KEGG PATHWAY: map04072

PATHWAY: map04072

Entry

map04072                    Pathway

Name

Phospholipase D signaling pathway

Description

Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. PLD activity can be stimulated by a large number of cell surface receptors and is elaborately regulated by intracellular factors, including protein kinase C isoforms, small GTPases of the ARF, Rho and Ras families and the phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP2). The PLD-produced PA activates signaling proteins and acts as a node within the membrane to which signaling proteins translocate. Several signaling proteins, including Raf-1 and mTOR, directly bind PA to mediate translocation or activation, respectively.

Class

Environmental Information Processing; Signal transduction

Pathway map

map04072

Phospholipase D signaling pathway

Reference

PMID:17245604

Authors

Oude Weernink PA, Lopez de Jesus M, Schmidt M

Title

Phospholipase D signaling: orchestration by PIP2 and small GTPases.

Journal

Naunyn Schmiedebergs Arch Pharmacol 374:399-411 (2007)
DOI:10.1007/s00210-007-0131-4

Reference

PMID:21936578

Authors

Selvy PE, Lavieri RR, Lindsley CW, Brown HA

Title

Phospholipase D: enzymology, functionality, and chemical modulation.

Journal

Chem Rev 111:6064-119 (2011)
DOI:10.1021/cr200296t

Reference

PMID:24995811

Authors

Brandenburg LO, Pufe T, Koch T

Title

Role of phospholipase d in g-protein coupled receptor function.

Journal

Membranes (Basel) 4:302-18 (2014)
DOI:10.3390/membranes4030302

Reference

PMID:17054901

Authors

Oude Weernink PA, Han L, Jakobs KH, Schmidt M

Title

Dynamic phospholipid signaling by G protein-coupled receptors.

Journal

Biochim Biophys Acta 1768:888-900 (2007)
DOI:10.1016/j.bbamem.2006.09.012

Reference

PMID:24990952

Authors

Foster DA, Salloum D, Menon D, Frias MA

Title

Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR).

Journal

J Biol Chem 289:22583-8 (2014)
DOI:10.1074/jbc.R114.566091

Reference

PMID:16143829

Authors

Jenkins GM, Frohman MA

Title

Phospholipase D: a lipid centric review.

Journal

Cell Mol Life Sci 62:2305-16 (2005)
DOI:10.1007/s00018-005-5195-z

Reference

PMID:19815110

Authors

Metcalfe DD, Peavy RD, Gilfillan AM

Title

Mechanisms of mast cell signaling in anaphylaxis.

Journal

J Allergy Clin Immunol 124:639-46; quiz 647-8 (2009)
DOI:10.1016/j.jaci.2009.08.035

Reference

PMID:18936782

Authors

Kalesnikoff J, Galli SJ

Title

New developments in mast cell biology.

Journal

Nat Immunol 9:1215-23 (2008)
DOI:10.1038/ni.f.216

Reference

PMID:12217395

Authors

Cockcroft S, Way G, O'Luanaigh N, Pardo R, Sarri E, Fensome A

Title

Signalling role for ARF and phospholipase D in mast cell exocytosis stimulated by crosslinking of the high affinity FcepsilonR1 receptor.

Journal

Mol Immunol 38:1277-82 (2002)
DOI:10.1016/S0161-5890(02)00075-5

Reference

PMID:19410013

Authors

Lee CS, Kim KL, Jang JH, Choi YS, Suh PG, Ryu SH

Title

The roles of phospholipase D in EGFR signaling.

Journal

Biochim Biophys Acta 1791:862-8 (2009)
DOI:10.1016/j.bbalip.2009.04.007

Reference

PMID:16622417

Authors

Lee CS, Kim IS, Park JB, Lee MN, Lee HY, Suh PG, Ryu SH

Title

The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis.

Journal

Nat Cell Biol 8:477-84 (2006)
DOI:10.1038/ncb1401

Reference

PMID:14769825

Authors

Kam Y, Exton JH

Title

Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid.

Journal

FASEB J 18:311-9 (2004)
DOI:10.1096/fj.03-0731com

Reference

PMID:9310372

Authors

Kozawa O, Blume-Jensen P, Heldin CH, Ronnstrand L

Title

Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release.

Journal

Eur J Biochem 248:149-55 (1997)
DOI:10.1111/j.1432-1033.1997.00149.x

Reference

PMID:11042115

Authors

Slaaby R, Du G, Altshuller YM, Frohman MA, Seedorf K

Title

Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade.

Journal

Biochem J 351 Pt 3:613-9 (2000)
DOI:10.1042/bj3510613

Reference

PMID:11991733

Authors

Fahimi-Vahid M, Gosau N, Michalek C, Han L, Jakobs KH, Schmidt M, Roberts N, Avkiran M, Wieland T

Title

Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin.

Journal

J Mol Cell Cardiol 34:441-53 (2002)
DOI:10.1006/jmcc.2002.1525

Reference

PMID:10666319

Authors

Freeman EJ

Title

The Ang II-induced growth of vascular smooth muscle cells involves a phospholipase D-mediated signaling mechanism.

Journal

Arch Biochem Biophys 374:363-70 (2000)
DOI:10.1006/abbi.1999.1608

Reference

PMID:9119890

Authors

Naro F, Donchenko V, Minotti S, Zolla L, Molinaro M, Adamo S

Title

Role of phospholipase C and D signalling pathways in vasopressin-dependent myogenic differentiation.

Journal

J Cell Physiol 171:34-42 (1997)
DOI:10.1002/(SICI)1097-4652(199704)171:1<34::AID-JCP5>3.0.CO;2-I

Reference

PMID:10807766

Authors

Murdoch C, Finn A

Title

Chemokine receptors and their role in inflammation and infectious diseases.

Journal

Blood 95:3032-43 (2000)

Reference

PMID:8135758

Authors

Sugiyama T, Sakai T, Nozawa Y, Oka N

Title

Prostaglandin F2 alpha-stimulated phospholipase D activation in osteoblast-like MC3T3-E1 cells: involvement in sustained 1,2-diacylglycerol production.

Journal

Biochem J 298 ( Pt 2):479-84 (1994)
DOI:10.1042/bj2980479

Reference

PMID:17210675

Authors

Foster DA

Title

Regulation of mTOR by phosphatidic acid?

Journal

Cancer Res 67:1-4 (2007)
DOI:10.1158/0008-5472.CAN-06-3016

Reference

PMID:15310762

Authors

Delon C, Manifava M, Wood E, Thompson D, Krugmann S, Pyne S, Ktistakis NT

Title

Sphingosine kinase 1 is an intracellular effector of phosphatidic acid.

Journal

J Biol Chem 279:44763-74 (2004)
DOI:10.1074/jbc.M405771200

Reference

PMID:23076158

Authors

Park JB, Lee CS, Jang JH, Ghim J, Kim YJ, You S, Hwang D, Suh PG, Ryu SH

Title

Phospholipase signalling networks in cancer.

Journal

Nat Rev Cancer 12:782-92 (2012)
DOI:10.1038/nrc3379

Reference

PMID:19264150

Authors

Foster DA

Title

Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells.

Journal

Biochim Biophys Acta 1791:949-55 (2009)
DOI:10.1016/j.bbalip.2009.02.009

Related
pathway

map00561

Glycerolipid metabolism

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04020

Calcium signaling pathway

map04024

cAMP signaling pathway

map04071

Sphingolipid signaling pathway

map04144

Endocytosis

map04150

mTOR signaling pathway

map04151

PI3K-Akt signaling pathway

map04664

Fc epsilon RI signaling pathway

KO pathway

ko04072

All links

Chemical substance (11)   
   KEGG COMPOUND (11)   
Gene (174996)   
   KEGG ORTHOLOGY (108)   
   RefGene (174888)   
Literature (23)   
   PubMed (23)   
All databases (175030)   

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