KEGG   Phascolarctos cinereus (koala): 110218307
Entry
110218307         CDS       T05867                                 
Symbol
PRKCA
Name
(RefSeq) protein kinase C alpha type
  KO
K02677  classical protein kinase C alpha type [EC:2.7.11.13]
Organism
pcw  Phascolarctos cinereus (koala)
Pathway
pcw01521  EGFR tyrosine kinase inhibitor resistance
pcw04010  MAPK signaling pathway
pcw04012  ErbB signaling pathway
pcw04014  Ras signaling pathway
pcw04015  Rap1 signaling pathway
pcw04020  Calcium signaling pathway
pcw04066  HIF-1 signaling pathway
pcw04070  Phosphatidylinositol signaling system
pcw04071  Sphingolipid signaling pathway
pcw04072  Phospholipase D signaling pathway
pcw04150  mTOR signaling pathway
pcw04151  PI3K-Akt signaling pathway
pcw04261  Adrenergic signaling in cardiomyocytes
pcw04270  Vascular smooth muscle contraction
pcw04310  Wnt signaling pathway
pcw04360  Axon guidance
pcw04370  VEGF signaling pathway
pcw04510  Focal adhesion
pcw04540  Gap junction
pcw04613  Neutrophil extracellular trap formation
pcw04650  Natural killer cell mediated cytotoxicity
pcw04664  Fc epsilon RI signaling pathway
pcw04666  Fc gamma R-mediated phagocytosis
pcw04670  Leukocyte transendothelial migration
pcw04713  Circadian entrainment
pcw04720  Long-term potentiation
pcw04723  Retrograde endocannabinoid signaling
pcw04724  Glutamatergic synapse
pcw04725  Cholinergic synapse
pcw04726  Serotonergic synapse
pcw04727  GABAergic synapse
pcw04728  Dopaminergic synapse
pcw04730  Long-term depression
pcw04750  Inflammatory mediator regulation of TRP channels
pcw04911  Insulin secretion
pcw04912  GnRH signaling pathway
pcw04916  Melanogenesis
pcw04918  Thyroid hormone synthesis
pcw04919  Thyroid hormone signaling pathway
pcw04921  Oxytocin signaling pathway
pcw04925  Aldosterone synthesis and secretion
pcw04926  Relaxin signaling pathway
pcw04928  Parathyroid hormone synthesis, secretion and action
pcw04929  GnRH secretion
pcw04933  AGE-RAGE signaling pathway in diabetic complications
pcw04935  Growth hormone synthesis, secretion and action
pcw04960  Aldosterone-regulated sodium reabsorption
pcw04961  Endocrine and other factor-regulated calcium reabsorption
pcw04970  Salivary secretion
pcw04971  Gastric acid secretion
pcw04972  Pancreatic secretion
pcw05017  Spinocerebellar ataxia
pcw05022  Pathways of neurodegeneration - multiple diseases
pcw05031  Amphetamine addiction
pcw05032  Morphine addiction
pcw05143  African trypanosomiasis
pcw05146  Amoebiasis
pcw05161  Hepatitis B
pcw05163  Human cytomegalovirus infection
pcw05164  Influenza A
pcw05170  Human immunodeficiency virus 1 infection
pcw05171  Coronavirus disease - COVID-19
pcw05200  Pathways in cancer
pcw05205  Proteoglycans in cancer
pcw05206  MicroRNAs in cancer
pcw05207  Chemical carcinogenesis - receptor activation
pcw05214  Glioma
pcw05223  Non-small cell lung cancer
pcw05225  Hepatocellular carcinoma
pcw05231  Choline metabolism in cancer
pcw05415  Diabetic cardiomyopathy
pcw05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pcw00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    110218307 (PRKCA)
   04012 ErbB signaling pathway
    110218307 (PRKCA)
   04014 Ras signaling pathway
    110218307 (PRKCA)
   04015 Rap1 signaling pathway
    110218307 (PRKCA)
   04310 Wnt signaling pathway
    110218307 (PRKCA)
   04370 VEGF signaling pathway
    110218307 (PRKCA)
   04066 HIF-1 signaling pathway
    110218307 (PRKCA)
   04020 Calcium signaling pathway
    110218307 (PRKCA)
   04070 Phosphatidylinositol signaling system
    110218307 (PRKCA)
   04072 Phospholipase D signaling pathway
    110218307 (PRKCA)
   04071 Sphingolipid signaling pathway
    110218307 (PRKCA)
   04151 PI3K-Akt signaling pathway
    110218307 (PRKCA)
   04150 mTOR signaling pathway
    110218307 (PRKCA)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    110218307 (PRKCA)
   04540 Gap junction
    110218307 (PRKCA)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    110218307 (PRKCA)
   04650 Natural killer cell mediated cytotoxicity
    110218307 (PRKCA)
   04664 Fc epsilon RI signaling pathway
    110218307 (PRKCA)
   04666 Fc gamma R-mediated phagocytosis
    110218307 (PRKCA)
   04670 Leukocyte transendothelial migration
    110218307 (PRKCA)
  09152 Endocrine system
   04911 Insulin secretion
    110218307 (PRKCA)
   04929 GnRH secretion
    110218307 (PRKCA)
   04912 GnRH signaling pathway
    110218307 (PRKCA)
   04921 Oxytocin signaling pathway
    110218307 (PRKCA)
   04926 Relaxin signaling pathway
    110218307 (PRKCA)
   04935 Growth hormone synthesis, secretion and action
    110218307 (PRKCA)
   04918 Thyroid hormone synthesis
    110218307 (PRKCA)
   04919 Thyroid hormone signaling pathway
    110218307 (PRKCA)
   04928 Parathyroid hormone synthesis, secretion and action
    110218307 (PRKCA)
   04916 Melanogenesis
    110218307 (PRKCA)
   04925 Aldosterone synthesis and secretion
    110218307 (PRKCA)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    110218307 (PRKCA)
   04270 Vascular smooth muscle contraction
    110218307 (PRKCA)
  09154 Digestive system
   04970 Salivary secretion
    110218307 (PRKCA)
   04971 Gastric acid secretion
    110218307 (PRKCA)
   04972 Pancreatic secretion
    110218307 (PRKCA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    110218307 (PRKCA)
   04961 Endocrine and other factor-regulated calcium reabsorption
    110218307 (PRKCA)
  09156 Nervous system
   04724 Glutamatergic synapse
    110218307 (PRKCA)
   04727 GABAergic synapse
    110218307 (PRKCA)
   04725 Cholinergic synapse
    110218307 (PRKCA)
   04728 Dopaminergic synapse
    110218307 (PRKCA)
   04726 Serotonergic synapse
    110218307 (PRKCA)
   04720 Long-term potentiation
    110218307 (PRKCA)
   04730 Long-term depression
    110218307 (PRKCA)
   04723 Retrograde endocannabinoid signaling
    110218307 (PRKCA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    110218307 (PRKCA)
  09158 Development and regeneration
   04360 Axon guidance
    110218307 (PRKCA)
  09159 Environmental adaptation
   04713 Circadian entrainment
    110218307 (PRKCA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110218307 (PRKCA)
   05206 MicroRNAs in cancer
    110218307 (PRKCA)
   05205 Proteoglycans in cancer
    110218307 (PRKCA)
   05207 Chemical carcinogenesis - receptor activation
    110218307 (PRKCA)
   05231 Choline metabolism in cancer
    110218307 (PRKCA)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    110218307 (PRKCA)
   05214 Glioma
    110218307 (PRKCA)
   05223 Non-small cell lung cancer
    110218307 (PRKCA)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    110218307 (PRKCA)
   05161 Hepatitis B
    110218307 (PRKCA)
   05171 Coronavirus disease - COVID-19
    110218307 (PRKCA)
   05164 Influenza A
    110218307 (PRKCA)
   05163 Human cytomegalovirus infection
    110218307 (PRKCA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    110218307 (PRKCA)
   05143 African trypanosomiasis
    110218307 (PRKCA)
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    110218307 (PRKCA)
   05022 Pathways of neurodegeneration - multiple diseases
    110218307 (PRKCA)
  09165 Substance dependence
   05031 Amphetamine addiction
    110218307 (PRKCA)
   05032 Morphine addiction
    110218307 (PRKCA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    110218307 (PRKCA)
   05415 Diabetic cardiomyopathy
    110218307 (PRKCA)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    110218307 (PRKCA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    110218307 (PRKCA)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pcw01001]
    110218307 (PRKCA)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pcw04131]
    110218307 (PRKCA)
Enzymes [BR:pcw01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     110218307 (PRKCA)
Protein kinases [BR:pcw01001]
 Serine/threonine kinases: AGC group
  PKC family [OT]
   110218307 (PRKCA)
Membrane trafficking [BR:pcw04131]
 Endocytosis
  Lipid raft mediated endocytosis
   Caveolin-mediated endocytosis
    110218307 (PRKCA)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr C1_1 C2 Pkinase_C ABC1 C1_2
Other DBs
NCBI-GeneID: 110218307
NCBI-ProteinID: XP_020856594
UniProt: A0A6P5LJ25
Position
Unknown
AA seq 674 aa
MADVFSVNDSTESLDVANRFARKGALRQKNVHEVKDHRFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLLHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTGEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPTDKDRRL
SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME
LRQKFEKAKLGPAGNKVISPSDDRKSNIPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADR
KGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVME
YVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKQGIIYRDLKLDNVMLDSEGHIK
IADFGMCKEHMLDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPF
DGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGSEGERDIREHAFFR
RIDWDKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQADFEGFSY
VNPQFLHPILQSSV
NT seq 2025 nt   +upstreamnt  +downstreamnt
atggccgacgttttctcggtcaacgactccacagagtctctggacgtggccaaccgcttc
gcccgcaaaggggcgctaaggcagaagaacgtgcacgaagtcaaggaccacagattcatc
gcccgcttcttcaagcagcccaccttctgcagccattgcactgacttcatctgggggttt
ggaaaacaaggtttccagtgccaagtttgctgttttgtcgttcacaagaggtgccatgaa
tttgtcactttctcttgtccgggtgcagataaaggacctgacactgatgaccccagaagt
aagcacaagtttaaaatccacacatatggaagccctacattttgtgatcactgtggctca
ctgctctatggacttctacatcaagggatgaaatgtgacacttgtgatatgaatgttcac
aaacaatgtgtaataaatgttccaagcctctgtggaatggaccatacagaaaaaagaggg
cgaatttatctgaaagcggaagtcacaggtgaaaaactacatgtcacagtacgagatgca
aaaaacttaatccctatggatccaaatggactttcagatccctatgtgaagctgaaactt
atcccagaccctaagaatgaaagtaaacaaaaaaccaagacgatccgctccacactaaac
ccacagtggaatgagtcattcacattcaaattaaaacctacagataaagatagacggcta
tctgtcgagatctgggactgggatcgaacaacaagaaatgattttatgggctcactttca
tttggggtatcggagcttatgaaaatgccagcaagtggatggtataagttgcttaatcaa
gaagaaggtgaatactacaatgtgcccattccagaaggagatgaagaaggaaatatggaa
ctgaggcagaagtttgaaaaagccaagcttggccctgctggtaacaaggtgatcagtcca
tcagatgacagaaaatccaatataccatccaacaaccttgacagagtcaaactcacagac
tttaattttctcatggtcctggggaagggtagttttggaaaggtgatgttggctgaccga
aaggggacagaagaactatatgcgatcaaaattttgaaaaaagatgtggtgatacaagat
gatgatgttgaatgcacgatggtagaaaagagagtactggctctcctagacaaacctcct
ttcttaacacaattgcactcctgcttccagacagtcgatcgtctttattttgtcatggaa
tatgtcaatggcggagacctcatgtaccacattcagcaagtaggaaagtttaaggagcca
caagcagtgttctatgcagcagagatttcaattggattattcttccttcataaacaaggg
atcatttatagagatttgaaattagacaatgtcatgttggattcagaaggacatatcaag
attgctgattttggaatgtgcaaggagcatatgttagatggagtcacaaccaggacattc
tgtggaactccggattacattgccccagagatcattgcttatcagccgtatggaaaatct
gtggactggtgggcctatggtgtcctgttatatgaaatgttagctggacagcccccattt
gatggtgaagatgaggatgaactcttccaatccataatggaacacaatgtttcctatcca
aaatcattgtccaaagaagctgtttccatctgcaaaggactaatgacaaagcaccctgca
aaacgcctgggttgtgggtctgagggagaaagggacatcagagaacatgcatttttcaga
agaattgactgggacaaactggagaacagagaaatccaaccaccgttcaaacctaaagtg
tgtggcaaaggagcagaaaactttgacaaattcttcacacgagggcagccggtgttaaca
ccacctgatcaactggtcattgctaacatagaccaagccgattttgaagggttctcttat
gtcaatccacagtttctccaccccatcttgcagagctcggtatga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (72)   
   KEGG PATHWAY (72)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (7)   
   Pfam (7)   
All databases (91)   

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