Entry Name Adrenergic signaling in cardiomyocytes
Description Cardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, and alpha-1C). In the human heart the beta-1-AR is the pre- dominate receptor. Acute sympathetic stimulation of cardiac beta-1-ARs induces positive inotropic and chronotropic effects, the most effective mechanism to acutely increase output of the heart, by coupling to Gs, formation of cAMP by adenylyl cyclase (AC), and PKA- dependent phosphorylation of various target proteins (e.g., ryanodine receptor [RyR]; phospholamban [PLB], troponin I [TnI], and the L-type Ca2+ channel [LTCC]). Chronic beta-1-AR stimulation is detrimental and induces cardiomyocyte hypertrophy and apoptosis. beta-2-AR coupled to Gs exerts a proapoptotic action as well as beta-1-AR, while beta-2-AR coupled to Gi exerts an antiapoptotic action.
Class Organismal Systems; Circulatory systemBRITE hierarchy
Pathway map map04261 Adrenergic signaling in cardiomyocytes
Ortholog table Other DBs Reference Authors Grimm M, Brown JH
Title Beta-adrenergic receptor signaling in the heart: role of CaMKII.
Journal Reference Authors Yang JH, Saucerman JJ
Title Computational models reduce complexity and accelerate insight into cardiac signaling networks.
Journal Reference Authors Schaub MC, Hefti MA, Zaugg M
Title Integration of calcium with the signaling network in cardiac myocytes.
Journal Reference Authors Taggart P, Boyett MR, Logantha S, Lambiase PD
Title Anger, emotion, and arrhythmias: from brain to heart.
Journal Reference Authors Bers DM
Title Calcium cycling and signaling in cardiac myocytes.
Journal Reference Authors Soltis AR, Saucerman JJ
Title Synergy between CaMKII substrates and beta-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling.
Journal Reference Authors Wallukat G
Title The beta-adrenergic receptors.
Journal Reference Authors Xiao RP
Title Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins.
Journal Reference Authors Xiao RP, Cheng H, Zhou YY, Kuschel M, Lakatta EG
Title Recent advances in cardiac beta(2)-adrenergic signal transduction.
Journal Reference Authors Zheng M, Zhu W, Han Q, Xiao RP
Title Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling.
Journal Reference Authors Kuzumoto M, Takeuchi A, Nakai H, Oka C, Noma A, Matsuoka S
Title Simulation analysis of intracellular Na+ and Cl- homeostasis during beta 1-adrenergic stimulation of cardiac myocyte.
Journal Reference Authors Bers DM
Title Cardiac excitation-contraction coupling.
Journal Reference Authors Ho D, Yan L, Iwatsubo K, Vatner DE, Vatner SF
Title Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.
Journal Reference Authors Saucerman JJ, McCulloch AD
Title Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
Journal Reference Authors Yano M, Ikeda Y, Matsuzaki M
Title Altered intracellular Ca2+ handling in heart failure.
Journal Reference Authors Wehrens XH, Marks AR
Title Novel therapeutic approaches for heart failure by normalizing calcium cycling.
Journal Reference Authors Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
Title The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
Journal Reference Authors Barry SP, Davidson SM, Townsend PA
Title Molecular regulation of cardiac hypertrophy.
Journal Related KO pathway
