#=GF ID   DUF4354
#=GF AC   PF14263.10
#=GF DE   Domain of unknown function (DUF4354)
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   JCSG:Target416839_SP17692A
#=GF GA   25.50 25.50;
#=GF TC   28.90 32.00;
#=GF NC   25.20 25.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF CL   CL0524
#=GF DR   INTERPRO; IPR025581;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Several members of this family are annotated as being
#=GF CC   ATP/GTP-binding site motif A (P-loop) proteins, but this could
#=GF CC   not be confirmed. The one PDB:3NRF structure solved for this
#=GF CC   family exhibits an immunoglobin-like beta-sandwich fold. 
#=GF CC   Crystal packing suggests that a tetramer is a significant
#=GF CC   oligomerisation state, and a disulfide bridge is formed between
#=GF CC   Cys 125 at the C-terminal end of the monomer, and Cys 69.
#=GF SQ   23
#=GS L0EUW8_LIBCB/1-121      AC L0EUW8.1
#=GS B2VCP2_ERWT9/1-118      AC B2VCP2.1
#=GS A0A8J7GY05_9ENTR/1-123  AC A0A8J7GY05.1
#=GS A0A366DXJ7_9HYPH/1-127  AC A0A366DXJ7.1
#=GS A0A0N1KIM1_9GAMM/1-126  AC A0A0N1KIM1.1
#=GS A0A2I0FUH6_9GAMM/1-123  AC A0A2I0FUH6.1
#=GS A0A089PZL0_9ENTR/1-123  AC A0A089PZL0.1
#=GS A0A3B0IR84_9GAMM/1-83   AC A0A3B0IR84.1
#=GS A0A2V3U6U9_9HYPH/1-123  AC A0A2V3U6U9.1
#=GS A0A348HI30_9GAMM/2-124  AC A0A348HI30.1
#=GS Q9I2H0_PSEAE/1-123      AC Q9I2H0.1
#=GS A0A0Q4MHG1_9GAMM/1-123  AC A0A0Q4MHG1.1
#=GS D8MW40_ERWBE/1-120      AC D8MW40.1
#=GS Q2YR31_BRUA2/1-111      AC Q2YR31.1
#=GS A0A3B0JGG4_9GAMM/1-121  AC A0A3B0JGG4.1
#=GS C4K5R4_HAMD5/1-123      AC C4K5R4.1
#=GS D3V905_XENNA/1-123      AC D3V905.1
#=GS A0A841M558_9HYPH/1-126  AC A0A841M558.1
#=GS A0A1Y3FXR1_9PROT/1-124  AC A0A1Y3FXR1.1
#=GS A0A4V1BWJ4_9GAMM/1-121  AC A0A4V1BWJ4.1
#=GS A0A2A2HQF3_9GAMM/1-123  AC A0A2A2HQF3.1
#=GS W1JCY7_9GAMM/1-123      AC W1JCY7.1
#=GS A0A0F5FHI2_9HYPH/1-118  AC A0A0F5FHI2.1
L0EUW8_LIBCB/1-121                 ..............MKK...-SYLLLYPICF..LFS..I.AASSVPPEV...IVYAKQKETGSIFSPHKFTYTKDFDVTVVNFSQGEIDLS..KY..CFKAM-LGMKEFNVDTIDEKLASKKLKNGERLRGVVVFSSNNSDVTQANIVQLTD........
B2VCP2_ERWT9/1-118                 .............m---...AASVTVAGFCS..VAH..-.--AAVPDNA...AVYATEHSKGSMSIAGKDVYTKTFEVMVANLADKEFDLS..TL..CLKAVAPDHQEFKLDTVDEKLTTGKVKKGQSVKGIAVFASDNAAVQQTALVKLTD........
A0A8J7GY05_9ENTR/1-123             ........mkilmi---...VATLALAGFSF..AAN..-.--ASMPDNI...AVYATAQSNGSISVGNKLAYTKSFDVSVVKLFGDDVDLS..KL..CLKAYSPDNKAFRLDTVDEELTTGILKEGKSIKGIAMFASENAAVLDAAVVKITD........
A0A366DXJ7_9HYPH/1-127             ...........mfn---...IKSIFLTLYLV..AVS.gG.AYAAAPDQNvqpMVISSVREHSTTVYGDKIEYNITFDVAISNLGKKPLDLS..KG..CFEAVMPDNSTRSLSMIDEELTEGLLKVGDNRKSFVEFSASDNSIYKAVAVK---yqt.....
A0A0N1KIM1_9GAMM/1-126             mkktlgtlcllyls---...---------CS..GQA..T.TLNVEKNSL...SVETFSSKNGTLVINGQALYERKLAITVVNRGESKVELT..GFsgCYKAFDKQGKRYVARTTQLDLLGSIEKNAAKW-GEISIVGKDDSVYKAIFVE---wss.....
A0A2I0FUH6_9GAMM/1-123             .........mkssh---...-VFIVLAMLAS..SFS..-.VSAKAPADI...AVFATEKSQGSMSIGDNSAYTRTFEVTLANLADKSIDLS..KR..CLKAYLHDKTELQLDTLDEKLMTNTLAAGTSIKGIAVFSSTNENIFSAAQVKIS-e.......
A0A089PZL0_9ENTR/1-123             ..............MKVltlVSSLALAGFCF..SAV..-.--AETPANI...AVYATHKSTGSMSVGGKSAYTNTFEVMVANVSDKDIDLS..KV..CLKATAPDHKEFALDTVDEALSKGSLRAGKMVKGIAVFASEDAKVNDALLITLS-a.......
A0A3B0IR84_9GAMM/1-83              ...........meg---...-----------..---..-.---------...----------------QPKYEKTFNVVVSSVIDQPIQLTgdVD..CYKAFDEKGKEFDERLVQAELL-GILKDSPK-TGAATFVSDDESVYNAKFVKWS-s.......
A0A2V3U6U9_9HYPH/1-123             ..............MRK...I-FISVFSIIT..LIA..FgAQASPLNNV...ILLASPADTTTKSYLGKFTYLKKFQIALANVSETAIDLR..NA..CYLLIGNNGQTYHVDTMEDTVSGGKLEPGKSVNGFVVFAGADEDIFL--------qskviian
A0A348HI30_9GAMM/2-124             ......lkrngila---...---IMLS--MM..VGS..A.VAATPADSV...MVIASPDGTQTTTQGTTTYFTRLFEVSLTNVGHQPVDLA..HG..CFKAYDRRGTSYSLDIAEEGLLKGMLKPGLHKKGDMGFSSLQPDVYDADVIRFS-t.......
Q9I2H0_PSEAE/1-123                 ..............MKN...AMALTLAGLLA..APS..L.GFAAAPDAV...MVFARQGDKGSVSVGDKHFRTQAFKVRLVNAAKSEISLK..NS..CLVAQSAAGQSFRLDTVDEELTADTLKPGASVEGDAIFASEDDAVYGASLVRLSD........
A0A0Q4MHG1_9GAMM/1-123             ....mkslfiactm---...---------LF..SAAcgA.AVANAPANL...LVYAQAKSEGSMWAGSKSAFTKTFNVSIVNLTDQDIDLA..TL..CLRAYATDTQSFGVDTADELLTKGWLKKGSTVSGVVDFSSGKRDVYQAGMVKV--fh......
D8MW40_ERWBE/1-120                 ..............MKK...ILMLALLMVGV..PAY..-.-ANQLFQPG...PIYATNEDVGSMTDHNKAQYMVSYRISIFNPLDSAATLS..KG..CFVLFNRAGKEIVARGVELNLQQ-EFAPGESKTGTVYFFSDNEAIYTLPFVK---wie.....
Q2YR31_BRUA2/1-111                 ...........maq---...-----------..-AS..Y.AETASTNDL...MIIATPKTQSATSSEDKVFFSQTFDIGVANTGATDINLD..KV..CFIALGDKGKTFNADTIDQKLTSGLLKSGESVKGFAAFAGSDKSIYDVRIVKAS-e.......
A0A3B0JGG4_9GAMM/1-121             ..............MKK...ASLLLSFLFCC..SFS..-.IMASVPDGI...TVFASQKEDGSISSVKKSYYTKTFHVTVVNASEKYIDLS..KY..CFKAF-LGSREFKVDTIDENLHNKVLKNNESAKGMIVFASINRDINKAAVVKLTD........
C4K5R4_HAMD5/1-123                 ..............MRKkifIASILLAGCCL..TAA..-.--AKTVDKI...IVFSTEKSKGALSIGRQQTYTKTFDIALSNNSQQDIELS..TS..CLKAFDSNGKEFKLDTVDEKLIPNKLKKGELVKGIAMFVSDDASVYGANIVRLVK........
D3V905_XENNA/1-123                 ..............MKVstfVASIALAGFCF..VAN..-.--ASTLDRV...AVYSTEKSNGSVSVGGKNAYTKSFEVAVANLSDKDIDLS..KL..CLKAYSPDKKEFRLDTVDEDLNQGTLKAGKSVRGIAVLASENDVVHKAALIKIS-a.......
A0A841M558_9HYPH/1-126             .mkikfyilpilfl---...-------SSSI..HSS..F.AQTTPSNNI...IVIASPKSQSSTSFQNEVSYAKTFDIMIMNTGETDVDLE..KI..CLKAYDESGKAYHMDAVDEKLISGKLPSEQSLKGFVSFSDTKPAVYATQVVKIS-s.......
A0A1Y3FXR1_9PROT/1-124             ..............MKF...SAYIIAASLLLgsVTS..-.AYANAYDSI...SVYAIEKSHGSIATGSNTAYVKTYNITISNLSDTEADLS..KI..CLKAYSAENKELRLDTVDANLVTGFLKKGQPATGTAIFASHDDIISKPVIVKLSD........
A0A4V1BWJ4_9GAMM/1-121             ..............MKK...ASLLLSFLFCC..SFS..-.IMASVPNGV...TVFASQKEAGSISTPKKSYYTKKFDVMVANLSEKELDLS..KY..CFKAF-LGSREFKVDTIDENLHNKVLKNNENAKGMIVFASINRDITKAAMVKLTD........
A0A2A2HQF3_9GAMM/1-123             ..........mkgk---...---ILLTALAFssVSM..I.ASAVETDNL...VVYSTQQDKGATSLGNQAFYTKSFDVTLANVGDKDADLS..KF..CLKAYNKHGKTFKLDTIEETLTTGNLLPKKTVKGMAVFASNDESVYDASIVKLS-y.......
W1JCY7_9GAMM/1-123                 ..............MKVstlVASVALAGFCF..TAH..-.--ASALDNV...AVYSTEKSNGSISVGGKNAYTKSFEVAVANLSDKDIDLS..KL..CLKAYSPDKKEFSLDTVDEDLNQGTLKAGKSVKGIAVFASENDVVHKAALIKISD........
A0A0F5FHI2_9HYPH/1-118             ............ma---...----ALAAFTT..LAV..A.TPALANDDI...AIIATERANGSMALGDTIAYSKSFDIALTNTVDEPVALE..DL..CLVAVTAEGDTFVLDTVDESLTTGMIEPGAALNGIAVFSSDSITVHTASAVR---ags.....
#=GC seq_cons                      .......................lhlhhhsh..ssu....h.Asssssl...hVaAop+spGShShusKstYTKoF-VslsNlu-p-lDLS..Kh..ChKAastcs+pFplDTlDEpLssGhLKsGpsl+GhssFuSpscsVapAslVKlo.........
//