Entry
Name
Fc gamma R-mediated phagocytosis - Rattus norvegicus (rat)
Description
Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
rno04666 Fc gamma R-mediated phagocytosis
Ortholog table
Other DBs
Organism
Rattus norvegicus (rat) [GN:
rno ]
Gene
295279 Fcgr1a; high affinity immunoglobulin gamma Fc receptor I precursor [KO:K06498 ]
134481532 low affinity immunoglobulin gamma Fc region receptor III isoform X1 [KO:K06472 ]
116591 Fcgr2a; low affinity immunoglobulin gamma Fc region receptor III isoform 1 [KO:K06463 ]
304966 Fcgr3a; low affinity immunoglobulin gamma Fc region receptor III-A precursor [KO:K06463 ]
24699 Ptprc; receptor-type tyrosine-protein phosphatase C isoform 4 precursor [KO:K06478 ] [EC:3.1.3.48 ]
85243 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
170911 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
366508 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
134484121 LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
25513 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
60664 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
29741 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
25738 Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116 ] [EC:3.1.4.11 ]
29337 Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859 ] [EC:3.1.4.11 ]
360426 Pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform 1 [KO:K16343 ] [EC:3.1.1.4 ]
25603 Marcks; myristoylated alanine-rich C-kinase substrate [KO:K12561 ]
295378 Vav3; guanine nucleotide exchange factor VAV3 [KO:K05730 ]
296603 Vav2; guanine nucleotide exchange factor VAV2 [KO:K05730 ]
64465 Cdc42; cell division control protein 42 homolog [KO:K04393 ]
361517 Vasp; vasodilator-stimulated phosphoprotein [KO:K06274 ]
54227 Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757 ]
81824 Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757 ]
301511 Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758 ]
288669 Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756 ]
297518 Arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755 ]
296710 Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
360854 Arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754 ]
363875 Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
366957 Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860 ]
314641 Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform c [KO:K00889 ] [EC:2.7.1.68 ]
309081 Dock1; dedicator of cytokinesis protein 1 [KO:K13708 ]
684122 Asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488 ]
314961 Asap1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [KO:K12488 ]
362719 Asap2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [KO:K12488 ]
289211 Fcgr2b; low affinity immunoglobulin gamma Fc region receptor II [KO:K12560 ]
54259 Inpp5d; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084 ] [EC:3.1.3.86 ]
65038 Inppl1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform 1 [KO:K15909 ] [EC:3.1.3.86 ]
84477 Gab2; GRB2-associated-binding protein 2 [KO:K08091 ]
81511 Lat; linker for activation of T-cells family member 1 [KO:K07362 ]
117028 Bin1; myc box-dependent-interacting protein 1 [KO:K12562 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C06124 Sphingosine 1-phosphate
Reference
Authors
Garcia-Garcia E, Rosales C
Title
Signal transduction during Fc receptor-mediated phagocytosis.
Journal
Reference
Authors
Cox D, Greenberg S
Title
Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system.
Journal
Reference
Authors
Swanson JA, Hoppe AD
Title
The coordination of signaling during Fc receptor-mediated phagocytosis.
Journal
Reference
Authors
Ravetch JV, Bolland S
Title
IgG Fc receptors.
Journal
Reference
Authors
Groves E, Dart AE, Covarelli V, Caron E
Title
Molecular mechanisms of phagocytic uptake in mammalian cells.
Journal
Reference
Authors
Kwiatkowska K, Sobota A
Title
Signaling pathways in phagocytosis.
Journal
Reference
Authors
Greenberg S
Title
Modular components of phagocytosis.
Journal
Reference
Authors
Lennartz MR
Title
Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis.
Journal
Reference
Authors
May RC, Machesky LM
Title
Phagocytosis and the actin cytoskeleton.
Journal
J Cell Sci 114:1061-77 (2001)
Reference
Authors
Joshi T, Butchar JP, Tridandapani S
Title
Fcgamma receptor signaling in phagocytes.
Journal
Reference
Authors
Lee WL, Cosio G, Ireton K, Grinstein S
Title
Role of CrkII in Fcgamma receptor-mediated phagocytosis.
Journal
Reference
Authors
Uchida H, Kondo A, Yoshimura Y, Mazaki Y, Sabe H
Title
PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages.
Journal
Reference
Authors
Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S
Title
The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.
Journal
Reference
Authors
Melendez A, Floto RA, Gillooly DJ, Harnett MM, Allen JM
Title
FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking.
Journal
Reference
Authors
Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG
Title
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.
Journal
Reference
Authors
Dana R, Leto TL, Malech HL, Levy R
Title
Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.
Journal
Reference
Authors
Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A
Title
Dynamin 2 is required for phagocytosis in macrophages.
Journal
Reference
Authors
Gold ES, Morrissette NS, Underhill DM, Guo J, Bassetti M, Aderem A
Title
Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis.
Journal
Reference
Authors
Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Shayman JA, Boxer LA
Title
Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.
Journal
J Immunol 163:6785-93 (1999)
Reference
Authors
Sanchez-Mejorada G, Rosales C
Title
Signal transduction by immunoglobulin Fc receptors.
Journal
Reference
Authors
Rosales C (ed).
Title
Molecular Mechanisms of Phagocytosis
Journal
Springer (2005)
Related pathway
rno04810 Regulation of actin cytoskeleton
KO pathway