KEGG PATHWAY: map05203

PATHWAY: map05203

Entry

map05203                    Pathway

Name

Viral carcinogenesis

Description

There is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Via expression of many potent oncoproteins, these tumor viruses promote an aberrant cell-proliferation via modulating cellular cell-signaling pathways and escape from cellular defense system such as blocking apoptosis. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Viruses that encode such activities can contribute to initiation as well as progression of human cancers.

Class

Human Diseases; Cancer: overview

Pathway map

map05203

Viral carcinogenesis

Reference

PMID:18201576

Authors

McLaughlin-Drubin ME, Munger K

Title

Viruses associated with human cancer.

Journal

Biochim Biophys Acta 1782:127-50 (2008)
DOI:10.1016/j.bbadis.2007.12.005

Reference

PMID:21102637

Authors

Moore PS, Chang Y

Title

Why do viruses cause cancer? Highlights of the first century of human tumour virology.

Journal

Nat Rev Cancer 10:878-89 (2010)
DOI:10.1038/nrc2961

Reference

PMID:19400863

Authors

Kalland KH, Ke XS, Oyan AM

Title

Tumour virology--history, status and future challenges.

Journal

APMIS 117:382-99 (2009)
DOI:10.1111/j.1600-0463.2009.02452.x

Reference

PMID:17979705

Authors

Boccardo E, Villa LL

Title

Viral origins of human cancer.

Journal

Curr Med Chem 14:2526-39 (2007)
DOI:10.2174/092986707782023316

Reference

PMID:21084867

Authors

Saha A, Kaul R, Murakami M, Robertson ES

Title

Tumor viruses and cancer biology: Modulating signaling pathways for therapeutic intervention.

Journal

Cancer Biol Ther 10:961-78 (2010)
DOI:10.4161/cbt.10.10.13923

Reference

PMID:21152115

Authors

Zheng ZM

Title

Viral oncogenes, noncoding RNAs, and RNA splicing in human tumor viruses.

Journal

Int J Biol Sci 6:730-55 (2010)
DOI:10.7150/ijbs.6.730

Reference

PMID:19956178

Authors

Martin D, Gutkind JS

Title

Human tumor-associated viruses and new insights into the molecular mechanisms of cancer.

Journal

Oncogene 27 Suppl 2:S31-42 (2008)
DOI:10.1038/onc.2009.351

Reference

PMID:16459163

Authors

Zhang X, Zhang H, Ye L

Title

Effects of hepatitis B virus X protein on the development of liver cancer.

Journal

J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003

Reference

PMID:12686421

Authors

Panteva M, Korkaya H, Jameel S

Title

Hepatitis viruses and the MAPK pathway: is this a survival strategy?

Journal

Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8

Reference

PMID:21647825

Authors

Ng SA, Lee C

Title

Hepatitis B virus X gene and hepatocarcinogenesis.

Journal

J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9

Reference

PMID:21966251

Authors

Nishida N, Goel A

Title

Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review.

Journal

Curr Genomics 12:130-7 (2011)
DOI:10.2174/138920211795564359

Reference

PMID:19854353

Authors

Benhenda S, Cougot D, Buendia MA, Neuveut C

Title

Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.

Journal

Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8

Reference

PMID:18251977

Authors

Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ

Title

Viral hepatocarcinogenesis: from infection to cancer.

Journal

Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x

Reference

PMID:9343405

Authors

Klein NP, Schneider RJ

Title

Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras.

Journal

Mol Cell Biol 17:6427-36 (1997)
DOI:10.1128/MCB.17.11.6427

Reference

PMID:16039586

Authors

Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, Hung MC

Title

Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.

Journal

Mol Cell 19:159-70 (2005)
DOI:10.1016/j.molcel.2005.06.009

Reference

PMID:21994562

Authors

Benhenda S, Cougot D, Neuveut C, Buendia MA

Title

Liver cell transformation in chronic HBV infection.

Journal

Viruses 1:630-46 (2009)
DOI:10.3390/v1030630

Reference

PMID:11099494

Authors

Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD

Title

X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.

Journal

J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200

Reference

PMID:10824878

Authors

Arbuthnot P, Capovilla A, Kew M

Title

Putative role of hepatitis B virus X protein in hepatocarcinogenesis: effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways.

Journal

J Gastroenterol Hepatol 15:357-68 (2000)
DOI:10.1046/j.1440-1746.2000.02069.x

Reference

PMID:9837909

Authors

Gottlob K, Fulco M, Levrero M, Graessmann A

Title

The hepatitis B virus HBx protein inhibits caspase 3 activity.

Journal

J Biol Chem 273:33347-53 (1998)
DOI:10.1074/jbc.273.50.33347

Reference

PMID:15614436

Authors

Zhang JL, Zhao WG, Wu KL, Wang K, Zhang X, Gu CF, Li Y, Zhu Y, Wu JG

Title

Human hepatitis B virus X protein promotes cell proliferation and inhibits cell apoptosis through interacting with a serine protease Hepsin.

Journal

Arch Virol 150:721-41 (2005)
DOI:10.1007/s00705-004-0446-0

Reference

PMID:15105524

Authors

Cooray S

Title

The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival.

Journal

J Gen Virol 85:1065-76 (2004)
DOI:10.1099/vir.0.19771-0

Reference

PMID:16939421

Authors

Mukherji A, Janbandhu VC, Kumar V

Title

HBx-dependent cell cycle deregulation involves interaction with cyclin E/A-cdk2 complex and destabilization of p27Kip1.

Journal

Biochem J 401:247-56 (2007)
DOI:10.1042/BJ20061091

Reference

PMID:15173177

Authors

Yoo YG, Lee MO

Title

Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.

Journal

J Biol Chem 279:36242-9 (2004)
DOI:10.1074/jbc.M401290200

Reference

PMID:11604508

Authors

Waris G, Huh KW, Siddiqui A

Title

Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress.

Journal

Mol Cell Biol 21:7721-30 (2001)
DOI:10.1128/MCB.21.22.7721-7730.2001

Reference

PMID:17894800

Authors

Kasprzak A, Adamek A

Title

Role of hepatitis C virus proteins (C, NS3, NS5A) in hepatic oncogenesis.

Journal

Hepatol Res 38:1-26 (2008)
DOI:10.1111/j.1872-034X.2007.00261.x

Reference

PMID:9882379

Authors

You LR, Chen CM, Lee YH

Title

Hepatitis C virus core protein enhances NF-kappaB signal pathway triggering by lymphotoxin-beta receptor ligand and tumor necrosis factor alpha.

Journal

J Virol 73:1672-81 (1999)
DOI:10.1128/JVI.73.2.1672-1681.1999

Reference

PMID:16581947

Authors

Sato Y, Kato J, Takimoto R, Takada K, Kawano Y, Miyanishi K, Kobune M, Sato Y, Takayama T, Matunaga T, Niitsu Y

Title

Hepatitis C virus core protein promotes proliferation of human hepatoma cells through enhancement of transforming growth factor alpha expression via activation of nuclear factor-kappaB.

Journal

Gut 55:1801-8 (2006)
DOI:10.1136/gut.2005.070417

Reference

PMID:14559998

Authors

Watashi K, Hijikata M, Tagawa A, Doi T, Marusawa H, Shimotohno K

Title

Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus.

Journal

Mol Cell Biol 23:7498-509 (2003)
DOI:10.1128/MCB.23.21.7498-7509.2003

Reference

PMID:9651361

Authors

Hsieh TY, Matsumoto M, Chou HC, Schneider R, Hwang SB, Lee AS, Lai MM

Title

Hepatitis C virus core protein interacts with heterogeneous nuclear ribonucleoprotein K.

Journal

J Biol Chem 273:17651-9 (1998)
DOI:10.1074/jbc.273.28.17651

Reference

PMID:10873631

Authors

Wang F, Yoshida I, Takamatsu M, Ishido S, Fujita T, Oka K, Hotta H

Title

Complex formation between hepatitis C virus core protein and p21Waf1/Cip1/Sdi1.

Journal

Biochem Biophys Res Commun 273:479-84 (2000)
DOI:10.1006/bbrc.2000.2970

Reference

PMID:10074132

Authors

You LR, Chen CM, Yeh TS, Tsai TY, Mai RT, Lin CH, Lee YH

Title

Hepatitis C virus core protein interacts with cellular putative RNA helicase.

Journal

J Virol 73:2841-53 (1999)
DOI:10.1128/JVI.73.4.2841-2853.1999

Reference

PMID:10644344

Authors

Aoki H, Hayashi J, Moriyama M, Arakawa Y, Hino O

Title

Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1.

Journal

J Virol 74:1736-41 (2000)
DOI:10.1128/JVI.74.4.1736-1741.2000

Reference

PMID:17267064

Authors

Yan XB, Battaglia S, Boucreux D, Chen Z, Brechot C, Pavio N

Title

Mapping of the interacting domains of hepatitis C virus core protein and the double-stranded RNA-activated protein kinase PKR.

Journal

Virus Res 125:79-87 (2007)
DOI:10.1016/j.virusres.2006.12.010

Reference

PMID:9060639

Authors

Borowski P, Oehlmann K, Heiland M, Laufs R

Title

Nonstructural protein 3 of hepatitis C virus blocks the distribution of the free catalytic subunit of cyclic AMP-dependent protein kinase.

Journal

J Virol 71:2838-43 (1997)
DOI:10.1128/JVI.71.4.2838-2843.1997

Reference

PMID:10405893

Authors

Borowski P, Kuhl R, Laufs R, Schulze zur Wiesch J, Heiland M

Title

Identification and characterization of a histone binding site of the non-structural protein 3 of hepatitis C virus.

Journal

J Clin Virol 13:61-9 (1999)
DOI:10.1016/S1386-6532(99)00007-4

Reference

PMID:12101418

Authors

Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD

Title

HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.

Journal

Oncogene 21:4801-11 (2002)
DOI:10.1038/sj.onc.1205589

Reference

PMID:12925958

Authors

Chung YL, Sheu ML, Yen SH

Title

Hepatitis C virus NS5A as a potential viral Bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma.

Journal

Int J Cancer 107:65-73 (2003)
DOI:10.1002/ijc.11303

Reference

PMID:10400746

Authors

Gale M Jr, Kwieciszewski B, Dossett M, Nakao H, Katze MG

Title

Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase.

Journal

J Virol 73:6506-16 (1999)
DOI:10.1128/JVI.73.8.6506-6516.1999

Reference

PMID:12186904

Authors

He Y, Nakao H, Tan SL, Polyak SJ, Neddermann P, Vijaysri S, Jacobs BL, Katze MG

Title

Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase.

Journal

J Virol 76:9207-17 (2002)
DOI:10.1128/JVI.76.18.9207-9217.2002

Reference

PMID:15795286

Authors

Street A, Macdonald A, McCormick C, Harris M

Title

Hepatitis C virus NS5A-mediated activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and stimulation of beta-catenin-responsive transcription.

Journal

J Virol 79:5006-16 (2005)
DOI:10.1128/JVI.79.8.5006-5016.2005

Reference

PMID:11886269

Authors

Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB

Title

Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.

Journal

Virology 294:94-105 (2002)
DOI:10.1006/viro.2001.1309

Reference

PMID:11278402

Authors

Arima N, Kao CY, Licht T, Padmanabhan R, Sasaguri Y, Padmanabhan R

Title

Modulation of cell growth by the hepatitis C virus nonstructural protein NS5A.

Journal

J Biol Chem 276:12675-84 (2001)
DOI:10.1074/jbc.M008329200

Reference

PMID:21250384

Authors

He Y, Staschke KA, Tan SL

Title

HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication

Journal

Hepatitis C Viruses: Genomes and Molecular Biology (2006)

Reference

PMID:12379483

Authors

Qadri I, Iwahashi M, Simon F

Title

Hepatitis C virus NS5A protein binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3.

Journal

Biochim Biophys Acta 1592:193-204 (2002)
DOI:10.1016/S0167-4889(02)00315-4

Reference

PMID:22110506

Authors

Spender LC, Inman GJ

Title

Inhibition of germinal centre apoptotic programmes by epstein-barr virus.

Journal

Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525

Reference

PMID:20494113

Authors

Klein G, Klein E, Kashuba E

Title

Interaction of Epstein-Barr virus (EBV) with human B-lymphocytes.

Journal

Biochem Biophys Res Commun 396:67-73 (2010)
DOI:10.1016/j.bbrc.2010.02.146

Reference

PMID:21372216

Authors

Saha A, Robertson ES

Title

Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.

Journal

Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578

Reference

PMID:15510157

Authors

Young LS, Rickinson AB.

Title

Epstein-Barr virus: 40 years on.

Journal

Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452

Reference

PMID:14506283

Authors

Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L

Title

Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.

Journal

J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200

Reference

PMID:11160754

Authors

Harada S, Yalamanchili R, Kieff E

Title

Epstein-Barr virus nuclear protein 2 has at least two N-terminal domains that mediate self-association.

Journal

J Virol 75:2482-7 (2001)
DOI:10.1128/JVI.75.5.2482-2487.2001

Reference

PMID:15452270

Authors

Peng CW, Zhao B, Kieff E

Title

Four EBNA2 domains are important for EBNALP coactivation.

Journal

J Virol 78:11439-42 (2004)
DOI:10.1128/JVI.78.20.11439-11442.2004

Reference

PMID:15767449

Authors

Peng R, Moses SC, Tan J, Kremmer E, Ling PD

Title

The Epstein-Barr virus EBNA-LP protein preferentially coactivates EBNA2-mediated stimulation of latent membrane proteins expressed from the viral divergent promoter.

Journal

J Virol 79:4492-505 (2005)
DOI:10.1128/JVI.79.7.4492-4505.2005

Reference

PMID:21177815

Authors

Saha A, Bamidele A, Murakami M, Robertson ES

Title

EBNA3C attenuates the function of p53 through interaction with inhibitor of growth family proteins 4 and 5.

Journal

J Virol 85:2079-88 (2011)
DOI:10.1128/JVI.02279-10

Reference

PMID:21347341

Authors

Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES

Title

Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.

Journal

PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275

Reference

PMID:15542638

Authors

Knight JS, Sharma N, Kalman DE, Robertson ES

Title

A cyclin-binding motif within the amino-terminal homology domain of EBNA3C binds cyclin A and modulates cyclin A-dependent kinase activity in Epstein-Barr virus-infected cells.

Journal

J Virol 78:12857-67 (2004)
DOI:10.1128/JVI.78.23.12857-12867.2004

Reference

PMID:14747563

Authors

Knight JS, Robertson ES

Title

Epstein-Barr virus nuclear antigen 3C regulates cyclin A/p27 complexes and enhances cyclin A-dependent kinase activity.

Journal

J Virol 78:1981-91 (2004)
DOI:10.1128/JVI.78.4.1981-1991.2004

Reference

PMID:16352731

Authors

Knight JS, Sharma N, Robertson ES

Title

Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase.

Journal

Proc Natl Acad Sci U S A 102:18562-6 (2005)
DOI:10.1073/pnas.0503886102

Reference

PMID:18391203

Authors

Kashuba E, Yurchenko M, Yenamandra SP, Snopok B, Isaguliants M, Szekely L, Klein G

Title

EBV-encoded EBNA-6 binds and targets MRS18-2 to the nucleus, resulting in the disruption of pRb-E2F1 complexes.

Journal

Proc Natl Acad Sci U S A 105:5489-94 (2008)
DOI:10.1073/pnas.0801053105

Reference

PMID:11091847

Authors

Young LS, Dawson CW, Eliopoulos AG

Title

The expression and function of Epstein-Barr virus encoded latent genes.

Journal

Mol Pathol 53:238-47 (2000)
DOI:10.1136/mp.53.5.238

Reference

PMID:19078975

Authors

Kuppers R

Title

The biology of Hodgkin's lymphoma.

Journal

Nat Rev Cancer 9:15-27 (2009)
DOI:10.1038/nrc2542

Reference

PMID:17049016

Authors

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Title

The role of Epstein-Barr virus in cancer.

Journal

Expert Opin Biol Ther 6:1193-205 (2006)
DOI:10.1517/14712598.6.11.1193

Reference

PMID:11905817

Authors

Thorley-Lawson DA

Title

Epstein-Barr virus: exploiting the immune system.

Journal

Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584

Reference

PMID:11669605

Authors

Eliopoulos AG, Young LS

Title

LMP1 structure and signal transduction.

Journal

Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410

Reference

PMID:11766888

Authors

Dell G, Gaston K

Title

Human papillomaviruses and their role in cervical cancer.

Journal

Cell Mol Life Sci 58:1923-42 (2001)
DOI:10.1007/PL00000827

Reference

PMID:10793105

Authors

zur Hausen H

Title

Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.

Journal

J Natl Cancer Inst 92:690-8 (2000)
DOI:10.1093/jnci/92.9.690

Reference

PMID:19156753

Authors

Yugawa T, Kiyono T

Title

Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.

Journal

Rev Med Virol 19:97-113 (2009)
DOI:10.1002/rmv.605

Reference

PMID:17645777

Authors

Narisawa-Saito M, Kiyono T

Title

Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.

Journal

Cancer Sci 98:1505-11 (2007)
DOI:10.1111/j.1349-7006.2007.00546.x

Reference

PMID:15342967

Authors

Motoyama S, Ladines-Llave CA, Luis Villanueva S, Maruo T

Title

The role of human papilloma virus in the molecular biology of cervical carcinogenesis.

Journal

Kobe J Med Sci 50:9-19 (2004)

Reference

PMID:20592731

Authors

Moody CA, Laimins LA

Title

Human papillomavirus oncoproteins: pathways to transformation.

Journal

Nat Rev Cancer 10:550-60 (2010)
DOI:10.1038/nrc2886

Reference

PMID:15956361

Authors

McCance DJ

Title

Human papillomaviruses and cell signaling.

Journal

Sci STKE 2005:pe29 (2005)
DOI:10.1126/stke.2882005pe29

Reference

PMID:18385245

Authors

Wade R, Brimer N, Vande Pol S

Title

Transformation by bovine papillomavirus type 1 E6 requires paxillin.

Journal

J Virol 82:5962-6 (2008)
DOI:10.1128/JVI.02747-07

Reference

PMID:9374493

Authors

Berezutskaya E, Bagchi S

Title

The human papillomavirus E7 oncoprotein functionally interacts with the S4 subunit of the 26 S proteasome.

Journal

J Biol Chem 272:30135-40 (1997)
DOI:10.1074/jbc.272.48.30135

Reference

PMID:16381817

Authors

Zhang B, Chen W, Roman A

Title

The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradation.

Journal

Proc Natl Acad Sci U S A 103:437-42 (2006)
DOI:10.1073/pnas.0510012103

Reference

PMID:12970441

Authors

He W, Staples D, Smith C, Fisher C

Title

Direct activation of cyclin-dependent kinase 2 by human papillomavirus E7.

Journal

J Virol 77:10566-74 (2003)
DOI:10.1128/JVI.77.19.10566-10574.2003

Reference

PMID:9349482

Authors

Massimi P, Pim D, Banks L

Title

Human papillomavirus type 16 E7 binds to the conserved carboxy-terminal region of the TATA box binding protein and this contributes to E7 transforming activity.

Journal

J Gen Virol 78 ( Pt 10):2607-13 (1997)
DOI:10.1099/0022-1317-78-10-2607

Reference

PMID:8617242

Authors

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Title

The human papillomavirus type 16 E7 gene product interacts with and trans-activates the AP1 family of transcription factors.

Journal

EMBO J 15:1950-60 (1996)
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Reference

PMID:9990017

Authors

Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Durr P

Title

Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.

Journal

Proc Natl Acad Sci U S A 96:1291-6 (1999)
DOI:10.1073/pnas.96.4.1291

Reference

PMID:17384582

Authors

Matsuoka M, Jeang KT

Title

Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.

Journal

Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111

Reference

PMID:15310405

Authors

Azran I, Schavinsky-Khrapunsky Y, Aboud M

Title

Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.

Journal

Retrovirology 1:20 (2004)
DOI:10.1186/1742-4690-1-20

Reference

PMID:12910250

Authors

Matsuoka M

Title

Human T-cell leukemia virus type I and adult T-cell leukemia.

Journal

Oncogene 22:5131-40 (2003)
DOI:10.1038/sj.onc.1206551

Reference

PMID:11244044

Authors

Yoshida M

Title

Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.

Journal

Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475

Reference

PMID:18702816

Authors

Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L

Title

The HTLV-1 Tax interactome.

Journal

Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76

Reference

PMID:8223437

Authors

Caron C, Rousset R, Beraud C, Moncollin V, Egly JM, Jalinot P

Title

Functional and biochemical interaction of the HTLV-I Tax1 transactivator with TBP.

Journal

EMBO J 12:4269-78 (1993)
DOI:10.1002/j.1460-2075.1993.tb06111.x

Reference

PMID:8756622

Authors

Clemens KE, Piras G, Radonovich MF, Choi KS, Duvall JF, DeJong J, Roeder R, Brady JN

Title

Interaction of the human T-cell lymphotropic virus type 1 tax transactivator with transcription factor IIA.

Journal

Mol Cell Biol 16:4656-64 (1996)
DOI:10.1128/MCB.16.9.4656

Reference

PMID:16036567

Authors

Harhaj EW, Harhaj NS

Title

Mechanisms of persistent NF-kappaB activation by HTLV-I tax.

Journal

IUBMB Life 57:83-91 (2005)
DOI:10.1080/15216540500078715

Reference

PMID:21743832

Authors

Qu Z, Xiao G

Title

Human T-cell lymphotropic virus: a model of NF-kappaB-associated tumorigenesis.

Journal

Viruses 3:714-49 (2011)
DOI:10.3390/v3060714

Reference

PMID:16155601

Authors

Kashanchi F, Brady JN

Title

Transcriptional and post-transcriptional gene regulation of HTLV-1.

Journal

Oncogene 24:5938-51 (2005)
DOI:10.1038/sj.onc.1208973

Reference

PMID:14530271

Authors

Wu K, Bottazzi ME, de la Fuente C, Deng L, Gitlin SD, Maddukuri A, Dadgar S, Li H, Vertes A, Pumfery A, Kashanchi F

Title

Protein profile of tax-associated complexes.

Journal

J Biol Chem 279:495-508 (2004)
DOI:10.1074/jbc.M310069200

Reference

PMID:16155604

Authors

Grassmann R, Aboud M, Jeang KT

Title

Molecular mechanisms of cellular transformation by HTLV-1 Tax.

Journal

Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978

Reference

PMID:16308315

Authors

Tabakin-Fix Y, Azran I, Schavinky-Khrapunsky Y, Levy O, Aboud M

Title

Functional inactivation of p53 by human T-cell leukemia virus type 1 Tax protein: mechanisms and clinical implications.

Journal

Carcinogenesis 27:673-81 (2006)
DOI:10.1093/carcin/bgi274

Reference

PMID:16760382

Authors

Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ

Title

Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.

Journal

J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0

Reference

PMID:17457345

Authors

Coscoy L

Title

Immune evasion by Kaposi's sarcoma-associated herpesvirus.

Journal

Nat Rev Immunol 7:391-401 (2007)
DOI:10.1038/nri2076

Reference

PMID:21040832

Authors

Cai Q, Verma SC, Lu J, Robertson ES

Title

Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.

Journal

Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3

Reference

PMID:16828973

Authors

Jarviluoma A, Ojala PM

Title

Cell signaling pathways engaged by KSHV.

Journal

Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001

Reference

PMID:18948197

Authors

Liang C, Lee JS, Jung JU

Title

Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.

Journal

Semin Cancer Biol 18:423-36 (2008)
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Reference

PMID:19715458

Authors

Lee HR, Kim MH, Lee JS, Liang C, Jung JU

Title

Viral interferon regulatory factors.

Journal

J Interferon Cytokine Res 29:621-7 (2009)
DOI:10.1089/jir.2009.0067

Reference

PMID:22566809

Authors

Jacobs SR, Damania B

Title

The Viral Interferon Regulatory Factors of KSHV: Immunosuppressors or Oncogenes?

Journal

Front Immunol 2:19 (2011)
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Reference

PMID:19651473

Authors

Wen KW, Damania B

Title

Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis.

Journal

Cancer Lett 289:140-50 (2010)
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PMID:15967719

Authors

Wang HW, Boshoff C

Title

Linking Kaposi virus to cancer-associated cytokines.

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Trends Mol Med 11:309-12 (2005)
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Reference

PMID:15692053

Authors

McCormick C, Ganem D

Title

The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.

Journal

Science 307:739-41 (2005)
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Reference

PMID:12770701

Authors

Verma SC, Robertson ES

Title

Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.

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FEMS Microbiol Lett 222:155-63 (2003)
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PMID:10354594

Authors

Schulz TF, Moore PS

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Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?

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Trends Microbiol 7:196-200 (1999)
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PMID:10855768

Authors

Schulz TF

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Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8): epidemiology and pathogenesis.

Journal

J Antimicrob Chemother 45 Suppl T3:15-27 (2000)
DOI:10.1093/jac/45.suppl_4.15

Reference

PMID:9594662

Authors

Moore PS, Chang Y

Title

Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.

Journal

Trends Genet 14:144-50 (1998)
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Reference

PMID:20534855

Authors

Pietrek M, Brinkmann MM, Glowacka I, Enlund A, Havemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF

Title

Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation.

Journal

J Virol 84:8231-40 (2010)
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Reference

PMID:21421561

Authors

Bagneris C, Briggs LC, Savva R, Ebrahimi B, Barrett TE

Title

Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff.

Journal

Nucleic Acids Res 39:5744-56 (2011)
DOI:10.1093/nar/gkr111

Reference

PMID:15919895

Authors

Glaunsinger B, Chavez L, Ganem D

Title

The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable.

Journal

J Virol 79:7396-401 (2005)
DOI:10.1128/JVI.79.12.7396-7401.2005

Related
pathway

map03022

Basal transcription factors

map03320

PPAR signaling pathway

map04010

MAPK signaling pathway

map04062

Chemokine signaling pathway

map04064

NF-kappa B signaling pathway

map04110

Cell cycle

map04115

p53 signaling pathway

map04142

Lysosome

map04151

PI3K-Akt signaling pathway

map04210

Apoptosis

map04630

JAK-STAT signaling pathway

map04662

B cell receptor signaling pathway

map04810

Regulation of actin cytoskeleton

map05160

Hepatitis C

map05161

Hepatitis B

map05165

Human papillomavirus infection

map05166

Human T-cell leukemia virus 1 infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05169

Epstein-Barr virus infection

KO pathway

ko05203

All links

Gene (420373)   
   KEGG ORTHOLOGY (174)   
   RefGene (420199)   
Literature (107)   
   PubMed (107)   
All databases (420480)   

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