KEGG PATHWAY: map05202

PATHWAY: map05202

Entry

map05202                    Pathway

Name

Transcriptional misregulation in cancer

Description

In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.

Class

Human Diseases; Cancer: overview

Pathway map

map05202

Transcriptional misregulation in cancer

Reference

PMID:11607818

Authors

Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG

Title

Common themes in the pathogenesis of acute myeloid leukemia.

Journal

Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642

Reference

PMID:12032780

Authors

Scandura JM, Boccuni P, Cammenga J, Nimer SD

Title

Transcription factor fusions in acute leukemia: variations on a theme.

Journal

Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315

Reference

PMID:12529654

Authors

Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C

Title

New mechanisms of AML1 gene alteration in hematological malignancies.

Journal

Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766

Reference

PMID:10717473

Authors

Lutterbach B, Hiebert SW

Title

Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.

Journal

Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7

Reference

PMID:19075268

Authors

Koschmieder S, Halmos B, Levantini E, Tenen DG

Title

Dysregulation of the C/EBPalpha differentiation pathway in human cancer.

Journal

J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812

Reference

PMID:11340171

Authors

Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG

Title

c-Myc is a critical target for c/EBPalpha in granulopoiesis.

Journal

Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001

Reference

PMID:15985538

Authors

Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP

Title

Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.

Journal

Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358

Reference

PMID:12393465

Authors

Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G

Title

The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.

Journal

Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288

Reference

PMID:12130514

Authors

Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG

Title

Heterozygous PU.1 mutations are associated with acute myeloid leukemia.

Journal

Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998

Reference

PMID:15160934

Authors

Jing Y

Title

The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.

Journal

Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933

Reference

PMID:15024077

Authors

Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H

Title

Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.

Journal

Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004

Reference

PMID:19855079

Authors

Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD

Title

Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.

Journal

Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524

Reference

PMID:10500199

Authors

McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C

Title

Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.

Journal

Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464

Reference

PMID:15156184

Authors

Zelent A, Greaves M, Enver T

Title

Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.

Journal

Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672

Reference

PMID:14630078

Authors

Sawinska M, Ladon D

Title

Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.

Journal

Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7

Reference

PMID:19141473

Authors

Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA

Title

Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.

Journal

Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408

Reference

PMID:16169901

Authors

Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ

Title

The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.

Journal

Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102

Reference

PMID:21518926

Authors

Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ

Title

MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.

Journal

Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699

Reference

PMID:14701735

Authors

Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK

Title

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.

Journal

Mol Cell Biol 24:617-28 (2004)
DOI:10.1128/MCB.24.2.617-628.2004

Reference

PMID:19133982

Authors

Riz I, Hawley TS, Johnston H, Hawley RG

Title

Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis.

Journal

Br J Haematol 145:140-3 (2009)
DOI:10.1111/j.1365-2141.2008.07556.x

Reference

PMID:12511414

Authors

Barth TF, Martin-Subero JI, Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Mooller P

Title

Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.

Journal

Blood 101:3681-6 (2003)
DOI:10.1182/blood-2002-08-2577

Reference

PMID:11313274

Authors

Hinz M, Loser P, Mathas S, Krappmann D, Dorken B, Scheidereit C

Title

Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.

Journal

Blood 97:2798-807 (2001)
DOI:10.1182/blood.V97.9.2798

Reference

PMID:12670461

Authors

Zuzel M, Cawley JC.

Title

The biology of hairy cells.

Journal

Best Pract Res Clin Haematol 16:1-13 (2003)
DOI:10.1016/S1521-6926(02)00082-8

Reference

PMID:14998494

Authors

Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T, Bergsagel PL, Kuehl WM, Staudt LM

Title

Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.

Journal

Cancer Cell 5:191-9 (2004)
DOI:10.1016/S1535-6108(04)00019-4

Reference

PMID:20974671

Authors

Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD

Title

The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.

Journal

Blood 117:211-20 (2011)
DOI:10.1182/blood-2010-07-298349

Reference

PMID:19059936

Authors

Brito JL, Walker B, Jenner M, Dickens NJ, Brown NJ, Ross FM, Avramidou A, Irving JA, Gonzalez D, Davies FE, Morgan GJ

Title

MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells.

Journal

Haematologica 94:78-86 (2009)
DOI:10.3324/haematol.13426

Reference

PMID:10350329

Authors

Iida S, Rao PH, Ueda R, Chaganti RS, Dalla-Favera R

Title

Chromosomal rearrangement of the PAX-5 locus in lymphoplasmacytic lymphoma with t(9;14)(p13;q32).

Journal

Leuk Lymphoma 34:25-33 (1999)
DOI:10.3109/10428199909083377

Reference

PMID:10784387

Authors

Ohno H, Ueda C, Akasaka T

Title

The t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma.

Journal

Leuk Lymphoma 36:435-45 (2000)
DOI:10.3109/10428190009148390

Reference

PMID:19233641

Authors

Prensner JR, Chinnaiyan AM

Title

Oncogenic gene fusions in epithelial carcinomas.

Journal

Curr Opin Genet Dev 19:82-91 (2009)
DOI:10.1016/j.gde.2008.11.008

Reference

PMID:19406209

Authors

Brenner JC, Chinnaiyan AM

Title

Translocations in epithelial cancers.

Journal

Biochim Biophys Acta 1796:201-15 (2009)
DOI:10.1016/j.bbcan.2009.04.005

Reference

PMID:16946003

Authors

Reddi HV, McIver B, Grebe SK, Eberhardt NL

Title

The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.

Journal

Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926

Reference

PMID:19422821

Authors

Medendorp K, van Groningen JJ, Vreede L, Hetterschijt L, Brugmans L, van den Hurk WH, van Kessel AG

Title

The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay.

Journal

Exp Cell Res 315:2399-409 (2009)
DOI:10.1016/j.yexcr.2009.04.022

Reference

PMID:18563191

Authors

Kumar-Sinha C, Tomlins SA, Chinnaiyan AM

Title

Recurrent gene fusions in prostate cancer.

Journal

Nat Rev Cancer 8:497-511 (2008)
DOI:10.1038/nrc2402

Reference

PMID:20478527

Authors

Yu J, Yu J, Mani RS, Cao Q, Brenner CJ, Cao X, Wang X, Wu L, Li J, Hu M, Gong Y, Cheng H, Laxman B, Vellaichamy A, Shankar S, Li Y, Dhanasekaran SM, Morey R, Barrette T, Lonigro RJ, Tomlins SA, Varambally S, Qin ZS, Chinnaiyan AM

Title

An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.

Journal

Cancer Cell 17:443-54 (2010)
DOI:10.1016/j.ccr.2010.03.018

Reference

PMID:21747944

Authors

Leshem O, Madar S, Kogan-Sakin I, Kamer I, Goldstein I, Brosh R, Cohen Y, Jacob-Hirsch J, Ehrlich M, Ben-Sasson S, Goldfinger N, Loewenthal R, Gazit E, Rotter V, Berger R

Title

TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.

Journal

PLoS One 6:e21650 (2011)
DOI:10.1371/journal.pone.0021650

Reference

PMID:17505060

Authors

Cai C, Hsieh CL, Omwancha J, Zheng Z, Chen SY, Baert JL, Shemshedini L

Title

ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.

Journal

Mol Endocrinol 21:1835-46 (2007)
DOI:10.1210/me.2006-0480

Reference

PMID:18172298

Authors

Helgeson BE, Tomlins SA, Shah N, Laxman B, Cao Q, Prensner JR, Cao X, Singla N, Montie JE, Varambally S, Mehra R, Chinnaiyan AM

Title

Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.

Journal

Cancer Res 68:73-80 (2008)
DOI:10.1158/0008-5472.CAN-07-5352

Reference

PMID:21849159

Authors

Westermark UK, Wilhelm M, Frenzel A, Henriksson MA

Title

The MYCN oncogene and differentiation in neuroblastoma.

Journal

Semin Cancer Biol 21:256-66 (2011)
DOI:10.1016/j.semcancer.2011.08.001

Reference

PMID:20153925

Authors

Bell E, Chen L, Liu T, Marshall GM, Lunec J, Tweddle DA

Title

MYCN oncoprotein targets and their therapeutic potential.

Journal

Cancer Lett 293:144-57 (2010)
DOI:10.1016/j.canlet.2010.01.015

Reference

PMID:15644444

Authors

Slack A, Chen Z, Tonelli R, Pule M, Hunt L, Pession A, Shohet JM

Title

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

Journal

Proc Natl Acad Sci U S A 102:731-6 (2005)
DOI:10.1073/pnas.0405495102

Reference

PMID:20190806

Authors

Ochiai H, Takenobu H, Nakagawa A, Yamaguchi Y, Kimura M, Ohira M, Okimoto Y, Fujimura Y, Koseki H, Kohno Y, Nakagawara A, Kamijo T

Title

Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.

Journal

Oncogene 29:2681-90 (2010)
DOI:10.1038/onc.2010.22

Reference

PMID:20145147

Authors

Chen L, Iraci N, Gherardi S, Gamble LD, Wood KM, Perini G, Lunec J, Tweddle DA

Title

p53 is a direct transcriptional target of MYCN in neuroblastoma.

Journal

Cancer Res 70:1377-88 (2010)
DOI:10.1158/0008-5472.CAN-09-2598

Reference

PMID:17327229

Authors

Beierle EA, Trujillo A, Nagaram A, Kurenova EV, Finch R, Ma X, Vella J, Cance WG, Golubovskaya VM

Title

N-MYC regulates focal adhesion kinase expression in human neuroblastoma.

Journal

J Biol Chem 282:12503-16 (2007)
DOI:10.1074/jbc.M701450200

Reference

PMID:21123453

Authors

Iraci N, Diolaiti D, Papa A, Porro A, Valli E, Gherardi S, Herold S, Eilers M, Bernardoni R, Della Valle G, Perini G

Title

A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF.

Journal

Cancer Res 71:404-12 (2011)
DOI:10.1158/0008-5472.CAN-10-2627

Reference

PMID:17024155

Authors

Dreijerink KM, Hoppener JW, Timmers HM, Lips CJ

Title

Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation.

Journal

Nat Clin Pract Endocrinol Metab 2:562-70 (2006)
DOI:10.1038/ncpendmet0292

Reference

PMID:19075677

Authors

Wu X, Hua X

Title

Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.

Journal

Curr Mol Med 8:805-15 (2008)
DOI:10.2174/156652408786733702

Reference

PMID:19564705

Authors

Sakurai A, Murakami A, Sano K, Uchino S, Fukushima Y

Title

Unusual clinical and pathological presentation of a neuroendocrine tumor in a patient with multiple endocrine neoplasia type 1.

Journal

Endocr J 56:887-95 (2009)
DOI:10.1507/endocrj.K09E-126

Reference

PMID:17222504

Authors

Yang Y, Hua X

Title

In search of tumor suppressing functions of menin.

Journal

Mol Cell Endocrinol 265-266:34-41 (2007)
DOI:10.1016/j.mce.2006.12.032

Reference

PMID:15826838

Authors

Aman P

Title

Fusion oncogenes in tumor development.

Journal

Semin Cancer Biol 15:236-43 (2005)
DOI:10.1016/j.semcancer.2005.01.009

Reference

PMID:12527902

Authors

Fukuma M, Okita H, Hata J, Umezawa A

Title

Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma.

Journal

Oncogene 22:1-9 (2003)
DOI:10.1038/sj.onc.1206055

Reference

PMID:18648544

Authors

Cironi L, Riggi N, Provero P, Wolf N, Suva ML, Suva D, Kindler V, Stamenkovic I

Title

IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.

Journal

PLoS One 3:e2634 (2008)
DOI:10.1371/journal.pone.0002634

Reference

PMID:17250957

Authors

Riggi N, Stamenkovic I.

Title

The Biology of Ewing sarcoma.

Journal

Cancer Lett 254:1-10 (2007)
DOI:10.1016/j.canlet.2006.12.009

Reference

PMID:20490326

Authors

Jedlicka P

Title

Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.

Journal

Int J Clin Exp Pathol 3:338-47 (2010)

Reference

PMID:19738075

Authors

Ordonez JL, Osuna D, Herrero D, de Alava E, Madoz-Gurpide J

Title

Advances in Ewing's sarcoma research: where are we now and what lies ahead?

Journal

Cancer Res 69:7140-50 (2009)
DOI:10.1158/0008-5472.CAN-08-4041

Reference

PMID:12527906

Authors

Jishage M, Fujino T, Yamazaki Y, Kuroda H, Nakamura T

Title

Identification of target genes for EWS/ATF-1 chimeric transcription factor.

Journal

Oncogene 22:41-9 (2003)
DOI:10.1038/sj.onc.1206074

Reference

PMID:15826834

Authors

Gerald WL, Haber DA

Title

The EWS-WT1 gene fusion in desmoplastic small round cell tumor.

Journal

Semin Cancer Biol 15:197-205 (2005)
DOI:10.1016/j.semcancer.2005.01.005

Reference

PMID:18855877

Authors

Filion C, Motoi T, Olshen AB, Lae M, Emnett RJ, Gutmann DH, Perry A, Ladanyi M, Labelle Y

Title

The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene.

Journal

J Pathol 217:83-93 (2009)
DOI:10.1002/path.2445

Reference

PMID:18330902

Authors

Kim S, Lee HJ, Jun HJ, Kim J

Title

The hTAF II 68-TEC fusion protein functions as a strong transcriptional activator.

Journal

Int J Cancer 122:2446-53 (2008)
DOI:10.1002/ijc.23379

Reference

PMID:10537274

Authors

Sjogren H, Meis-Kindblom J, Kindblom LG, Aman P, Stenman G

Title

Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.

Journal

Cancer Res 59:5064-7 (1999)

Reference

PMID:15688424

Authors

Goransson M, Elias E, Stahlberg A, Olofsson A, Andersson C, Aman P

Title

Myxoid liposarcoma FUS-DDIT3 fusion oncogene induces C/EBP beta-mediated interleukin 6 expression.

Journal

Int J Cancer 115:556-60 (2005)
DOI:10.1002/ijc.20893

Reference

PMID:18850010

Authors

Goransson M, Andersson MK, Forni C, Stahlberg A, Andersson C, Olofsson A, Mantovani R, Aman P

Title

The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ.

Journal

Oncogene 28:270-8 (2009)
DOI:10.1038/onc.2008.378

Reference

PMID:20863376

Authors

Willems SM, Schrage YM, Bruijn IH, Szuhai K, Hogendoorn PC, Bovee JV

Title

Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.

Journal

Mol Cancer 9:257 (2010)
DOI:10.1186/1476-4598-9-257

Reference

PMID:18457914

Authors

Linardic CM

Title

PAX3-FOXO1 fusion gene in rhabdomyosarcoma.

Journal

Cancer Lett 270:10-8 (2008)
DOI:10.1016/j.canlet.2008.03.035

Reference

PMID:11863357

Authors

Barber TD, Barber MC, Tomescu O, Barr FG, Ruben S, Friedman TB

Title

Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.

Journal

Genomics 79:278-84 (2002)
DOI:10.1006/geno.2002.6703

Reference

PMID:17101797

Authors

Ishida M, Miyamoto M, Naitoh S, Tatsuda D, Hasegawa T, Nemoto T, Yokozeki H, Nishioka K, Matsukage A, Ohki M, Ohta T

Title

The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.

Journal

Mol Cell Biol 27:1348-55 (2007)
DOI:10.1128/MCB.00658-06

Reference

PMID:19472090

Authors

Jun HJ, Lee J, Lim do H, Park JO, Ahn G, Seo SW, Sung KS, Lim do H, Yoo KH, Choi YL

Title

Expression of MET in alveolar soft part sarcoma.

Journal

Med Oncol 27:459-65 (2010)
DOI:10.1007/s12032-009-9234-8

Reference

PMID:21779514

Authors

Rivlin N, Brosh R, Oren M, Rotter V

Title

Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.

Journal

Genes Cancer 2:466-74 (2011)
DOI:10.1177/1947601911408889

Reference

PMID:21765642

Authors

Suzuki K, Matsubara H

Title

Recent advances in p53 research and cancer treatment.

Journal

J Biomed Biotechnol 2011:978312 (2011)
DOI:10.1155/2011/978312

Related
pathway

map04115

p53 signaling pathway

map05211

Renal cell carcinoma

map05215

Prostate cancer

map05216

Thyroid cancer

map05221

Acute myeloid leukemia

KO pathway

ko05202

All links

Gene (150211)   
   KEGG ORTHOLOGY (162)   
   RefGene (150049)   
Literature (68)   
   PubMed (68)   
All databases (150279)   

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