Entry Name Human T-cell leukemia virus 1 infection
Description Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class Human Diseases; Infectious disease: viralBRITE hierarchy
Pathway map map05166 Human T-cell leukemia virus 1 infection
Ortholog table Disease Reference Authors Matsuoka M, Jeang KT
Title Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
Journal Reference Authors Grassmann R, Aboud M, Jeang KT
Title Molecular mechanisms of cellular transformation by HTLV-1 Tax.
Journal Reference Authors Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
Title The HTLV-1 Tax interactome.
Journal Reference Authors Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
Title Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
Journal Reference Authors Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
Title Current concepts regarding the HTLV-1 receptor complex.
Journal Reference Authors Sinet F.
Title Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
Journal BioSciences Master Reviews, July 2013
Reference Authors Sattentau Q
Title Avoiding the void: cell-to-cell spread of human viruses.
Journal Reference Authors Vicente-Manzanares M, Sanchez-Madrid F
Title Role of the cytoskeleton during leukocyte responses.
Journal Reference Authors Dutartre H, Claviere M, Journo C, Mahieux R
Title Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
Journal Reference Authors Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Luscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
Title A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
Journal Reference Authors Edwards D, Fenizia C, Gold H, de Castro-Amarante MF, Buchmann C, Pise-Masison CA, Franchini G
Title Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
Journal Reference Authors Nakano K, Watanabe T
Title HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
Journal Reference Authors Shida H
Title Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
Journal Reference Authors Bai XT, Nicot C
Title Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
Journal Reference Authors Taylor JM, Nicot C
Title HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
Journal Reference Authors D'Agostino DM, Silic-Benussi M, Hiraragi H, Lairmore MD, Ciminale V
Title The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth.
Journal Reference Authors Silic-Benussi M, Biasiotto R, Andresen V, Franchini G, D'Agostino DM, Ciminale V
Title HTLV-1 p13, a small protein with a busy agenda.
Journal Reference Authors Fuentes-Gonzalez AM, Contreras-Paredes A, Manzo-Merino J, Lizano M
Title The modulation of apoptosis by oncogenic viruses.
Journal Reference Authors Qu Z, Xiao G
Title Human T-cell lymphotropic virus: a model of NF-kappaB-associated tumorigenesis.
Journal Reference Authors Saggioro D
Title Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
Journal Reference Authors Harhaj EW, Harhaj NS
Title Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
Journal Reference Authors Sun SC, Yamaoka S
Title Activation of NF-kappaB by HTLV-I and implications for cell transformation.
Journal Reference Authors Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC
Title Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
Journal Reference Authors Nakachi S, Nakazato T, Ishikawa C, Kimura R, Mann DA, Senba M, Masuzaki H, Mori N
Title Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
Journal Reference Authors James CD, Roberts S
Title Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
Journal Reference Authors Cherian MA, Baydoun HH, Al-Saleem J, Shkriabai N, Kvaratskhelia M, Green P, Ratner L
Title Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.
Journal Reference Authors Mori N, Morishita M, Tsukazaki T, Giam CZ, Kumatori A, Tanaka Y, Yamamoto N
Title Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
Journal Reference Authors Azran I, Schavinsky-Khrapunsky Y, Aboud M
Title Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
Journal Reference Authors Yoshida M
Title Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
Journal Reference Authors Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
Title Inactivation of hTERT transcription by Tax.
Journal Related map04612 Antigen processing and presentation
map04660 T cell receptor signaling pathway
KO pathway
