KEGG   PATHWAY: ecg03440
Entry
ecg03440                    Pathway                                
Name
Homologous recombination - Escherichia coli O127:H6 E2348/69 (EPEC)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
ecg03440  Homologous recombination
ecg03440

Other DBs
GO: 0000724
Organism
Escherichia coli O127:H6 E2348/69 (EPEC) [GN:ecg]
Gene
E2348C_3145  recJ; ssDNA exonuclease, 5-3'-specific [KO:K07462] [EC:3.1.-.-]
E2348C_4383  ssb; single-stranded DNA-binding protein [KO:K03111]
E2348C_0986  predicted single-stranded DNA-binding protein [KO:K03111]
E2348C_0662  predicted single-stranded DNA-binding protein [KO:K03111]
E2348C_2547  predicted single stranded DNA-binding protein [KO:K03111]
E2348C_4011  recF; gap repair protein [KO:K03629]
E2348C_2842  recO; gap repair protein [KO:K03584]
E2348C_0407  recR; gap repair protein RecR [KO:K06187]
E2348C_2962  recA; DNA strand exchange and recombination protein with protease and nuclease activity [KO:K03553]
E2348C_4170  polA; fused DNA polymerase I 5'->3' exonuclease/3'->5'polymerase/3'->5' exonuclease [KO:K02335] [EC:2.7.7.7]
E2348C_1986  ruvA; RuvA component of RuvABC resolvasome, regulatory subunit [KO:K03550]
E2348C_1985  ruvB; ATP-dependent DNA helicase RuvB, component of RuvABC resolvasome [KO:K03551] [EC:5.6.2.4]
E2348C_1988  ruvC; RuvC component of RuvABC resolvasome, endonuclease [KO:K01159] [EC:3.1.21.10]
E2348C_3916  recG; ATP-dependent DNA helicase [KO:K03655] [EC:5.6.2.4]
E2348C_3089  recB; exonuclease V (RecBCD complex), beta subunit RecB [KO:K03582] [EC:3.1.11.5]
E2348C_3091  recC; exonuclease V (RecBCD complex), gamma chain [KO:K03583] [EC:3.1.11.5]
E2348C_3088  recD; exonuclease V (RecBCD complex), alpha chain [KO:K03581] [EC:3.1.11.5]
E2348C_0189  dnaE; DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
E2348C_4012  dnaN; DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
E2348C_0405  dnaX; DNA polymerase III/DNA elongation factor III, tau and gamma subunits [KO:K02343] [EC:2.7.7.7]
E2348C_0540  holA; DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
E2348C_1191  holB; DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
E2348C_0215  dnaQ; DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
E2348C_1967  holE; DNA polymerase III, theta subunit [KO:K02345] [EC:2.7.7.7]
E2348C_4583  holC; DNA polymerase III, chi subunit [KO:K02339] [EC:2.7.7.7]
E2348C_4669  holD; DNA polymerase III, psi subunit [KO:K02344] [EC:2.7.7.7]
E2348C_4239  priA; Primosome factor n' (replication factor Y) [KO:K04066] [EC:5.6.2.4]
E2348C_4524  priB; primosomal protein N [KO:K02686]
E2348C_0402  priC; primosomal replication protein N'' [KO:K04067]
E2348C_4661  dnaT; DNA biosynthesis protein (primosomal protein I) [KO:K02317]
E2348C_2768  predicted primosomal protein [KO:K02317]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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Genome (1)   
   KEGG GENOME (1)   
Gene (31)   
   KEGG GENES (31)   
All databases (32)   

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