HEADER TRANSCRIPTION/RNA/DNA 12-NOV-18 6IR9
TITLE RNA POLYMERASE II ELONGATION COMPLEX BOUND WITH ELF1 AND SPT4/5,
TITLE 2 STALLED AT SHL(-1) OF THE NUCLEOSOME
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: DNA-DIRECTED RNA POLYMERASE SUBUNIT;
COMPND 3 CHAIN: A;
COMPND 4 EC: 2.7.7.6;
COMPND 5 MOL_ID: 2;
COMPND 6 MOLECULE: DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA;
COMPND 7 CHAIN: B;
COMPND 8 EC: 2.7.7.6;
COMPND 9 MOL_ID: 3;
COMPND 10 MOLECULE: RNA POLYMERASE II THIRD LARGEST SUBUNIT B44, PART OF
COMPND 11 CENTRAL CORE;
COMPND 12 CHAIN: C;
COMPND 13 MOL_ID: 4;
COMPND 14 MOLECULE: RNA POLYMERASE II SUBUNIT B32;
COMPND 15 CHAIN: D;
COMPND 16 MOL_ID: 5;
COMPND 17 MOLECULE: RNA POLYMERASE SUBUNIT ABC27, COMMON TO RNA POLYMERASES I,
COMPND 18 II, AND III;
COMPND 19 CHAIN: E;
COMPND 20 MOL_ID: 6;
COMPND 21 MOLECULE: RNA POLYMERASE SUBUNIT ABC23, COMMON TO RNA POLYMERASES I,
COMPND 22 II, AND III;
COMPND 23 CHAIN: F;
COMPND 24 MOL_ID: 7;
COMPND 25 MOLECULE: RNA POLYMERASE II SUBUNIT;
COMPND 26 CHAIN: G;
COMPND 27 MOL_ID: 8;
COMPND 28 MOLECULE: DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3;
COMPND 29 CHAIN: H;
COMPND 30 MOL_ID: 9;
COMPND 31 MOLECULE: DNA-DIRECTED RNA POLYMERASE SUBUNIT;
COMPND 32 CHAIN: I;
COMPND 33 MOL_ID: 10;
COMPND 34 MOLECULE: RNA POLYMERASE SUBUNIT ABC10-BETA, COMMON TO RNA
COMPND 35 POLYMERASES I, II, AND III;
COMPND 36 CHAIN: J;
COMPND 37 MOL_ID: 11;
COMPND 38 MOLECULE: RNA POLYMERASE II SUBUNIT B12.5;
COMPND 39 CHAIN: K;
COMPND 40 MOL_ID: 12;
COMPND 41 MOLECULE: RNA POLYMERASE SUBUNIT ABC10-ALPHA;
COMPND 42 CHAIN: L;
COMPND 43 MOL_ID: 13;
COMPND 44 MOLECULE: RNA (5'-
COMPND 45 R(P*GP*CP*CP*UP*GP*GP*UP*GP*UP*CP*UP*UP*GP*GP*GP*U)-3');
COMPND 46 CHAIN: P;
COMPND 47 ENGINEERED: YES;
COMPND 48 MOL_ID: 14;
COMPND 49 MOLECULE: DNA (198-MER);
COMPND 50 CHAIN: T;
COMPND 51 ENGINEERED: YES;
COMPND 52 MOL_ID: 15;
COMPND 53 MOLECULE: DNA (198-MER);
COMPND 54 CHAIN: N;
COMPND 55 ENGINEERED: YES;
COMPND 56 MOL_ID: 16;
COMPND 57 MOLECULE: TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG;
COMPND 58 CHAIN: M;
COMPND 59 ENGINEERED: YES;
COMPND 60 MOL_ID: 17;
COMPND 61 MOLECULE: TRANSCRIPTION ELONGATION FACTOR SPT4;
COMPND 62 CHAIN: V;
COMPND 63 ENGINEERED: YES;
COMPND 64 MOL_ID: 18;
COMPND 65 MOLECULE: SPT5;
COMPND 66 CHAIN: W;
COMPND 67 SYNONYM: PROTEIN THAT FORMS A COMPLEX WITH SPT4P;
COMPND 68 ENGINEERED: YES;
COMPND 69 MOL_ID: 19;
COMPND 70 MOLECULE: HISTONE H3.3;
COMPND 71 CHAIN: a, e;
COMPND 72 ENGINEERED: YES;
COMPND 73 MOL_ID: 20;
COMPND 74 MOLECULE: HISTONE H4;
COMPND 75 CHAIN: b, f;
COMPND 76 ENGINEERED: YES;
COMPND 77 MOL_ID: 21;
COMPND 78 MOLECULE: HISTONE H2A TYPE 1-B/E;
COMPND 79 CHAIN: c, g;
COMPND 80 SYNONYM: HISTONE H2A.2,HISTONE H2A/A,HISTONE H2A/M;
COMPND 81 ENGINEERED: YES;
COMPND 82 MOL_ID: 22;
COMPND 83 MOLECULE: HISTONE H2B TYPE 1-J;
COMPND 84 CHAIN: d, h;
COMPND 85 SYNONYM: HISTONE H2B.1,HISTONE H2B.R,H2B/R;
COMPND 86 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: KOMAGATAELLA PHAFFII (STRAIN GS115 / ATCC
SOURCE 3 20864);
SOURCE 4 ORGANISM_COMMON: YEAST;
SOURCE 5 ORGANISM_TAXID: 64422;
SOURCE 6 STRAIN: GS115 / ATCC 20864;
SOURCE 7 MOL_ID: 2;
SOURCE 8 ORGANISM_SCIENTIFIC: KOMAGATAELLA PHAFFII (STRAIN GS115 / ATCC
SOURCE 9 20864);
SOURCE 10 ORGANISM_COMMON: YEAST;
SOURCE 11 ORGANISM_TAXID: 644223;
SOURCE 12 STRAIN: GS115 / ATCC 20864;
SOURCE 13 MOL_ID: 3;
SOURCE 14 ORGANISM_SCIENTIFIC: KOMAGATAELLA PHAFFII (STRAIN GS115 / ATCC
SOURCE 15 20864);
SOURCE 16 ORGANISM_COMMON: YEAST;
SOURCE 17 ORGANISM_TAXID: 644223;
SOURCE 18 STRAIN: GS115 / ATCC 20864;
SOURCE 19 MOL_ID: 4;
SOURCE 20 ORGANISM_SCIENTIFIC: KOMAGATAELLA PHAFFII (STRAIN GS115 / ATCC
SOURCE 21 20864);
SOURCE 22 ORGANISM_COMMON: YEAST;
SOURCE 23 ORGANISM_TAXID: 644223;
SOURCE 24 STRAIN: GS115 / ATCC 20864;
SOURCE 25 MOL_ID: 5;
SOURCE 26 ORGANISM_SCIENTIFIC: KOMAGATAELLA PHAFFII (STRAIN GS115 / ATCC
SOURCE 27 20864);
SOURCE 28 ORGANISM_COMMON: YEAST;
SOURCE 29 ORGANISM_TAXID: 644223;
SOURCE 30 STRAIN: GS115 / ATCC 20864;
SOURCE 31 MOL_ID: 6;
SOURCE 32 ORGANISM_SCIENTIFIC: KOMAGATAELLA PHAFFII (STRAIN GS115 / ATCC
SOURCE 33 20864);
SOURCE 34 ORGANISM_COMMON: YEAST;
SOURCE 35 ORGANISM_TAXID: 644223;
SOURCE 36 STRAIN: GS115 / ATCC 20864;
SOURCE 37 MOL_ID: 7;
SOURCE 38 ORGANISM_SCIENTIFIC: KOMAGATAELLA PHAFFII (STRAIN GS115 / ATCC
SOURCE 39 20864);
SOURCE 40 ORGANISM_COMMON: YEAST;
SOURCE 41 ORGANISM_TAXID: 644223;
SOURCE 42 STRAIN: GS115 / ATCC 20864;
SOURCE 43 MOL_ID: 8;
SOURCE 44 ORGANISM_SCIENTIFIC: KOMAGATAELLA PHAFFII (STRAIN GS115 / ATCC
SOURCE 45 20864);
SOURCE 46 ORGANISM_COMMON: YEAST;
SOURCE 47 ORGANISM_TAXID: 644223;
SOURCE 48 STRAIN: GS115 / ATCC 20864;
SOURCE 49 MOL_ID: 9;
SOURCE 50 ORGANISM_SCIENTIFIC: KOMAGATAELLA PHAFFII (STRAIN ATCC 76273 / CBS
SOURCE 51 7435 / CECT 11047 / NRRL Y-11430 / WEGNER 21-1);
SOURCE 52 ORGANISM_COMMON: YEAST;
SOURCE 53 ORGANISM_TAXID: 981350;
SOURCE 54 STRAIN: ATCC 76273 / CBS 7435 / CECT 11047 / NRRL Y-11430 / WEGNER
SOURCE 55 21-1;
SOURCE 56 MOL_ID: 10;
SOURCE 57 ORGANISM_SCIENTIFIC: KOMAGATAELLA PHAFFII (STRAIN GS115 / ATCC
SOURCE 58 20864);
SOURCE 59 ORGANISM_COMMON: YEAST;
SOURCE 60 ORGANISM_TAXID: 644223;
SOURCE 61 STRAIN: GS115 / ATCC 20864;
SOURCE 62 MOL_ID: 11;
SOURCE 63 ORGANISM_SCIENTIFIC: KOMAGATAELLA PHAFFII (STRAIN GS115 / ATCC
SOURCE 64 20864);
SOURCE 65 ORGANISM_COMMON: YEAST;
SOURCE 66 ORGANISM_TAXID: 644223;
SOURCE 67 STRAIN: GS115 / ATCC 20864;
SOURCE 68 MOL_ID: 12;
SOURCE 69 ORGANISM_SCIENTIFIC: KOMAGATAELLA PHAFFII (STRAIN ATCC 76273 / CBS
SOURCE 70 7435 / CECT 11047 / NRRL Y-11430 / WEGNER 21-1);
SOURCE 71 ORGANISM_COMMON: YEAST;
SOURCE 72 ORGANISM_TAXID: 981350;
SOURCE 73 STRAIN: ATCC 76273 / CBS 7435 / CECT 11047 / NRRL Y-11430 / WEGNER
SOURCE 74 21-1;
SOURCE 75 MOL_ID: 13;
SOURCE 76 SYNTHETIC: YES;
SOURCE 77 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;
SOURCE 78 ORGANISM_TAXID: 32630;
SOURCE 79 MOL_ID: 14;
SOURCE 80 SYNTHETIC: YES;
SOURCE 81 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;
SOURCE 82 ORGANISM_TAXID: 32630;
SOURCE 83 MOL_ID: 15;
SOURCE 84 SYNTHETIC: YES;
SOURCE 85 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;
SOURCE 86 ORGANISM_TAXID: 32630;
SOURCE 87 MOL_ID: 16;
SOURCE 88 ORGANISM_SCIENTIFIC: KOMAGATAELLA PHAFFII (STRAIN GS115 / ATCC
SOURCE 89 20864);
SOURCE 90 ORGANISM_COMMON: YEAST;
SOURCE 91 ORGANISM_TAXID: 644223;
SOURCE 92 STRAIN: GS115 / ATCC 20864;
SOURCE 93 GENE: PAS_C121_0006;
SOURCE 94 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 95 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 96 MOL_ID: 17;
SOURCE 97 ORGANISM_SCIENTIFIC: KOMAGATAELLA PHAFFII;
SOURCE 98 ORGANISM_COMMON: YEAST;
SOURCE 99 ORGANISM_TAXID: 644223;
SOURCE 100 STRAIN: GS115 / ATCC 20864;
SOURCE 101 GENE: PAS_CHR2-1_0350;
SOURCE 102 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 103 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 104 MOL_ID: 18;
SOURCE 105 ORGANISM_SCIENTIFIC: KOMAGATAELLA PHAFFII (STRAIN GS115 / ATCC
SOURCE 106 20864);
SOURCE 107 ORGANISM_COMMON: YEAST;
SOURCE 108 ORGANISM_TAXID: 644223;
SOURCE 109 STRAIN: GS115 / ATCC 20864;
SOURCE 110 GENE: PAS_CHR3_1136;
SOURCE 111 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 112 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 113 MOL_ID: 19;
SOURCE 114 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 115 ORGANISM_COMMON: HUMAN;
SOURCE 116 ORGANISM_TAXID: 9606;
SOURCE 117 GENE: H3F3A, H3.3A, H3F3, PP781, H3F3B, H3.3B;
SOURCE 118 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 119 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 120 MOL_ID: 20;
SOURCE 121 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 122 ORGANISM_COMMON: HUMAN;
SOURCE 123 ORGANISM_TAXID: 9606;
SOURCE 124 GENE: HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G,
SOURCE 125 H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C,
SOURCE 126 H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E,
SOURCE 127 H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N,
SOURCE 128 H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4;
SOURCE 129 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 130 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 131 MOL_ID: 21;
SOURCE 132 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 133 ORGANISM_COMMON: HUMAN;
SOURCE 134 ORGANISM_TAXID: 9606;
SOURCE 135 GENE: HIST1H2AB, H2AFM, HIST1H2AE, H2AFA;
SOURCE 136 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 137 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 138 MOL_ID: 22;
SOURCE 139 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 140 ORGANISM_COMMON: HUMAN;
SOURCE 141 ORGANISM_TAXID: 9606;
SOURCE 142 GENE: HIST1H2BJ, H2BFR;
SOURCE 143 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 144 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS NUCLEOSOME, CHROMATIN, RNA POLYMERASE, TRANSCRIPTION, TRANSCRIPTION-
KEYWDS 2 RNA-DNA COMPLEX
EXPDTA ELECTRON MICROSCOPY
AUTHOR H.EHARA,T.KUJIRAI,Y.FUJINO,M.SHIROUZU,H.KURUMIZAKA,S.SEKINE
REVDAT 4 27-MAR-24 6IR9 1 LINK
REVDAT 3 06-NOV-19 6IR9 1 CRYST1
REVDAT 2 27-FEB-19 6IR9 1 JRNL
REVDAT 1 20-FEB-19 6IR9 0
JRNL AUTH H.EHARA,T.KUJIRAI,Y.FUJINO,M.SHIROUZU,H.KURUMIZAKA,
JRNL AUTH 2 S.I.SEKINE
JRNL TITL STRUCTURAL INSIGHT INTO NUCLEOSOME TRANSCRIPTION BY RNA
JRNL TITL 2 POLYMERASE II WITH ELONGATION FACTORS.
JRNL REF SCIENCE V. 363 744 2019
JRNL REFN ESSN 1095-9203
JRNL PMID 30733384
JRNL DOI 10.1126/SCIENCE.AAV8912
REMARK 2
REMARK 2 RESOLUTION. 3.80 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : SERIALEM, RELION
REMARK 3 RECONSTRUCTION SCHEMA : NULL
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : NULL
REMARK 3 REFINEMENT SPACE : NULL
REMARK 3 REFINEMENT PROTOCOL : NULL
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.800
REMARK 3 NUMBER OF PARTICLES : 96742
REMARK 3 CTF CORRECTION METHOD : NONE
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 6IR9 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 21-NOV-18.
REMARK 100 THE DEPOSITION ID IS D_1300009764.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : RNA POLYMERASE II ELONGATION
REMARK 245 COMPLEX BOUND WITH ELF1 AND
REMARK 245 SPT4/5, STALLED AT SHL(-1) OF
REMARK 245 THE NUCLEOSOME
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL
REMARK 245 SAMPLE SUPPORT DETAILS : NULL
REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 7.50
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : FEI TECNAI ARCTICA
REMARK 245 DETECTOR TYPE : GATAN K2 SUMMIT (4K X 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : NULL
REMARK 245 MAXIMUM DEFOCUS (NM) : NULL
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : NULL
REMARK 245 IMAGING MODE : BRIGHT FIELD
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5000.00
REMARK 245 ILLUMINATION MODE : FLOOD BEAM
REMARK 245 NOMINAL MAGNIFICATION : NULL
REMARK 245 CALIBRATED MAGNIFICATION : NULL
REMARK 245 SOURCE : FIELD EMISSION GUN
REMARK 245 ACCELERATION VOLTAGE (KV) : 200
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 26-MERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,
REMARK 350 AND CHAINS: K, L, P, T, N, M, V, W, a,
REMARK 350 AND CHAINS: b, c, d, e, f, g, h
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A 1
REMARK 465 VAL A 154
REMARK 465 ASP A 155
REMARK 465 GLU A 156
REMARK 465 TYR A 157
REMARK 465 SER A 158
REMARK 465 GLU A 159
REMARK 465 GLN A 160
REMARK 465 LYS A 161
REMARK 465 VAL A 162
REMARK 465 GLY A 190
REMARK 465 PHE A 191
REMARK 465 SER A 192
REMARK 465 ASP A 193
REMARK 465 THR A 1082
REMARK 465 LEU A 1083
REMARK 465 ASN A 1084
REMARK 465 THR A 1085
REMARK 465 PHE A 1086
REMARK 465 HIS A 1087
REMARK 465 TYR A 1088
REMARK 465 ALA A 1089
REMARK 465 GLY A 1090
REMARK 465 VAL A 1091
REMARK 465 SER A 1092
REMARK 465 SER A 1093
REMARK 465 LYS A 1094
REMARK 465 ILE A 1178
REMARK 465 PRO A 1179
REMARK 465 ASP A 1180
REMARK 465 GLU A 1181
REMARK 465 LYS A 1182
REMARK 465 VAL A 1183
REMARK 465 GLU A 1184
REMARK 465 GLU A 1185
REMARK 465 THR A 1186
REMARK 465 ILE A 1187
REMARK 465 ASP A 1188
REMARK 465 LYS A 1189
REMARK 465 ARG A 1246
REMARK 465 ASP A 1247
REMARK 465 PRO A 1248
REMARK 465 LYS A 1249
REMARK 465 ALA A 1250
REMARK 465 MET A 1251
REMARK 465 ASP A 1252
REMARK 465 GLU A 1253
REMARK 465 GLU A 1254
REMARK 465 LEU A 1255
REMARK 465 GLU A 1256
REMARK 465 ALA A 1257
REMARK 465 MET A 1464
REMARK 465 PRO A 1465
REMARK 465 LEU A 1466
REMARK 465 PHE A 1467
REMARK 465 LYS A 1468
REMARK 465 GLY A 1469
REMARK 465 LYS A 1470
REMARK 465 ALA A 1471
REMARK 465 THR A 1472
REMARK 465 GLN A 1473
REMARK 465 GLY A 1474
REMARK 465 SER A 1475
REMARK 465 ALA A 1476
REMARK 465 THR A 1477
REMARK 465 PRO A 1478
REMARK 465 TYR A 1479
REMARK 465 ASP A 1480
REMARK 465 ASN A 1481
REMARK 465 ASN A 1482
REMARK 465 ALA A 1483
REMARK 465 GLN A 1484
REMARK 465 TYR A 1485
REMARK 465 ASP A 1486
REMARK 465 ASP A 1487
REMARK 465 GLU A 1488
REMARK 465 PHE A 1489
REMARK 465 ASN A 1490
REMARK 465 HIS A 1491
REMARK 465 ASP A 1492
REMARK 465 ASP A 1493
REMARK 465 VAL A 1494
REMARK 465 ALA A 1495
REMARK 465 ASP A 1496
REMARK 465 VAL A 1497
REMARK 465 MET A 1498
REMARK 465 PHE A 1499
REMARK 465 SER A 1500
REMARK 465 PRO A 1501
REMARK 465 MET A 1502
REMARK 465 ALA A 1503
REMARK 465 GLU A 1504
REMARK 465 THR A 1505
REMARK 465 GLY A 1506
REMARK 465 SER A 1507
REMARK 465 GLY A 1508
REMARK 465 ASP A 1509
REMARK 465 ASP A 1510
REMARK 465 ARG A 1511
REMARK 465 SER A 1512
REMARK 465 GLY A 1513
REMARK 465 GLY A 1514
REMARK 465 LEU A 1515
REMARK 465 THR A 1516
REMARK 465 GLU A 1517
REMARK 465 TYR A 1518
REMARK 465 ALA A 1519
REMARK 465 GLY A 1520
REMARK 465 ILE A 1521
REMARK 465 GLN A 1522
REMARK 465 SER A 1523
REMARK 465 PRO A 1524
REMARK 465 TYR A 1525
REMARK 465 GLN A 1526
REMARK 465 PRO A 1527
REMARK 465 THR A 1528
REMARK 465 SER A 1529
REMARK 465 PRO A 1530
REMARK 465 GLY A 1531
REMARK 465 LEU A 1532
REMARK 465 SER A 1533
REMARK 465 ALA A 1534
REMARK 465 THR A 1535
REMARK 465 SER A 1536
REMARK 465 PRO A 1537
REMARK 465 GLY A 1538
REMARK 465 PHE A 1539
REMARK 465 ALA A 1540
REMARK 465 PRO A 1541
REMARK 465 THR A 1542
REMARK 465 SER A 1543
REMARK 465 PRO A 1544
REMARK 465 GLY A 1545
REMARK 465 PHE A 1546
REMARK 465 ALA A 1547
REMARK 465 PRO A 1548
REMARK 465 THR A 1549
REMARK 465 SER A 1550
REMARK 465 PRO A 1551
REMARK 465 ARG A 1552
REMARK 465 TYR A 1553
REMARK 465 SER A 1554
REMARK 465 PRO A 1555
REMARK 465 THR A 1556
REMARK 465 SER A 1557
REMARK 465 PRO A 1558
REMARK 465 GLY A 1559
REMARK 465 TYR A 1560
REMARK 465 SER A 1561
REMARK 465 PRO A 1562
REMARK 465 THR A 1563
REMARK 465 SER A 1564
REMARK 465 PRO A 1565
REMARK 465 SER A 1566
REMARK 465 TYR A 1567
REMARK 465 SER A 1568
REMARK 465 PRO A 1569
REMARK 465 THR A 1570
REMARK 465 SER A 1571
REMARK 465 PRO A 1572
REMARK 465 SER A 1573
REMARK 465 TYR A 1574
REMARK 465 SER A 1575
REMARK 465 PRO A 1576
REMARK 465 THR A 1577
REMARK 465 SER A 1578
REMARK 465 PRO A 1579
REMARK 465 SER A 1580
REMARK 465 TYR A 1581
REMARK 465 SER A 1582
REMARK 465 PRO A 1583
REMARK 465 THR A 1584
REMARK 465 SER A 1585
REMARK 465 PRO A 1586
REMARK 465 SER A 1587
REMARK 465 TYR A 1588
REMARK 465 SER A 1589
REMARK 465 PRO A 1590
REMARK 465 THR A 1591
REMARK 465 SER A 1592
REMARK 465 PRO A 1593
REMARK 465 SER A 1594
REMARK 465 TYR A 1595
REMARK 465 SER A 1596
REMARK 465 PRO A 1597
REMARK 465 THR A 1598
REMARK 465 SER A 1599
REMARK 465 PRO A 1600
REMARK 465 SER A 1601
REMARK 465 TYR A 1602
REMARK 465 SER A 1603
REMARK 465 PRO A 1604
REMARK 465 THR A 1605
REMARK 465 SER A 1606
REMARK 465 PRO A 1607
REMARK 465 SER A 1608
REMARK 465 TYR A 1609
REMARK 465 SER A 1610
REMARK 465 PRO A 1611
REMARK 465 THR A 1612
REMARK 465 SER A 1613
REMARK 465 PRO A 1614
REMARK 465 SER A 1615
REMARK 465 TYR A 1616
REMARK 465 SER A 1617
REMARK 465 PRO A 1618
REMARK 465 THR A 1619
REMARK 465 SER A 1620
REMARK 465 PRO A 1621
REMARK 465 SER A 1622
REMARK 465 TYR A 1623
REMARK 465 SER A 1624
REMARK 465 PRO A 1625
REMARK 465 THR A 1626
REMARK 465 SER A 1627
REMARK 465 PRO A 1628
REMARK 465 GLN A 1629
REMARK 465 TYR A 1630
REMARK 465 SER A 1631
REMARK 465 PRO A 1632
REMARK 465 THR A 1633
REMARK 465 SER A 1634
REMARK 465 PRO A 1635
REMARK 465 GLN A 1636
REMARK 465 TYR A 1637
REMARK 465 SER A 1638
REMARK 465 PRO A 1639
REMARK 465 THR A 1640
REMARK 465 SER A 1641
REMARK 465 PRO A 1642
REMARK 465 GLN A 1643
REMARK 465 TYR A 1644
REMARK 465 SER A 1645
REMARK 465 PRO A 1646
REMARK 465 THR A 1647
REMARK 465 SER A 1648
REMARK 465 PRO A 1649
REMARK 465 GLN A 1650
REMARK 465 TYR A 1651
REMARK 465 SER A 1652
REMARK 465 PRO A 1653
REMARK 465 THR A 1654
REMARK 465 SER A 1655
REMARK 465 PRO A 1656
REMARK 465 GLN A 1657
REMARK 465 TYR A 1658
REMARK 465 SER A 1659
REMARK 465 PRO A 1660
REMARK 465 THR A 1661
REMARK 465 SER A 1662
REMARK 465 PRO A 1663
REMARK 465 GLN A 1664
REMARK 465 TYR A 1665
REMARK 465 SER A 1666
REMARK 465 PRO A 1667
REMARK 465 THR A 1668
REMARK 465 SER A 1669
REMARK 465 PRO A 1670
REMARK 465 GLN A 1671
REMARK 465 TYR A 1672
REMARK 465 SER A 1673
REMARK 465 PRO A 1674
REMARK 465 THR A 1675
REMARK 465 SER A 1676
REMARK 465 PRO A 1677
REMARK 465 GLN A 1678
REMARK 465 TYR A 1679
REMARK 465 SER A 1680
REMARK 465 PRO A 1681
REMARK 465 THR A 1682
REMARK 465 SER A 1683
REMARK 465 PRO A 1684
REMARK 465 GLN A 1685
REMARK 465 TYR A 1686
REMARK 465 SER A 1687
REMARK 465 PRO A 1688
REMARK 465 THR A 1689
REMARK 465 SER A 1690
REMARK 465 PRO A 1691
REMARK 465 GLN A 1692
REMARK 465 TYR A 1693
REMARK 465 SER A 1694
REMARK 465 PRO A 1695
REMARK 465 THR A 1696
REMARK 465 SER A 1697
REMARK 465 PRO A 1698
REMARK 465 GLN A 1699
REMARK 465 TYR A 1700
REMARK 465 SER A 1701
REMARK 465 PRO A 1702
REMARK 465 THR A 1703
REMARK 465 SER A 1704
REMARK 465 PRO A 1705
REMARK 465 GLN A 1706
REMARK 465 TYR A 1707
REMARK 465 SER A 1708
REMARK 465 PRO A 1709
REMARK 465 THR A 1710
REMARK 465 SER A 1711
REMARK 465 PRO A 1712
REMARK 465 GLN A 1713
REMARK 465 TYR A 1714
REMARK 465 SER A 1715
REMARK 465 PRO A 1716
REMARK 465 THR A 1717
REMARK 465 SER A 1718
REMARK 465 PRO A 1719
REMARK 465 GLN A 1720
REMARK 465 TYR A 1721
REMARK 465 SER A 1722
REMARK 465 PRO A 1723
REMARK 465 ALA A 1724
REMARK 465 SER A 1725
REMARK 465 PRO A 1726
REMARK 465 GLN A 1727
REMARK 465 TYR A 1728
REMARK 465 SER A 1729
REMARK 465 PRO A 1730
REMARK 465 SER A 1731
REMARK 465 ARG A 1732
REMARK 465 HIS A 1733
REMARK 465 SER A 1734
REMARK 465 PRO A 1735
REMARK 465 ASN A 1736
REMARK 465 GLY A 1737
REMARK 465 GLU A 1738
REMARK 465 SER A 1739
REMARK 465 LYS A 1740
REMARK 465 GLU A 1741
REMARK 465 GLY A 1742
REMARK 465 GLU A 1743
REMARK 465 MET B 1
REMARK 465 SER B 2
REMARK 465 TYR B 3
REMARK 465 ASP B 4
REMARK 465 PRO B 5
REMARK 465 TYR B 6
REMARK 465 SER B 7
REMARK 465 ILE B 8
REMARK 465 THR B 65
REMARK 465 ASN B 66
REMARK 465 GLU B 67
REMARK 465 LYS B 68
REMARK 465 ASP B 129
REMARK 465 GLU B 130
REMARK 465 GLY B 131
REMARK 465 ASN B 132
REMARK 465 PRO B 133
REMARK 465 ASN B 134
REMARK 465 ALA B 135
REMARK 465 THR B 136
REMARK 465 LEU B 137
REMARK 465 ASP B 138
REMARK 465 TRP B 139
REMARK 465 GLN B 140
REMARK 465 GLN B 141
REMARK 465 VAL B 142
REMARK 465 HIS B 143
REMARK 465 GLU B 144
REMARK 465 PRO B 145
REMARK 465 ILE B 146
REMARK 465 LYS B 147
REMARK 465 ASP B 148
REMARK 465 GLY B 149
REMARK 465 VAL B 150
REMARK 465 GLU B 151
REMARK 465 GLU B 152
REMARK 465 ALA B 663
REMARK 465 MET B 664
REMARK 465 ASN B 665
REMARK 465 ASP B 666
REMARK 465 ASP B 667
REMARK 465 SER B 668
REMARK 465 GLU B 669
REMARK 465 GLU B 670
REMARK 465 GLN B 671
REMARK 465 GLU B 672
REMARK 465 GLN B 673
REMARK 465 ASP B 674
REMARK 465 LEU B 712
REMARK 465 GLU B 713
REMARK 465 GLN B 714
REMARK 465 LYS B 715
REMARK 465 GLU B 716
REMARK 465 ILE B 717
REMARK 465 ASP B 718
REMARK 465 ASP B 921
REMARK 465 THR B 922
REMARK 465 GLU B 923
REMARK 465 GLU B 924
REMARK 465 LEU B 925
REMARK 465 GLY B 926
REMARK 465 GLN B 927
REMARK 465 ARG B 928
REMARK 465 THR B 929
REMARK 465 LYS B 930
REMARK 465 VAL B 1223
REMARK 465 SER B 1224
REMARK 465 MET B 1225
REMARK 465 ARG B 1226
REMARK 465 SER B 1227
REMARK 465 MET C 1
REMARK 465 SER C 2
REMARK 465 LYS C 3
REMARK 465 PRO C 267
REMARK 465 ALA C 268
REMARK 465 ASN C 269
REMARK 465 THR C 270
REMARK 465 THR C 271
REMARK 465 ALA C 272
REMARK 465 TYR C 273
REMARK 465 GLY C 274
REMARK 465 GLY C 275
REMARK 465 ALA C 276
REMARK 465 THR C 277
REMARK 465 ALA C 278
REMARK 465 TYR C 279
REMARK 465 GLY C 280
REMARK 465 GLY C 281
REMARK 465 GLN C 282
REMARK 465 THR C 283
REMARK 465 VAL C 284
REMARK 465 TYR C 285
REMARK 465 GLY C 286
REMARK 465 ARG C 287
REMARK 465 GLU C 288
REMARK 465 THR C 289
REMARK 465 SER C 290
REMARK 465 TYR C 291
REMARK 465 GLY C 292
REMARK 465 GLY C 293
REMARK 465 ASN C 294
REMARK 465 THR C 295
REMARK 465 ASN C 296
REMARK 465 TYR C 297
REMARK 465 GLY C 298
REMARK 465 ASP C 299
REMARK 465 TYR C 300
REMARK 465 ASN C 301
REMARK 465 ALA C 302
REMARK 465 PRO C 303
REMARK 465 TYR C 304
REMARK 465 MET D 1
REMARK 465 ASN D 2
REMARK 465 ASP D 76
REMARK 465 ILE D 77
REMARK 465 GLU D 78
REMARK 465 SER D 79
REMARK 465 SER D 80
REMARK 465 ASN D 81
REMARK 465 GLY D 82
REMARK 465 GLU D 83
REMARK 465 ASN D 130
REMARK 465 SER D 131
REMARK 465 SER D 132
REMARK 465 ASP D 133
REMARK 465 CYS D 134
REMARK 465 SER D 135
REMARK 465 VAL D 136
REMARK 465 LYS D 186
REMARK 465 MET E 1
REMARK 465 MET F 1
REMARK 465 SER F 2
REMARK 465 GLU F 3
REMARK 465 ASP F 4
REMARK 465 GLU F 5
REMARK 465 ALA F 6
REMARK 465 PHE F 7
REMARK 465 ASN F 8
REMARK 465 GLU F 9
REMARK 465 GLN F 10
REMARK 465 THR F 11
REMARK 465 GLU F 12
REMARK 465 ASN F 13
REMARK 465 PHE F 14
REMARK 465 GLU F 15
REMARK 465 ASN F 16
REMARK 465 PHE F 17
REMARK 465 GLU F 18
REMARK 465 ASP F 19
REMARK 465 GLU F 20
REMARK 465 HIS F 21
REMARK 465 PHE F 22
REMARK 465 SER F 23
REMARK 465 ASP F 24
REMARK 465 ASP F 25
REMARK 465 ASN F 26
REMARK 465 PHE F 27
REMARK 465 GLU F 28
REMARK 465 ASP F 29
REMARK 465 ARG F 30
REMARK 465 SER F 31
REMARK 465 THR F 32
REMARK 465 GLN F 33
REMARK 465 PRO F 34
REMARK 465 GLU F 35
REMARK 465 ASP F 36
REMARK 465 TYR F 37
REMARK 465 ALA F 38
REMARK 465 VAL F 39
REMARK 465 GLY F 40
REMARK 465 VAL F 41
REMARK 465 THR F 42
REMARK 465 ALA F 43
REMARK 465 ASP F 44
REMARK 465 GLY F 45
REMARK 465 ARG F 46
REMARK 465 GLN F 47
REMARK 465 ILE F 48
REMARK 465 ILE F 49
REMARK 465 ASN F 50
REMARK 465 GLY F 51
REMARK 465 ASP F 52
REMARK 465 GLY F 53
REMARK 465 ILE F 54
REMARK 465 GLN F 55
REMARK 465 GLU F 56
REMARK 465 VAL F 57
REMARK 465 ASN F 58
REMARK 465 GLY F 59
REMARK 465 THR F 60
REMARK 465 ILE F 61
REMARK 465 LYS F 62
REMARK 465 ALA F 63
REMARK 465 HIS F 64
REMARK 465 ARG F 65
REMARK 465 LYS F 66
REMARK 465 ARG F 67
REMARK 465 SER F 68
REMARK 465 ASN F 69
REMARK 465 LYS F 70
REMARK 465 ASN F 155
REMARK 465 MET H 1
REMARK 465 SER H 2
REMARK 465 ASP H 66
REMARK 465 GLY H 67
REMARK 465 GLU H 68
REMARK 465 ASP H 69
REMARK 465 GLU H 70
REMARK 465 SER H 71
REMARK 465 ALA H 72
REMARK 465 ASN H 73
REMARK 465 PHE H 74
REMARK 465 SER H 75
REMARK 465 MET I 1
REMARK 465 ALA I 2
REMARK 465 SER I 114
REMARK 465 GLU I 115
REMARK 465 LYS J 67
REMARK 465 LYS J 68
REMARK 465 ASP J 69
REMARK 465 PHE J 70
REMARK 465 ASP J 71
REMARK 465 SER J 72
REMARK 465 PHE K 114
REMARK 465 SER K 115
REMARK 465 LEU K 116
REMARK 465 ASN K 117
REMARK 465 ASP K 118
REMARK 465 MET L 1
REMARK 465 SER L 2
REMARK 465 ARG L 3
REMARK 465 GLU L 4
REMARK 465 GLY L 5
REMARK 465 PHE L 6
REMARK 465 VAL L 7
REMARK 465 ALA L 8
REMARK 465 PRO L 9
REMARK 465 SER L 10
REMARK 465 GLY L 11
REMARK 465 THR L 12
REMARK 465 ASP L 13
REMARK 465 LEU L 14
REMARK 465 ALA L 15
REMARK 465 ALA L 16
REMARK 465 ALA L 17
REMARK 465 ALA L 18
REMARK 465 SER L 19
REMARK 465 GLY L 20
REMARK 465 VAL L 21
REMARK 465 ALA L 22
REMARK 465 PRO L 23
REMARK 465 ASN L 24
REMARK 465 LYS L 25
REMARK 465 HIS L 26
REMARK 465 TYR L 27
REMARK 465 DC T 56
REMARK 465 DA T 57
REMARK 465 DG T 58
REMARK 465 DA T 59
REMARK 465 DA T 60
REMARK 465 DA T 61
REMARK 465 DA T 62
REMARK 465 DA T 63
REMARK 465 DA T 64
REMARK 465 DA T 65
REMARK 465 DC T 66
REMARK 465 DA T 67
REMARK 465 DA T 68
REMARK 465 DC T 69
REMARK 465 DG T 70
REMARK 465 DA T 71
REMARK 465 DA T 72
REMARK 465 DA T 73
REMARK 465 DA T 74
REMARK 465 DC T 75
REMARK 465 DG T 76
REMARK 465 DG T 77
REMARK 465 DC T 78
REMARK 465 DC T 79
REMARK 465 DA T 80
REMARK 465 DC T 81
REMARK 465 DC T 82
REMARK 465 DA T 83
REMARK 465 DC T 84
REMARK 465 DC T 85
REMARK 465 DC T 86
REMARK 465 DA T 87
REMARK 465 DA T 88
REMARK 465 DA T 89
REMARK 465 DC T 90
REMARK 465 DA T 91
REMARK 465 DC T 92
REMARK 465 DA T 93
REMARK 465 DC T 94
REMARK 465 DC T 95
REMARK 465 DA T 96
REMARK 465 DA T 97
REMARK 465 DA T 98
REMARK 465 DC T 99
REMARK 465 DA T 100
REMARK 465 DC T 101
REMARK 465 DA T 102
REMARK 465 DA T 103
REMARK 465 DG T 104
REMARK 465 DA T 105
REMARK 465 DG T 106
REMARK 465 DC T 107
REMARK 465 DT T 108
REMARK 465 DA T 109
REMARK 465 DA T 110
REMARK 465 DT T 111
REMARK 465 DT T 112
REMARK 465 DG T 113
REMARK 465 DA T 114
REMARK 465 DC T 115
REMARK 465 DT T 116
REMARK 465 DG T 117
REMARK 465 DA T 118
REMARK 465 DC T 119
REMARK 465 DG T 120
REMARK 465 DT T 121
REMARK 465 DA T 122
REMARK 465 DA T 123
REMARK 465 DG T 124
REMARK 465 DC T 125
REMARK 465 DG N -125
REMARK 465 DC N -124
REMARK 465 DT N -123
REMARK 465 DT N -122
REMARK 465 DA N -121
REMARK 465 DC N -120
REMARK 465 DG N -119
REMARK 465 DT N -118
REMARK 465 DC N -117
REMARK 465 DA N -116
REMARK 465 DG N -115
REMARK 465 DT N -114
REMARK 465 DC N -113
REMARK 465 DT N -112
REMARK 465 DG N -111
REMARK 465 DG N -110
REMARK 465 DC N -109
REMARK 465 DC N -108
REMARK 465 DA N -107
REMARK 465 DT N -106
REMARK 465 DC N -105
REMARK 465 DT N -104
REMARK 465 DT N -103
REMARK 465 DT N -102
REMARK 465 DG N -101
REMARK 465 DT N -100
REMARK 465 DG N -99
REMARK 465 DT N -98
REMARK 465 DT N -97
REMARK 465 DT N -96
REMARK 465 DG N -95
REMARK 465 DG N -94
REMARK 465 DT N -93
REMARK 465 DG N -92
REMARK 465 DT N -91
REMARK 465 DG N -90
REMARK 465 DT N -89
REMARK 465 DT N -88
REMARK 465 DT N -87
REMARK 465 DG N -86
REMARK 465 DG N -85
REMARK 465 DG N -84
REMARK 465 DT N -83
REMARK 465 DG N -82
REMARK 465 DG N -81
REMARK 465 DT N -80
REMARK 465 DG N -79
REMARK 465 DG N -78
REMARK 465 DC N -77
REMARK 465 DC N -76
REMARK 465 DG N -75
REMARK 465 DT N -74
REMARK 465 DT N -73
REMARK 465 DT N -72
REMARK 465 DT N -71
REMARK 465 DC N -70
REMARK 465 DG N -69
REMARK 465 DT N -68
REMARK 465 DT N -67
REMARK 465 DG N -66
REMARK 465 DT N -65
REMARK 465 DT N -64
REMARK 465 DT N -63
REMARK 465 DT N -62
REMARK 465 DT N -61
REMARK 465 DT N -60
REMARK 465 DT N -59
REMARK 465 DC N -58
REMARK 465 DT N -57
REMARK 465 DG N -56
REMARK 465 DG N -37
REMARK 465 DG N -36
REMARK 465 DG N -35
REMARK 465 DT N -34
REMARK 465 DG N -33
REMARK 465 GLY M -2
REMARK 465 PRO M -1
REMARK 465 GLY M 0
REMARK 465 MET M 1
REMARK 465 GLY M 2
REMARK 465 LYS M 3
REMARK 465 ARG M 4
REMARK 465 LYS M 5
REMARK 465 SER M 6
REMARK 465 SER M 7
REMARK 465 ALA M 8
REMARK 465 ARG M 9
REMARK 465 LYS M 10
REMARK 465 PRO M 11
REMARK 465 ALA M 12
REMARK 465 PRO M 13
REMARK 465 LYS M 14
REMARK 465 ALA M 79
REMARK 465 VAL M 80
REMARK 465 ALA M 81
REMARK 465 GLU M 82
REMARK 465 GLU M 83
REMARK 465 ASN M 84
REMARK 465 ALA M 85
REMARK 465 ASP M 86
REMARK 465 VAL M 87
REMARK 465 ASN M 88
REMARK 465 GLY M 89
REMARK 465 ASP M 90
REMARK 465 ASN M 91
REMARK 465 PHE M 92
REMARK 465 ILE M 93
REMARK 465 GLU M 94
REMARK 465 ASN M 95
REMARK 465 ASP M 96
REMARK 465 GLY M 97
REMARK 465 ALA M 98
REMARK 465 ASP M 99
REMARK 465 ARG M 100
REMARK 465 GLU M 101
REMARK 465 GLN M 102
REMARK 465 ASP M 103
REMARK 465 ASP M 104
REMARK 465 ASP M 105
REMARK 465 TYR M 106
REMARK 465 ASP M 107
REMARK 465 ASP M 108
REMARK 465 GLU M 109
REMARK 465 PHE M 110
REMARK 465 MET V 7
REMARK 465 ARG V 8
REMARK 465 SER V 111
REMARK 465 VAL V 112
REMARK 465 ILE V 113
REMARK 465 ASP V 114
REMARK 465 GLY W -2
REMARK 465 PRO W -1
REMARK 465 GLY W 0
REMARK 465 MET W 1
REMARK 465 SER W 2
REMARK 465 GLU W 3
REMARK 465 THR W 4
REMARK 465 HIS W 5
REMARK 465 LYS W 6
REMARK 465 ASN W 7
REMARK 465 GLN W 8
REMARK 465 LEU W 9
REMARK 465 ASP W 10
REMARK 465 LYS W 11
REMARK 465 VAL W 12
REMARK 465 SER W 13
REMARK 465 THR W 14
REMARK 465 VAL W 15
REMARK 465 SER W 16
REMARK 465 PRO W 17
REMARK 465 ASP W 18
REMARK 465 GLY W 19
REMARK 465 PRO W 20
REMARK 465 SER W 21
REMARK 465 GLU W 22
REMARK 465 ALA W 23
REMARK 465 VAL W 24
REMARK 465 LYS W 25
REMARK 465 GLU W 26
REMARK 465 HIS W 27
REMARK 465 SER W 28
REMARK 465 LEU W 29
REMARK 465 GLN W 30
REMARK 465 SER W 31
REMARK 465 LYS W 32
REMARK 465 ASP W 33
REMARK 465 LEU W 34
REMARK 465 SER W 35
REMARK 465 LYS W 36
REMARK 465 ASN W 37
REMARK 465 ASP W 38
REMARK 465 GLY W 39
REMARK 465 GLN W 40
REMARK 465 PHE W 41
REMARK 465 ILE W 42
REMARK 465 VAL W 43
REMARK 465 PRO W 44
REMARK 465 LEU W 45
REMARK 465 ASP W 46
REMARK 465 ARG W 47
REMARK 465 ASN W 48
REMARK 465 VAL W 49
REMARK 465 ILE W 50
REMARK 465 GLU W 51
REMARK 465 GLN W 52
REMARK 465 GLU W 53
REMARK 465 GLU W 54
REMARK 465 HIS W 55
REMARK 465 LYS W 56
REMARK 465 GLN W 57
REMARK 465 VAL W 58
REMARK 465 LYS W 59
REMARK 465 SER W 60
REMARK 465 SER W 61
REMARK 465 ALA W 62
REMARK 465 GLN W 63
REMARK 465 ALA W 64
REMARK 465 HIS W 65
REMARK 465 ASN W 66
REMARK 465 THR W 67
REMARK 465 THR W 68
REMARK 465 GLY W 69
REMARK 465 ASP W 70
REMARK 465 ALA W 71
REMARK 465 ALA W 72
REMARK 465 ASP W 73
REMARK 465 ASN W 74
REMARK 465 GLU W 75
REMARK 465 ILE W 76
REMARK 465 GLU W 77
REMARK 465 ASP W 78
REMARK 465 GLY W 79
REMARK 465 VAL W 80
REMARK 465 PRO W 81
REMARK 465 SER W 82
REMARK 465 GLU W 83
REMARK 465 ASP W 84
REMARK 465 VAL W 85
REMARK 465 GLU W 86
REMARK 465 PHE W 87
REMARK 465 ASP W 88
REMARK 465 LYS W 89
REMARK 465 PHE W 90
REMARK 465 LYS W 91
REMARK 465 GLU W 92
REMARK 465 ASP W 93
REMARK 465 ASP W 94
REMARK 465 TYR W 95
REMARK 465 ASP W 96
REMARK 465 GLU W 97
REMARK 465 ASP W 98
REMARK 465 ASP W 99
REMARK 465 GLU W 100
REMARK 465 VAL W 101
REMARK 465 GLU W 102
REMARK 465 GLU W 103
REMARK 465 GLU W 104
REMARK 465 GLY W 105
REMARK 465 ASP W 106
REMARK 465 ILE W 107
REMARK 465 ARG W 108
REMARK 465 SER W 109
REMARK 465 ARG W 110
REMARK 465 LYS W 111
REMARK 465 ARG W 112
REMARK 465 ARG W 113
REMARK 465 ARG W 114
REMARK 465 HIS W 115
REMARK 465 ASN W 116
REMARK 465 GLN W 117
REMARK 465 PHE W 118
REMARK 465 LEU W 119
REMARK 465 ASP W 120
REMARK 465 VAL W 121
REMARK 465 GLU W 122
REMARK 465 ALA W 123
REMARK 465 GLU W 124
REMARK 465 VAL W 125
REMARK 465 ASP W 126
REMARK 465 ASP W 127
REMARK 465 GLU W 128
REMARK 465 GLU W 129
REMARK 465 ASP W 130
REMARK 465 ASP W 131
REMARK 465 ASP W 132
REMARK 465 ASP W 133
REMARK 465 ASP W 134
REMARK 465 ASP W 135
REMARK 465 ASP W 136
REMARK 465 ASP W 137
REMARK 465 VAL W 138
REMARK 465 GLU W 139
REMARK 465 LEU W 140
REMARK 465 LYS W 141
REMARK 465 HIS W 142
REMARK 465 ASP W 143
REMARK 465 PHE W 144
REMARK 465 ILE W 145
REMARK 465 GLN W 146
REMARK 465 ASP W 147
REMARK 465 ASP W 148
REMARK 465 HIS W 149
REMARK 465 ILE W 150
REMARK 465 GLN W 151
REMARK 465 HIS W 152
REMARK 465 GLU W 153
REMARK 465 THR W 154
REMARK 465 GLN W 155
REMARK 465 ASN W 156
REMARK 465 GLU W 157
REMARK 465 GLY W 158
REMARK 465 PHE W 159
REMARK 465 ILE W 160
REMARK 465 ALA W 161
REMARK 465 GLY W 162
REMARK 465 HIS W 163
REMARK 465 VAL W 164
REMARK 465 ASP W 165
REMARK 465 ASP W 166
REMARK 465 ASP W 167
REMARK 465 ARG W 168
REMARK 465 LEU W 169
REMARK 465 HIS W 170
REMARK 465 ARG W 171
REMARK 465 LYS W 172
REMARK 465 LEU W 173
REMARK 465 ASP W 174
REMARK 465 GLN W 175
REMARK 465 SER W 176
REMARK 465 ARG W 177
REMARK 465 GLU W 178
REMARK 465 LYS W 179
REMARK 465 ILE W 180
REMARK 465 ALA W 181
REMARK 465 ASP W 182
REMARK 465 GLN W 183
REMARK 465 ASP W 184
REMARK 465 ALA W 185
REMARK 465 GLN W 186
REMARK 465 GLU W 187
REMARK 465 LEU W 188
REMARK 465 ALA W 189
REMARK 465 ASP W 190
REMARK 465 GLU W 191
REMARK 465 PHE W 192
REMARK 465 LYS W 193
REMARK 465 GLN W 194
REMARK 465 ARG W 195
REMARK 465 TYR W 196
REMARK 465 GLY W 197
REMARK 465 ARG W 198
REMARK 465 SER W 199
REMARK 465 ALA W 200
REMARK 465 SER W 201
REMARK 465 SER W 202
REMARK 465 LYS W 203
REMARK 465 TYR W 204
REMARK 465 MET W 205
REMARK 465 GLY W 206
REMARK 465 SER W 207
REMARK 465 ALA W 208
REMARK 465 SER W 209
REMARK 465 THR W 210
REMARK 465 THR W 211
REMARK 465 ALA W 212
REMARK 465 LYS W 314
REMARK 465 SER W 315
REMARK 465 SER W 316
REMARK 465 ASP W 317
REMARK 465 VAL W 318
REMARK 465 HIS W 366
REMARK 465 LEU W 367
REMARK 465 SER W 368
REMARK 465 THR W 369
REMARK 465 SER W 370
REMARK 465 SER W 371
REMARK 465 SER W 372
REMARK 465 VAL W 373
REMARK 465 ASP W 374
REMARK 465 SER W 375
REMARK 465 THR W 376
REMARK 465 LYS W 377
REMARK 465 ASN W 378
REMARK 465 ARG W 379
REMARK 465 ARG W 380
REMARK 465 LYS W 381
REMARK 465 PHE W 382
REMARK 465 PRO W 404
REMARK 465 THR W 405
REMARK 465 GLN W 451
REMARK 465 SER W 452
REMARK 465 ASN W 453
REMARK 465 GLU W 454
REMARK 465 GLU W 455
REMARK 465 SER W 456
REMARK 465 THR W 457
REMARK 465 THR W 458
REMARK 465 ILE W 459
REMARK 465 ASP W 460
REMARK 465 LEU W 461
REMARK 465 SER W 462
REMARK 465 THR W 463
REMARK 465 ILE W 464
REMARK 465 ALA W 465
REMARK 465 ASP W 466
REMARK 465 SER W 467
REMARK 465 LEU W 468
REMARK 465 LYS W 469
REMARK 465 GLU W 470
REMARK 465 THR W 471
REMARK 465 ALA W 472
REMARK 465 LYS W 473
REMARK 465 ASN W 474
REMARK 465 LEU W 475
REMARK 465 VAL W 476
REMARK 465 SER W 477
REMARK 465 PHE W 478
REMARK 465 GLN W 479
REMARK 465 PRO W 480
REMARK 465 GLY W 481
REMARK 465 ASP W 482
REMARK 465 ASN W 483
REMARK 465 VAL W 484
REMARK 465 GLU W 485
REMARK 465 ILE W 486
REMARK 465 ILE W 487
REMARK 465 ASN W 488
REMARK 465 GLY W 489
REMARK 465 GLU W 490
REMARK 465 LEU W 491
REMARK 465 ASN W 492
REMARK 465 HIS W 493
REMARK 465 LEU W 494
REMARK 465 THR W 495
REMARK 465 GLY W 496
REMARK 465 THR W 497
REMARK 465 VAL W 498
REMARK 465 SER W 499
REMARK 465 SER W 500
REMARK 465 VAL W 501
REMARK 465 ASN W 502
REMARK 465 GLN W 503
REMARK 465 SER W 504
REMARK 465 THR W 505
REMARK 465 ILE W 506
REMARK 465 VAL W 507
REMARK 465 SER W 508
REMARK 465 VAL W 509
REMARK 465 ARG W 510
REMARK 465 LEU W 511
REMARK 465 HIS W 512
REMARK 465 SER W 513
REMARK 465 ASP W 514
REMARK 465 ASP W 515
REMARK 465 ASP W 516
REMARK 465 THR W 517
REMARK 465 ILE W 518
REMARK 465 ASN W 519
REMARK 465 SER W 520
REMARK 465 GLU W 521
REMARK 465 THR W 522
REMARK 465 VAL W 523
REMARK 465 GLU W 524
REMARK 465 ILE W 525
REMARK 465 PRO W 526
REMARK 465 THR W 527
REMARK 465 SER W 528
REMARK 465 ASP W 529
REMARK 465 LEU W 530
REMARK 465 ARG W 531
REMARK 465 LYS W 532
REMARK 465 ILE W 533
REMARK 465 PHE W 534
REMARK 465 ASN W 535
REMARK 465 VAL W 536
REMARK 465 GLY W 537
REMARK 465 ASP W 538
REMARK 465 HIS W 539
REMARK 465 VAL W 540
REMARK 465 ARG W 541
REMARK 465 VAL W 542
REMARK 465 ILE W 543
REMARK 465 HIS W 544
REMARK 465 GLY W 545
REMARK 465 LYS W 546
REMARK 465 HIS W 547
REMARK 465 THR W 548
REMARK 465 ASP W 549
REMARK 465 ASP W 550
REMARK 465 THR W 551
REMARK 465 GLY W 552
REMARK 465 LEU W 553
REMARK 465 ILE W 554
REMARK 465 VAL W 555
REMARK 465 GLU W 556
REMARK 465 VAL W 557
REMARK 465 ASN W 558
REMARK 465 GLY W 559
REMARK 465 ASP W 560
REMARK 465 LYS W 561
REMARK 465 VAL W 562
REMARK 465 GLU W 563
REMARK 465 PHE W 564
REMARK 465 ILE W 565
REMARK 465 SER W 566
REMARK 465 ASN W 567
REMARK 465 GLN W 568
REMARK 465 THR W 569
REMARK 465 LYS W 570
REMARK 465 ARG W 571
REMARK 465 THR W 572
REMARK 465 VAL W 573
REMARK 465 ILE W 574
REMARK 465 VAL W 575
REMARK 465 PHE W 576
REMARK 465 SER W 577
REMARK 465 ASN W 578
REMARK 465 TYR W 579
REMARK 465 LEU W 580
REMARK 465 ILE W 581
REMARK 465 LYS W 582
REMARK 465 SER W 583
REMARK 465 THR W 584
REMARK 465 ASP W 585
REMARK 465 SER W 586
REMARK 465 THR W 587
REMARK 465 VAL W 588
REMARK 465 SER W 589
REMARK 465 ILE W 590
REMARK 465 ASN W 591
REMARK 465 GLU W 592
REMARK 465 SER W 593
REMARK 465 GLY W 594
REMARK 465 ARG W 595
REMARK 465 PHE W 596
REMARK 465 GLU W 597
REMARK 465 LEU W 598
REMARK 465 HIS W 599
REMARK 465 ASP W 600
REMARK 465 LEU W 601
REMARK 465 VAL W 602
REMARK 465 GLN W 603
REMARK 465 VAL W 604
REMARK 465 ASN W 605
REMARK 465 SER W 606
REMARK 465 ASP W 607
REMARK 465 LEU W 608
REMARK 465 VAL W 609
REMARK 465 GLY W 610
REMARK 465 ILE W 611
REMARK 465 VAL W 612
REMARK 465 ILE W 613
REMARK 465 ARG W 614
REMARK 465 ALA W 615
REMARK 465 GLN W 616
REMARK 465 LYS W 617
REMARK 465 ASP W 618
REMARK 465 SER W 619
REMARK 465 PHE W 620
REMARK 465 ASP W 621
REMARK 465 VAL W 622
REMARK 465 LEU W 623
REMARK 465 CYS W 624
REMARK 465 SER W 625
REMARK 465 ASP W 626
REMARK 465 GLY W 627
REMARK 465 LYS W 628
REMARK 465 LEU W 629
REMARK 465 LEU W 630
REMARK 465 SER W 631
REMARK 465 LEU W 632
REMARK 465 PRO W 633
REMARK 465 PRO W 634
REMARK 465 VAL W 635
REMARK 465 SER W 636
REMARK 465 ILE W 637
REMARK 465 TYR W 638
REMARK 465 SER W 639
REMARK 465 LYS W 640
REMARK 465 LEU W 641
REMARK 465 ASN W 642
REMARK 465 LEU W 643
REMARK 465 ASN W 644
REMARK 465 PRO W 645
REMARK 465 ASN W 646
REMARK 465 GLN W 647
REMARK 465 GLN W 648
REMARK 465 ILE W 649
REMARK 465 ALA W 650
REMARK 465 ILE W 651
REMARK 465 ASP W 652
REMARK 465 SER W 653
REMARK 465 ASN W 654
REMARK 465 GLY W 655
REMARK 465 VAL W 656
REMARK 465 GLU W 657
REMARK 465 VAL W 658
REMARK 465 LYS W 659
REMARK 465 VAL W 660
REMARK 465 GLY W 661
REMARK 465 ASP W 662
REMARK 465 THR W 663
REMARK 465 VAL W 664
REMARK 465 ARG W 665
REMARK 465 GLU W 666
REMARK 465 PHE W 667
REMARK 465 THR W 668
REMARK 465 GLY W 669
REMARK 465 GLU W 670
REMARK 465 ARG W 671
REMARK 465 ARG W 672
REMARK 465 GLN W 673
REMARK 465 GLY W 674
REMARK 465 THR W 675
REMARK 465 ILE W 676
REMARK 465 LEU W 677
REMARK 465 HIS W 678
REMARK 465 VAL W 679
REMARK 465 TYR W 680
REMARK 465 ARG W 681
REMARK 465 ASN W 682
REMARK 465 PHE W 683
REMARK 465 LEU W 684
REMARK 465 PHE W 685
REMARK 465 LEU W 686
REMARK 465 ARG W 687
REMARK 465 SER W 688
REMARK 465 ARG W 689
REMARK 465 GLU W 690
REMARK 465 ILE W 691
REMARK 465 VAL W 692
REMARK 465 GLU W 693
REMARK 465 ASN W 694
REMARK 465 GLN W 695
REMARK 465 GLY W 696
REMARK 465 VAL W 697
REMARK 465 PHE W 698
REMARK 465 VAL W 699
REMARK 465 THR W 700
REMARK 465 SER W 701
REMARK 465 SER W 702
REMARK 465 ASN W 703
REMARK 465 ARG W 704
REMARK 465 VAL W 705
REMARK 465 LYS W 706
REMARK 465 THR W 707
REMARK 465 ILE W 708
REMARK 465 THR W 709
REMARK 465 SER W 710
REMARK 465 LYS W 711
REMARK 465 SER W 712
REMARK 465 ASN W 713
REMARK 465 GLY W 714
REMARK 465 THR W 715
REMARK 465 GLY W 716
REMARK 465 GLY W 717
REMARK 465 GLN W 718
REMARK 465 ILE W 719
REMARK 465 SER W 720
REMARK 465 GLY W 721
REMARK 465 PRO W 722
REMARK 465 ASP W 723
REMARK 465 LEU W 724
REMARK 465 SER W 725
REMARK 465 ARG W 726
REMARK 465 MET W 727
REMARK 465 ASN W 728
REMARK 465 PRO W 729
REMARK 465 SER W 730
REMARK 465 ARG W 731
REMARK 465 VAL W 732
REMARK 465 ILE W 733
REMARK 465 PRO W 734
REMARK 465 PRO W 735
REMARK 465 PRO W 736
REMARK 465 SER W 737
REMARK 465 ILE W 738
REMARK 465 PRO W 739
REMARK 465 VAL W 740
REMARK 465 ALA W 741
REMARK 465 ASN W 742
REMARK 465 GLN W 743
REMARK 465 ARG W 744
REMARK 465 MET W 745
REMARK 465 THR W 746
REMARK 465 GLY W 747
REMARK 465 ARG W 748
REMARK 465 PHE W 810
REMARK 465 VAL W 811
REMARK 465 ALA W 812
REMARK 465 SER W 813
REMARK 465 ASP W 814
REMARK 465 ARG W 815
REMARK 465 ARG W 816
REMARK 465 GLY W 817
REMARK 465 GLY W 818
REMARK 465 ASN W 819
REMARK 465 ILE W 820
REMARK 465 PRO W 821
REMARK 465 ARG W 822
REMARK 465 HIS W 823
REMARK 465 GLU W 824
REMARK 465 ILE W 825
REMARK 465 SER W 826
REMARK 465 GLY W 827
REMARK 465 HIS W 828
REMARK 465 VAL W 829
REMARK 465 GLN W 830
REMARK 465 GLN W 831
REMARK 465 PRO W 832
REMARK 465 GLN W 833
REMARK 465 HIS W 834
REMARK 465 GLY W 835
REMARK 465 ARG W 836
REMARK 465 ALA W 837
REMARK 465 PRO W 838
REMARK 465 ALA W 839
REMARK 465 TRP W 840
REMARK 465 GLY W 841
REMARK 465 SER W 842
REMARK 465 GLY W 843
REMARK 465 GLY W 844
REMARK 465 LYS W 845
REMARK 465 THR W 846
REMARK 465 PRO W 847
REMARK 465 ALA W 848
REMARK 465 TRP W 849
REMARK 465 GLY W 850
REMARK 465 SER W 851
REMARK 465 GLY W 852
REMARK 465 GLY W 853
REMARK 465 LYS W 854
REMARK 465 THR W 855
REMARK 465 PRO W 856
REMARK 465 ALA W 857
REMARK 465 TRP W 858
REMARK 465 GLY W 859
REMARK 465 SER W 860
REMARK 465 GLY W 861
REMARK 465 GLY W 862
REMARK 465 SER W 863
REMARK 465 GLY W 864
REMARK 465 GLY W 865
REMARK 465 LYS W 866
REMARK 465 THR W 867
REMARK 465 PRO W 868
REMARK 465 ALA W 869
REMARK 465 TRP W 870
REMARK 465 GLY W 871
REMARK 465 SER W 872
REMARK 465 GLY W 873
REMARK 465 GLY W 874
REMARK 465 LYS W 875
REMARK 465 THR W 876
REMARK 465 PRO W 877
REMARK 465 THR W 878
REMARK 465 TRP W 879
REMARK 465 GLY W 880
REMARK 465 SER W 881
REMARK 465 GLY W 882
REMARK 465 ALA W 883
REMARK 465 LYS W 884
REMARK 465 THR W 885
REMARK 465 PRO W 886
REMARK 465 ALA W 887
REMARK 465 TRP W 888
REMARK 465 GLY W 889
REMARK 465 SER W 890
REMARK 465 GLY W 891
REMARK 465 SER W 892
REMARK 465 LYS W 893
REMARK 465 THR W 894
REMARK 465 PRO W 895
REMARK 465 ALA W 896
REMARK 465 TRP W 897
REMARK 465 SER W 898
REMARK 465 GLY W 899
REMARK 465 LEU W 900
REMARK 465 ASP W 901
REMARK 465 GLU W 902
REMARK 465 GLU W 903
REMARK 465 ASP W 904
REMARK 465 ARG W 905
REMARK 465 ARG W 906
REMARK 465 ASP W 907
REMARK 465 PHE W 908
REMARK 465 GLY a -3
REMARK 465 SER a -2
REMARK 465 HIS a -1
REMARK 465 MET a 0
REMARK 465 ALA a 1
REMARK 465 ARG a 2
REMARK 465 THR a 3
REMARK 465 LYS a 4
REMARK 465 GLN a 5
REMARK 465 THR a 6
REMARK 465 ALA a 7
REMARK 465 ARG a 8
REMARK 465 LYS a 9
REMARK 465 SER a 10
REMARK 465 THR a 11
REMARK 465 GLY a 12
REMARK 465 GLY a 13
REMARK 465 LYS a 14
REMARK 465 ALA a 15
REMARK 465 PRO a 16
REMARK 465 ARG a 17
REMARK 465 LYS a 18
REMARK 465 GLN a 19
REMARK 465 LEU a 20
REMARK 465 ALA a 21
REMARK 465 THR a 22
REMARK 465 LYS a 23
REMARK 465 ALA a 24
REMARK 465 ALA a 25
REMARK 465 ARG a 26
REMARK 465 LYS a 27
REMARK 465 SER a 28
REMARK 465 ALA a 29
REMARK 465 PRO a 30
REMARK 465 SER a 31
REMARK 465 THR a 32
REMARK 465 GLY a 33
REMARK 465 GLY a 34
REMARK 465 VAL a 35
REMARK 465 LYS a 36
REMARK 465 LYS a 37
REMARK 465 ALA a 135
REMARK 465 GLY b -3
REMARK 465 SER b -2
REMARK 465 HIS b -1
REMARK 465 MET b 0
REMARK 465 SER b 1
REMARK 465 GLY b 2
REMARK 465 ARG b 3
REMARK 465 GLY b 4
REMARK 465 LYS b 5
REMARK 465 GLY b 6
REMARK 465 GLY b 7
REMARK 465 LYS b 8
REMARK 465 GLY b 9
REMARK 465 LEU b 10
REMARK 465 GLY b 11
REMARK 465 LYS b 12
REMARK 465 GLY b 13
REMARK 465 GLY b 14
REMARK 465 ALA b 15
REMARK 465 LYS b 16
REMARK 465 ARG b 17
REMARK 465 HIS b 18
REMARK 465 ARG b 19
REMARK 465 LYS b 20
REMARK 465 VAL b 21
REMARK 465 LEU b 22
REMARK 465 GLY c -3
REMARK 465 SER c -2
REMARK 465 HIS c -1
REMARK 465 MET c 0
REMARK 465 SER c 1
REMARK 465 GLY c 2
REMARK 465 ARG c 3
REMARK 465 GLY c 4
REMARK 465 LYS c 5
REMARK 465 GLN c 6
REMARK 465 GLY c 7
REMARK 465 GLY c 8
REMARK 465 LYS c 9
REMARK 465 ALA c 10
REMARK 465 ARG c 11
REMARK 465 ALA c 12
REMARK 465 LYS c 13
REMARK 465 ALA c 14
REMARK 465 LYS c 15
REMARK 465 LYS c 119
REMARK 465 THR c 120
REMARK 465 GLU c 121
REMARK 465 SER c 122
REMARK 465 HIS c 123
REMARK 465 HIS c 124
REMARK 465 LYS c 125
REMARK 465 ALA c 126
REMARK 465 LYS c 127
REMARK 465 GLY c 128
REMARK 465 LYS c 129
REMARK 465 GLY d -6
REMARK 465 SER d -5
REMARK 465 HIS d -4
REMARK 465 MET d -3
REMARK 465 PRO d -2
REMARK 465 GLU d -1
REMARK 465 PRO d 0
REMARK 465 ALA d 1
REMARK 465 LYS d 2
REMARK 465 SER d 3
REMARK 465 ALA d 4
REMARK 465 PRO d 5
REMARK 465 ALA d 6
REMARK 465 PRO d 7
REMARK 465 LYS d 8
REMARK 465 LYS d 9
REMARK 465 GLY d 10
REMARK 465 SER d 11
REMARK 465 LYS d 12
REMARK 465 LYS d 13
REMARK 465 ALA d 14
REMARK 465 VAL d 15
REMARK 465 THR d 16
REMARK 465 LYS d 17
REMARK 465 ALA d 18
REMARK 465 GLN d 19
REMARK 465 LYS d 20
REMARK 465 LYS d 21
REMARK 465 ASP d 22
REMARK 465 GLY d 23
REMARK 465 LYS d 24
REMARK 465 LYS d 25
REMARK 465 ARG d 26
REMARK 465 LYS d 27
REMARK 465 GLY e -3
REMARK 465 SER e -2
REMARK 465 HIS e -1
REMARK 465 MET e 0
REMARK 465 ALA e 1
REMARK 465 ARG e 2
REMARK 465 THR e 3
REMARK 465 LYS e 4
REMARK 465 GLN e 5
REMARK 465 THR e 6
REMARK 465 ALA e 7
REMARK 465 ARG e 8
REMARK 465 LYS e 9
REMARK 465 SER e 10
REMARK 465 THR e 11
REMARK 465 GLY e 12
REMARK 465 GLY e 13
REMARK 465 LYS e 14
REMARK 465 ALA e 15
REMARK 465 PRO e 16
REMARK 465 ARG e 17
REMARK 465 LYS e 18
REMARK 465 GLN e 19
REMARK 465 LEU e 20
REMARK 465 ALA e 21
REMARK 465 THR e 22
REMARK 465 LYS e 23
REMARK 465 ALA e 24
REMARK 465 ALA e 25
REMARK 465 ARG e 26
REMARK 465 LYS e 27
REMARK 465 SER e 28
REMARK 465 ALA e 29
REMARK 465 PRO e 30
REMARK 465 SER e 31
REMARK 465 THR e 32
REMARK 465 GLY e 33
REMARK 465 GLY e 34
REMARK 465 VAL e 35
REMARK 465 LYS e 36
REMARK 465 LYS e 37
REMARK 465 PRO e 38
REMARK 465 GLY f -3
REMARK 465 SER f -2
REMARK 465 HIS f -1
REMARK 465 MET f 0
REMARK 465 SER f 1
REMARK 465 GLY f 2
REMARK 465 ARG f 3
REMARK 465 GLY f 4
REMARK 465 LYS f 5
REMARK 465 GLY f 6
REMARK 465 GLY f 7
REMARK 465 LYS f 8
REMARK 465 GLY f 9
REMARK 465 LEU f 10
REMARK 465 GLY f 11
REMARK 465 LYS f 12
REMARK 465 GLY f 13
REMARK 465 GLY f 14
REMARK 465 ALA f 15
REMARK 465 LYS f 16
REMARK 465 ARG f 17
REMARK 465 HIS f 18
REMARK 465 ARG f 19
REMARK 465 LYS f 20
REMARK 465 VAL f 21
REMARK 465 LEU f 22
REMARK 465 ARG f 23
REMARK 465 ASP f 24
REMARK 465 GLY g -3
REMARK 465 SER g -2
REMARK 465 HIS g -1
REMARK 465 MET g 0
REMARK 465 SER g 1
REMARK 465 GLY g 2
REMARK 465 ARG g 3
REMARK 465 GLY g 4
REMARK 465 LYS g 5
REMARK 465 GLN g 6
REMARK 465 GLY g 7
REMARK 465 GLY g 8
REMARK 465 LYS g 9
REMARK 465 ALA g 10
REMARK 465 ARG g 11
REMARK 465 ALA g 12
REMARK 465 LYS g 13
REMARK 465 LYS g 119
REMARK 465 THR g 120
REMARK 465 GLU g 121
REMARK 465 SER g 122
REMARK 465 HIS g 123
REMARK 465 HIS g 124
REMARK 465 LYS g 125
REMARK 465 ALA g 126
REMARK 465 LYS g 127
REMARK 465 GLY g 128
REMARK 465 LYS g 129
REMARK 465 GLY h -6
REMARK 465 SER h -5
REMARK 465 HIS h -4
REMARK 465 MET h -3
REMARK 465 PRO h -2
REMARK 465 GLU h -1
REMARK 465 PRO h 0
REMARK 465 ALA h 1
REMARK 465 LYS h 2
REMARK 465 SER h 3
REMARK 465 ALA h 4
REMARK 465 PRO h 5
REMARK 465 ALA h 6
REMARK 465 PRO h 7
REMARK 465 LYS h 8
REMARK 465 LYS h 9
REMARK 465 GLY h 10
REMARK 465 SER h 11
REMARK 465 LYS h 12
REMARK 465 LYS h 13
REMARK 465 ALA h 14
REMARK 465 VAL h 15
REMARK 465 THR h 16
REMARK 465 LYS h 17
REMARK 465 ALA h 18
REMARK 465 GLN h 19
REMARK 465 LYS h 20
REMARK 465 LYS h 21
REMARK 465 ASP h 22
REMARK 465 GLY h 23
REMARK 465 LYS h 24
REMARK 465 LYS h 25
REMARK 465 ARG h 26
REMARK 465 LYS h 27
REMARK 465 ARG h 28
REMARK 465 SER h 29
REMARK 465 ARG h 30
REMARK 465 LYS h 122
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE
REMARK 500 NH1 ARG V 85 OD1 ASP V 87 2.07
REMARK 500 OE1 GLN M 57 N ASP e 81 2.07
REMARK 500 O SER M 55 CG LYS f 79 2.07
REMARK 500 CD1 LEU M 46 OD1 ASP e 81 2.11
REMARK 500 N1 DA T -25 N3 DT N 25 2.12
REMARK 500 O2 DC T 18 N2 DG N -18 2.12
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION
REMARK 500 G P -5 C1' G P -5 N9 -0.103
REMARK 500 G P -1 C1' G P -1 N9 -0.102
REMARK 500 G P 2 C1' G P 2 N9 -0.102
REMARK 500 C P 4 C1' C P 4 N1 0.108
REMARK 500 DG T -7 O3' DG T -7 C3' -0.040
REMARK 500 DT T 3 O3' DT T 3 C3' -0.044
REMARK 500 DA T 17 C1' DA T 17 N9 -0.119
REMARK 500 DG T 27 C1' DG T 27 N9 -0.092
REMARK 500 DA T 39 O3' DA T 39 C3' -0.049
REMARK 500 DG T 40 C1' DG T 40 N9 -0.092
REMARK 500 DA T 43 C1' DA T 43 N9 -0.090
REMARK 500 DC N -54 C1' DC N -54 N1 0.082
REMARK 500 DC N -52 C1' DC N -52 N1 0.080
REMARK 500 DA N -15 C1' DA N -15 N9 -0.110
REMARK 500 PHE e 84 C GLN e 85 N 0.196
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3
REMARK 500 LEU A 473 CA - CB - CG ANGL. DEV. = -18.9 DEGREES
REMARK 500 ARG A 721 NE - CZ - NH1 ANGL. DEV. = -3.2 DEGREES
REMARK 500 GLN B 63 N - CA - CB ANGL. DEV. = -13.8 DEGREES
REMARK 500 GLN B 63 N - CA - C ANGL. DEV. = -18.7 DEGREES
REMARK 500 ARG I 5 NE - CZ - NH2 ANGL. DEV. = -3.1 DEGREES
REMARK 500 DG T -68 O4' - C1' - N9 ANGL. DEV. = 2.0 DEGREES
REMARK 500 DT T -59 C3' - C2' - C1' ANGL. DEV. = -5.5 DEGREES
REMARK 500 DT T -59 O4' - C1' - N1 ANGL. DEV. = 1.8 DEGREES
REMARK 500 DG T -30 O4' - C1' - N9 ANGL. DEV. = 2.4 DEGREES
REMARK 500 DT T -26 O4' - C4' - C3' ANGL. DEV. = -2.8 DEGREES
REMARK 500 DC T -8 O4' - C1' - N1 ANGL. DEV. = 2.2 DEGREES
REMARK 500 DC T 10 O4' - C1' - N1 ANGL. DEV. = 2.2 DEGREES
REMARK 500 DA T 17 O4' - C1' - N9 ANGL. DEV. = 2.2 DEGREES
REMARK 500 DC T 33 O4' - C1' - N1 ANGL. DEV. = 1.9 DEGREES
REMARK 500 DC T 35 O4' - C1' - N1 ANGL. DEV. = 1.9 DEGREES
REMARK 500 DA T 38 O4' - C1' - N9 ANGL. DEV. = 2.7 DEGREES
REMARK 500 DA T 39 O4' - C1' - N9 ANGL. DEV. = 2.1 DEGREES
REMARK 500 DT N -32 O4' - C1' - N1 ANGL. DEV. = 1.9 DEGREES
REMARK 500 DA N -31 O4' - C1' - N9 ANGL. DEV. = 3.0 DEGREES
REMARK 500 DT N -16 C3' - C2' - C1' ANGL. DEV. = -5.1 DEGREES
REMARK 500 DG N 12 O4' - C1' - N9 ANGL. DEV. = 2.8 DEGREES
REMARK 500 DT N 13 O4' - C1' - N1 ANGL. DEV. = 2.7 DEGREES
REMARK 500 DA N 16 O4' - C1' - N9 ANGL. DEV. = 2.6 DEGREES
REMARK 500 DG N 27 O4' - C1' - N9 ANGL. DEV. = 3.0 DEGREES
REMARK 500 DC N 37 O4' - C1' - N1 ANGL. DEV. = 1.9 DEGREES
REMARK 500 DG N 38 O4' - C1' - N9 ANGL. DEV. = 2.3 DEGREES
REMARK 500 DC N 58 C3' - C2' - C1' ANGL. DEV. = -5.8 DEGREES
REMARK 500 DT N 66 O4' - C1' - N1 ANGL. DEV. = 2.1 DEGREES
REMARK 500 DT N 67 C3' - C2' - C1' ANGL. DEV. = -5.3 DEGREES
REMARK 500 PRO W 389 C - N - CA ANGL. DEV. = 9.5 DEGREES
REMARK 500 PRO W 389 CA - N - CD ANGL. DEV. = -12.2 DEGREES
REMARK 500 ASP W 749 CB - CG - OD1 ANGL. DEV. = 5.8 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 GLU A 43 39.48 -167.36
REMARK 500 ARG A 45 42.33 -109.52
REMARK 500 GLN A 46 155.81 67.05
REMARK 500 ARG A 47 115.61 66.80
REMARK 500 ALA A 196 -127.86 -131.43
REMARK 500 GLU A 255 -66.66 50.01
REMARK 500 ASP A 283 -141.76 -161.33
REMARK 500 PRO A 286 41.45 -71.64
REMARK 500 GLN A 287 -65.02 44.56
REMARK 500 ARG A 421 50.33 -110.40
REMARK 500 TYR A 466 158.27 70.95
REMARK 500 GLN A 526 -122.75 44.10
REMARK 500 SER A 600 71.39 31.51
REMARK 500 LYS A 753 141.02 -172.87
REMARK 500 PRO A 786 1.93 -69.27
REMARK 500 GLU A 871 6.26 59.80
REMARK 500 MET A 903 -64.03 -100.10
REMARK 500 TYR A 916 23.77 -79.15
REMARK 500 ILE A 947 -51.20 -121.09
REMARK 500 VAL A 960 102.39 18.26
REMARK 500 LEU A 975 31.16 -73.08
REMARK 500 ARG A 977 140.71 107.09
REMARK 500 LYS A 979 99.06 -53.82
REMARK 500 ALA A 980 139.11 -36.27
REMARK 500 GLN A1080 35.51 -140.87
REMARK 500 VAL A1109 68.00 10.95
REMARK 500 SER A1223 -96.78 30.39
REMARK 500 LEU A1273 -18.71 -142.90
REMARK 500 ASN A1315 73.75 -161.26
REMARK 500 ASP A1362 38.15 -83.76
REMARK 500 PHE A1405 -73.89 -94.57
REMARK 500 ALA B 62 97.83 -32.91
REMARK 500 LYS B 155 61.99 -30.37
REMARK 500 THR B 174 -119.77 -97.06
REMARK 500 LEU B 175 -59.34 64.19
REMARK 500 ASP B 176 137.00 75.63
REMARK 500 GLU B 177 -37.48 -27.39
REMARK 500 PRO B 222 35.89 -75.21
REMARK 500 SER B 239 19.53 101.29
REMARK 500 ILE B 242 -61.51 -124.06
REMARK 500 ARG B 252 -167.97 -79.16
REMARK 500 THR B 257 -118.27 45.21
REMARK 500 ARG B 259 58.71 -100.05
REMARK 500 ILE B 293 -71.68 -97.01
REMARK 500 ASP B 299 84.63 -59.92
REMARK 500 SER B 331 13.64 53.13
REMARK 500 ALA B 332 -158.62 -81.67
REMARK 500 ARG B 337 153.04 37.62
REMARK 500 GLU B 352 -36.92 78.27
REMARK 500 LEU B 401 -162.68 -104.26
REMARK 500
REMARK 500 THIS ENTRY HAS 122 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500 MODEL OMEGA
REMARK 500 ARG a 42 PRO a 43 -145.13
REMARK 500 ARG a 63 LYS a 64 -143.78
REMARK 500 ARG e 63 LYS e 64 -142.22
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY
REMARK 500
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 500 I=INSERTION CODE).
REMARK 500
REMARK 500 M RES CSSEQI ANGLE
REMARK 500 ILE B 336 -10.77
REMARK 500
REMARK 500 REMARK: NULL
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN A1801 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS A 67 SG
REMARK 620 2 CYS A 70 SG 101.1
REMARK 620 3 CYS A 77 SG 106.1 104.6
REMARK 620 4 HIS A 80 NE2 98.1 123.1 120.4
REMARK 620 N 1 2 3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN A1802 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS A 107 SG
REMARK 620 2 CYS A 110 N 84.6
REMARK 620 3 CYS A 110 SG 95.2 75.0
REMARK 620 4 CYS A 168 SG 80.8 133.6 149.8
REMARK 620 N 1 2 3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 MG A1803 MG
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP A 482 OD1
REMARK 620 2 ASP A 484 OD1 78.4
REMARK 620 3 ASP A 486 OD1 101.8 100.5
REMARK 620 4 U P 10 O3' 160.6 111.2 93.2
REMARK 620 N 1 2 3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN B1301 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS B1163 SG
REMARK 620 2 CYS B1166 SG 111.3
REMARK 620 3 CYS B1182 SG 103.6 118.7
REMARK 620 4 CYS B1185 SG 100.3 109.2 112.0
REMARK 620 N 1 2 3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN C 401 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS C 85 SG
REMARK 620 2 CYS C 91 SG 118.8
REMARK 620 3 CYS C 94 SG 115.5 120.4
REMARK 620 N 1 2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN I 202 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS I 29 SG
REMARK 620 2 CYS I 32 SG 100.6
REMARK 620 N 1
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN I 201 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS I 78 SG
REMARK 620 2 CYS I 103 SG 91.4
REMARK 620 3 CYS I 106 N 143.6 103.1
REMARK 620 N 1 2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN J 101 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS J 7 SG
REMARK 620 2 CYS J 10 SG 86.5
REMARK 620 3 CYS J 44 SG 118.1 82.9
REMARK 620 4 CYS J 45 N 113.7 159.7 85.2
REMARK 620 5 CYS J 45 SG 127.3 81.8 111.2 87.2
REMARK 620 N 1 2 3 4
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN L 101 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS L 33 SG
REMARK 620 2 CYS L 36 SG 99.2
REMARK 620 3 CYS L 50 SG 92.5 113.9
REMARK 620 4 CYS L 53 SG 93.4 127.1 116.7
REMARK 620 N 1 2 3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN M 201 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS M 25 SG
REMARK 620 2 CYS M 28 SG 83.7
REMARK 620 3 CYS M 49 SG 119.2 82.8
REMARK 620 4 CYS M 52 SG 130.2 93.9 109.7
REMARK 620 N 1 2 3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN V 300 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS V 12 SG
REMARK 620 2 CYS V 15 SG 115.7
REMARK 620 3 CYS V 29 SG 115.5 95.7
REMARK 620 4 CYS V 32 SG 114.3 107.6 106.1
REMARK 620 N 1 2 3
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN A 1801
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN A 1802
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MG A 1803
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN B 1301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN C 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN I 201
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN I 202
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN J 101
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN L 101
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN M 201
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN V 300
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-9713 RELATED DB: EMDB
REMARK 900 RNA POLYMERASE II ELONGATION COMPLEX BOUND WITH ELF1 AND SPT4/5,
REMARK 900 STALLED AT SHL(-1) OF THE NUCLEOSOME
DBREF 6IR9 A 1 1743 UNP C4R4Y0 C4R4Y0_KOMPG 1 1743
DBREF 6IR9 B 1 1227 UNP C4QZQ7 C4QZQ7_KOMPG 1 1227
DBREF 6IR9 C 1 304 UNP C4R7L2 C4R7L2_KOMPG 1 304
DBREF 6IR9 D 1 186 UNP C4R2U9 C4R2U9_KOMPG 1 186
DBREF 6IR9 E 1 214 UNP C4R3P8 C4R3P8_KOMPG 1 214
DBREF 6IR9 F 1 155 UNP C4R1V1 C4R1V1_KOMPG 1 155
DBREF 6IR9 G 1 171 UNP C4R9A1 C4R9A1_KOMPG 1 171
DBREF 6IR9 H 1 145 UNP C4R273 C4R273_KOMPG 1 145
DBREF 6IR9 I 1 115 UNP F2QPE6 F2QPE6_KOMPC 1 115
DBREF 6IR9 J 1 72 UNP C4R009 C4R009_KOMPG 1 72
DBREF 6IR9 K 1 118 UNP C4R3Z5 C4R3Z5_KOMPG 1 118
DBREF 6IR9 L 1 72 UNP F2QMI1 F2QMI1_KOMPC 1 72
DBREF 6IR9 P -5 10 PDB 6IR9 6IR9 -5 10
DBREF 6IR9 T -72 125 PDB 6IR9 6IR9 -72 125
DBREF 6IR9 N -125 72 PDB 6IR9 6IR9 -125 72
DBREF 6IR9 M 1 110 UNP C4QZ45 C4QZ45_KOMPG 1 110
DBREF 6IR9 V 8 114 UNP C4R0E6 C4R0E6_KOMPG 8 114
DBREF 6IR9 W 1 908 UNP C4R370 C4R370_KOMPG 1 908
DBREF 6IR9 a 0 135 UNP P84243 H33_HUMAN 1 136
DBREF 6IR9 b 0 102 UNP P62805 H4_HUMAN 1 103
DBREF 6IR9 c 0 129 UNP P04908 H2A1B_HUMAN 1 130
DBREF 6IR9 d -3 122 UNP P06899 H2B1J_HUMAN 1 126
DBREF 6IR9 e 0 135 UNP P84243 H33_HUMAN 1 136
DBREF 6IR9 f 0 102 UNP P62805 H4_HUMAN 1 103
DBREF 6IR9 g 0 129 UNP P04908 H2A1B_HUMAN 1 130
DBREF 6IR9 h -3 122 UNP P06899 H2B1J_HUMAN 1 126
SEQADV 6IR9 GLY M -2 UNP C4QZ45 EXPRESSION TAG
SEQADV 6IR9 PRO M -1 UNP C4QZ45 EXPRESSION TAG
SEQADV 6IR9 GLY M 0 UNP C4QZ45 EXPRESSION TAG
SEQADV 6IR9 MET V 7 UNP C4R0E6 EXPRESSION TAG
SEQADV 6IR9 GLY W -2 UNP C4R370 EXPRESSION TAG
SEQADV 6IR9 PRO W -1 UNP C4R370 EXPRESSION TAG
SEQADV 6IR9 GLY W 0 UNP C4R370 EXPRESSION TAG
SEQADV 6IR9 GLY a -3 UNP P84243 EXPRESSION TAG
SEQADV 6IR9 SER a -2 UNP P84243 EXPRESSION TAG
SEQADV 6IR9 HIS a -1 UNP P84243 EXPRESSION TAG
SEQADV 6IR9 GLY b -3 UNP P62805 EXPRESSION TAG
SEQADV 6IR9 SER b -2 UNP P62805 EXPRESSION TAG
SEQADV 6IR9 HIS b -1 UNP P62805 EXPRESSION TAG
SEQADV 6IR9 GLY c -3 UNP P04908 EXPRESSION TAG
SEQADV 6IR9 SER c -2 UNP P04908 EXPRESSION TAG
SEQADV 6IR9 HIS c -1 UNP P04908 EXPRESSION TAG
SEQADV 6IR9 GLY d -6 UNP P06899 EXPRESSION TAG
SEQADV 6IR9 SER d -5 UNP P06899 EXPRESSION TAG
SEQADV 6IR9 HIS d -4 UNP P06899 EXPRESSION TAG
SEQADV 6IR9 GLY e -3 UNP P84243 EXPRESSION TAG
SEQADV 6IR9 SER e -2 UNP P84243 EXPRESSION TAG
SEQADV 6IR9 HIS e -1 UNP P84243 EXPRESSION TAG
SEQADV 6IR9 GLY f -3 UNP P62805 EXPRESSION TAG
SEQADV 6IR9 SER f -2 UNP P62805 EXPRESSION TAG
SEQADV 6IR9 HIS f -1 UNP P62805 EXPRESSION TAG
SEQADV 6IR9 GLY g -3 UNP P04908 EXPRESSION TAG
SEQADV 6IR9 SER g -2 UNP P04908 EXPRESSION TAG
SEQADV 6IR9 HIS g -1 UNP P04908 EXPRESSION TAG
SEQADV 6IR9 GLY h -6 UNP P06899 EXPRESSION TAG
SEQADV 6IR9 SER h -5 UNP P06899 EXPRESSION TAG
SEQADV 6IR9 HIS h -4 UNP P06899 EXPRESSION TAG
SEQRES 1 A 1743 MET SER GLN PHE PRO TYR SER SER ALA PRO LEU ARG SER
SEQRES 2 A 1743 VAL LYS GLU VAL GLN PHE GLY LEU LEU SER PRO GLU GLU
SEQRES 3 A 1743 ILE ARG ALA ILE SER VAL VAL LYS ILE GLU TYR PRO GLU
SEQRES 4 A 1743 ILE MET ASP GLU SER ARG GLN ARG PRO ARG GLU GLY GLY
SEQRES 5 A 1743 LEU ASN ASP PRO LYS LEU GLY SER ILE ASP ARG ASN PHE
SEQRES 6 A 1743 LYS CYS GLN THR CYS GLY GLU GLY MET ALA GLU CYS PRO
SEQRES 7 A 1743 GLY HIS PHE GLY HIS MET GLU LEU ALA LYS PRO VAL PHE
SEQRES 8 A 1743 HIS ILE GLY PHE ILE PRO LYS ILE LYS LYS VAL CYS GLU
SEQRES 9 A 1743 CYS ILE CYS MET ASN CYS GLY LYS LEU LEU LEU ASP GLU
SEQRES 10 A 1743 THR ASN PRO THR MET ALA GLN ALA ILE ARG ILE ARG ASP
SEQRES 11 A 1743 PRO LYS LYS ARG PHE ASN ALA VAL TRP GLN LEU CYS LYS
SEQRES 12 A 1743 THR LYS MET VAL CYS GLU ALA ASP ALA PRO VAL ASP GLU
SEQRES 13 A 1743 TYR SER GLU GLN LYS VAL VAL SER ARG GLY GLY CYS GLY
SEQRES 14 A 1743 ASN THR GLN PRO VAL VAL ARG LYS ASP GLY MET LYS LEU
SEQRES 15 A 1743 TRP GLY THR TRP LYS LYS SER GLY PHE SER ASP ARG ASP
SEQRES 16 A 1743 ALA GLN PRO GLU ARG LYS LEU LEU THR PRO GLY GLU ILE
SEQRES 17 A 1743 LEU ASN VAL PHE LYS HIS ILE SER PRO GLU ASP CYS PHE
SEQRES 18 A 1743 ARG LEU GLY PHE ASN GLU ASP TYR ALA ARG PRO GLU TRP
SEQRES 19 A 1743 MET ILE ILE THR VAL LEU PRO VAL PRO PRO PRO GLN VAL
SEQRES 20 A 1743 ARG PRO SER ILE ALA MET ASP GLU THR THR GLN GLY GLN
SEQRES 21 A 1743 ASP ASP LEU THR HIS LYS LEU SER ASP ILE LEU LYS ALA
SEQRES 22 A 1743 ASN ILE ASN VAL GLN LYS LEU GLU MET ASP GLY SER PRO
SEQRES 23 A 1743 GLN HIS ILE ILE ASN GLU VAL GLU GLN LEU LEU GLN PHE
SEQRES 24 A 1743 HIS VAL ALA THR TYR MET ASP ASN ASP ILE ALA GLY GLN
SEQRES 25 A 1743 PRO GLN ALA LEU GLN LYS SER GLY ARG PRO VAL LYS ALA
SEQRES 26 A 1743 ILE ARG ALA ARG LEU LYS GLY LYS GLU GLY ARG LEU ARG
SEQRES 27 A 1743 GLY ASN LEU MET GLY LYS ARG VAL ASP PHE SER ALA ARG
SEQRES 28 A 1743 THR VAL ILE SER GLY ASP PRO ASN LEU GLU LEU ASP GLN
SEQRES 29 A 1743 VAL GLY VAL PRO ILE SER ILE ALA LYS THR LEU SER TYR
SEQRES 30 A 1743 PRO GLU THR VAL THR GLN TYR ASN ILE HIS ARG LEU THR
SEQRES 31 A 1743 GLU TYR VAL ARG ASN GLY PRO ASN GLU HIS PRO GLY ALA
SEQRES 32 A 1743 LYS TYR VAL ILE ARG ASP ASN GLY ASP ARG ILE ASP LEU
SEQRES 33 A 1743 ARG TYR HIS LYS ARG ALA GLY ASP ILE VAL LEU GLN TYR
SEQRES 34 A 1743 GLY TRP LYS VAL GLU ARG HIS LEU MET ASP ASP ASP PRO
SEQRES 35 A 1743 VAL LEU PHE ASN ARG GLN PRO SER LEU HIS LYS MET SER
SEQRES 36 A 1743 MET MET ALA HIS ARG VAL LYS VAL MET PRO TYR SER THR
SEQRES 37 A 1743 PHE ARG LEU ASN LEU SER VAL THR SER PRO TYR ASN ALA
SEQRES 38 A 1743 ASP PHE ASP GLY ASP GLU MET ASN LEU HIS VAL PRO GLN
SEQRES 39 A 1743 SER GLU GLU THR ARG ALA GLU LEU SER GLN LEU CYS ALA
SEQRES 40 A 1743 VAL PRO LEU GLN ILE VAL SER PRO GLN SER ASN LYS PRO
SEQRES 41 A 1743 VAL MET GLY ILE VAL GLN ASP THR LEU CYS GLY VAL ARG
SEQRES 42 A 1743 LYS MET THR LEU ARG ASP THR PHE ILE GLU TYR GLU GLN
SEQRES 43 A 1743 VAL MET ASN MET LEU PHE TRP VAL PRO SER TRP ASP GLY
SEQRES 44 A 1743 VAL VAL PRO GLN PRO ALA ILE LEU LYS PRO LYS PRO LEU
SEQRES 45 A 1743 TRP THR GLY LYS GLN LEU LEU SER ILE ALA ILE PRO SER
SEQRES 46 A 1743 GLY ILE HIS LEU GLN ARG THR ASP GLY GLY ASN SER LEU
SEQRES 47 A 1743 LEU SER PRO LYS ASP ASN GLY MET LEU ILE VAL ASP GLY
SEQRES 48 A 1743 LYS VAL MET PHE GLY VAL VAL ASP LYS LYS THR VAL GLY
SEQRES 49 A 1743 SER GLY GLY GLY GLY LEU ILE HIS THR VAL MET ARG GLU
SEQRES 50 A 1743 LYS GLY PRO LYS ILE CYS ALA GLU LEU PHE GLY ASN ILE
SEQRES 51 A 1743 GLN LYS VAL VAL ASN TYR TRP LEU LEU HIS ASN GLY PHE
SEQRES 52 A 1743 SER ILE GLY ILE GLY ASP ALA ILE ALA ASP ALA SER THR
SEQRES 53 A 1743 MET LYS GLU ILE THR HIS ALA ILE SER SER ALA LYS GLU
SEQRES 54 A 1743 GLN VAL GLN GLU ILE ILE TYR LYS ALA GLN HIS ASN GLU
SEQRES 55 A 1743 LEU GLU LEU LYS PRO GLY MET THR LEU ARG GLU SER PHE
SEQRES 56 A 1743 GLU GLY GLU VAL SER ARG THR LEU ASN ASP ALA ARG ASP
SEQRES 57 A 1743 SER ALA GLY ARG SER ALA GLU MET ASN LEU LYS ASP LEU
SEQRES 58 A 1743 ASN ASN VAL LYS GLN MET VAL SER ALA GLY SER LYS GLY
SEQRES 59 A 1743 SER PHE ILE ASN ILE ALA GLN MET SER ALA CYS VAL GLY
SEQRES 60 A 1743 GLN GLN MET VAL GLU GLY LYS ARG ILE ALA PHE GLY PHE
SEQRES 61 A 1743 ALA ASP ARG SER LEU PRO HIS PHE THR LYS ASP ASP PHE
SEQRES 62 A 1743 SER PRO GLU SER LYS GLY PHE VAL GLU ASN SER TYR LEU
SEQRES 63 A 1743 ARG GLY LEU THR PRO GLN GLU PHE PHE PHE HIS ALA MET
SEQRES 64 A 1743 ALA GLY ARG GLU GLY LEU ILE ASP THR ALA VAL LYS THR
SEQRES 65 A 1743 ALA GLU THR GLY TYR ILE GLN ARG ARG LEU VAL LYS ALA
SEQRES 66 A 1743 LEU GLU ASP ILE MET VAL HIS TYR ASP GLY THR THR ARG
SEQRES 67 A 1743 ASN SER LEU GLY ASP ILE ILE GLN PHE LEU TYR GLY GLU
SEQRES 68 A 1743 ASP GLY LEU ASP GLY THR GLN VAL GLU ARG GLN THR ILE
SEQRES 69 A 1743 ASP THR ILE PRO GLY SER ASP LYS ALA PHE HIS LYS ARG
SEQRES 70 A 1743 TYR TYR VAL ASP LEU MET ASP GLU LYS ASN SER ILE LYS
SEQRES 71 A 1743 PRO ASP VAL ILE GLU TYR ALA ALA ASP ILE LEU GLY ASP
SEQRES 72 A 1743 VAL GLU LEU GLN LYS GLU LEU ASN SER GLU TYR GLU GLN
SEQRES 73 A 1743 LEU VAL SER ASP ARG LYS PHE LEU ARG GLU ILE VAL PHE
SEQRES 74 A 1743 VAL ASN GLY ASP HIS ASN TRP PRO LEU PRO VAL ASN LEU
SEQRES 75 A 1743 ARG ARG ILE ILE GLN ASN ALA GLN GLN ILE PHE HIS LEU
SEQRES 76 A 1743 ASP ARG ALA LYS ALA SER ASP LEU THR ILE PRO GLU ILE
SEQRES 77 A 1743 ILE HIS GLY VAL ARG ASP LEU CYS LYS LYS LEU PHE VAL
SEQRES 78 A 1743 LEU ARG GLY GLU ASN GLU LEU ILE LYS GLU ALA GLN GLN
SEQRES 79 A 1743 ASN ALA THR SER LEU PHE GLN CYS LEU VAL ARG ALA ARG
SEQRES 80 A 1743 LEU ALA THR ARG ARG ILE LEU GLU GLU PHE ARG LEU ASN
SEQRES 81 A 1743 ARG ASP ALA PHE GLU TRP VAL LEU GLY THR ILE GLU ALA
SEQRES 82 A 1743 GLN PHE GLN ARG SER LEU VAL HIS PRO GLY GLU MET VAL
SEQRES 83 A 1743 GLY VAL ILE ALA ALA GLN SER ILE GLY GLU PRO ALA THR
SEQRES 84 A 1743 GLN MET THR LEU ASN THR PHE HIS TYR ALA GLY VAL SER
SEQRES 85 A 1743 SER LYS ASN VAL THR LEU GLY VAL PRO ARG LEU LYS GLU
SEQRES 86 A 1743 ILE LEU ASN VAL ALA LYS ASN ILE LYS THR PRO ALA LEU
SEQRES 87 A 1743 THR VAL TYR LEU ASP ARG GLU ILE ALA LEU ASP ILE GLU
SEQRES 88 A 1743 LYS ALA LYS VAL ILE GLN SER SER ILE GLU TYR THR THR
SEQRES 89 A 1743 LEU LYS ASN VAL THR SER ALA THR GLU ILE TYR TYR ASP
SEQRES 90 A 1743 PRO ASP PRO THR SER THR VAL ILE GLU GLU ASP PHE ASP
SEQRES 91 A 1743 THR VAL GLU ALA TYR PHE SER ILE PRO ASP GLU LYS VAL
SEQRES 92 A 1743 GLU GLU THR ILE ASP LYS GLN SER PRO TRP LEU LEU ARG
SEQRES 93 A 1743 LEU GLU LEU ASP ARG ALA ARG MET LEU ASP LYS GLN LEU
SEQRES 94 A 1743 THR MET ASN GLN VAL ALA ASP LYS ILE SER GLU VAL PHE
SEQRES 95 A 1743 SER ASP ASP LEU PHE VAL MET TRP SER GLU ASP ASN ALA
SEQRES 96 A 1743 ASP LYS LEU ILE ILE ARG CYS ARG VAL ILE ARG ASP PRO
SEQRES 97 A 1743 LYS ALA MET ASP GLU GLU LEU GLU ALA GLU GLU ASP GLN
SEQRES 98 A 1743 MET LEU LYS ARG ILE GLU ALA HIS MET LEU ASP LEU ILE
SEQRES 99 A 1743 ALA LEU ARG GLY ILE PRO GLY ILE SER LYS VAL TYR MET
SEQRES 100 A 1743 VAL LYS HIS LYS VAL SER VAL PRO ASP GLU SER GLY GLU
SEQRES 101 A 1743 TYR LYS ASN GLU GLU LEU TRP ALA LEU GLU THR ASP GLY
SEQRES 102 A 1743 ILE ASN LEU ALA GLU VAL MET ALA VAL PRO GLY VAL ASP
SEQRES 103 A 1743 SER SER ARG THR TYR SER ASN SER PHE VAL GLU ILE LEU
SEQRES 104 A 1743 SER VAL LEU GLY ILE GLU ALA THR ARG SER SER LEU TYR
SEQRES 105 A 1743 LYS GLU ILE LEU ASN VAL ILE ALA PHE ASP GLY SER TYR
SEQRES 106 A 1743 VAL ASN TYR ARG HIS MET ALA LEU LEU VAL ASP VAL MET
SEQRES 107 A 1743 THR SER ARG GLY TYR LEU MET ALA ILE THR ARG HIS GLY
SEQRES 108 A 1743 ILE ASN ARG ALA ASP THR GLY ALA LEU MET ARG CYS SER
SEQRES 109 A 1743 PHE GLU GLU THR VAL GLU ILE LEU PHE GLU ALA GLY ALA
SEQRES 110 A 1743 ALA ALA GLU LEU ASP ASP CYS ARG GLY VAL SER GLU ASN
SEQRES 111 A 1743 VAL MET LEU GLY GLN LEU ALA PRO MET GLY THR GLY ALA
SEQRES 112 A 1743 PHE ASP VAL MET ILE ASP GLU LYS LEU LEU THR SER LEU
SEQRES 113 A 1743 PRO ALA ASP TYR ALA PRO THR MET PRO LEU PHE LYS GLY
SEQRES 114 A 1743 LYS ALA THR GLN GLY SER ALA THR PRO TYR ASP ASN ASN
SEQRES 115 A 1743 ALA GLN TYR ASP ASP GLU PHE ASN HIS ASP ASP VAL ALA
SEQRES 116 A 1743 ASP VAL MET PHE SER PRO MET ALA GLU THR GLY SER GLY
SEQRES 117 A 1743 ASP ASP ARG SER GLY GLY LEU THR GLU TYR ALA GLY ILE
SEQRES 118 A 1743 GLN SER PRO TYR GLN PRO THR SER PRO GLY LEU SER ALA
SEQRES 119 A 1743 THR SER PRO GLY PHE ALA PRO THR SER PRO GLY PHE ALA
SEQRES 120 A 1743 PRO THR SER PRO ARG TYR SER PRO THR SER PRO GLY TYR
SEQRES 121 A 1743 SER PRO THR SER PRO SER TYR SER PRO THR SER PRO SER
SEQRES 122 A 1743 TYR SER PRO THR SER PRO SER TYR SER PRO THR SER PRO
SEQRES 123 A 1743 SER TYR SER PRO THR SER PRO SER TYR SER PRO THR SER
SEQRES 124 A 1743 PRO SER TYR SER PRO THR SER PRO SER TYR SER PRO THR
SEQRES 125 A 1743 SER PRO SER TYR SER PRO THR SER PRO SER TYR SER PRO
SEQRES 126 A 1743 THR SER PRO GLN TYR SER PRO THR SER PRO GLN TYR SER
SEQRES 127 A 1743 PRO THR SER PRO GLN TYR SER PRO THR SER PRO GLN TYR
SEQRES 128 A 1743 SER PRO THR SER PRO GLN TYR SER PRO THR SER PRO GLN
SEQRES 129 A 1743 TYR SER PRO THR SER PRO GLN TYR SER PRO THR SER PRO
SEQRES 130 A 1743 GLN TYR SER PRO THR SER PRO GLN TYR SER PRO THR SER
SEQRES 131 A 1743 PRO GLN TYR SER PRO THR SER PRO GLN TYR SER PRO THR
SEQRES 132 A 1743 SER PRO GLN TYR SER PRO THR SER PRO GLN TYR SER PRO
SEQRES 133 A 1743 THR SER PRO GLN TYR SER PRO ALA SER PRO GLN TYR SER
SEQRES 134 A 1743 PRO SER ARG HIS SER PRO ASN GLY GLU SER LYS GLU GLY
SEQRES 135 A 1743 GLU
SEQRES 1 B 1227 MET SER TYR ASP PRO TYR SER ILE ASP ASP THR ILE THR
SEQRES 2 B 1227 THR GLU ASP CYS TRP THR VAL ILE SER ALA PHE PHE GLU
SEQRES 3 B 1227 GLU LYS GLY LEU VAL SER GLN GLN LEU ASP SER PHE ASP
SEQRES 4 B 1227 GLU PHE MET GLU THR SER ILE GLN ASP LEU VAL TRP GLU
SEQRES 5 B 1227 GLU PRO ARG LEU ILE LEU ASP GLN PRO ALA GLN HIS THR
SEQRES 6 B 1227 ASN GLU LYS ASP ASN ILE ASN LYS ARG TYR GLU ILE ARG
SEQRES 7 B 1227 PHE GLY LYS ILE TYR LEU SER ARG PRO THR MET THR GLU
SEQRES 8 B 1227 ALA ASP GLY THR THR HIS ALA MET PHE PRO GLN GLU ALA
SEQRES 9 B 1227 ARG LEU ARG ASN LEU THR TYR SER SER PRO VAL TYR LEU
SEQRES 10 B 1227 ASP MET GLU LYS SER MET PHE THR SER ILE ASP ASP GLU
SEQRES 11 B 1227 GLY ASN PRO ASN ALA THR LEU ASP TRP GLN GLN VAL HIS
SEQRES 12 B 1227 GLU PRO ILE LYS ASP GLY VAL GLU GLU GLY ASN LYS VAL
SEQRES 13 B 1227 HIS ILE GLY LYS VAL PRO ILE MET LEU ARG SER LYS PHE
SEQRES 14 B 1227 CYS SER LEU ARG THR LEU ASP GLU VAL ASP LEU TYR LYS
SEQRES 15 B 1227 MET LYS GLU CYS PRO TYR ASP MET GLY GLY TYR PHE VAL
SEQRES 16 B 1227 ILE ASN GLY SER GLU LYS VAL LEU ILE ALA GLN GLU ARG
SEQRES 17 B 1227 SER ALA ALA ASN ILE VAL GLN VAL PHE LYS LYS ALA ALA
SEQRES 18 B 1227 PRO SER PRO ILE SER HIS VAL ALA GLU ILE ARG SER ALA
SEQRES 19 B 1227 LEU GLU LYS GLY SER ARG LEU ILE SER THR MET GLN ILE
SEQRES 20 B 1227 LYS LEU TYR GLY ARG GLU ASP LYS GLY THR GLY ARG THR
SEQRES 21 B 1227 ILE LYS ALA THR LEU PRO TYR VAL LYS GLN ASP ILE PRO
SEQRES 22 B 1227 ILE VAL ILE VAL PHE ARG ALA LEU GLY VAL VAL PRO ASP
SEQRES 23 B 1227 GLY GLU ILE LEU GLN HIS ILE CYS TYR ASP GLU ASN ASP
SEQRES 24 B 1227 TRP GLN MET LEU GLU MET LEU LYS PRO CYS ILE GLU GLU
SEQRES 25 B 1227 GLY PHE VAL ILE GLN ASP LYS GLU VAL ALA LEU ASP PHE
SEQRES 26 B 1227 ILE GLY ARG ARG GLY SER ALA ALA LEU GLY ILE ARG ARG
SEQRES 27 B 1227 GLU LYS ARG ILE GLN TYR ALA LYS ASP ILE LEU GLN LYS
SEQRES 28 B 1227 GLU LEU LEU PRO HIS ILE THR GLN GLU GLU GLY PHE GLU
SEQRES 29 B 1227 THR ARG LYS THR PHE PHE LEU GLY TYR MET VAL ASN ARG
SEQRES 30 B 1227 LEU LEU LEU CYS ALA LEU GLU ARG LYS ASP GLN ASP ASP
SEQRES 31 B 1227 ARG ASP HIS PHE GLY LYS LYS ARG LEU ASP LEU ALA GLY
SEQRES 32 B 1227 PRO LEU LEU ALA ASN LEU PHE ARG ILE LEU PHE ARG LYS
SEQRES 33 B 1227 LEU THR ARG GLU ILE TYR ARG TYR MET GLN ARG CYS ILE
SEQRES 34 B 1227 GLU THR ASP ARG ASP PHE ASN LEU ASN LEU ALA VAL LYS
SEQRES 35 B 1227 SER THR THR ILE THR SER GLY LEU LYS TYR SER LEU ALA
SEQRES 36 B 1227 THR GLY ASN TRP GLY GLU GLN LYS LYS ALA MET SER SER
SEQRES 37 B 1227 ARG ALA GLY VAL SER GLN VAL LEU ASN ARG TYR THR TYR
SEQRES 38 B 1227 SER SER THR LEU SER HIS LEU ARG ARG THR ASN THR PRO
SEQRES 39 B 1227 ILE GLY ARG ASP GLY LYS LEU ALA LYS PRO ARG GLN LEU
SEQRES 40 B 1227 HIS ASN THR HIS TRP GLY LEU VAL CYS PRO ALA GLU THR
SEQRES 41 B 1227 PRO GLU GLY GLN ALA CYS GLY LEU VAL LYS ASN LEU SER
SEQRES 42 B 1227 LEU LEU SER GLY ILE SER ILE GLY SER PRO SER GLU PRO
SEQRES 43 B 1227 ILE ILE ASN PHE LEU GLU GLU TRP GLY MET GLU PRO LEU
SEQRES 44 B 1227 GLU ASP TYR ASP PRO ALA GLN HIS THR LYS SER THR ARG
SEQRES 45 B 1227 ILE PHE VAL ASN GLY VAL TRP THR GLY ILE HIS ARG ASP
SEQRES 46 B 1227 PRO SER MET LEU VAL SER THR MET ARG ASP LEU ARG ARG
SEQRES 47 B 1227 SER GLY ALA ILE SER PRO GLU VAL SER ILE ILE ARG ASP
SEQRES 48 B 1227 ILE ARG GLU ARG GLU PHE LYS ILE PHE THR ASP VAL GLY
SEQRES 49 B 1227 ARG VAL TYR ARG PRO LEU PHE ILE VAL GLU ASP ASP GLU
SEQRES 50 B 1227 SER LYS ASP ASN LYS GLY GLU LEU ARG ILE THR LYS GLU
SEQRES 51 B 1227 HIS ILE ARG LYS ILE GLN GLN GLY TYR ASP ASP ASP ALA
SEQRES 52 B 1227 MET ASN ASP ASP SER GLU GLU GLN GLU GLN ASP VAL TYR
SEQRES 53 B 1227 GLY TRP SER SER LEU VAL THR SER GLY VAL ILE GLU TYR
SEQRES 54 B 1227 VAL ASP GLY GLU GLU GLU GLU THR ILE MET ILE ALA MET
SEQRES 55 B 1227 THR PRO GLU ASP LEU GLN THR ARG SER LEU GLU GLN LYS
SEQRES 56 B 1227 GLU ILE ASP LEU ASN ASP THR ALA LYS ARG ILE LYS PRO
SEQRES 57 B 1227 GLU MET SER THR SER SER HIS HIS THR PHE THR HIS CYS
SEQRES 58 B 1227 GLU ILE HIS PRO SER MET ILE LEU GLY VAL ALA ALA SER
SEQRES 59 B 1227 ILE ILE PRO PHE PRO ASP HIS ASN GLN SER PRO ARG ASN
SEQRES 60 B 1227 THR TYR GLN SER ALA MET GLY LYS GLN ALA MET GLY VAL
SEQRES 61 B 1227 PHE LEU THR ASN TYR ASN VAL ARG MET ASP THR MET ALA
SEQRES 62 B 1227 ASN ILE LEU TYR TYR PRO GLN LYS PRO LEU ALA LYS THR
SEQRES 63 B 1227 GLN ALA MET GLU TYR LEU LYS PHE ARG GLU LEU PRO ALA
SEQRES 64 B 1227 GLY GLN ASN ALA ILE VAL ALA ILE ALA CYS TYR SER GLY
SEQRES 65 B 1227 TYR ASN GLN GLU ASP SER MET ILE MET ASN GLN SER SER
SEQRES 66 B 1227 ILE ASP ARG GLY LEU PHE ARG SER LEU PHE PHE ARG SER
SEQRES 67 B 1227 TYR MET ASP GLN GLU LYS ARG PHE GLY ILE SER ILE VAL
SEQRES 68 B 1227 GLU GLU PHE GLU LYS PRO THR ARG ALA THR THR LEU ARG
SEQRES 69 B 1227 LEU LYS HIS GLY THR TYR GLU LYS LEU ASP GLU ASP GLY
SEQRES 70 B 1227 LEU ILE ALA PRO GLY VAL ARG VAL SER GLY ASP ASP ILE
SEQRES 71 B 1227 ILE ILE GLY LYS THR THR PRO ILE PRO PRO ASP THR GLU
SEQRES 72 B 1227 GLU LEU GLY GLN ARG THR LYS TYR HIS THR LYS ARG ASP
SEQRES 73 B 1227 ALA SER THR PRO LEU ARG SER THR GLU ASN GLY ILE VAL
SEQRES 74 B 1227 ASP GLN VAL LEU LEU THR THR ASN GLN GLU GLY LEU LYS
SEQRES 75 B 1227 PHE VAL LYS VAL ARG MET ARG THR THR LYS VAL PRO GLN
SEQRES 76 B 1227 ILE GLY ASP LYS PHE ALA SER ARG HIS GLY GLN LYS GLY
SEQRES 77 B 1227 THR ILE GLY VAL THR TYR ARG HIS GLU ASP MET PRO PHE
SEQRES 78 B 1227 SER ALA GLU GLY ILE VAL PRO ASP LEU ILE ILE ASN PRO
SEQRES 79 B 1227 HIS ALA ILE PRO SER ARG MET THR VAL ALA HIS LEU ILE
SEQRES 80 B 1227 GLU CYS LEU LEU SER LYS VAL GLY SER ILE ARG GLY TYR
SEQRES 81 B 1227 GLU GLY ASP ALA THR PRO PHE THR ASP LEU THR VAL ASP
SEQRES 82 B 1227 ALA VAL SER ASN LEU LEU ARG ASP ASN GLY TYR GLN SER
SEQRES 83 B 1227 ARG GLY PHE GLU VAL MET TYR ASN GLY HIS THR GLY LYS
SEQRES 84 B 1227 LYS LEU MET ALA GLN VAL PHE PHE GLY PRO THR TYR TYR
SEQRES 85 B 1227 GLN ARG LEU ARG HIS MET VAL ASP ASP LYS ILE HIS ALA
SEQRES 86 B 1227 ARG ALA ARG GLY PRO VAL GLN VAL LEU THR ARG GLN PRO
SEQRES 87 B 1227 VAL GLU GLY ARG SER ARG ASP GLY GLY LEU ARG PHE GLY
SEQRES 88 B 1227 GLU MET GLU ARG ASP CYS MET ILE ALA HIS GLY ALA ALA
SEQRES 89 B 1227 GLY PHE LEU LYS GLU ARG LEU MET GLU ALA SER ASP ALA
SEQRES 90 B 1227 PHE ARG VAL HIS VAL CYS GLY ILE CYS GLY LEU MET SER
SEQRES 91 B 1227 VAL ILE ALA ASN LEU LYS LYS ASN GLN PHE GLU CYS ARG
SEQRES 92 B 1227 SER CYS LYS ASN LYS THR ASN ILE TYR GLN LEU HIS ILE
SEQRES 93 B 1227 PRO TYR ALA ALA LYS LEU LEU PHE GLN GLU LEU MET ALA
SEQRES 94 B 1227 MET ASN ILE ALA PRO ARG LEU TYR THR GLU ARG SER GLY
SEQRES 95 B 1227 VAL SER MET ARG SER
SEQRES 1 C 304 MET SER LYS GLU PRO LYS VAL ASN ILE ILE ASN ALA GLN
SEQRES 2 C 304 ASP ASP GLU VAL GLU LEU MET LEU SER ASP VAL ASN LEU
SEQRES 3 C 304 SER LEU ALA ASN SER LEU ARG ARG THR MET LEU ALA GLU
SEQRES 4 C 304 VAL PRO THR LEU ALA ILE ASP LEU VAL GLU ILE LYS MET
SEQRES 5 C 304 ASN THR SER VAL LEU ALA ASP GLU PHE ILE SER HIS ARG
SEQRES 6 C 304 LEU GLY LEU ILE PRO LEU VAL SER GLU ASP VAL GLU GLU
SEQRES 7 C 304 MET LYS TYR SER ARG ASP CYS THR CYS GLU ASP TYR CYS
SEQRES 8 C 304 ASP GLU CYS SER VAL VAL LEU GLU LEU SER ALA ARG HIS
SEQRES 9 C 304 GLU GLY GLU GLU GLY THR THR ASP VAL TYR SER SER SER
SEQRES 10 C 304 LEU ILE LYS VAL SER GLY PRO GLY ASN LEU ASN VAL GLY
SEQRES 11 C 304 GLU PRO VAL ARG ARG ASP ASP TYR ASP GLN GLY ILE LEU
SEQRES 12 C 304 LEU CYS LYS LEU ARG ASN HIS GLN GLU LEU ASN ILE ARG
SEQRES 13 C 304 CYS ILE ALA LYS LYS GLY ILE ALA LYS GLU HIS ALA LYS
SEQRES 14 C 304 TRP SER PRO CYS SER ALA ILE ALA PHE GLU TYR ASP PRO
SEQRES 15 C 304 HIS ASN LYS LEU LYS HIS THR ASP PHE TRP PHE GLU VAL
SEQRES 16 C 304 ASP ALA LYS LYS GLU TRP PRO ASP SER LYS TYR ALA THR
SEQRES 17 C 304 TRP GLU GLU PRO PRO LYS PRO GLY GLU VAL PHE ASP TYR
SEQRES 18 C 304 LYS ALA LYS PRO ASN ARG PHE TYR MET THR VAL GLU THR
SEQRES 19 C 304 THR GLY SER LEU LYS ALA ASN GLN VAL PHE SER ARG GLY
SEQRES 20 C 304 ILE LYS THR LEU GLN GLU LYS LEU ALA ASN VAL LEU PHE
SEQRES 21 C 304 GLU LEU GLU ASN SER ARG PRO ALA ASN THR THR ALA TYR
SEQRES 22 C 304 GLY GLY ALA THR ALA TYR GLY GLY GLN THR VAL TYR GLY
SEQRES 23 C 304 ARG GLU THR SER TYR GLY GLY ASN THR ASN TYR GLY ASP
SEQRES 24 C 304 TYR ASN ALA PRO TYR
SEQRES 1 D 186 MET ASN VAL SER THR SER THR VAL GLY ALA ARG ARG ARG
SEQRES 2 D 186 ARG ALA LYS GLN GLN VAL ASP ASP GLU GLU ASN ALA THR
SEQRES 3 D 186 LEU LEU ARG LEU GLY PRO GLU PHE ALA LEU LYS GLN TYR
SEQRES 4 D 186 ASP HIS ASP GLY ASN GLU HIS ASP LEU ILE ALA LEU SER
SEQRES 5 D 186 LEU SER GLU SER ARG LEU LEU ILE ARG GLU ALA LEU LYS
SEQRES 6 D 186 ALA ARG SER ARG ALA ARG ASN GLY GLY VAL ASP ILE GLU
SEQRES 7 D 186 SER SER ASN GLY GLU ILE ASP ASP ASP GLU LEU ALA LYS
SEQRES 8 D 186 VAL THR SER GLY ALA VAL ALA ASN GLY VAL VAL LYS LYS
SEQRES 9 D 186 THR LEU ASP TYR LEU ASN THR PHE ALA ARG PHE LYS ASP
SEQRES 10 D 186 GLU GLU THR CYS THR ALA VAL ASP GLN LEU LEU HIS ASN
SEQRES 11 D 186 SER SER ASP CYS SER VAL LEU HIS PRO PHE GLU ILE ALA
SEQRES 12 D 186 GLN LEU SER SER LEU GLY CYS GLU ASP VAL ASP GLU ALA
SEQRES 13 D 186 ILE THR LEU ILE PRO SER LEU ALA ALA LYS LYS GLU VAL
SEQRES 14 D 186 ASN LEU GLN ARG ILE LEU ASP GLU LEU ASN ARG LEU GLU
SEQRES 15 D 186 ASP PRO TYR LYS
SEQRES 1 E 214 MET GLU ASP ASN ASN ARG ILE ILE SER ARG LEU TRP ARG
SEQRES 2 E 214 SER PHE ARG THR VAL LYS GLU MET ALA ALA ASP ARG GLY
SEQRES 3 E 214 TYR PHE ILE SER GLN GLU GLU MET ASP GLN SER LEU GLU
SEQRES 4 E 214 GLU PHE ARG SER LYS ILE CYS ASP SER MET GLY ASN PRO
SEQRES 5 E 214 GLN ARG LYS LEU MET SER PHE LEU ALA ASN PRO THR PRO
SEQRES 6 E 214 GLU ALA LEU GLU LYS TYR SER ASP LEU GLY THR LEU TRP
SEQRES 7 E 214 VAL GLU PHE CYS ASP GLU PRO SER VAL GLY ILE LYS THR
SEQRES 8 E 214 MET ARG ASN PHE CYS LEU ARG ILE GLN GLU LYS ASN PHE
SEQRES 9 E 214 SER THR GLY ILE PHE ILE TYR GLN ASN ASN ILE THR PRO
SEQRES 10 E 214 SER ALA ASN LYS MET ILE PRO THR VAL SER PRO ALA ILE
SEQRES 11 E 214 ILE GLU THR PHE GLN GLU SER ASP LEU VAL VAL ASN ILE
SEQRES 12 E 214 THR HIS HIS GLU LEU VAL PRO LYS HIS ILE ARG LEU SER
SEQRES 13 E 214 ASP GLY GLU LYS SER GLN LEU LEU GLN ARG TYR LYS LEU
SEQRES 14 E 214 LYS GLU SER GLN LEU PRO ARG ILE GLN ARG GLU ASP PRO
SEQRES 15 E 214 VAL ALA ARG TYR LEU GLY LEU LYS ARG GLY GLN VAL VAL
SEQRES 16 E 214 LYS ILE ILE ARG ARG SER GLU THR SER GLY ARG TYR ALA
SEQRES 17 E 214 SER TYR ARG ILE CYS LEU
SEQRES 1 F 155 MET SER GLU ASP GLU ALA PHE ASN GLU GLN THR GLU ASN
SEQRES 2 F 155 PHE GLU ASN PHE GLU ASP GLU HIS PHE SER ASP ASP ASN
SEQRES 3 F 155 PHE GLU ASP ARG SER THR GLN PRO GLU ASP TYR ALA VAL
SEQRES 4 F 155 GLY VAL THR ALA ASP GLY ARG GLN ILE ILE ASN GLY ASP
SEQRES 5 F 155 GLY ILE GLN GLU VAL ASN GLY THR ILE LYS ALA HIS ARG
SEQRES 6 F 155 LYS ARG SER ASN LYS GLU LEU ALA ILE LEU LYS GLU GLU
SEQRES 7 F 155 ARG THR THR THR PRO TYR LEU THR LYS TYR GLU ARG ALA
SEQRES 8 F 155 ARG ILE LEU GLY THR ARG ALA LEU GLN ILE SER MET ASN
SEQRES 9 F 155 ALA PRO VAL LEU VAL ASP ILE GLU GLY GLU THR ASP PRO
SEQRES 10 F 155 LEU GLN ILE ALA MET LYS GLU LEU SER GLN ARG LYS ILE
SEQRES 11 F 155 PRO LEU VAL ILE ARG ARG TYR LEU PRO ASP GLY SER TYR
SEQRES 12 F 155 GLU ASP TRP GLY CYS ASP GLU LEU ILE VAL ASP ASN
SEQRES 1 G 171 MET PHE PHE LEU LYS ASP LEU SER LEU ILE LEU THR LEU
SEQRES 2 G 171 HIS PRO SER TYR PHE GLY PRO GLN MET ASN GLN TYR LEU
SEQRES 3 G 171 ARG GLU LYS LEU LEU THR ASP VAL GLU GLY THR CYS THR
SEQRES 4 G 171 GLY GLN PHE GLY TYR ILE VAL THR VAL LEU ASP GLY MET
SEQRES 5 G 171 ASN ILE ASP VAL GLY LYS GLY ARG ILE ILE PRO GLY SER
SEQRES 6 G 171 GLY SER ALA GLU PHE GLU VAL LYS TYR ARG ALA VAL VAL
SEQRES 7 G 171 TRP LYS PRO PHE LYS GLY GLU VAL VAL ASP ALA ILE VAL
SEQRES 8 G 171 SER ASN VAL SER PRO ILE GLY PHE PHE ALA ASP VAL GLY
SEQRES 9 G 171 PRO LEU ASN VAL PHE VAL SER THR ARG LEU ILE PRO ASP
SEQRES 10 G 171 ASN LEU VAL TYR ASN PRO SER ASN SER PRO PRO ALA TYR
SEQRES 11 G 171 MET SER ASN ASP GLU LEU ILE THR LYS GLY SER LYS VAL
SEQRES 12 G 171 ARG LEU LYS VAL VAL GLY THR ARG THR ASP VAL ASN GLU
SEQRES 13 G 171 ILE TYR ALA ILE GLY SER ILE LYS GLU ASP PHE LEU GLY
SEQRES 14 G 171 ALA ILE
SEQRES 1 H 145 MET SER SER ALA LEU PHE ASP ASP ILE PHE THR VAL GLN
SEQRES 2 H 145 THR VAL ASP ASN GLY ARG TYR ASN LYS VAL SER ARG ILE
SEQRES 3 H 145 ILE GLY ILE SER THR THR ASN SER ALA ILE LYS LEU THR
SEQRES 4 H 145 LEU ASP ILE ASN ASN GLU MET PHE PRO VAL SER GLN ASP
SEQRES 5 H 145 ASP SER LEU THR VAL THR LEU ALA ASN SER LEU SER LEU
SEQRES 6 H 145 ASP GLY GLU ASP GLU SER ALA ASN PHE SER LYS SER TRP
SEQRES 7 H 145 ARG PRO PRO LYS PRO THR ASP LYS SER LEU ALA ASP ASP
SEQRES 8 H 145 TYR ASP TYR VAL MET PHE GLY THR VAL TYR LYS PHE GLU
SEQRES 9 H 145 GLU GLY ASP GLU ASP LYS ILE LYS VAL TYR VAL SER PHE
SEQRES 10 H 145 GLY GLY LEU LEU MET CYS LEU GLU GLY GLY TYR LYS SER
SEQRES 11 H 145 LEU ALA SER LEU LYS GLN ASP ASN LEU TYR ILE LEU ILE
SEQRES 12 H 145 ARG ARG
SEQRES 1 I 115 MET ALA SER PHE ARG PHE CYS LEU GLU CYS ASN ASN MET
SEQRES 2 I 115 LEU TYR PRO LYS GLU ASP LYS GLU ASN GLN ARG LEU LEU
SEQRES 3 I 115 TYR SER CYS ARG ASN CYS ASP TYR THR GLU LEU ALA GLU
SEQRES 4 I 115 ASP PRO LYS VAL TYR ARG HIS GLU LEU ILE THR ASN ILE
SEQRES 5 I 115 GLY GLU THR ALA GLY ILE VAL ASP ASP ILE GLY GLN ASP
SEQRES 6 I 115 PRO THR LEU PRO ARG SER ASP LYS GLU CYS PRO GLU CYS
SEQRES 7 I 115 HIS SER ARG ASP CYS VAL PHE PHE GLN SER GLN GLN ARG
SEQRES 8 I 115 ARG LYS ASP THR ASN MET THR LEU PHE TYR VAL CYS LEU
SEQRES 9 I 115 ASN CYS LYS LYS THR PHE ARG ASP GLU SER GLU
SEQRES 1 J 72 MET ILE ILE PRO VAL ARG CYS PHE SER CYS GLY LYS VAL
SEQRES 2 J 72 VAL GLY ASP LYS TRP ASP ALA TYR LEU ARG LEU LEU GLU
SEQRES 3 J 72 GLU GLY LYS GLN GLU GLY ASP ALA LEU ASP GLU LEU LYS
SEQRES 4 J 72 LEU LYS ARG TYR CYS CYS ARG ARG MET VAL LEU THR HIS
SEQRES 5 J 72 VAL ASP LEU ILE GLU LYS PHE LEU ARG TYR ASN PRO LEU
SEQRES 6 J 72 GLU LYS LYS ASP PHE ASP SER
SEQRES 1 K 118 MET ASN ALA PRO ASP ARG PHE GLU LEU PHE ILE LEU PRO
SEQRES 2 K 118 ASP ASP VAL PRO LYS LEU LYS ILE THR PRO ASP SER ARG
SEQRES 3 K 118 VAL PRO ASN CYS ILE ILE ILE LYS PHE GLU ARG GLU ASP
SEQRES 4 K 118 HIS THR LEU ALA ASN LEU LEU ARG GLU GLU LEU ALA LEU
SEQRES 5 K 118 TYR PRO ASP VAL THR PHE VAL ALA TYR LYS VAL GLU HIS
SEQRES 6 K 118 PRO LEU PHE ALA ASN PHE VAL MET ARG LEU GLN THR GLU
SEQRES 7 K 118 GLU GLY THR ARG PRO LYS GLN ALA LEU GLU ARG ALA CYS
SEQRES 8 K 118 ALA SER ILE ILE ASN LYS LEU LYS THR LEU ASP HIS LYS
SEQRES 9 K 118 PHE ASN GLU GLU TRP ASN ILE LYS ASN PHE SER LEU ASN
SEQRES 10 K 118 ASP
SEQRES 1 L 72 MET SER ARG GLU GLY PHE VAL ALA PRO SER GLY THR ASP
SEQRES 2 L 72 LEU ALA ALA ALA ALA SER GLY VAL ALA PRO ASN LYS HIS
SEQRES 3 L 72 TYR GLY VAL LYS TYR THR CYS GLY ALA CYS ALA HIS ASN
SEQRES 4 L 72 PHE SER LEU ASN LYS SER ASP PRO VAL ARG CYS LYS GLU
SEQRES 5 L 72 CYS GLY HIS ARG VAL ILE TYR LYS ALA ARG THR LYS ARG
SEQRES 6 L 72 MET ILE GLN PHE ASP ALA ARG
SEQRES 1 P 16 G C C U G G U G U C U U G
SEQRES 2 P 16 G G U
SEQRES 1 T 198 DA DT DC DA DG DA DA DT DC DC DC DG DG
SEQRES 2 T 198 DT DG DC DC DG DA DG DG DC DC DG DC DT
SEQRES 3 T 198 DC DA DA DT DT DG DG DT DC DG DT DA DG
SEQRES 4 T 198 DA DC DA DG DC DT DC DT DA DG DC DA DC
SEQRES 5 T 198 DC DG DC DT DT DA DA DA DC DG DC DA DC
SEQRES 6 T 198 DG DT DA DC DG DC DG DC DT DG DT DC DC
SEQRES 7 T 198 DC DC DC DG DC DG DT DT DT DT DA DA DC
SEQRES 8 T 198 DC DG DC DC DA DA DG DG DG DG DA DT DT
SEQRES 9 T 198 DA DC DA DC DC DC DA DA DG DA DC DA DC
SEQRES 10 T 198 DC DA DG DG DC DA DC DG DA DG DA DC DA
SEQRES 11 T 198 DG DA DA DA DA DA DA DA DC DA DA DC DG
SEQRES 12 T 198 DA DA DA DA DC DG DG DC DC DA DC DC DA
SEQRES 13 T 198 DC DC DC DA DA DA DC DA DC DA DC DC DA
SEQRES 14 T 198 DA DA DC DA DC DA DA DG DA DG DC DT DA
SEQRES 15 T 198 DA DT DT DG DA DC DT DG DA DC DG DT DA
SEQRES 16 T 198 DA DG DC
SEQRES 1 N 198 DG DC DT DT DA DC DG DT DC DA DG DT DC
SEQRES 2 N 198 DT DG DG DC DC DA DT DC DT DT DT DG DT
SEQRES 3 N 198 DG DT DT DT DG DG DT DG DT DG DT DT DT
SEQRES 4 N 198 DG DG DG DT DG DG DT DG DG DC DC DG DT
SEQRES 5 N 198 DT DT DT DC DG DT DT DG DT DT DT DT DT
SEQRES 6 N 198 DT DT DC DT DG DT DC DT DC DG DT DG DC
SEQRES 7 N 198 DC DT DG DG DT DG DT DC DT DT DG DG DG
SEQRES 8 N 198 DT DG DT DA DA DT DC DC DC DC DT DT DG
SEQRES 9 N 198 DG DC DG DG DT DT DA DA DA DA DC DG DC
SEQRES 10 N 198 DG DG DG DG DG DA DC DA DG DC DG DC DG
SEQRES 11 N 198 DT DA DC DG DT DG DC DG DT DT DT DA DA
SEQRES 12 N 198 DG DC DG DG DT DG DC DT DA DG DA DG DC
SEQRES 13 N 198 DT DG DT DC DT DA DC DG DA DC DC DA DA
SEQRES 14 N 198 DT DT DG DA DG DC DG DG DC DC DT DC DG
SEQRES 15 N 198 DG DC DA DC DC DG DG DG DA DT DT DC DT
SEQRES 16 N 198 DG DA DT
SEQRES 1 M 113 GLY PRO GLY MET GLY LYS ARG LYS SER SER ALA ARG LYS
SEQRES 2 M 113 PRO ALA PRO LYS ILE LYS GLN LYS LEU GLU THR GLN PHE
SEQRES 3 M 113 THR CYS LEU PHE CYS ASN HIS ASP ASN SER VAL VAL CYS
SEQRES 4 M 113 THR LEU ASP LYS LYS ASN SER ILE GLY LEU LEU GLU CYS
SEQRES 5 M 113 LYS LYS CYS ASN LEU SER PHE GLN ALA PRO ILE ASN SER
SEQRES 6 M 113 LEU SER GLN PRO ILE ASP ILE TYR SER ASP TRP ILE ASP
SEQRES 7 M 113 ALA CYS GLU ALA VAL ALA GLU GLU ASN ALA ASP VAL ASN
SEQRES 8 M 113 GLY ASP ASN PHE ILE GLU ASN ASP GLY ALA ASP ARG GLU
SEQRES 9 M 113 GLN ASP ASP ASP TYR ASP ASP GLU PHE
SEQRES 1 V 108 MET ARG GLU ARG ALA CYS MET LEU CYS GLY ILE VAL LEU
SEQRES 2 V 108 PRO GLY ARG VAL PHE MET GLN ASN GLY CYS PRO ASN CYS
SEQRES 3 V 108 ASP SER VAL LEU ASN LEU ARG ASP SER ASP GLN ALA THR
SEQRES 4 V 108 VAL ASN GLU CYS THR SER SER SER PHE GLU GLY LEU VAL
SEQRES 5 V 108 ALA VAL GLY ASP ASN GLU HIS SER TRP VAL ALA LYS TRP
SEQRES 6 V 108 LEU ARG VAL ASP ARG PHE GLN PRO GLY LEU TYR ALA VAL
SEQRES 7 V 108 ARG VAL ASP GLY ARG LEU PRO SER ASP ILE VAL ALA ALA
SEQRES 8 V 108 LEU GLU GLN TYR GLY VAL TYR TYR ARG PRO ARG ASP GLY
SEQRES 9 V 108 SER VAL ILE ASP
SEQRES 1 W 911 GLY PRO GLY MET SER GLU THR HIS LYS ASN GLN LEU ASP
SEQRES 2 W 911 LYS VAL SER THR VAL SER PRO ASP GLY PRO SER GLU ALA
SEQRES 3 W 911 VAL LYS GLU HIS SER LEU GLN SER LYS ASP LEU SER LYS
SEQRES 4 W 911 ASN ASP GLY GLN PHE ILE VAL PRO LEU ASP ARG ASN VAL
SEQRES 5 W 911 ILE GLU GLN GLU GLU HIS LYS GLN VAL LYS SER SER ALA
SEQRES 6 W 911 GLN ALA HIS ASN THR THR GLY ASP ALA ALA ASP ASN GLU
SEQRES 7 W 911 ILE GLU ASP GLY VAL PRO SER GLU ASP VAL GLU PHE ASP
SEQRES 8 W 911 LYS PHE LYS GLU ASP ASP TYR ASP GLU ASP ASP GLU VAL
SEQRES 9 W 911 GLU GLU GLU GLY ASP ILE ARG SER ARG LYS ARG ARG ARG
SEQRES 10 W 911 HIS ASN GLN PHE LEU ASP VAL GLU ALA GLU VAL ASP ASP
SEQRES 11 W 911 GLU GLU ASP ASP ASP ASP ASP ASP ASP ASP VAL GLU LEU
SEQRES 12 W 911 LYS HIS ASP PHE ILE GLN ASP ASP HIS ILE GLN HIS GLU
SEQRES 13 W 911 THR GLN ASN GLU GLY PHE ILE ALA GLY HIS VAL ASP ASP
SEQRES 14 W 911 ASP ARG LEU HIS ARG LYS LEU ASP GLN SER ARG GLU LYS
SEQRES 15 W 911 ILE ALA ASP GLN ASP ALA GLN GLU LEU ALA ASP GLU PHE
SEQRES 16 W 911 LYS GLN ARG TYR GLY ARG SER ALA SER SER LYS TYR MET
SEQRES 17 W 911 GLY SER ALA SER THR THR ALA PRO GLN ARG LEU LEU ILE
SEQRES 18 W 911 PRO THR VAL ASP ASP PRO GLY ILE TRP GLY VAL LYS VAL
SEQRES 19 W 911 ARG LEU GLY LYS GLU LYS ASP VAL VAL ARG GLN ILE LEU
SEQRES 20 W 911 LYS LYS LYS LEU ALA ARG GLU GLY THR LYS ASN PRO LEU
SEQRES 21 W 911 GLU ILE TYR SER ALA PHE GLN ARG ASP SER PHE LYS GLY
SEQRES 22 W 911 HIS VAL TYR ILE GLU ALA ARG LYS ALA GLU ALA ILE ASN
SEQRES 23 W 911 ASP ALA LEU LYS GLY ASN VAL ASN VAL PHE SER ASN ASN
SEQRES 24 W 911 SER LYS PHE LEU VAL GLY ILE VAL GLU TYR LYS ASP LEU
SEQRES 25 W 911 LEU ARG PRO VAL LYS SER SER ASP VAL LYS LEU THR ARG
SEQRES 26 W 911 GLY SER TYR VAL ARG VAL LYS ASN GLY LYS PHE LYS GLY
SEQRES 27 W 911 ASP LEU ALA GLN VAL ASP GLU VAL LEU GLU ASN GLY LEU
SEQRES 28 W 911 GLU ALA ARG LEU LYS LEU VAL PRO ARG LEU ASP TYR GLY
SEQRES 29 W 911 LYS ASP LEU SER HIS LEU SER THR SER SER SER VAL ASP
SEQRES 30 W 911 SER THR LYS ASN ARG ARG LYS PHE TYR THR SER LYS PHE
SEQRES 31 W 911 ARG PRO ALA GLN ARG LEU PHE SER GLU ALA GLU ALA ARG
SEQRES 32 W 911 VAL HIS GLU PRO THR ILE ARG ARG ASP ARG ASP GLY PHE
SEQRES 33 W 911 VAL THR TYR GLY GLY GLU GLU TYR TYR GLU GLY PHE LEU
SEQRES 34 W 911 TYR LYS THR PHE ARG LEU GLN ASN LEU ILE VAL ASN SER
SEQRES 35 W 911 ILE ASN PRO THR LEU ASN GLU LEU SER LEU PHE GLN SER
SEQRES 36 W 911 ASN GLU GLU SER THR THR ILE ASP LEU SER THR ILE ALA
SEQRES 37 W 911 ASP SER LEU LYS GLU THR ALA LYS ASN LEU VAL SER PHE
SEQRES 38 W 911 GLN PRO GLY ASP ASN VAL GLU ILE ILE ASN GLY GLU LEU
SEQRES 39 W 911 ASN HIS LEU THR GLY THR VAL SER SER VAL ASN GLN SER
SEQRES 40 W 911 THR ILE VAL SER VAL ARG LEU HIS SER ASP ASP ASP THR
SEQRES 41 W 911 ILE ASN SER GLU THR VAL GLU ILE PRO THR SER ASP LEU
SEQRES 42 W 911 ARG LYS ILE PHE ASN VAL GLY ASP HIS VAL ARG VAL ILE
SEQRES 43 W 911 HIS GLY LYS HIS THR ASP ASP THR GLY LEU ILE VAL GLU
SEQRES 44 W 911 VAL ASN GLY ASP LYS VAL GLU PHE ILE SER ASN GLN THR
SEQRES 45 W 911 LYS ARG THR VAL ILE VAL PHE SER ASN TYR LEU ILE LYS
SEQRES 46 W 911 SER THR ASP SER THR VAL SER ILE ASN GLU SER GLY ARG
SEQRES 47 W 911 PHE GLU LEU HIS ASP LEU VAL GLN VAL ASN SER ASP LEU
SEQRES 48 W 911 VAL GLY ILE VAL ILE ARG ALA GLN LYS ASP SER PHE ASP
SEQRES 49 W 911 VAL LEU CYS SER ASP GLY LYS LEU LEU SER LEU PRO PRO
SEQRES 50 W 911 VAL SER ILE TYR SER LYS LEU ASN LEU ASN PRO ASN GLN
SEQRES 51 W 911 GLN ILE ALA ILE ASP SER ASN GLY VAL GLU VAL LYS VAL
SEQRES 52 W 911 GLY ASP THR VAL ARG GLU PHE THR GLY GLU ARG ARG GLN
SEQRES 53 W 911 GLY THR ILE LEU HIS VAL TYR ARG ASN PHE LEU PHE LEU
SEQRES 54 W 911 ARG SER ARG GLU ILE VAL GLU ASN GLN GLY VAL PHE VAL
SEQRES 55 W 911 THR SER SER ASN ARG VAL LYS THR ILE THR SER LYS SER
SEQRES 56 W 911 ASN GLY THR GLY GLY GLN ILE SER GLY PRO ASP LEU SER
SEQRES 57 W 911 ARG MET ASN PRO SER ARG VAL ILE PRO PRO PRO SER ILE
SEQRES 58 W 911 PRO VAL ALA ASN GLN ARG MET THR GLY ARG ASP PRO THR
SEQRES 59 W 911 LEU ASN LYS THR VAL LYS ILE ARG GLN GLY GLY TYR LYS
SEQRES 60 W 911 GLY LYS ILE GLY ILE VAL LYS GLU ALA ASN GLY ASP ARG
SEQRES 61 W 911 PHE ARG VAL GLU LEU HIS ASN PRO ASN LYS THR ILE PRO
SEQRES 62 W 911 ILE PRO CYS SER PHE LEU LEU ILE GLU SER THR HIS GLY
SEQRES 63 W 911 TRP VAL PRO TYR GLU ASP PHE VAL ALA SER ASP ARG ARG
SEQRES 64 W 911 GLY GLY ASN ILE PRO ARG HIS GLU ILE SER GLY HIS VAL
SEQRES 65 W 911 GLN GLN PRO GLN HIS GLY ARG ALA PRO ALA TRP GLY SER
SEQRES 66 W 911 GLY GLY LYS THR PRO ALA TRP GLY SER GLY GLY LYS THR
SEQRES 67 W 911 PRO ALA TRP GLY SER GLY GLY SER GLY GLY LYS THR PRO
SEQRES 68 W 911 ALA TRP GLY SER GLY GLY LYS THR PRO THR TRP GLY SER
SEQRES 69 W 911 GLY ALA LYS THR PRO ALA TRP GLY SER GLY SER LYS THR
SEQRES 70 W 911 PRO ALA TRP SER GLY LEU ASP GLU GLU ASP ARG ARG ASP
SEQRES 71 W 911 PHE
SEQRES 1 a 139 GLY SER HIS MET ALA ARG THR LYS GLN THR ALA ARG LYS
SEQRES 2 a 139 SER THR GLY GLY LYS ALA PRO ARG LYS GLN LEU ALA THR
SEQRES 3 a 139 LYS ALA ALA ARG LYS SER ALA PRO SER THR GLY GLY VAL
SEQRES 4 a 139 LYS LYS PRO HIS ARG TYR ARG PRO GLY THR VAL ALA LEU
SEQRES 5 a 139 ARG GLU ILE ARG ARG TYR GLN LYS SER THR GLU LEU LEU
SEQRES 6 a 139 ILE ARG LYS LEU PRO PHE GLN ARG LEU VAL ARG GLU ILE
SEQRES 7 a 139 ALA GLN ASP PHE LYS THR ASP LEU ARG PHE GLN SER ALA
SEQRES 8 a 139 ALA ILE GLY ALA LEU GLN GLU ALA SER GLU ALA TYR LEU
SEQRES 9 a 139 VAL GLY LEU PHE GLU ASP THR ASN LEU CYS ALA ILE HIS
SEQRES 10 a 139 ALA LYS ARG VAL THR ILE MET PRO LYS ASP ILE GLN LEU
SEQRES 11 a 139 ALA ARG ARG ILE ARG GLY GLU ARG ALA
SEQRES 1 b 106 GLY SER HIS MET SER GLY ARG GLY LYS GLY GLY LYS GLY
SEQRES 2 b 106 LEU GLY LYS GLY GLY ALA LYS ARG HIS ARG LYS VAL LEU
SEQRES 3 b 106 ARG ASP ASN ILE GLN GLY ILE THR LYS PRO ALA ILE ARG
SEQRES 4 b 106 ARG LEU ALA ARG ARG GLY GLY VAL LYS ARG ILE SER GLY
SEQRES 5 b 106 LEU ILE TYR GLU GLU THR ARG GLY VAL LEU LYS VAL PHE
SEQRES 6 b 106 LEU GLU ASN VAL ILE ARG ASP ALA VAL THR TYR THR GLU
SEQRES 7 b 106 HIS ALA LYS ARG LYS THR VAL THR ALA MET ASP VAL VAL
SEQRES 8 b 106 TYR ALA LEU LYS ARG GLN GLY ARG THR LEU TYR GLY PHE
SEQRES 9 b 106 GLY GLY
SEQRES 1 c 133 GLY SER HIS MET SER GLY ARG GLY LYS GLN GLY GLY LYS
SEQRES 2 c 133 ALA ARG ALA LYS ALA LYS THR ARG SER SER ARG ALA GLY
SEQRES 3 c 133 LEU GLN PHE PRO VAL GLY ARG VAL HIS ARG LEU LEU ARG
SEQRES 4 c 133 LYS GLY ASN TYR SER GLU ARG VAL GLY ALA GLY ALA PRO
SEQRES 5 c 133 VAL TYR LEU ALA ALA VAL LEU GLU TYR LEU THR ALA GLU
SEQRES 6 c 133 ILE LEU GLU LEU ALA GLY ASN ALA ALA ARG ASP ASN LYS
SEQRES 7 c 133 LYS THR ARG ILE ILE PRO ARG HIS LEU GLN LEU ALA ILE
SEQRES 8 c 133 ARG ASN ASP GLU GLU LEU ASN LYS LEU LEU GLY ARG VAL
SEQRES 9 c 133 THR ILE ALA GLN GLY GLY VAL LEU PRO ASN ILE GLN ALA
SEQRES 10 c 133 VAL LEU LEU PRO LYS LYS THR GLU SER HIS HIS LYS ALA
SEQRES 11 c 133 LYS GLY LYS
SEQRES 1 d 129 GLY SER HIS MET PRO GLU PRO ALA LYS SER ALA PRO ALA
SEQRES 2 d 129 PRO LYS LYS GLY SER LYS LYS ALA VAL THR LYS ALA GLN
SEQRES 3 d 129 LYS LYS ASP GLY LYS LYS ARG LYS ARG SER ARG LYS GLU
SEQRES 4 d 129 SER TYR SER ILE TYR VAL TYR LYS VAL LEU LYS GLN VAL
SEQRES 5 d 129 HIS PRO ASP THR GLY ILE SER SER LYS ALA MET GLY ILE
SEQRES 6 d 129 MET ASN SER PHE VAL ASN ASP ILE PHE GLU ARG ILE ALA
SEQRES 7 d 129 GLY GLU ALA SER ARG LEU ALA HIS TYR ASN LYS ARG SER
SEQRES 8 d 129 THR ILE THR SER ARG GLU ILE GLN THR ALA VAL ARG LEU
SEQRES 9 d 129 LEU LEU PRO GLY GLU LEU ALA LYS HIS ALA VAL SER GLU
SEQRES 10 d 129 GLY THR LYS ALA VAL THR LYS TYR THR SER ALA LYS
SEQRES 1 e 139 GLY SER HIS MET ALA ARG THR LYS GLN THR ALA ARG LYS
SEQRES 2 e 139 SER THR GLY GLY LYS ALA PRO ARG LYS GLN LEU ALA THR
SEQRES 3 e 139 LYS ALA ALA ARG LYS SER ALA PRO SER THR GLY GLY VAL
SEQRES 4 e 139 LYS LYS PRO HIS ARG TYR ARG PRO GLY THR VAL ALA LEU
SEQRES 5 e 139 ARG GLU ILE ARG ARG TYR GLN LYS SER THR GLU LEU LEU
SEQRES 6 e 139 ILE ARG LYS LEU PRO PHE GLN ARG LEU VAL ARG GLU ILE
SEQRES 7 e 139 ALA GLN ASP PHE LYS THR ASP LEU ARG PHE GLN SER ALA
SEQRES 8 e 139 ALA ILE GLY ALA LEU GLN GLU ALA SER GLU ALA TYR LEU
SEQRES 9 e 139 VAL GLY LEU PHE GLU ASP THR ASN LEU CYS ALA ILE HIS
SEQRES 10 e 139 ALA LYS ARG VAL THR ILE MET PRO LYS ASP ILE GLN LEU
SEQRES 11 e 139 ALA ARG ARG ILE ARG GLY GLU ARG ALA
SEQRES 1 f 106 GLY SER HIS MET SER GLY ARG GLY LYS GLY GLY LYS GLY
SEQRES 2 f 106 LEU GLY LYS GLY GLY ALA LYS ARG HIS ARG LYS VAL LEU
SEQRES 3 f 106 ARG ASP ASN ILE GLN GLY ILE THR LYS PRO ALA ILE ARG
SEQRES 4 f 106 ARG LEU ALA ARG ARG GLY GLY VAL LYS ARG ILE SER GLY
SEQRES 5 f 106 LEU ILE TYR GLU GLU THR ARG GLY VAL LEU LYS VAL PHE
SEQRES 6 f 106 LEU GLU ASN VAL ILE ARG ASP ALA VAL THR TYR THR GLU
SEQRES 7 f 106 HIS ALA LYS ARG LYS THR VAL THR ALA MET ASP VAL VAL
SEQRES 8 f 106 TYR ALA LEU LYS ARG GLN GLY ARG THR LEU TYR GLY PHE
SEQRES 9 f 106 GLY GLY
SEQRES 1 g 133 GLY SER HIS MET SER GLY ARG GLY LYS GLN GLY GLY LYS
SEQRES 2 g 133 ALA ARG ALA LYS ALA LYS THR ARG SER SER ARG ALA GLY
SEQRES 3 g 133 LEU GLN PHE PRO VAL GLY ARG VAL HIS ARG LEU LEU ARG
SEQRES 4 g 133 LYS GLY ASN TYR SER GLU ARG VAL GLY ALA GLY ALA PRO
SEQRES 5 g 133 VAL TYR LEU ALA ALA VAL LEU GLU TYR LEU THR ALA GLU
SEQRES 6 g 133 ILE LEU GLU LEU ALA GLY ASN ALA ALA ARG ASP ASN LYS
SEQRES 7 g 133 LYS THR ARG ILE ILE PRO ARG HIS LEU GLN LEU ALA ILE
SEQRES 8 g 133 ARG ASN ASP GLU GLU LEU ASN LYS LEU LEU GLY ARG VAL
SEQRES 9 g 133 THR ILE ALA GLN GLY GLY VAL LEU PRO ASN ILE GLN ALA
SEQRES 10 g 133 VAL LEU LEU PRO LYS LYS THR GLU SER HIS HIS LYS ALA
SEQRES 11 g 133 LYS GLY LYS
SEQRES 1 h 129 GLY SER HIS MET PRO GLU PRO ALA LYS SER ALA PRO ALA
SEQRES 2 h 129 PRO LYS LYS GLY SER LYS LYS ALA VAL THR LYS ALA GLN
SEQRES 3 h 129 LYS LYS ASP GLY LYS LYS ARG LYS ARG SER ARG LYS GLU
SEQRES 4 h 129 SER TYR SER ILE TYR VAL TYR LYS VAL LEU LYS GLN VAL
SEQRES 5 h 129 HIS PRO ASP THR GLY ILE SER SER LYS ALA MET GLY ILE
SEQRES 6 h 129 MET ASN SER PHE VAL ASN ASP ILE PHE GLU ARG ILE ALA
SEQRES 7 h 129 GLY GLU ALA SER ARG LEU ALA HIS TYR ASN LYS ARG SER
SEQRES 8 h 129 THR ILE THR SER ARG GLU ILE GLN THR ALA VAL ARG LEU
SEQRES 9 h 129 LEU LEU PRO GLY GLU LEU ALA LYS HIS ALA VAL SER GLU
SEQRES 10 h 129 GLY THR LYS ALA VAL THR LYS TYR THR SER ALA LYS
HET ZN A1801 1
HET ZN A1802 1
HET MG A1803 1
HET ZN B1301 1
HET ZN C 401 1
HET ZN I 201 1
HET ZN I 202 1
HET ZN J 101 1
HET ZN L 101 1
HET ZN M 201 1
HET ZN V 300 1
HETNAM ZN ZINC ION
HETNAM MG MAGNESIUM ION
FORMUL 27 ZN 10(ZN 2+)
FORMUL 29 MG MG 2+
HELIX 1 AA1 SER A 23 SER A 31 1 9
HELIX 2 AA2 ASP A 55 GLY A 59 5 5
HELIX 3 AA3 PHE A 95 ILE A 106 1 12
HELIX 4 AA4 ASN A 119 ILE A 126 1 8
HELIX 5 AA5 ASP A 130 LYS A 143 1 14
HELIX 6 AA6 THR A 204 HIS A 214 1 11
HELIX 7 AA7 SER A 216 LEU A 223 1 8
HELIX 8 AA8 ARG A 231 TRP A 234 5 4
HELIX 9 AA9 PRO A 244 ARG A 248 5 5
HELIX 10 AB1 ASP A 261 LYS A 279 1 19
HELIX 11 AB2 ILE A 289 ASP A 306 1 18
HELIX 12 AB3 ALA A 325 LYS A 331 1 7
HELIX 13 AB4 GLY A 335 LEU A 341 1 7
HELIX 14 AB5 ILE A 369 LEU A 375 1 7
HELIX 15 AB6 ASN A 385 GLY A 396 1 12
HELIX 16 AB7 ARG A 421 ILE A 425 5 5
HELIX 17 AB8 HIS A 452 MET A 454 5 3
HELIX 18 AB9 VAL A 475 ASN A 480 1 6
HELIX 19 AC1 SER A 495 CYS A 506 1 12
HELIX 20 AC2 ALA A 507 GLN A 511 5 5
HELIX 21 AC3 VAL A 525 THR A 536 1 12
HELIX 22 AC4 TYR A 544 TRP A 553 1 10
HELIX 23 AC5 GLY A 575 ILE A 583 1 9
HELIX 24 AC6 ASP A 619 GLY A 624 1 6
HELIX 25 AC7 GLY A 629 GLY A 639 1 11
HELIX 26 AC8 GLY A 639 GLY A 662 1 24
HELIX 27 AC9 GLY A 666 ILE A 671 5 6
HELIX 28 AD1 ASP A 673 HIS A 700 1 28
HELIX 29 AD2 THR A 710 LEU A 738 1 29
HELIX 30 AD3 ASN A 742 GLY A 751 1 10
HELIX 31 AD4 SER A 755 ALA A 764 1 10
HELIX 32 AD5 PRO A 795 LYS A 798 5 4
HELIX 33 AD6 THR A 810 GLU A 847 1 38
HELIX 34 AD7 LEU A 868 ASP A 872 5 5
HELIX 35 AD8 ASP A 875 THR A 877 5 3
HELIX 36 AD9 SER A 890 TYR A 899 1 10
HELIX 37 AE1 ASP A 904 SER A 908 5 5
HELIX 38 AE2 LYS A 910 ILE A 914 5 5
HELIX 39 AE3 ASP A 923 ILE A 947 1 25
HELIX 40 AE4 ASN A 961 PHE A 973 1 13
HELIX 41 AE5 THR A 984 CYS A 996 1 13
HELIX 42 AE6 ASN A 1006 THR A 1017 1 12
HELIX 43 AE7 THR A 1017 LEU A 1028 1 12
HELIX 44 AE8 ALA A 1029 GLU A 1035 1 7
HELIX 45 AE9 ASN A 1040 SER A 1058 1 19
HELIX 46 AF1 MET A 1065 THR A 1079 1 15
HELIX 47 AF2 LEU A 1098 ASN A 1108 1 11
HELIX 48 AF3 ASP A 1123 LEU A 1128 1 6
HELIX 49 AF4 ASP A 1129 GLU A 1141 1 13
HELIX 50 AF5 LEU A 1145 VAL A 1148 1 4
HELIX 51 AF6 ASP A 1168 SER A 1177 1 10
HELIX 52 AF7 ASP A 1200 LYS A 1207 1 8
HELIX 53 AF8 THR A 1210 SER A 1223 1 14
HELIX 54 AF9 GLU A 1259 ASP A 1272 1 14
HELIX 55 AG1 ASN A 1315 ALA A 1321 1 7
HELIX 56 AG2 SER A 1334 GLY A 1343 1 10
HELIX 57 AG3 GLY A 1343 ASP A 1362 1 20
HELIX 58 AG4 ASN A 1367 SER A 1380 1 14
HELIX 59 AG5 THR A 1388 ASN A 1393 1 6
HELIX 60 AG6 GLY A 1398 SER A 1404 1 7
HELIX 61 AG7 GLU A 1407 ALA A 1418 1 12
HELIX 62 AG8 GLY A 1426 LEU A 1433 1 8
HELIX 63 AG9 MET A 1439 GLY A 1442 5 4
HELIX 64 AH1 ASP A 1449 THR A 1454 1 6
HELIX 65 AH2 SER A 1455 LEU A 1456 5 2
HELIX 66 AH3 PRO A 1457 ALA A 1461 5 5
HELIX 67 AH4 THR B 13 GLY B 29 1 17
HELIX 68 AH5 VAL B 31 THR B 44 1 14
HELIX 69 AH6 THR B 44 TRP B 51 1 8
HELIX 70 AH7 PHE B 100 ARG B 107 1 8
HELIX 71 AH8 ASP B 176 MET B 183 1 8
HELIX 72 AH9 ILE B 274 ALA B 280 1 7
HELIX 73 AI1 PRO B 285 CYS B 294 1 10
HELIX 74 AI2 ASP B 299 GLU B 312 1 14
HELIX 75 AI3 ASP B 318 ARG B 328 1 11
HELIX 76 AI4 ARG B 337 LYS B 351 1 15
HELIX 77 AI5 PHE B 363 LEU B 383 1 21
HELIX 78 AI6 HIS B 393 GLY B 395 5 3
HELIX 79 AI7 LEU B 401 ILE B 429 1 29
HELIX 80 AI8 SER B 443 GLY B 457 1 15
HELIX 81 AI9 GLU B 461 ALA B 465 5 5
HELIX 82 AJ1 THR B 480 ARG B 489 1 10
HELIX 83 AJ2 HIS B 508 TRP B 512 5 5
HELIX 84 AJ3 SER B 544 TRP B 554 1 11
HELIX 85 AJ4 PRO B 558 TYR B 562 5 5
HELIX 86 AJ5 ASP B 585 GLY B 600 1 16
HELIX 87 AJ6 THR B 648 GLY B 658 1 11
HELIX 88 AJ7 GLY B 677 THR B 683 1 7
HELIX 89 AJ8 GLY B 692 GLU B 696 1 5
HELIX 90 AJ9 THR B 703 GLN B 708 5 6
HELIX 91 AK1 HIS B 744 LEU B 749 5 6
HELIX 92 AK2 ALA B 752 ILE B 756 5 5
HELIX 93 AK3 PHE B 758 ASN B 762 5 5
HELIX 94 AK4 GLN B 763 GLY B 774 1 12
HELIX 95 AK5 LYS B 775 ALA B 777 5 3
HELIX 96 AK6 THR B 806 TYR B 811 5 6
HELIX 97 AK7 GLN B 843 ARG B 848 1 6
HELIX 98 AK8 ARG B 995 MET B 999 5 5
HELIX 99 AK9 ASN B 1013 ILE B 1017 5 5
HELIX 100 AL1 THR B 1022 GLY B 1039 1 18
HELIX 101 AL2 THR B 1051 ASP B 1061 1 11
HELIX 102 AL3 MET B 1098 LYS B 1102 5 5
HELIX 103 AL4 GLY B 1121 ASP B 1125 5 5
HELIX 104 AL5 GLY B 1131 GLY B 1142 1 12
HELIX 105 AL6 ALA B 1143 LEU B 1151 1 9
HELIX 106 AL7 TYR B 1198 MET B 1210 1 13
HELIX 107 AL8 ASN C 25 GLU C 39 1 15
HELIX 108 AL9 ALA C 58 LEU C 68 1 11
HELIX 109 AM1 ASP C 75 MET C 79 5 5
HELIX 110 AM2 TYR C 81 CYS C 85 5 5
HELIX 111 AM3 SER C 116 LEU C 118 5 3
HELIX 112 AM4 HIS C 167 SER C 171 5 5
HELIX 113 AM5 ASP C 196 TRP C 201 1 6
HELIX 114 AM6 TYR C 206 GLU C 210 5 5
HELIX 115 AM7 LYS C 239 ARG C 266 1 28
HELIX 116 AM8 SER D 52 ASN D 72 1 21
HELIX 117 AM9 ASP D 85 ALA D 90 1 6
HELIX 118 AN1 LYS D 91 THR D 93 5 3
HELIX 119 AN2 GLY D 95 THR D 111 1 17
HELIX 120 AN3 ASP D 117 HIS D 129 1 13
HELIX 121 AN4 HIS D 138 LEU D 148 1 11
HELIX 122 AN5 ASP D 152 ILE D 160 1 9
HELIX 123 AN6 PRO D 161 LYS D 167 5 7
HELIX 124 AN7 ASN D 170 GLU D 182 1 13
HELIX 125 AN8 ASP E 3 ARG E 25 1 23
HELIX 126 AN9 SER E 37 CYS E 46 1 10
HELIX 127 AO1 GLN E 53 MET E 57 5 5
HELIX 128 AO2 THR E 64 TYR E 71 1 8
HELIX 129 AO3 GLY E 88 LYS E 102 1 15
HELIX 130 AO4 SER E 118 SER E 127 5 10
HELIX 131 AO5 SER E 137 VAL E 140 5 4
HELIX 132 AO6 ASN E 142 HIS E 146 5 5
HELIX 133 AO7 SER E 156 LYS E 168 1 13
HELIX 134 AO8 LYS E 170 LEU E 174 5 5
HELIX 135 AO9 ASP E 181 GLY E 188 1 8
HELIX 136 AP1 LEU F 75 ARG F 79 5 5
HELIX 137 AP2 THR F 86 MET F 103 1 18
HELIX 138 AP3 ASP F 116 GLN F 127 1 12
HELIX 139 AP4 HIS G 14 PHE G 18 5 5
HELIX 140 AP5 GLN G 21 GLU G 35 1 15
HELIX 141 AP6 ASP G 50 ILE G 54 5 5
HELIX 142 AP7 ARG G 113 ILE G 115 5 3
HELIX 143 AP8 SER H 87 TYR H 92 5 6
HELIX 144 AP9 GLY H 127 ALA H 132 1 6
HELIX 145 AQ1 SER H 133 LYS H 135 5 3
HELIX 146 AQ2 ASP I 61 ASP I 65 5 5
HELIX 147 AQ3 LYS J 17 GLU J 27 1 11
HELIX 148 AQ4 GLN J 30 LEU J 38 1 9
HELIX 149 AQ5 ARG J 42 THR J 51 1 10
HELIX 150 AQ6 LEU J 55 ARG J 61 1 7
HELIX 151 AQ7 ASP K 5 PHE K 10 5 6
HELIX 152 AQ8 ASP K 39 LEU K 52 1 14
HELIX 153 AQ9 ARG K 82 ASN K 113 1 32
HELIX 154 AR1 GLN M 65 GLU M 78 1 14
HELIX 155 AR2 PRO V 20 ASN V 27 1 8
HELIX 156 AR3 CYS V 32 ASN V 37 1 6
HELIX 157 AR4 ASP V 42 CYS V 49 1 8
HELIX 158 AR5 SER V 66 LEU V 72 1 7
HELIX 159 AR6 PRO V 91 TYR V 101 1 11
HELIX 160 AR7 PRO W 213 ILE W 218 5 6
HELIX 161 AR8 LYS W 235 GLU W 251 1 17
HELIX 162 AR9 LYS W 278 LYS W 287 1 10
HELIX 163 AS1 GLY W 302 VAL W 304 5 3
HELIX 164 AS2 GLU W 305 LEU W 310 1 6
HELIX 165 AS3 SER W 395 GLU W 403 1 9
HELIX 166 AS4 THR W 443 PHE W 450 1 8
HELIX 167 AS5 GLY a 44 SER a 57 1 14
HELIX 168 AS6 ARG a 63 GLN a 76 1 14
HELIX 169 AS7 GLN a 85 ALA a 114 1 30
HELIX 170 AS8 MET a 120 ARG a 131 1 12
HELIX 171 AS9 ASP b 24 ILE b 29 5 6
HELIX 172 AT1 THR b 30 GLY b 41 1 12
HELIX 173 AT2 ILE b 50 LYS b 77 1 28
HELIX 174 AT3 THR b 82 GLY b 94 1 13
HELIX 175 AT4 ARG c 17 ALA c 21 1 5
HELIX 176 AT5 PRO c 26 LYS c 36 1 11
HELIX 177 AT6 GLY c 46 LYS c 74 1 29
HELIX 178 AT7 ILE c 79 ASP c 90 1 12
HELIX 179 AT8 ASP c 90 LEU c 97 1 8
HELIX 180 AT9 GLN c 112 LEU c 116 5 5
HELIX 181 AU1 TYR d 34 HIS d 46 1 13
HELIX 182 AU2 SER d 52 TYR d 80 1 29
HELIX 183 AU3 THR d 87 LEU d 99 1 13
HELIX 184 AU4 PRO d 100 ALA d 121 1 22
HELIX 185 AU5 GLY e 44 GLN e 55 1 12
HELIX 186 AU6 ARG e 63 GLN e 76 1 14
HELIX 187 AU7 GLN e 85 ALA e 114 1 30
HELIX 188 AU8 MET e 120 GLY e 132 1 13
HELIX 189 AU9 ASN f 25 ILE f 29 5 5
HELIX 190 AV1 THR f 30 GLY f 42 1 13
HELIX 191 AV2 LEU f 49 LYS f 77 1 29
HELIX 192 AV3 THR f 82 GLN f 93 1 12
HELIX 193 AV4 THR g 16 GLY g 22 1 7
HELIX 194 AV5 PRO g 26 LYS g 36 1 11
HELIX 195 AV6 ALA g 45 ASP g 72 1 28
HELIX 196 AV7 ILE g 79 ASP g 90 1 12
HELIX 197 AV8 GLU g 91 LEU g 97 1 7
HELIX 198 AV9 TYR h 34 HIS h 46 1 13
HELIX 199 AW1 SER h 52 LYS h 82 1 31
HELIX 200 AW2 THR h 87 LEU h 99 1 13
HELIX 201 AW3 PRO h 100 ALA h 121 1 22
SHEET 1 AA1 3 LEU A1421 ASP A1422 0
SHEET 2 AA1 3 GLU A 16 GLN A 18 -1 N VAL A 17 O ASP A1422
SHEET 3 AA1 3 ARG B1215 TYR B1217 -1 O ARG B1215 N GLN A 18
SHEET 1 AA2 2 GLY A 82 PHE A 91 0
SHEET 2 AA2 2 ILE A 236 VAL A 242 -1 O LEU A 240 N MET A 84
SHEET 1 AA3 3 VAL A 174 ASP A 178 0
SHEET 2 AA3 3 LYS A 181 TRP A 186 -1 O TRP A 183 N ARG A 176
SHEET 3 AA3 3 GLU A 199 LEU A 202 -1 O LYS A 201 N GLY A 184
SHEET 1 AA4 2 ILE A 251 ALA A 252 0
SHEET 2 AA4 2 GLN A 258 GLY A 259 -1 O GLY A 259 N ILE A 251
SHEET 1 AA5 2 LYS A 344 VAL A 346 0
SHEET 2 AA5 2 LEU B1128 PHE B1130 -1 O PHE B1130 N LYS A 344
SHEET 1 AA6 8 HIS B1104 ARG B1106 0
SHEET 2 AA6 8 SER A 349 GLY A 356 -1 N ARG A 351 O HIS B1104
SHEET 3 AA6 8 GLU A 487 HIS A 491 -1 O LEU A 490 N ALA A 350
SHEET 4 AA6 8 PRO A 442 ASN A 446 -1 N ASN A 446 O ASN A 489
SHEET 5 AA6 8 MET A 456 MET A 464 -1 O MET A 457 N PHE A 445
SHEET 6 AA6 8 GLN A 364 PRO A 368 1 N VAL A 365 O LYS A 462
SHEET 7 AA6 8 PHE A 469 LEU A 471 -1 O ARG A 470 N GLY A 366
SHEET 8 AA6 8 SER A 349 GLY A 356 1 N SER A 355 O PHE A 469
SHEET 1 AA7 4 SER A 376 THR A 380 0
SHEET 2 AA7 4 LYS A 432 HIS A 436 -1 O VAL A 433 N GLU A 379
SHEET 3 AA7 4 ALA A 403 ILE A 407 -1 N ILE A 407 O LYS A 432
SHEET 4 AA7 4 ARG A 413 ASP A 415 -1 O ILE A 414 N VAL A 406
SHEET 1 AA8 2 VAL A 513 SER A 514 0
SHEET 2 AA8 2 LYS A 519 PRO A 520 -1 O LYS A 519 N SER A 514
SHEET 1 AA9 2 PHE A 541 GLU A 543 0
SHEET 2 AA9 2 LEU A 572 THR A 574 -1 O TRP A 573 N ILE A 542
SHEET 1 AB110 ILE A 566 LYS A 568 0
SHEET 2 AB110 TYR H 94 GLU H 104 -1 O VAL H 95 N LEU A 567
SHEET 3 AB110 ASN H 138 ARG H 144 -1 O LEU H 139 N GLY H 98
SHEET 4 AB110 SER H 54 ALA H 60 -1 N ALA H 60 O TYR H 140
SHEET 5 AB110 PHE H 6 ASP H 16 -1 N PHE H 10 O LEU H 55
SHEET 6 AB110 VAL H 23 SER H 30 -1 O ILE H 27 N GLN H 13
SHEET 7 AB110 LYS H 37 ASN H 43 -1 O LEU H 40 N ILE H 26
SHEET 8 AB110 LEU H 120 GLY H 126 -1 O GLU H 125 N LYS H 37
SHEET 9 AB110 ILE H 111 PHE H 117 -1 N PHE H 117 O LEU H 120
SHEET 10 AB110 TYR H 94 GLU H 104 -1 N THR H 99 O SER H 116
SHEET 1 AB2 3 LEU A 589 ARG A 591 0
SHEET 2 AB2 3 MET A 606 VAL A 609 -1 O ILE A 608 N LEU A 589
SHEET 3 AB2 3 LYS A 612 PHE A 615 -1 O MET A 614 N LEU A 607
SHEET 1 AB3 2 GLY A 767 GLN A 768 0
SHEET 2 AB3 2 PHE A 800 VAL A 801 -1 O VAL A 801 N GLY A 767
SHEET 1 AB4 3 MET A 850 VAL A 851 0
SHEET 2 AB4 3 THR A 857 ARG A 858 -1 O ARG A 858 N MET A 850
SHEET 3 AB4 3 ILE A 864 GLN A 866 -1 O ILE A 865 N THR A 857
SHEET 1 AB5 2 VAL A 879 THR A 883 0
SHEET 2 AB5 2 ASN A 955 PRO A 959 -1 O TRP A 956 N GLN A 882
SHEET 1 AB6 4 LYS A1284 PRO A1295 0
SHEET 2 AB6 4 TYR A1301 ASP A1312 -1 O LEU A1306 N HIS A1290
SHEET 3 AB6 4 ALA A1117 VAL A1120 -1 N VAL A1120 O LEU A1309
SHEET 4 AB6 4 TYR A1331 SER A1332 -1 O TYR A1331 N THR A1119
SHEET 1 AB7 2 THR A1143 THR A1144 0
SHEET 2 AB7 2 ALA A1275 ARG A1277 -1 O LEU A1276 N THR A1143
SHEET 1 AB8 5 LEU A1226 TRP A1230 0
SHEET 2 AB8 5 LEU A1238 VAL A1244 -1 O ARG A1241 N MET A1229
SHEET 3 AB8 5 TRP A1193 LEU A1199 -1 N LEU A1195 O CYS A1242
SHEET 4 AB8 5 THR A1149 TYR A1156 -1 N ALA A1151 O GLU A1198
SHEET 5 AB8 5 LYS I 42 GLU I 47 -1 O VAL I 43 N ILE A1154
SHEET 1 AB9 3 PHE A1444 ILE A1448 0
SHEET 2 AB9 3 LEU F 132 TYR F 137 -1 O VAL F 133 N MET A1447
SHEET 3 AB9 3 TYR F 143 GLY F 147 -1 O TRP F 146 N ILE F 134
SHEET 1 AC1 4 ARG B 55 ILE B 57 0
SHEET 2 AC1 4 ASN B 72 LEU B 84 -1 O ILE B 77 N LEU B 56
SHEET 3 AC1 4 SER B 112 SER B 126 -1 O ASP B 118 N GLY B 80
SHEET 4 AC1 4 VAL B 156 PRO B 162 -1 O GLY B 159 N VAL B 115
SHEET 1 AC2 2 THR B 88 THR B 90 0
SHEET 2 AC2 2 THR B 96 ALA B 98 -1 O HIS B 97 N MET B 89
SHEET 1 AC3 3 PHE B 194 ILE B 196 0
SHEET 2 AC3 3 SER B 199 LEU B 203 -1 O LYS B 201 N PHE B 194
SHEET 3 AC3 3 SER B 473 VAL B 475 -1 O GLN B 474 N VAL B 202
SHEET 1 AC4 4 LYS B 397 ASP B 400 0
SHEET 2 AC4 4 ALA B 205 SER B 209 -1 N GLN B 206 O ASP B 400
SHEET 3 AC4 4 ARG B 490 ASN B 492 1 O ASN B 492 N GLU B 207
SHEET 4 AC4 4 VAL B 529 ASN B 531 -1 O LYS B 530 N THR B 491
SHEET 1 AC5 5 GLN B 215 LYS B 218 0
SHEET 2 AC5 5 HIS B 227 ALA B 234 -1 O VAL B 228 N PHE B 217
SHEET 3 AC5 5 LEU B 241 LEU B 249 -1 O MET B 245 N ILE B 231
SHEET 4 AC5 5 ILE B 261 THR B 264 -1 O THR B 264 N GLN B 246
SHEET 5 AC5 5 ILE B 272 PRO B 273 -1 O ILE B 272 N ALA B 263
SHEET 1 AC6 3 GLY B 537 ILE B 538 0
SHEET 2 AC6 3 VAL B 626 ILE B 632 -1 O TYR B 627 N GLY B 537
SHEET 3 AC6 3 ILE B 687 ASP B 691 -1 O VAL B 690 N ARG B 628
SHEET 1 AC7 4 GLY B 537 ILE B 538 0
SHEET 2 AC7 4 VAL B 626 ILE B 632 -1 O TYR B 627 N GLY B 537
SHEET 3 AC7 4 HIS B 740 CYS B 741 -1 O CYS B 741 N PHE B 631
SHEET 4 AC7 4 ILE B 700 ALA B 701 1 N ALA B 701 O HIS B 740
SHEET 1 AC8 4 VAL B 578 HIS B 583 0
SHEET 2 AC8 4 THR B 571 VAL B 575 -1 N THR B 571 O HIS B 583
SHEET 3 AC8 4 GLU B 616 PHE B 620 1 O PHE B 617 N PHE B 574
SHEET 4 AC8 4 SER B 607 ASP B 611 -1 N ILE B 609 O LYS B 618
SHEET 1 AC9 5 MET B 792 LEU B 796 0
SHEET 2 AC9 5 SER B 853 GLN B 862 -1 O LEU B 854 N ILE B 795
SHEET 3 AC9 5 LYS B 962 LYS B 972 -1 O MET B 968 N ARG B 857
SHEET 4 AC9 5 ASN B 946 THR B 956 -1 N ILE B 948 O ARG B 969
SHEET 5 AC9 5 ARG B 904 SER B 906 -1 N VAL B 905 O GLY B 947
SHEET 1 AD1 7 MET B 792 LEU B 796 0
SHEET 2 AD1 7 SER B 853 GLN B 862 -1 O LEU B 854 N ILE B 795
SHEET 3 AD1 7 LYS B 962 LYS B 972 -1 O MET B 968 N ARG B 857
SHEET 4 AD1 7 ASN B 946 THR B 956 -1 N ILE B 948 O ARG B 969
SHEET 5 AD1 7 ILE L 58 LYS L 60 -1 O ILE L 58 N LEU B 954
SHEET 6 AD1 7 LYS L 30 CYS L 33 -1 N THR L 32 O TYR L 59
SHEET 7 AD1 7 ASN L 39 SER L 41 -1 O PHE L 40 N TYR L 31
SHEET 1 AD2 2 ALA B 804 LYS B 805 0
SHEET 2 AD2 2 GLY B1042 ASP B1043 1 O GLY B1042 N LYS B 805
SHEET 1 AD3 8 PHE B1069 GLU B1070 0
SHEET 2 AD3 8 VAL B1085 ARG B1094 -1 O VAL B1085 N GLU B1070
SHEET 3 AD3 8 LYS B 979 SER B 982 -1 N ALA B 981 O GLN B1093
SHEET 4 AD3 8 LYS B 987 TYR B 994 -1 O GLY B 988 N PHE B 980
SHEET 5 AD3 8 SER B 838 ASN B 842 1 N MET B 839 O GLY B 991
SHEET 6 AD3 8 LEU B1010 ILE B1012 -1 O ILE B1011 N ILE B 840
SHEET 7 AD3 8 GLN B 821 ILE B 827 1 N ALA B 826 O LEU B1010
SHEET 8 AD3 8 VAL B1085 ARG B1094 -1 O TYR B1092 N GLN B 821
SHEET 1 AD4 4 GLU B 873 PHE B 874 0
SHEET 2 AD4 4 LYS B 914 PRO B 917 -1 O THR B 915 N GLU B 873
SHEET 3 AD4 4 LYS B 934 ASP B 936 -1 O ARG B 935 N THR B 916
SHEET 4 AD4 4 THR B 882 LEU B 883 1 N LEU B 883 O LYS B 934
SHEET 1 AD5 2 ILE B 910 ILE B 912 0
SHEET 2 AD5 2 THR B 939 PRO B 940 -1 O THR B 939 N ILE B 912
SHEET 1 AD6 2 PHE B1001 SER B1002 0
SHEET 2 AD6 2 MET B1072 TYR B1073 -1 O TYR B1073 N PHE B1001
SHEET 1 AD7 2 ALA B1157 CYS B1163 0
SHEET 2 AD7 2 ILE B1191 PRO B1197 -1 O TYR B1192 N VAL B1162
SHEET 1 AD8 2 ILE B1172 ASN B1174 0
SHEET 2 AD8 2 GLN B1179 GLU B1181 -1 O GLN B1179 N ASN B1174
SHEET 1 AD9 4 LYS C 6 ALA C 12 0
SHEET 2 AD9 4 GLU C 16 SER C 22 -1 O MET C 20 N ASN C 8
SHEET 3 AD9 4 ARG C 227 THR C 234 -1 O PHE C 228 N LEU C 21
SHEET 4 AD9 4 CYS C 173 TYR C 180 -1 N GLU C 179 O TYR C 229
SHEET 1 AE1 5 ILE C 119 LYS C 120 0
SHEET 2 AE1 5 VAL C 96 ARG C 103 -1 N GLU C 99 O ILE C 119
SHEET 3 AE1 5 GLU C 152 GLY C 162 -1 O CYS C 157 N LEU C 98
SHEET 4 AE1 5 THR C 42 ASN C 53 -1 N GLU C 49 O ARG C 156
SHEET 5 AE1 5 ILE L 67 PHE L 69 -1 O PHE L 69 N VAL C 48
SHEET 1 AE2 2 LEU C 71 SER C 73 0
SHEET 2 AE2 2 VAL C 129 PRO C 132 -1 O GLU C 131 N VAL C 72
SHEET 1 AE3 2 THR C 111 TYR C 114 0
SHEET 2 AE3 2 LEU C 143 LEU C 147 -1 O LEU C 147 N THR C 111
SHEET 1 AE4 5 SER D 4 SER D 6 0
SHEET 2 AE4 5 PHE G 2 LEU G 13 -1 O SER G 8 N THR D 5
SHEET 3 AE4 5 ALA G 68 TRP G 79 -1 O ALA G 68 N LEU G 13
SHEET 4 AE4 5 GLY G 43 LEU G 49 -1 N THR G 47 O VAL G 77
SHEET 5 AE4 5 CYS G 38 THR G 39 -1 N THR G 39 O GLY G 43
SHEET 1 AE5 4 ALA D 50 LEU D 51 0
SHEET 2 AE5 4 PHE G 2 LEU G 13 -1 O PHE G 2 N LEU D 51
SHEET 3 AE5 4 ALA G 68 TRP G 79 -1 O ALA G 68 N LEU G 13
SHEET 4 AE5 4 ARG G 60 ILE G 61 -1 N ARG G 60 O GLU G 69
SHEET 1 AE6 2 LYS D 37 TYR D 39 0
SHEET 2 AE6 2 GLU D 45 ASP D 47 -1 O HIS D 46 N GLN D 38
SHEET 1 AE7 5 TYR E 27 PHE E 28 0
SHEET 2 AE7 5 PHE E 59 PRO E 63 -1 O ASN E 62 N PHE E 28
SHEET 3 AE7 5 LEU E 77 PHE E 81 -1 O VAL E 79 N PHE E 59
SHEET 4 AE7 5 THR E 106 TYR E 111 1 O THR E 106 N TRP E 78
SHEET 5 AE7 5 ILE E 130 GLN E 135 1 O GLU E 132 N PHE E 109
SHEET 1 AE8 2 SER E 86 VAL E 87 0
SHEET 2 AE8 2 ASN E 114 ILE E 115 1 O ASN E 114 N VAL E 87
SHEET 1 AE9 4 HIS E 152 ARG E 154 0
SHEET 2 AE9 4 VAL E 194 SER E 201 -1 O LYS E 196 N ILE E 153
SHEET 3 AE9 4 GLY E 205 CYS E 213 -1 O SER E 209 N ILE E 197
SHEET 4 AE9 4 ARG E 176 ILE E 177 1 N ILE E 177 O ILE E 212
SHEET 1 AF1 7 GLY G 169 ALA G 170 0
SHEET 2 AF1 7 VAL G 143 THR G 152 -1 N ARG G 144 O GLY G 169
SHEET 3 AF1 7 ILE G 157 SER G 162 -1 O TYR G 158 N ARG G 151
SHEET 4 AF1 7 LEU G 106 SER G 111 1 N PHE G 109 O GLY G 161
SHEET 5 AF1 7 GLY G 98 VAL G 103 -1 N ALA G 101 O VAL G 108
SHEET 6 AF1 7 VAL G 86 SER G 95 -1 N SER G 92 O PHE G 100
SHEET 7 AF1 7 VAL G 143 THR G 152 -1 O LEU G 145 N VAL G 87
SHEET 1 AF2 3 VAL G 120 ASN G 122 0
SHEET 2 AF2 3 ALA G 129 MET G 131 -1 O ALA G 129 N ASN G 122
SHEET 3 AF2 3 LEU G 136 ILE G 137 -1 O ILE G 137 N TYR G 130
SHEET 1 AF3 3 TYR I 15 ASP I 19 0
SHEET 2 AF3 3 ARG I 24 SER I 28 -1 O SER I 28 N TYR I 15
SHEET 3 AF3 3 THR I 35 LEU I 37 -1 O GLU I 36 N TYR I 27
SHEET 1 AF4 4 ARG I 70 SER I 71 0
SHEET 2 AF4 4 CYS I 83 GLN I 87 -1 O CYS I 83 N SER I 71
SHEET 3 AF4 4 LEU I 99 CYS I 103 -1 O PHE I 100 N PHE I 86
SHEET 4 AF4 4 THR I 109 PHE I 110 -1 O PHE I 110 N TYR I 101
SHEET 1 AF5 4 LEU K 19 PRO K 23 0
SHEET 2 AF5 4 CYS K 30 GLU K 36 -1 O LYS K 34 N LYS K 20
SHEET 3 AF5 4 ASN K 70 THR K 77 -1 O MET K 73 N ILE K 33
SHEET 4 AF5 4 VAL K 56 LYS K 62 -1 N ALA K 60 O ARG K 74
SHEET 1 AF6 4 GLN M 17 GLU M 20 0
SHEET 2 AF6 4 VAL M 34 ASP M 39 -1 O CYS M 36 N LEU M 19
SHEET 3 AF6 4 ILE M 44 CYS M 49 -1 O LEU M 46 N THR M 37
SHEET 4 AF6 4 SER M 55 PRO M 59 -1 O PHE M 56 N LEU M 47
SHEET 1 AF7 3 VAL V 18 LEU V 19 0
SHEET 2 AF7 3 ARG V 10 CYS V 12 -1 N ARG V 10 O LEU V 19
SHEET 3 AF7 3 THR V 50 SER V 51 -1 O SER V 51 N ALA V 11
SHEET 1 AF8 6 GLY V 80 VAL V 86 0
SHEET 2 AF8 6 PHE V 54 VAL V 60 -1 N VAL V 58 O TYR V 82
SHEET 3 AF8 6 ILE W 259 GLN W 264 -1 O ALA W 262 N ALA V 59
SHEET 4 AF8 6 HIS W 271 ALA W 276 -1 O TYR W 273 N PHE W 263
SHEET 5 AF8 6 GLY W 225 LYS W 230 -1 N TRP W 227 O ILE W 274
SHEET 6 AF8 6 LYS W 298 LEU W 300 -1 O PHE W 299 N GLY W 228
SHEET 1 AF9 8 ARG W 407 ARG W 410 0
SHEET 2 AF9 8 PHE W 413 TYR W 416 -1 O PHE W 413 N ASP W 409
SHEET 3 AF9 8 GLU W 419 TYR W 422 -1 O TYR W 421 N VAL W 414
SHEET 4 AF9 8 PHE W 425 ARG W 431 -1 O PHE W 425 N TYR W 422
SHEET 5 AF9 8 GLU W 349 LEU W 354 -1 N ALA W 350 O PHE W 430
SHEET 6 AF9 8 LEU W 337 VAL W 343 -1 N GLU W 342 O ARG W 351
SHEET 7 AF9 8 TYR W 325 VAL W 328 -1 N VAL W 326 O ALA W 338
SHEET 8 AF9 8 LEU W 435 ILE W 436 -1 O ILE W 436 N ARG W 327
SHEET 1 AG1 6 THR W 788 PRO W 792 0
SHEET 2 AG1 6 ARG W 777 LEU W 782 -1 N PHE W 778 O ILE W 791
SHEET 3 AG1 6 ILE W 767 GLU W 772 -1 N LYS W 771 O ARG W 779
SHEET 4 AG1 6 THR W 755 ILE W 758 -1 N VAL W 756 O GLY W 768
SHEET 5 AG1 6 LEU W 796 GLU W 799 -1 O LEU W 797 N LYS W 757
SHEET 6 AG1 6 TRP W 804 VAL W 805 -1 O VAL W 805 N ILE W 798
SHEET 1 AG2 2 ARG a 83 PHE a 84 0
SHEET 2 AG2 2 THR b 80 VAL b 81 1 O VAL b 81 N ARG a 83
SHEET 1 AG3 2 ARG c 77 ILE c 78 0
SHEET 2 AG3 2 GLY d 50 ILE d 51 1 O GLY d 50 N ILE c 78
SHEET 1 AG4 2 ARG g 42 VAL g 43 0
SHEET 2 AG4 2 THR h 85 ILE h 86 1 O ILE h 86 N ARG g 42
SHEET 1 AG5 2 ARG g 77 ILE g 78 0
SHEET 2 AG5 2 GLY h 50 ILE h 51 1 O GLY h 50 N ILE g 78
LINK SG CYS A 67 ZN ZN A1801 1555 1555 2.42
LINK SG CYS A 70 ZN ZN A1801 1555 1555 2.38
LINK SG CYS A 77 ZN ZN A1801 1555 1555 2.41
LINK NE2 HIS A 80 ZN ZN A1801 1555 1555 2.13
LINK SG CYS A 107 ZN ZN A1802 1555 1555 2.52
LINK N CYS A 110 ZN ZN A1802 1555 1555 2.69
LINK SG CYS A 110 ZN ZN A1802 1555 1555 2.46
LINK SG CYS A 168 ZN ZN A1802 1555 1555 2.96
LINK OD1 ASP A 482 MG MG A1803 1555 1555 2.48
LINK OD1 ASP A 484 MG MG A1803 1555 1555 2.15
LINK OD1 ASP A 486 MG MG A1803 1555 1555 2.54
LINK MG MG A1803 O3' U P 10 1555 1555 2.16
LINK SG CYS B1163 ZN ZN B1301 1555 1555 2.42
LINK SG CYS B1166 ZN ZN B1301 1555 1555 2.43
LINK SG CYS B1182 ZN ZN B1301 1555 1555 2.42
LINK SG CYS B1185 ZN ZN B1301 1555 1555 2.42
LINK SG CYS C 85 ZN ZN C 401 1555 1555 2.86
LINK SG CYS C 91 ZN ZN C 401 1555 1555 2.58
LINK SG CYS C 94 ZN ZN C 401 1555 1555 2.60
LINK SG CYS I 29 ZN ZN I 202 1555 1555 2.60
LINK SG CYS I 32 ZN ZN I 202 1555 1555 2.73
LINK SG CYS I 78 ZN ZN I 201 1555 1555 2.66
LINK SG CYS I 103 ZN ZN I 201 1555 1555 2.48
LINK N CYS I 106 ZN ZN I 201 1555 1555 2.63
LINK SG CYS J 7 ZN ZN J 101 1555 1555 2.40
LINK SG CYS J 10 ZN ZN J 101 1555 1555 2.92
LINK SG CYS J 44 ZN ZN J 101 1555 1555 2.47
LINK N CYS J 45 ZN ZN J 101 1555 1555 2.19
LINK SG CYS J 45 ZN ZN J 101 1555 1555 2.43
LINK SG CYS L 33 ZN ZN L 101 1555 1555 2.50
LINK SG CYS L 36 ZN ZN L 101 1555 1555 2.51
LINK SG CYS L 50 ZN ZN L 101 1555 1555 2.44
LINK SG CYS L 53 ZN ZN L 101 1555 1555 2.46
LINK SG CYS M 25 ZN ZN M 201 1555 1555 2.25
LINK SG CYS M 28 ZN ZN M 201 1555 1555 2.91
LINK SG CYS M 49 ZN ZN M 201 1555 1555 2.32
LINK SG CYS M 52 ZN ZN M 201 1555 1555 2.25
LINK SG CYS V 12 ZN ZN V 300 1555 1555 2.25
LINK SG CYS V 15 ZN ZN V 300 1555 1555 2.27
LINK SG CYS V 29 ZN ZN V 300 1555 1555 2.41
LINK SG CYS V 32 ZN ZN V 300 1555 1555 2.45
CISPEP 1 HIS A 400 PRO A 401 0 7.79
CISPEP 2 GLN A 448 PRO A 449 0 -0.73
CISPEP 3 LYS A 568 PRO A 569 0 6.17
CISPEP 4 GLY C 125 ASN C 126 0 -3.75
CISPEP 5 SER E 127 PRO E 128 0 -0.39
CISPEP 6 SER G 126 PRO G 127 0 0.41
SITE 1 AC1 4 CYS A 67 CYS A 70 CYS A 77 HIS A 80
SITE 1 AC2 4 CYS A 107 ASN A 109 CYS A 110 CYS A 168
SITE 1 AC3 4 ASP A 482 ASP A 484 ASP A 486 U P 10
SITE 1 AC4 4 CYS B1163 CYS B1166 CYS B1182 CYS B1185
SITE 1 AC5 5 CYS C 85 CYS C 87 CYS C 91 GLU C 93
SITE 2 AC5 5 CYS C 94
SITE 1 AC6 5 CYS I 75 CYS I 78 CYS I 103 ASN I 105
SITE 2 AC6 5 CYS I 106
SITE 1 AC7 3 CYS I 10 CYS I 29 CYS I 32
SITE 1 AC8 4 CYS J 7 CYS J 10 CYS J 44 CYS J 45
SITE 1 AC9 5 CYS L 33 CYS L 36 CYS L 50 GLU L 52
SITE 2 AC9 5 CYS L 53
SITE 1 AD1 5 CYS M 25 CYS M 28 CYS M 49 CYS M 52
SITE 2 AD1 5 LEU M 54
SITE 1 AD2 4 CYS V 12 CYS V 15 CYS V 29 CYS V 32
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
(ATOM LINES ARE NOT SHOWN.)
END
