform X3 [KO:K07861]
398126  pak1.S; p21-activated kinase 1 [KO:K04409] [EC:2.7.11.1]
398782  MGC68680; uncharacterized protein LOC398782 [KO:K04409] [EC:2.7.11.1]
399090  pak2.S; p21-activated kinase 2 [KO:K04410] [EC:2.7.11.1]
108717139  pak2.L; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
378493  pak3.L; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
108700104  pak3.S; serine/threonine-protein kinase PAK 3-like isoform X2 [KO:K05733] [EC:2.7.11.1]
398224  pak4.L; p21-activated kinase 4 [KO:K05734] [EC:2.7.11.1]
108700290  pak4.S; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
108717760  pak5.S; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
108716398  pak5.L; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
108700316  pak6.S; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
108699252  pak6.L; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
379055  cdc42.L; cell division cycle 42 L homeolog [KO:K04393]
108697660  cdc42.S; cell division control protein 42 homolog isoform X1 [KO:K04393]
398756  bcar1.L; BCAR1, Cas family scaffold protein L homeolog [KO:K05726]
108715363  bcar1.S; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
398951  crk.L; adapter molecule crk [KO:K04438]
447419  crkl.L; v-crk avian sarcoma virus CT10 oncogene homolog-like L homeolog [KO:K04438]
414569  crkl.S; uncharacterized protein LOC414569 [KO:K04438]
108709342  crk.S; adapter molecule crk-like isoform X1 [KO:K04438]
108697392  dock1.S; dedicator of cytokinesis protein 1 isoform X3 [KO:K13708]
108696117  dock1.L; dedicator of cytokinesis protein 1 isoform X2 [KO:K13708]
444199  rapgef1.S; Rap guanine nucleotide exchange factor 1 S homeolog [KO:K06277]
108698866  rapgef1.L; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
414290  rap1a.S; RAP1A, member of RAS oncogene family S homeolog [KO:K04353]
779127  rap1a.L; RAP1A, member of RAS oncogene family L homeolog [KO:K04353]
379883  rap1b.L; ras-related protein Rap-1b [KO:K07836]
108713157  ras-related protein Rap-1b [KO:K07836]
379876  mapk8.L; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
108704101  mapk10.S; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
398499  mapk8.S; mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
108711504  mapk10.L; mitogen-activated protein kinase 10 L homeolog isoform 1 [KO:K04440] [EC:2.7.11.24]
379050  jun.S; jun proto-oncogene S homeolog [KO:K04448]
399400  jun.L; jun proto-oncogene L homeolog [KO:K04448]
108700666  transcription factor AP-1-like [KO:K04448]
447268  braf.L; B-Raf proto-oncogene, serine/threonine kinase L homeolog [KO:K04365] [EC:2.7.11.1]
398973  braf.S; B-Raf [KO:K04365] [EC:2.7.11.1]
399006  cav1.S; caveolin 1 S homeolog [KO:K06278]
398392  cav1.L; caveolin 1 L homeolog [KO:K06278]
398391  cav2.L; caveolin 2 L homeolog [KO:K12958]
108698293  XB5932841.L; caveolin-2 [KO:K12958]
108700040  XB5932841.S; caveolin-2 [KO:K12958]
443832  cav2.S; caveolin 2 S homeolog [KO:K12958]
379866  cav3.2.S; caveolin 3, gene 2 S homeolog [KO:K12959]
108714631  cav3.1.L; caveolin-3 [KO:K12959]
108698292  cav3.2.L; caveolin-3 [KO:K12959]
379812  fyn.S; proto-oncogene tyrosine-protein kinase fyn [KO:K05703] [EC:2.7.10.2]
373609  fyn.L; tyrosine-protein kinase Fyn [KO:K05703] [EC:2.7.10.2]
399198  shc1.L; SHC-transforming protein 1 [KO:K06279]
108700442  shc1.S; SHC-transforming protein 1-like isoform X1 [KO:K06279]
108713169  shc2.L; SHC-transforming protein 2 [KO:K17447]
108706896  shc2.S; SHC-transforming protein 2 [KO:K17447]
108714850  SHC-transforming protein 3 [KO:K17448]
108706999  SHC-transforming protein 3 [KO:K17448]
108712318  shc4.S; SHC-transforming protein 4 [KO:K17449]
108711398  shc4.L; SHC-transforming protein 4 [KO:K17449]
444095  grb2.S; growth factor receptor-bound protein 2-B [KO:K04364]
399458  grb2.L; growth factor receptor-bound protein 2-A [KO:K04364]
108717808  sos1.S; son of sevenless homolog 1 [KO:K03099]
108699793  sos2.S; son of sevenless homolog 2 [KO:K03099]
108698752  sos2.L; son of sevenless homolog 2 isoform X2 [KO:K03099]
108716660  sos1.L; son of sevenless homolog 1 [KO:K03099]
399406  hras.L; Harvey rat sarcoma viral oncogene homolog L homeolog [KO:K02833]
397857  raf1.S; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
379991  map2k1.L; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108712802  map2k1.S; dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
398985  mapk1.S; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
397785  mapk1.L; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100190767  elk1.S; ELK1, member of ETS oncogene family S homeolog [KO:K04375]
108698108  elk1.L; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
379161  ccnd1.S; G1/S-specific cyclin-D1 b [KO:K04503]
379937  ccnd1.L; G1/S-specific cyclin-D1 [KO:K04503]
447748  ccndx.L; G1/S-specific cyclin-D1 [KO:K04503]
447541  MGC83948 protein [KO:K04503]
734882  ccnd2.S; cyclin D2 S homeolog [KO:K10151]
373667  ccnd2.L; G1/S-specific cyclin-D2 [KO:K10151]
100036859  birc2.S; uncharacterized protein LOC100036859 [KO:K16060]
446568  birc2.L; baculoviral IAP repeat containing 2 L homeolog [KO:K16060]
733235  xiap.L; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
108715151  bcl2-associated agonist of cell death-like isoform X2 [KO:K02158]
108713905  bcl2-associated agonist of cell death [KO:K02158]
100271914  bcl2.S; B-cell CLL/lymphoma 2 S homeolog [KO:K02161]
108719105  bcl2.L; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
xla04010  MAPK signaling pathway
xla04060  Cytokine-cytokine receptor interaction
xla04070  Phosphatidylinositol signaling system
xla04110  Cell cycle
xla04310  Wnt signaling pathway
xla04512  ECM-receptor interaction
xla04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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Genome (1)   
   KEGG GENOME (1)   
Gene (365)   
   KEGG GENES (365)   
All databases (366)   

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