#=GF ID   ActA
#=GF AC   PF05058.16
#=GF DE   ActA Protein
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_5981 (release 7.7)
#=GF GA   23.80 23.80;
#=GF TC   35.80 1476.20;
#=GF NC   23.20 22.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11886549
#=GF RT   Systematic mutational analysis of the amino-terminal domain of
#=GF RT   the Listeria monocytogenes ActA protein reveals novel functions
#=GF RT   in actin-based motility. 
#=GF RA   Lauer P, Theriot JA, Skoble J, Welch MD, Portnoy DA; 
#=GF RL   Mol Microbiol 2001;42:1163-1177.
#=GF RN   [2]
#=GF RM   11854187
#=GF RT   Intracellular induction of Listeria monocytogenes actA
#=GF RT   expression. 
#=GF RA   Shetron-Rama LM, Marquis H, Bouwer HG, Freitag NE; 
#=GF RL   Infect Immun 2002;70:1087-1096.
#=GF DR   INTERPRO; IPR007752;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The ActA family is found in Listeria and is associated with
#=GF CC   motility. ActA protein acts as a scaffold to assemble and
#=GF CC   activate host cell actin cytoskeletal factors at the bacterial
#=GF CC   surface, resulting in directional actin polymerisation and
#=GF CC   propulsion of the bacterium through the cytoplasm of the host
#=GF CC   cell [1,2]. 
#=GF SQ   1
#=GS ACTA_LISMO/7-639  AC P33379.1
ACTA_LISMO/7-639             MRAMMVVFITANCITINPDIIFAATDSEDSSLNTDEWEEEKTEEQPSEVNTGPRYETAREVSSRDIKELEKSNKVRNTNKADLIAMLKEKAEKGPNINNNNSEQTENAAINEEASGADRPAIQVERRHPGLPSDSAAEIKKRRKAIASSDSELESLTYPDKPTKVNKKKVAKESVADASESDLDSSMQSADESSPQPLKANQQPFFPKVFKKIKDAGKWVRDKIDENPEVKKAIVDKSAGLIDQLLTKKKSEEVNASDFPPPPTDEELRLALPETPMLLGFNAPATSEPSSFEFPPPPTDEELRLALPETPMLLGFNAPATSEPSSFEFPPPPTEDELEIIRETASSLDSSFTRGDLASLRNAINRHSQNFSDFPPIPTEEELNGRGGRPTSEEFSSLNSGDFTDDENSETTEEEIDRLADLRDRGTGKHSRNAGFLPLNPFASSPVPSLSPKVSKISAPALISDITKKTPFKNPSQPLNVFNKKTTTKTVTKKPTPVKTAPKLAELPATKPQETVLRENKTPFIEKQAETNKQSINMPSLPVIQKEATESDKEEMKPQTEEKMVEESESANNANGKNRSAGIEEGKLIAKSAEDEKAKEEPGNHTTLILAMLAIGVFSLGAFIKIIQLRKNN
#=GC seq_cons                MRAMMVVFITANCITINPDIIFAATDSEDSSLNTDEWEEEKTEEQPSEVNTGPRYETAREVSSRDIKELEKSNKVRNTNKADLIAMLKEKAEKGPNINNNNSEQTENAAINEEASGADRPAIQVERRHPGLPSDSAAEIKKRRKAIASSDSELESLTYPDKPTKVNKKKVAKESVADASESDLDSSMQSADESSPQPLKANQQPFFPKVFKKIKDAGKWVRDKIDENPEVKKAIVDKSAGLIDQLLTKKKSEEVNASDFPPPPTDEELRLALPETPMLLGFNAPATSEPSSFEFPPPPTDEELRLALPETPMLLGFNAPATSEPSSFEFPPPPTEDELEIIRETASSLDSSFTRGDLASLRNAINRHSQNFSDFPPIPTEEELNGRGGRPTSEEFSSLNSGDFTDDENSETTEEEIDRLADLRDRGTGKHSRNAGFLPLNPFASSPVPSLSPKVSKISAPALISDITKKTPFKNPSQPLNVFNKKTTTKTVTKKPTPVKTAPKLAELPATKPQETVLRENKTPFIEKQAETNKQSINMPSLPVIQKEATESDKEEMKPQTEEKMVEESESANNANGKNRSAGIEEGKLIAKSAEDEKAKEEPGNHTTLILAMLAIGVFSLGAFIKIIQLRKNN
//