#=GF ID   DHFR_2
#=GF AC   PF06442.15
#=GF DE   R67 dihydrofolate reductase
#=GF PI   DHFR;
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Pfam-B_27527 (release 9.0)
#=GF GA   25.00 25.00;
#=GF TC   27.20 38.70;
#=GF NC   24.60 23.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF WK   Dihydrofolate_reductase
#=GF CL   CL0010
#=GF RN   [1]
#=GF RM   7583655
#=GF RT   A plasmid-encoded dihydrofolate reductase from
#=GF RT   trimethoprim-resistant bacteria has a novel D2-symmetric active
#=GF RT   site. 
#=GF RA   Narayana N, Matthews DA, Howell EE, Nguyen-huu X; 
#=GF RL   Nat Struct Biol 1995;2:1018-1025.
#=GF DR   INTERPRO; IPR009159;
#=GF DR   SCOP; 1vif; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   R67 dihydrofolate reductase is a plasmid encoded enzyme that
#=GF CC   provides resistance to the antibacterial  drug trimethoprim. 
#=GF CC   The R67 dihydrofolate reductase does not share significant
#=GF CC   similarity to the chromosomal encoded dihydrofolate reductase
#=GF CC   [1].
#=GF SQ   16
#=GS A0A7S5R8G6_9CAUD/146-203  AC A0A7S5R8G6.1
#=GS A0A0H5ARK7_9CAUD/77-155   AC A0A0H5ARK7.1
#=GS A0A0N7CEH1_9CAUD/1-66     AC A0A0N7CEH1.1
#=GS A0A7L5Y1D1_9HYPH/1-53     AC A0A7L5Y1D1.1
#=GS A0A7S5QZK4_9CAUD/4-70     AC A0A7S5QZK4.1
#=GS A0A0F6R7A8_9CAUD/1-61     AC A0A0F6R7A8.1
#=GS A0A2W4DNN3_9HYPH/3-64     AC A0A2W4DNN3.1
#=GS A0A2U2DRI1_9HYPH/25-99    AC A0A2U2DRI1.1
#=GS A0A430DPI2_9SPHN/2-70     AC A0A430DPI2.1
#=GS A0A369Q4U0_9SPHN/7-66     AC A0A369Q4U0.1
#=GS A0A7S5V0L9_9CAUD/4-69     AC A0A7S5V0L9.1
#=GS A0A0J7Y2N3_9SPHN/1-58     AC A0A0J7Y2N3.1
#=GS A0A7S5UT03_9CAUD/4-70     AC A0A7S5UT03.1
#=GS A0A7S5R3B0_9CAUD/83-153   AC A0A7S5R3B0.1
#=GS H5WLJ1_9BURK/5-82         AC H5WLJ1.1
#=GS A0A7S5RCH8_9CAUD/146-203  AC A0A7S5RCH8.1
A0A7S5R8G6_9CAUD/146-203             .....................dgkr----------------------MFNRGDMVRKKSGSS.......WNGRVVGFYSTELTPVGYCVES.RRERG...SVQIYPESAL----ip..
A0A0H5ARK7_9CAUD/77-155              rknteaagipvrdlyaapiaqtapq---------------------GKFRMGDIVKKSTGSE.......WEGRVVGWYSTEQTKEGYAVES.EAHAG...SVQIYPA-------krwr
A0A0N7CEH1_9CAUD/1-66                ........................m---------------------ATFQRGDRVRKRTASAdiaraahWRGVVVGEYSTPVTSEGYAVMS.T-DPGslySVQVYPVGALE---ad..
A0A7L5Y1D1_9HYPH/1-53                .........................-------------------------MGDRVRKRHGSS.......WRGCVVGFYTSSVTTEGYCVES.EWEPG...SVQIYPWGALERI-p...
A0A7S5QZK4_9CAUD/4-70                ................vrsvafate--------------------NPPYEIGDWVHKKSGSY.......WEGRIVGYYSTRQTHEGYCVQLlGMENG...PVQIYPRSALN---lg..
A0A0F6R7A8_9CAUD/1-61                ...................mfecfg----------------------RFGFGERVTKTKGSS.......WTGRVVGFYSTELTPIGYAVES.ETEKG...SVQIYPEAALT---aa..
A0A2W4DNN3_9HYPH/3-64                .......................np-----------------WPSDAKFQMGDYAAKKGRAS.......WRGKIVGWYRTDLTNLGYAIES.YFEPG...SVQIYPETAIE---mw..
A0A2U2DRI1_9HYPH/25-99               ......rpascpaspprraptvadr----------------------KFQKDDYVRKTKGSW.......WEGYVRGFYDTEDNPDGICVQL.DKPNG...PVQIYPAAAFE---lae.
A0A430DPI2_9SPHN/2-70                ..................qprgeqq----------------DWPADAAFPNGALVQKKGRAS.......WRGKIVGWYRTDITALGYAVES.AFEPG...SVQIYPETAL----lawd
A0A369Q4U0_9SPHN/7-66                ...................salver----------------------KWALGDLVQKKRNSE.......WRGVVVGFYSTDATPEGYNVES.LFERG...SCQLWPASAL----id..
A0A7S5V0L9_9CAUD/4-69                ................irnvaivsd--------------------TVPFSIDDWVHKPKGSY.......WEGRVVGYYSTKQTPEGYCVQLlGMENG...PVQIYPRSAL----vl..
A0A0J7Y2N3_9SPHN/1-58                .......................mc----------------------AFNRGDHVEKISGSK.......WRGVVVGEYSTSLTPEGYAVES.DTETG...SVQIYPAKALR---sts.
A0A7S5UT03_9CAUD/4-70                ..............vrnvafateep----------------------PYEIGDWVHKKSGSY.......WEGRVVGYYSTKQTHEGYCVQLlGMENG...PVQIYPRSALN---lg..
A0A7S5R3B0_9CAUD/83-153              ..........lciaagecgcgagtr----------------------KFNLGDRVSKATGSS.......WNGRIVGFYSTSLTPVGYCVES.DRETG...SVQIYPERALEH--ap..
H5WLJ1_9BURK/5-82                    .....eatpaaielneglchswpat--------------------HKTFRMGDKVRKVRGSQ.......WHGRVVGWYSTDLTPEGYAVES.DTERG...SVQIYPASALER--ea..
A0A7S5RCH8_9CAUD/146-203             .....................dgkr----------------------MFNRGDMVRKKSGSS.......WNGRVVGFYSTELTPVGYCVES.RRERG...SVQIYPESAL----ip..
#=GC seq_cons                        ......................spp......................tFphGDhV+KpsGSp.......WcG+VVGaYSTclTs-GYsVES.phEsG...SVQIYPtuALp...hs..
//