KEGG PATHWAY: map04623

PATHWAY: map04623

Entry

map04623                    Pathway

Name

Cytosolic DNA-sensing pathway

Description

Specific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified sensor of cytosolic DNA which activates the IRF and NF-{kappa}B transcription factors, leading to production of type I interferon and other cytokines. The second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell.

Class

Organismal Systems; Immune system

Pathway map

map04623

Cytosolic DNA-sensing pathway

Reference

PMID:19362700

Authors

Yanai H, Savitsky D, Tamura T, Taniguchi T

Title

Regulation of the cytosolic DNA-sensing system in innate immunity: a current view.

Journal

Curr Opin Immunol 21:17-22 (2009)
DOI:10.1016/j.coi.2009.01.005

Reference

PMID:19497760

Authors

Vilaysane A, Muruve DA

Title

The innate immune response to DNA.

Journal

Semin Immunol 21:208-14 (2009)
DOI:10.1016/j.smim.2009.05.006

Reference

PMID:18573338

Authors

Takeshita F, Ishii KJ

Title

Intracellular DNA sensors in immunity.

Journal

Curr Opin Immunol 20:383-8 (2008)
DOI:10.1016/j.coi.2008.05.009

Reference

PMID:19122387

Authors

Takaoka A, Shinohara S

Title

DNA sensors in innate immune system.

Journal

Uirusu 58:37-46 (2008)
DOI:10.2222/jsv.58.37

Reference

PMID:18280611

Authors

Takaoka A, Taniguchi T

Title

Cytosolic DNA recognition for triggering innate immune responses.

Journal

Adv Drug Deliv Rev 60:847-57 (2008)
DOI:10.1016/j.addr.2007.12.002

Reference

PMID:18941233

Authors

Kaiser WJ, Upton JW, Mocarski ES

Title

Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors.

Journal

J Immunol 181:6427-34 (2008)
DOI:10.4049/jimmunol.181.9.6427

Reference

PMID:19590578

Authors

Rebsamen M, Heinz LX, Meylan E, Michallet MC, Schroder K, Hofmann K, Vazquez J, Benedict CA, Tschopp J

Title

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.

Journal

EMBO Rep 10:916-22 (2009)
DOI:10.1038/embor.2009.109

Reference

PMID:18375758

Authors

Wang Z, Choi MK, Ban T, Yanai H, Negishi H, Lu Y, Tamura T, Takaoka A, Nishikura K, Taniguchi T

Title

Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules.

Journal

Proc Natl Acad Sci U S A 105:5477-82 (2008)
DOI:10.1073/pnas.0801295105

Reference

PMID:18724932

Authors

Stetson DB, Ko JS, Heidmann T, Medzhitov R

Title

Trex1 prevents cell-intrinsic initiation of autoimmunity.

Journal

Cell 134:587-98 (2008)
DOI:10.1016/j.cell.2008.06.032

Reference

PMID:19321146

Authors

Schroder K, Muruve DA, Tschopp J

Title

Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.

Journal

Curr Biol 19:R262-5 (2009)
DOI:10.1016/j.cub.2009.02.011

Reference

PMID:19567913

Authors

Krieg AM

Title

AIMing 2 detect foreign DNA.

Journal

Sci Signal 2:pe39 (2009)
DOI:10.1126/scisignal.277pe39

Reference

PMID:19665965

Authors

O'Neill LA

Title

DNA makes RNA makes innate immunity.

Journal

Cell 138:428-30 (2009)
DOI:10.1016/j.cell.2009.07.021

Reference

PMID:16286919

Authors

Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S

Title

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

Journal

Nat Immunol 7:40-8 (2006)
DOI:10.1038/ni1282

Reference

PMID:19767723

Authors

Cao X

Title

New DNA-sensing pathway feeds RIG-I with RNA.

Journal

Nat Immunol 10:1049-51 (2009)
DOI:10.1038/ni1009-1049

Reference

PMID:23258413

Authors

Sun L, Wu J, Du F, Chen X, Chen ZJ

Title

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.

Journal

Science 339:786-91 (2013)
DOI:10.1126/science.1232458

Reference

PMID:35006429

Authors

Gao M, He Y, Tang H, Chen X, Liu S, Tao Y

Title

cGAS/STING: novel perspectives of the classic pathway.

Journal

Mol Biomed 1:7 (2020)
DOI:10.1186/s43556-020-00006-z

Reference

PMID:34949589

Authors

Benjamin P, Sudhakar S, D'Arco F, Lobel U, Carney O, Roux CJ, Boddaert N, Hemingway C, Eleftheriou D, Mankad K

Title

Spectrum of Neuroradiologic Findings Associated with Monogenic Interferonopathies.

Journal

AJNR Am J Neuroradiol 43:2-10 (2022)
DOI:10.3174/ajnr.A7362

Reference

PMID:32829024

Authors

Place DE, Lee S, Kanneganti TD

Title

PANoptosis in microbial infection.

Journal

Curr Opin Microbiol 59:42-49 (2021)
DOI:10.1016/j.mib.2020.07.012

Reference

PMID:34970269

Authors

Jiang W, Deng Z, Dai X, Zhao W

Title

PANoptosis: A New Insight Into Oral Infectious Diseases.

Journal

Front Immunol 12:789610 (2021)
DOI:10.3389/fimmu.2021.789610

Reference

PMID:34504660

Authors

Wang Y, Kanneganti TD

Title

From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways.

Journal

Comput Struct Biotechnol J 19:4641-4657 (2021)
DOI:10.1016/j.csbj.2021.07.038

Related
pathway

map04064

NF-kappa B signaling pathway

map04120

Ubiquitin mediated proteolysis

map04210

Apoptosis

map04217

Necroptosis

map04621

NOD-like receptor signaling pathway

map04622

RIG-I-like receptor signaling pathway

KO pathway

ko04623

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Chemical substance (2)   
   KEGG COMPOUND (2)   
Gene (44250)   
   KEGG ORTHOLOGY (68)   
   RefGene (44182)   
Literature (20)   
   PubMed (20)   
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