KEGG   PATHWAY: ype00290
Entry
ype00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Yersinia pestis CO92 (biovar Orientalis)
Class
Metabolism; Amino acid metabolism
Pathway map
ype00290  Valine, leucine and isoleucine biosynthesis
ype00290

Module
ype_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:ype00290]
ype_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:ype00290]
ype_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:ype00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Yersinia pestis CO92 (biovar Orientalis) [GN:ype]
Gene
YPO3896  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
YPO4089  pyridoxal-phosphate dependent enzyme [KO:K01754] [EC:4.3.1.19]
YPO0531  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
YPO0530  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
YPO0532  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
YPO0539  ilvI; acetolactate synthase isozyme III large subunit [KO:K01652] [EC:2.2.1.6]
YPO2293  ilvB; putative acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
YPO3901  ilvG; acetolactate synthase isozyme II large subunit [KO:K01652] [EC:2.2.1.6]
YPO0540  ilvH; acetolactate synthase isozyme III small subunit [KO:K01653] [EC:2.2.1.6]
YPO2294  ilvN; putative acetolactate synthase small subunit [KO:K01653] [EC:2.2.1.6]
YPO3900  ilvM; acetolactate synthase isozyme II small subunit [KO:K11258] [EC:2.2.1.6]
YPO3888  ilvC; ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
YPO3897  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
YPO3899  ilvE; branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
YPO4082  avtA; valine--pyruvate aminotransferase [KO:K00835] [EC:2.6.1.66]
YPO2558  aat; probable aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
YPO0533  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
ype00260  Glycine, serine and threonine metabolism
ype00280  Valine, leucine and isoleucine degradation
ype00620  Pyruvate metabolism
KO pathway
ko00290   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG GENES (17)   
All databases (18)   

Download RDF
DBGET integrated database retrieval system