Entry
Name
ABC transporters - Escherichia coli K-12 MG1655
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Escherichia coli K-12 MG1655 [GN:
eco ]
Gene
b2425 cysP; thiosulfate/sulfate ABC transporter periplasmic binding protein CysP [KO:K02048 ]
b3917 sbp; sulfate/thiosulfate ABC transporter periplasmic binding protein Sbp [KO:K23163 ]
b2424 cysU; sulfate/thiosulfate ABC transporter inner membrane subunit CysU [KO:K02046 ]
b2423 cysW; sulfate/thiosulfate ABC transporter inner membrane subunit CysW [KO:K02047 ]
b2422 cysA; sulfate/thiosulfate ABC transporter ATP binding subunit [KO:K02045 ] [EC:7.3.2.3 ]
b0365 tauA; taurine ABC transporter periplasmic binding protein [KO:K15551 ]
b0367 tauC; taurine ABC transporter membrane subunit [KO:K15552 ]
b0936 ssuA; aliphatic sulfonate ABC transporter periplasmic binding protein [KO:K15553 ]
b0934 ssuC; aliphatic sulfonate ABC transporter membrane subunit [KO:K15554 ]
b0763 modA; molybdate ABC transporter periplasmic binding protein [KO:K02020 ]
b0764 modB; molybdate ABC transporter membrane subunit [KO:K02018 ]
b0262 afuC; CP4-6 prophage; ABC transporter ATP-binding protein AfuC [KO:K02010 ] [EC:7.2.2.7 ]
b0068 thiB; thiamine ABC transporter periplasmic binding protein [KO:K02064 ]
b0067 thiP; thiamine ABC transporter membrane subunit [KO:K02063 ]
b1123 potD; spermidine preferential ABC transporter periplasmic binding protein [KO:K11069 ]
b1124 potC; spermidine preferential ABC transporter membrane subunit PotC [KO:K11070 ]
b1125 potB; spermidine preferential ABC transporter membrane subunit PotB [KO:K11071 ]
b1126 potA; spermidine preferential ABC transporter ATP binding subunit [KO:K11072 ] [EC:7.6.2.11 ]
b0854 potF; putrescine ABC transporter periplasmic binding protein [KO:K11073 ]
b0857 potI; putrescine ABC transporter membrane subunit PotI [KO:K11074 ]
b0856 potH; putrescine ABC transporter membrane subunit PotH [KO:K11075 ]
b2679 proX; glycine betaine ABC transporter periplasmic binding protein ProX [KO:K02002 ]
b2678 proW; glycine betaine ABC transporter membrane subunit ProW [KO:K02001 ]
b2677 proV; glycine betaine ABC transporter ATP binding subunit ProV [KO:K02000 ] [EC:7.6.2.9 ]
b2131 osmF; glycine betaine ABC transporter periplasmic binding protein OsmF [KO:K05845 ]
b2130 yehY; glycine betaine ABC transporter membrane subunit YehY [KO:K05846 ]
b2128 yehW; glycine betaine ABC transporter membrane subunit YehW [KO:K05846 ]
b2129 yehX; glycine betaine ABC transporter ATP binding subunit YehX [KO:K05847 ] [EC:7.6.2.9 ]
b4034 malE; maltose ABC transporter periplasmic binding protein [KO:K10108 ]
b4033 malF; maltose ABC transporter membrane subunit MalF [KO:K10109 ]
b4032 malG; maltose ABC transporter membrane subunit MalG [KO:K10110 ]
b4035 malK; maltose ABC transporter ATP binding subunit [KO:K10111 ] [EC:7.5.2.-]
b2548 yphF; putative ABC transporter periplasmic binding protein YphF [KO:K23545 ]
b2546 yphD; putative ABC transporter membrane subunit YphD [KO:K23546 ]
b2547 yphE; putative ABC transporter ATP-binding protein YphE [KO:K23547 ]
b3192 mlaC; intermembrane phospholipid transport system - periplasmic binding protein [KO:K07323 ]
b3193 mlaD; intermembrane phospholipid transport system, substrate binding protein MlaD [KO:K02067 ]
b3194 mlaE; intermembrane phospholipid transport system, integral membrane subunit MlaE [KO:K02066 ]
b3191 mlaB; intermembrane phospholipid transport system protein MlaB [KO:K07122 ]
b3195 mlaF; intermembrane phospholipid transport system, ATP binding subunit MlaF [KO:K02065 ]
b3751 rbsB; ribose ABC transporter periplasmic binding protein [KO:K10439 ]
b3750 rbsC; ribose ABC transporter membrane subunit [KO:K10440 ]
b1901 araF; arabinose ABC transporter periplasmic binding protein [KO:K10537 ]
b4460 araH; arabinose ABC transporter membrane subunit [KO:K10538 ]
b4227 ytfQ; galactofuranose ABC transporter periplasmic binding protein [KO:K23508 ]
b4230 ytfT; galactofuranose ABC transporter putative membrane subunit YtfT [KO:K23509 ]
b4231 yjfF; galactofuranose ABC transporter putative membrane subunit YjtF [KO:K23509 ]
b4485 ytfR; galactofuranose ABC transporter putative ATP binding subunit [KO:K10820 ] [EC:7.5.2.9 ]
b2150 mglB; D-galactose/methyl-galactoside ABC transporter periplasmic binding protein [KO:K10540 ]
b2148 mglC; D-galactose/methyl-galactoside ABC transporter membrane subunit [KO:K10541 ]
b2149 mglA; D-galactose/methyl-galactoside ABC transporter ATP binding subunit [KO:K10542 ] [EC:7.5.2.11 ]
b3566 xylF; xylose ABC transporter periplasmic binding protein [KO:K10543 ]
b3568 xylH; xylose ABC transporter membrane subunit [KO:K10544 ]
b4088 alsB; D-allose ABC transporter periplasmic binding protein [KO:K10549 ]
b4086 alsC; D-allose ABC transporter membrane subunit [KO:K10550 ]
b3453 ugpB; sn-glycerol 3-phosphate ABC transporter periplasmic binding protein [KO:K05813 ]
b3452 ugpA; sn-glycerol 3-phosphate ABC transporter membrane subunit UgpA [KO:K05814 ]
b3451 ugpE; sn-glycerol 3-phosphate ABC transporter membrane subunit UgpE [KO:K05815 ]
b3450 ugpC; sn-glycerol 3-phosphate ABC transporter ATP binding subunit [KO:K05816 ] [EC:7.6.2.10 ]
b3728 pstS; phosphate ABC transporter periplasmic binding protein [KO:K02040 ]
b3727 pstC; phosphate ABC transporter membrane subunit PstC [KO:K02037 ]
b3726 pstA; phosphate ABC transporter membrane subunit PstA [KO:K02038 ]
b4105 phnD; phosphonate/phosphate ABC transporter periplasmic binding protein [KO:K02044 ]
b4106 phnC; phosphonate/phosphate ABC transporter ATP binding subunit [KO:K02041 ] [EC:7.3.2.2 ]
b2310 argT; lysine/arginine/ornithine ABC transporter periplasmic binding protein [KO:K10013 ]
b2307 hisM; lysine/arginine/ornithine ABC transporter/histidine ABC transporter, membrane subunit HisM [KO:K10015 ]
b2308 hisQ; lysine/arginine/ornithine ABC transporter/histidine ABC transporter, membrane subunit HisQ [KO:K10016 ]
b2306 hisP; lysine/arginine/ornithine ABC transporter/histidine ABC transporter, ATP binding subunit [KO:K10017 ] [EC:7.4.2.1 ]
b2309 hisJ; histidine ABC transporter periplasmic binding protein [KO:K10014 ]
b0811 glnH; L-glutamine ABC transporter periplasmic binding protein [KO:K10036 ]
b0810 glnP; L-glutamine ABC transporter membrane subunit [KO:K10037 ]
b0860 artJ; L-arginine ABC transporter periplasmic binding protein [KO:K09996 ]
b0863 artI; putative ABC transporter periplasmic binding protein ArtI [KO:K09997 ]
b0861 artM; L-arginine ABC transporter membrane subunit ArtM [KO:K09998 ]
b0862 artQ; L-arginine ABC transporter membrane subunit ArtQ [KO:K09999 ]
b0655 gltI; glutamate/aspartate ABC transporter periplasmic binding protein [KO:K10001 ]
b0653 gltK; glutamate/aspartate ABC transporter membrane subunit GltK [KO:K10002 ]
b0654 gltJ; glutamate/aspartate ABC transporter membrane subunit GltJ [KO:K10003 ]
b0652 gltL; glutamate/aspartate ABC transporter ATP binding subunit [KO:K10004 ] [EC:7.4.2.1 ]
b3269 yhdX; putative ABC transporter membrane subunit YhdX [KO:K09970 ]
b3270 yhdY; putative ABC transporter membrane subunit YhdY [KO:K09971 ]
b1920 tcyJ; cystine ABC transporter periplasmic binding protein [KO:K02424 ]
b1918 tcyL; cystine ABC transporter membrane subunit [KO:K10009 ]
b3458 livK; L-leucine/L-phenylalanine ABC transporter periplasmic binding protein [KO:K01999 ]
b3460 livJ; branched chain amino acid/phenylalanine ABC transporter periplasmic binding protein [KO:K01999 ]
b3457 livH; branched chain amino acid/phenylalanine ABC transporter membrane subunit LivH [KO:K01997 ]
b3456 livM; branched chain amino acid/phenylalanine ABC transporter membrane subunit LivM [KO:K01998 ]
b3455 livG; branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivG [KO:K01995 ]
b3454 livF; branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivF [KO:K01996 ]
b0197 metQ; L-methionine/D-methionine ABC transporter membrane anchored binding protein [KO:K02073 ]
b0198 metI; L-methionine/D-methionine ABC transporter membrane subunit [KO:K02072 ]
b0199 metN; L-methionine/D-methionine ABC transporter ATP binding subunit [KO:K02071 ]
b1329 mppA; murein tripeptide ABC transporter periplasmic binding protein [KO:K15580 ]
b1243 oppA; oligopeptide ABC transporter periplasmic binding protein [KO:K15580 ]
b1244 oppB; murein tripeptide ABC transporter/oligopeptide ABC transporter inner membrane subunit OppB [KO:K15581 ]
b1245 oppC; murein tripeptide ABC transporter/oligopeptide ABC transporter inner membrane subunit OppC [KO:K15582 ]
b1246 oppD; murein tripeptide ABC transporter/oligopeptide ABC transporter ATP binding subunit OppD [KO:K15583 ]
b1247 oppF; murein tripeptide ABC transporter/oligopeptide ABC transporter ATP binding subunit OppF [KO:K10823 ]
b3544 dppA; dipeptide ABC transporter periplasmic binding protein [KO:K12368 ]
b3543 dppB; dipeptide ABC transporter membrane subunit DppB [KO:K12369 ]
b3542 dppC; dipeptide ABC transporter membrane subunit DppC [KO:K12370 ]
b3541 dppD; dipeptide ABC transporter ATP binding subunit DppD [KO:K12371 ]
b3540 dppF; dipeptide ABC transporter ATP binding subunit DppF [KO:K12372 ]
b1294 sapA; putative periplasmic binding protein SapA [KO:K19226 ]
b1293 sapB; putrescine ABC exporter membrane subunit SapB [KO:K19227 ]
b1292 sapC; putrescine ABC exporter membrane protein SapC [KO:K19228 ]
b1291 sapD; putrescine ABC exporter ATP binding protein SapD [KO:K19229 ]
b1290 sapF; putrescine ABC exporter ATP binding protein SapF [KO:K19230 ]
b3476 nikA; Ni(2(+)) ABC transporter periplasmic binding protein [KO:K15584 ]
b3477 nikB; Ni(2(+)) ABC transporter membrane subunit NikB [KO:K15585 ]
b3478 nikC; Ni(2(+)) ABC transporter membrane subunit NikC [KO:K15586 ]
b0830 gsiB; glutathione ABC transporter periplasmic binding protein [KO:K13889 ]
b0831 gsiC; glutathione ABC transporter membrane subunit GsiC [KO:K13890 ]
b0832 gsiD; glutathione ABC transporter membrane subunit GsiD [KO:K13891 ]
b0829 gsiA; glutathione ABC transporter ATP binding subunit GsiA [KO:K13892 ]
b2177 yejA; putative oligopeptide ABC transporter periplasmic binding protein YejA [KO:K13893 ]
b2178 yejB; putative oligopeptide ABC transporter membrane subunit YejB [KO:K13894 ]
b2179 yejE; putative oligopeptide ABC transporter membrane subunit YejE [KO:K13895 ]
b2180 yejF; putative oligopeptide ABC transporter ATP binding subunit YejF [KO:K13896 ]
b4290 fecB; ferric citrate ABC transporter periplasmic binding protein [KO:K23181 ]
b4288 fecD; ferric citrate ABC transporter membrane subunit FecD [KO:K23182 ]
b4289 fecC; ferric citrate ABC transporter membrane subunit FecC [KO:K23183 ]
b0592 fepB; ferric enterobactin ABC transporter periplasmic binding protein [KO:K23185 ]
b0590 fepD; ferric enterobactin ABC transporter membrane subunit FebD [KO:K23186 ]
b0589 fepG; ferric enterobactin ABC transporter membrane subunit FepG [KO:K23187 ]
b0588 fepC; ferric enterobactin ABC transporter ATP binding subunit [KO:K23188 ] [EC:7.2.2.17 7.2.2.-]
b0152 fhuD; iron(III) hydroxamate ABC transporter periplasmic binding protein [KO:K23227 ]
b0153 fhuB; iron(III) hydroxamate ABC transporter membrane subunit [KO:K23228 ]
b0151 fhuC; iron(III) hydroxamate ABC transporter ATP binding subunit [KO:K10829 ] [EC:7.2.2.16 ]
b0158 btuF; vitamin B12 ABC transporter periplasmic binding protein [KO:K06858 ]
b1711 btuC; vitamin B12 ABC transporter membrane subunit [KO:K06073 ]
b1857 znuA; Zn(2(+)) ABC transporter periplasmic binding protein [KO:K09815 ]
b1859 znuB; Zn(2(+)) ABC transporter membrane subunit [KO:K09816 ]
b1516 lsrB; Autoinducer-2 ABC transporter periplasmic binding protein [KO:K10555 ]
b1514 lsrC; Autoinducer-2 ABC transporter membrane subunit LsrC [KO:K10556 ]
b1515 lsrD; Autoinducer-2 ABC transporter membrane subunit LsrD [KO:K10557 ]
b1513 lsrA; Autoinducer-2 ABC transporter ATP binding subunit [KO:K10558 ]
b1116 lolC; lipoprotein release complex - inner membrane subunit [KO:K09808 ]
b1118 lolE; lipoprotein release complex - inner membrane subunit [KO:K09808 ]
b1117 lolD; lipoprotein release complex - ATP binding subunit [KO:K09810 ] [EC:7.6.2.-]
b2198 ccmD; cytochrome c maturation protein D [KO:K02196 ]
b2199 ccmC; cytochrome c maturation protein C [KO:K02195 ]
b2200 ccmB; cytochrome c maturation protein B [KO:K02194 ]
b4261 lptF; lipopolysaccharide transport system protein LptF [KO:K07091 ]
b4262 lptG; lipopolysaccharide transport system protein LptG [KO:K11720 ]
b3201 lptB; lipopolysaccharide transport system ATP binding protein LptB [KO:K06861 ] [EC:7.5.2.5 ]
b0448 mdlA; ABC transporter family protein MdlA [KO:K18889 ]
b0449 mdlB; ABC transporter family protein MdlB [KO:K18890 ]
b0886 cydC; glutathione/L-cysteine ABC exporter subunit CydC [KO:K16012 ]
b0887 cydD; glutathione/L-cysteine ABC exporter subunit CydD [KO:K16013 ]
b0879 macB; ABC-type tripartite efflux pump ATP binding/membrane subunit [KO:K05685 ] [EC:7.6.2.-]
b2211 yojI; ABC transporter family protein/microcin J25 efflux protein [KO:K06159 ]
b1496 yddA; ABC transporter family protein YddA [KO:K02471 ]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
KO pathway