KEGG PATHWAY: map05146

PATHWAY: map05146

Entry

map05146                    Pathway

Name

Amoebiasis

Description

Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.

Class

Human Diseases; Infectious disease: parasitic

Pathway map

map05146

Amoebiasis

Disease

H00360

Amoebiasis

Reference

PMID:11378035

Authors

Stanley SL

Title

Pathophysiology of amoebiasis.

Journal

Trends Parasitol 17:280-5 (2001)
DOI:10.1016/S1471-4922(01)01903-1

Reference

PMID:10756002

Authors

Espinosa-Cantellano M, Martinez-Palomo A

Title

Pathogenesis of intestinal amebiasis: from molecules to disease.

Journal

Clin Microbiol Rev 13:318-31 (2000)
DOI:10.1128/CMR.13.2.318-331.2000

Reference

PMID:9832261

Authors

Huston CD, Petri WA Jr

Title

Host-pathogen interaction in amebiasis and progress in vaccine development.

Journal

Eur J Clin Microbiol Infect Dis 17:601-14 (1998)
DOI:10.1007/BF01708342

Reference

PMID:14700586

Authors

Huston CD

Title

Parasite and host contributions to the pathogenesis of amebic colitis.

Journal

Trends Parasitol 20:23-6 (2004)
DOI:10.1016/j.pt.2003.10.013

Reference

PMID:15813717

Authors

Campos-Rodriguezp R, Jarillo-Luna A

Title

The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.

Journal

Parasite Immunol 27:1-8 (2005)
DOI:10.1111/j.1365-3024.2005.00743.x

Reference

PMID:19207103

Authors

Lejeune M, Rybicka JM, Chadee K

Title

Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.

Journal

Future Microbiol 4:105-18 (2009)
DOI:10.2217/17460913.4.1.105

Reference

PMID:17576362

Authors

Carrero JC, Cervantes-Rebolledo C, Aguilar-Diaz H, Diaz-Gallardo MY, Laclette JP, Morales-Montor J

Title

The role of the secretory immune response in the infection by Entamoeba histolytica.

Journal

Parasite Immunol 29:331-8 (2007)
DOI:10.1111/j.1365-3024.2007.00955.x

Reference

PMID:12660071

Authors

Stanley SL Jr

Title

Amoebiasis.

Journal

Lancet 361:1025-34 (2003)
DOI:10.1016/S0140-6736(03)12830-9

Reference

PMID:14502002

Authors

Stauffer W, Ravdin JI

Title

Entamoeba histolytica: an update.

Journal

Curr Opin Infect Dis 16:479-85 (2003)
DOI:10.1097/01.qco.0000092821.42392.ca

Reference

PMID:12142490

Authors

Petri WA Jr, Haque R, Mann BJ

Title

The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.

Journal

Annu Rev Microbiol 56:39-64 (2002)
DOI:10.1146/annurev.micro.56.012302.160959

Reference

PMID:18725798

Authors

Baxt LA, Singh U

Title

New insights into Entamoeba histolytica pathogenesis.

Journal

Curr Opin Infect Dis 21:489-94 (2008)
DOI:10.1097/QCO.0b013e32830ce75f

Reference

PMID:12160867

Authors

Petri WA Jr

Title

Pathogenesis of amebiasis.

Journal

Curr Opin Microbiol 5:443-7 (2002)
DOI:10.1016/S1369-5274(02)00335-1

Reference

PMID:17702556

Authors

Guo X, Houpt E, Petri WA Jr

Title

Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.

Journal

Curr Opin Immunol 19:376-84 (2007)
DOI:10.1016/j.coi.2007.07.005

Reference

PMID:20303955

Authors

Mortimer L, Chadee K

Title

The immunopathogenesis of Entamoeba histolytica.

Journal

Exp Parasitol 126:366-80 (2010)
DOI:10.1016/j.exppara.2010.03.005

Reference

PMID:16380324

Authors

Meza I, Talamas-Rohana P, Vargas MA

Title

The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.

Journal

Arch Med Res 37:234-43 (2006)
DOI:10.1016/j.arcmed.2005.09.008

Reference

PMID:10637584

Authors

Meza I

Title

Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness.

Journal

Parasitol Today 16:23-8 (2000)
DOI:10.1016/S0169-4758(99)01586-0

Reference

PMID:11352795

Authors

Stanley SL Jr, Reed SL

Title

Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.

Journal

Am J Physiol Gastrointest Liver Physiol 280:G1049-54 (2001)
DOI:10.1152/ajpgi.2001.280.6.G1049

Reference

PMID:20145703

Authors

Wong-Baeza I, Alcantara-Hernandez M, Mancilla-Herrera I, Ramirez-Saldivar I, Arriaga-Pizano L, Ferat-Osorio E, Lopez-Macias C, Isibasi A

Title

The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.

Journal

J Biomed Biotechnol 2010:254521 (2010)
DOI:10.1155/2010/254521

Related
pathway

map00330

Arginine and proline metabolism

map00590

Arachidonic acid metabolism

map04144

Endocytosis

map04210

Apoptosis

map04510

Focal adhesion

map04610

Complement and coagulation cascades

map04612

Antigen processing and presentation

map04620

Toll-like receptor signaling pathway

map04672

Intestinal immune network for IgA production

map04810

Regulation of actin cytoskeleton

KO pathway

ko05146

All links

Chemical substance (13)   
   KEGG COMPOUND (13)   
Gene (114939)   
   KEGG ORTHOLOGY (87)   
   RefGene (114852)   
Literature (18)   
   PubMed (18)   
All databases (114970)   

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