KEGG PATHWAY: map04913

PATHWAY: map04913

Entry

map04913                    Pathway

Name

Ovarian steroidogenesis

Description

The ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, the local effects that are essential for normal ovarian physiology are dependent on the endocrine, paracrine, and autocrine actions of E2, P4, and androgens. In most mammals (including humans and mice), ovarian steroidogenesis occurs according to the two-cell/two-gonadotropin theory. This theory describes how granulosa and theca cells work together to make the ovarian steroids. Theca cells respond to LH signaling by increasing the expression of enzymes necessary for the conversion of cholesterol to androgens, such as androstenedione (A) and testosterone (T). Granulosa cells respond to FSH signaling by increasing the expression of enzymes necessary for the conversion of theca-derived androgens into estrogens (E2 and estrone).

Class

Organismal Systems; Endocrine system

Pathway map

map04913

Ovarian steroidogenesis

Other DBs

GO:

0050810

Reference

PMID:15541573

Authors

Havelock JC, Rainey WE, Carr BR

Title

Ovarian granulosa cell lines.

Journal

Mol Cell Endocrinol 228:67-78 (2004)
DOI:10.1016/j.mce.2004.04.018

Reference

PMID:15831519

Authors

Stocco DM, Wang X, Jo Y, Manna PR

Title

Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression: more complicated than we thought.

Journal

Mol Endocrinol 19:2647-59 (2005)
DOI:10.1210/me.2004-0532

Reference

PMID:20937107

Authors

Wen X, Li D, Tozer AJ, Docherty SM, Iles RK

Title

Estradiol, progesterone, testosterone profiles in human follicular fluid and cultured granulosa cells from luteinized pre-ovulatory follicles.

Journal

Reprod Biol Endocrinol 8:117 (2010)
DOI:10.1186/1477-7827-8-117

Reference

PMID:11704115

Authors

Erickson GF, Shimasaki S

Title

The physiology of folliculogenesis: the role of novel growth factors.

Journal

Fertil Steril 76:943-9 (2001)
DOI:10.1016/S0015-0282(01)02859-X

Reference

PMID:11883103

Authors

Wood JR, Strauss JF 3rd

Title

Multiple signal transduction pathways regulate ovarian steroidogenesis.

Journal

Rev Endocr Metab Disord 3:33-46 (2002)
DOI:10.1023/A:1012748718150

Reference

PMID:16603089

Authors

Drummond AE

Title

The role of steroids in follicular growth.

Journal

Reprod Biol Endocrinol 4:16 (2006)
DOI:10.1186/1477-7827-4-16

Reference

PMID:21862696

Authors

Craig ZR, Wang W, Flaws JA

Title

Endocrine-disrupting chemicals in ovarian function: effects on steroidogenesis, metabolism and nuclear receptor signaling.

Journal

Reproduction 142:633-46 (2011)
DOI:10.1530/REP-11-0136

Reference

PMID:20628033

Authors

Young JM, McNeilly AS

Title

Theca: the forgotten cell of the ovarian follicle.

Journal

Reproduction 140:489-504 (2010)
DOI:10.1530/REP-10-0094

Reference

PMID:18440223

Authors

Diamanti-Kandarakis E, Argyrakopoulou G, Economou F, Kandaraki E, Koutsilieris M

Title

Defects in insulin signaling pathways in ovarian steroidogenesis and other tissues in polycystic ovary syndrome (PCOS).

Journal

J Steroid Biochem Mol Biol 109:242-6 (2008)
DOI:10.1016/j.jsbmb.2008.03.014

Reference

PMID:11408113

Authors

Spicer LJ

Title

Receptors for insulin-like growth factor-I and tumor necrosis factor-alpha are hormonally regulated in bovine granulosa and thecal cells.

Journal

Anim Reprod Sci 67:45-58 (2001)
DOI:10.1016/S0378-4320(01)00114-2

Reference

PMID:10630400

Authors

Wang X, Stocco DM

Title

Cyclic AMP and arachidonic acid: a tale of two pathways.

Journal

Mol Cell Endocrinol 158:7-12 (1999)
DOI:10.1016/S0303-7207(99)00130-6

Reference

PMID:17003287

Authors

Wang X, Shen CL, Dyson MT, Yin X, Schiffer RB, Grammas P, Stocco DM

Title

The involvement of epoxygenase metabolites of arachidonic acid in cAMP-stimulated steroidogenesis and steroidogenic acute regulatory protein gene expression.

Journal

J Endocrinol 190:871-8 (2006)
DOI:10.1677/joe.1.06933

Reference

PMID:17008391

Authors

Miyoshi T, Otsuka F, Inagaki K, Otani H, Takeda M, Suzuki J, Goto J, Ogura T, Makino H

Title

Differential regulation of steroidogenesis by bone morphogenetic proteins in granulosa cells: involvement of extracellularly regulated kinase signaling and oocyte actions in follicle-stimulating hormone-induced estrogen production.

Journal

Endocrinology 148:337-45 (2007)
DOI:10.1210/en.2006-0966

Reference

PMID:11447221

Authors

Otsuka F, Moore RK, Shimasaki S

Title

Biological function and cellular mechanism of bone morphogenetic protein-6 in the ovary.

Journal

J Biol Chem 276:32889-95 (2001)
DOI:10.1074/jbc.M103212200

Reference

PMID:14769828

Authors

Shimasaki S, Moore RK, Otsuka F, Erickson GF.

Title

The bone morphogenetic protein system in mammalian reproduction.

Journal

Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007

Reference

PMID:16414178

Authors

Lukacik P, Kavanagh KL, Oppermann U

Title

Structure and function of human 17beta-hydroxysteroid dehydrogenases.

Journal

Mol Cell Endocrinol 248:61-71 (2006)
DOI:10.1016/j.mce.2005.12.007

Related
pathway

map00140

Steroid hormone biosynthesis

map04350

TGF-beta signaling pathway

map04910

Insulin signaling pathway

map04912

GnRH signaling pathway

KO pathway

ko04913

All links

Chemical substance (24)   
   KEGG COMPOUND (24)   
Gene (33610)   
   KEGG ORTHOLOGY (40)   
   RefGene (33570)   
Literature (16)   
   PubMed (16)   
All databases (33650)   

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