#=GF ID Papilloma_E5
#=GF AC PF03025.18
#=GF DE Papillomavirus E5
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_1916 (release 6.4)
#=GF GA 25.00 25.00;
#=GF TC 37.60 37.40;
#=GF NC 19.00 18.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 9721230
#=GF RT Temporal and spatial expression of the E5a protein during the
#=GF RT differentiation-dependent life cycle of human papillomavirus
#=GF RT type 31b.
#=GF RA Mayer TJ, Meyers C;
#=GF RL Virology 1998;248:208-217.
#=GF RN [2]
#=GF RM 23731971
#=GF RT The E5 proteins.
#=GF RA DiMaio D, Petti LM;
#=GF RL Virology. 2013;445:99-114.
#=GF DR INTERPRO; IPR004270;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Human papillomaviruses (HPVs) are epitheliotropic viruses, and
#=GF CC their life cycle is intimately linked to the stratification and
#=GF CC differentiation state of the host epithelial tissues. The
#=GF CC kinetics of E5a protein expression during the complete viral
#=GF CC life cycle has been studied and the highest level was found to
#=GF CC be coincidental with the onset of virion morphogenesis [1]. The
#=GF CC E5 protein from papillomaviruses is about 80 amino acids long.
#=GF CC The proteins contain three predicted transmembrane alpha
#=GF CC helices. These proteins display transforming activity in
#=GF CC cultured cells and animals, and they presumably also play a role
#=GF CC in the productive virus life cycle [2]. The E5 proteins are
#=GF CC thought to act by modulating the activity of cellular proteins
#=GF CC [2].
#=GF SQ 15
#=GS VE5A_HPV11/20-91 AC P04017.1
#=GS Q81969_HPV59/2-73 AC Q81969.1
#=GS VE5_HPV31/11-83 AC P17385.1
#=GS A4U7F1_HPV67/1-73 AC A4U7F1.1
#=GS Q9QLP1_9PAPI/20-91 AC Q9QLP1.1
#=GS A0A0P0ERX0_HPV73/2-74 AC A0A0P0ERX0.1
#=GS C3PUK7_RHPV1/5-79 AC C3PUK7.1
#=GS VE5_HPV18/2-73 AC P06792.1
#=GS C3PU77_RHPV1/7-82 AC C3PU77.2
#=GS A0A0P0F0K8_HPV34/2-74 AC A0A0P0F0K8.1
#=GS VE5_HPV35/10-80 AC P27226.1
#=GS C3PU93_RHPV1/5-79 AC C3PU93.1
#=GS VE5_HPV16/11-83 AC P06927.2
#=GS Q9IR54_HPV82/9-81 AC Q9IR54.1
#=GS VE5_HPV33/1-73 AC P06426.1
VE5A_HPV11/20-91 .....VVIAFAVCILSIVLIILIS.DFVVYTSVLVLTLLLYLL.LW.LLLTTPLQFFLLTLCVCYFPAFYIHIYIVQTQQ...
Q81969_HPV59/2-73 .....ITLVFVCCVCVCLCVCCNV.PLLQSVYMCAYTWLLVFV.YI.VVITSSYECFLLYILFFIIPLLLLYAHAILSIQ...
VE5_HPV31/11-83 .....IVLCFLLCFCVLLFVCLVIrPLVLSVSVYATLLLLIVI.LW.VIATSPLRCFCIYVVFIYIPLFVIHTHASFLSQ...
A4U7F1_HPV67/1-73 .....MLAIFVFAFVLLLCFCIVLrPLLLSIYVYALLLVLVLV.LW.GFIGSPLRVFLAYLIFLYLPMMCIHLHAQYIV-s..
Q9QLP1_9PAPI/20-91 .....VIIAFVVCFVSIILIVWIS.DFIVYTSVLVLTLLLYLL.LW.LLLTTPLQFFLLTLLVCYCPACYIHHYIVNTQQ...
A0A0P0ERX0_HPV73/2-74 .....ILCIFVFLFCVGFCLCLCV.SLAVSVYIYPWLLVLIIItFI.HVSQSLLKVFFLYVLVFYIPMALVHYHATLQ--it.
C3PUK7_RHPV1/5-79 ..llf-LVVFLLLFLLGLVFCARVdSLLLCFSVYASVLLLMLL.FW.VSIVSPFAAFGLCLFCFLAPLFLIHLHALSV--vn.
VE5_HPV18/2-73 .....LSLIFLFCFCVCMYVCCHV.PLLPSVCMCAYAWVLVFV.YI.VVITSPATAFTVYVFCFLLPMLLLHIHAILSLQ...
C3PU77_RHPV1/7-82 .illf-IVVFLLLFLLGLVACARVqALLLCFDIYASVLLLMLL.FW.VTITPPLSAFALCLCCFLCPVALIHLHAVSV--vl.
A0A0P0F0K8_HPV34/2-74 .....IIFIFVILFVFGFYMCLSV.SLAVSVCVYAWLLLLIII.TFlHVSQSLLKVYILYVCVFYIPMALVHYHATL---qvt
VE5_HPV35/10-80 .....VLLCFLLCFCVLLCLCLLVrSLLLSVSLYSALILLVLI.LW.VTVATPLLAFVVSCFCIYL--WMINAHAQYL--av.
C3PU93_RHPV1/5-79 llflg---LFLLLFFLGLVVCAVVpSLLLCLYVYAGTLLLMLL.FW.VTLLPPSAAFALCVLCFLLPLLSIYTHVVSV--vn.
VE5_HPV16/11-83 .....LLACFLLCFCVLLCVCLLIrPLLLSVSTYTSLIILVLL.LW.ITAASAFRCFIVYIIFVYIPLFLIHTHARFLI-t..
Q9IR54_HPV82/9-81 .....LVCLFVLCVCVCLVLCCLL.PLLQSQYVFAAALLLIIC.FWfVVATSPLTTFTVYLICFYIPCFLLHLYTFSILQ...
VE5_HPV33/1-73 .....MIFVFVLCFILFLCLSLLLrPLILSISTYAWLLVLVLL.LW.VFVGSPLKIFFCYLLFLYLPMMCINFHAQHMTQ...
#=GC seq_cons .....llhlFllCFslhLslChll.sLLlSlslYAhlLLLlLl.hW.VslsSPLpsFhlYllshYlPhhlIHhHAhhh.....
//
