KEGG PATHWAY: map05168

PATHWAY: map05168

Entry

map05168                    Pathway

Name

Herpes simplex virus 1 infection

Description

Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.

Class

Human Diseases; Infectious disease: viral

Pathway map

map05168

Herpes simplex virus 1 infection

Disease

H00365

Herpes simplex virus infection

Reference

PMID:12787566

Authors

Granger SW, Rickert S

Title

LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.

Journal

Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5

Reference

PMID:19495760

Authors

Steinberg MW, Shui JW, Ware CF, Kronenberg M

Title

Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.

Journal

Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4

Reference

PMID:20221426

Authors

MacLeod IJ, Minson T

Title

Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.

Journal

PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560

Reference

PMID:23150579

Authors

Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G

Title

alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.

Journal

Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109

Reference

PMID:25375272

Authors

Gianni T, Campadelli-Fiume G

Title

The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.

Journal

PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477

Reference

PMID:15056211

Authors

Spear PG

Title

Herpes simplex virus: receptors and ligands for cell entry.

Journal

Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x

Reference

PMID:12855695

Authors

Boutell C, Everett RD

Title

The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.

Journal

J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200

Reference

PMID:24262390

Authors

Ma Y, He B

Title

Recognition of herpes simplex viruses: toll-like receptors and beyond.

Journal

J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012

Reference

PMID:26952111

Authors

Su C, Zhan G, Zheng C

Title

Evasion of host antiviral innate immunity by HSV-1, an update.

Journal

Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5

Reference

PMID:21994567

Authors

Melchjorsen J, Matikainen S, Paludan SR

Title

Activation and evasion of innate antiviral immunity by herpes simplex virus.

Journal

Viruses 1:737-59 (2009)
DOI:10.3390/v1030737

Reference

PMID:15276609

Authors

Morrison LA

Title

The Toll of herpes simplex virus infection.

Journal

Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001

Reference

PMID:29298887

Authors

Zheng C

Title

Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.

Journal

J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17

Reference

PMID:19344302

Authors

Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC

Title

Design and application of oncolytic HSV vectors for glioblastoma therapy.

Journal

Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9

Reference

PMID:23115300

Authors

Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A

Title

The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.

Journal

J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12

Reference

PMID:17229694

Authors

Sanchez R, Mohr I

Title

Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.

Journal

J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06

Reference

PMID:12826401

Authors

Wysocka J, Herr W

Title

The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.

Journal

Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4

Reference

PMID:27367734

Authors

Fleming SB

Title

Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.

Journal

Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023

Reference

PMID:15163721

Authors

Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N

Title

Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.

Journal

J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004

Reference

PMID:23864622

Authors

Gu H, Zheng Y, Roizman B

Title

Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.

Journal

J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13

Reference

PMID:21994592

Authors

Tavalai N, Stamminger T

Title

Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.

Journal

Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240

Reference

PMID:21146386

Authors

Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ

Title

Viral evasion of T cell immunity: ancient mechanisms offering new applications.

Journal

Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005

Reference

PMID:12960333

Authors

Neumann J, Eis-Hubinger AM, Koch N

Title

Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.

Journal

J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075

Reference

PMID:25798530

Authors

Liu X, Cohen JI

Title

The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.

Journal

Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040

Reference

PMID:28468873

Authors

Vink EI, Smiley JR, Mohr I

Title

Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.

Journal

J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17

Reference

PMID:18508584

Authors

Sandri-Goldin RM

Title

The many roles of the regulatory protein ICP27 during herpes simplex virus infection.

Journal

Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078

Reference

PMID:15078920

Authors

Sandri-Goldin RM

Title

Viral regulation of mRNA export.

Journal

J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004

Reference

PMID:27154074

Authors

Yu X, He S

Title

The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.

Journal

Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0

Related
pathway

map03040

Spliceosome

map03050

Proteasome

map04115

p53 signaling pathway

map04151

PI3K-Akt signaling pathway

map04210

Apoptosis

map04610

Complement and coagulation cascades

map04612

Antigen processing and presentation

map04620

Toll-like receptor signaling pathway

map04622

RIG-I-like receptor signaling pathway

map04630

JAK-STAT signaling pathway

KO pathway

ko05168

All links

Chemical substance (3)   
   KEGG COMPOUND (3)   
Gene (257903)   
   KEGG ORTHOLOGY (149)   
   RefGene (257754)   
Literature (27)   
   PubMed (27)   
All databases (257933)   

Download RDF

DBGET integrated database retrieval system