#=GF ID Imm41
#=GF AC PF15592.10
#=GF DE Immunity protein 41
#=GF PI Imm22;
#=GF AU Zhang D;0000-0001-8535-7620
#=GF AU de Souza RF;0000-0002-5284-4630
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE [1]
#=GF GA 26.90 26.90;
#=GF TC 27.70 27.40;
#=GF NC 26.40 26.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 22731697
#=GF RT Polymorphic toxin systems: comprehensive characterization of
#=GF RT trafficking modes, processing, mechanisms of action, immunity
#=GF RT and ecology using comparative genomics.
#=GF RA Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL Biol Direct. 2012;7:18.
#=GF DR INTERPRO; IPR028959;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC A predicted immunity protein with an alpha+beta fold and a
#=GF CC conserved SF motif and tryptophan residue. Proteins containing
#=GF CC this domain are present in bacterial polymorphic toxin systems
#=GF CC as an immediate gene neighbour of the toxin gene, usually
#=GF CC containing a domain of the Ntox21, Ntox29 or Tox-ART-RSE-like
#=GF CC ADP-ribosyltransferase families [1].
#=GF SQ 40
#=GS B9Y4S0_9FIRM/11-111 AC B9Y4S0.1
#=GS Q9K124_NEIMB/9-120 AC Q9K124.1
#=GS A0A3N9UEM9_9BACI/6-124 AC A0A3N9UEM9.1
#=GS A0A494X5L5_9BURK/9-116 AC A0A494X5L5.1
#=GS A0A268SFK3_9BACL/1-93 AC A0A268SFK3.1
#=GS A0A3D8VEE1_9GAMM/14-123 AC A0A3D8VEE1.1
#=GS C8PLA2_9PROT/8-123 AC C8PLA2.1
#=GS Q5F706_NEIG1/9-120 AC Q5F706.1
#=GS Q5F6G9_NEIG1/9-120 AC Q5F6G9.1
#=GS A0A128EDV8_9PROT/8-128 AC A0A128EDV8.1
#=GS Q9K127_NEIMB/12-123 AC Q9K127.1
#=GS A0A235B1N6_9BACL/9-80 AC A0A235B1N6.1
#=GS A0A1H9BEQ0_9FIRM/8-118 AC A0A1H9BEQ0.1
#=GS A0A235B4J0_9BACL/9-118 AC A0A235B4J0.1
#=GS A0A0C2RFW1_9BACL/6-119 AC A0A0C2RFW1.1
#=GS Q5F6G8_NEIG1/9-120 AC Q5F6G8.1
#=GS A0A318JAF4_9BURK/13-125 AC A0A318JAF4.1
#=GS A0A1D7XW03_9FLAO/8-110 AC A0A1D7XW03.1
#=GS A0A1H2G214_9FLAO/8-111 AC A0A1H2G214.1
#=GS Q9K123_NEIMB/9-120 AC Q9K123.1
#=GS A0A427DMK8_9PSED/9-124 AC A0A427DMK8.1
#=GS C8PLA1_9PROT/8-128 AC C8PLA1.1
#=GS A0A7W5FS17_9BACL/6-122 AC A0A7W5FS17.1
#=GS A0A1M5SGF6_9FIRM/6-123 AC A0A1M5SGF6.1
#=GS A0A2S0U6L7_9BACL/7-122 AC A0A2S0U6L7.1
#=GS A0A6N8F5V9_9GAMM/7-117 AC A0A6N8F5V9.1
#=GS A0A2M8S4E0_9PAST/9-113 AC A0A2M8S4E0.1
#=GS A0A5D8Z0V2_9GAMM/9-119 AC A0A5D8Z0V2.1
#=GS A0A5B7YJD1_9ALTE/6-118 AC A0A5B7YJD1.1
#=GS A0A172TG07_9BACL/6-120 AC A0A172TG07.1
#=GS A0A5D0CX57_9BACL/7-124 AC A0A5D0CX57.1
#=GS A0A090ZPG5_PAEMA/6-118 AC A0A090ZPG5.1
#=GS A0A345ZHP5_9GAMM/9-100 AC A0A345ZHP5.1
#=GS D3E9Z5_GEOS4/6-122 AC D3E9Z5.1
#=GS A0A5B7Y8Q3_9ALTE/6-118 AC A0A5B7Y8Q3.1
#=GS A0A1B1U6I7_9HELI/17-126 AC A0A1B1U6I7.1
#=GS A0A839UTH0_9GAMM/8-121 AC A0A839UTH0.1
#=GS A0A1B1U6F5_9HELI/12-128 AC A0A1B1U6F5.1
#=GS A0A345ZHN9_9GAMM/9-119 AC A0A345ZHN9.1
#=GS A0A128EC93_9PROT/8-123 AC A0A128EC93.1
B9Y4S0_9FIRM/11-111 .......ei--LNANWKAEDGSFLYYLHEENNFHEAAFLELCSCIY....SLSR....R.HPQDQTVSSKIVFVYG....QVL.KH.L..F....YHFDPq..dLSSI---SNLP--S..D.YS..EK........LELLE.QN.V-----.....----------iqyfqgd..................................
Q9K124_NEIMB/9-120 .........RNVPYFEGYDENSFIGKWYDDGVWDDEEYWKLENDLI....EVRK....K.YPYPMDIPRYVVIGIG....TII.DF.L..M....VPNWK....LFEIKASPWLPDSV..G.IH..ER........YERFT.TM.LRYIFT.....EKDIVNVRFD.........................................
A0A3N9UEM9_9BACI/6-124 ........e-VLKSNYEGKEGSFIYSLHEECKFNKSAFWDYYNSIV....DLTN....E.TLLQDSLDQELSLMLSttyvFIM.RS.L..L....WHFHPk..dMYKVKGVPK----N..K.LN..LY........IERLE.IA.YLGYFK.....G---------evfkeelhdenlin...........................
A0A494X5L5_9BURK/9-116 ........k-NLFSSLEYDENSFAGILHEQSIWQWEKYWLLEWALY....RLAA....E.GTNDADMCLGVFQIFS....GVL.NA.I..C....SHLDRd..dLFQIKNL----DHE..I.IY..DL........RERIL.MV.FEGFFQ.....----------tdagsirv.................................
A0A268SFK3_9BACL/1-93 ......mrn------ARAEENTFLYMLHEEARFDQSLFWKYVNSII....ELTL....L.TA-DHPLNREAAGAVSftysKIM.EY.L..Q....WHHSDs..dVYEIENFPYV----..-.--..--........-----.--.------.....----------yahhvvsllge..............................
A0A3D8VEE1_9GAMM/14-123 .......kn--HPASGEFETTSFRSRLYEDATWSQDEYWKVEWALF....QLAA....A.ADSDAELRWRVFRLFS....ATV.SL.F..V....AHYDPk..dIYVM----DGIDAE..G.LL..EA........RERFD.LV.FEGFFS.....QQ--------mpdvrswp.................................
C8PLA2_9PROT/8-123 ........r-NSTNSDKFSINSFVGKFIYQKTWSDCDYWKLDKTLM....QILS....F.YH-NKTLPREIFVAII....AIF.ND.V..I....GVEDKseiyVSNILCAKNS-DGVvpR.IY..DR........FERLN.VL.CNSIVF.....KEEFSN----sgfw.....................................
Q5F706_NEIG1/9-120 .........RNIPCFEEYDENSFIGKWYDDGVWDDEEYWKLENDLI....EVRR....K.YPYPMDIPRDIVIGIG....TII.DF.L..M....VPNWE....LFEIKASPWLPDSV..G.IH..ER........YERFT.TM.LRYIFT.....EKDIVNVRFD.........................................
Q5F6G9_NEIG1/9-120 .........RNIPCFEEYDENSFIGKWYDDGVWDDEEYWKLENALI....EVRK....K.YPYPMDIPRDIVIGIG....TII.DF.L..M....VQNWK....LFEIKASPWLPKSV..K.IN..ER........YERFR.VM.LRYIFT.....DLDAEDWKFF.........................................
A0A128EDV8_9PROT/8-128 ........r-NTAFDNRYDENSFIGKILNYNLWSDDEYWKLEADLQ....KLLR....L.NLNKIFIKQEIMEGIF....SICnDV.F..L....AQKWD....FIKIDSDILYKNNP..N.II..DKepn.iydrFRRLKrLL.VAVAYG.....DENFFNIDF-v........................................
Q9K127_NEIMB/12-123 .........RNITCFEGYDENSFIGKWYDDGVWDDEEYWKLENDLI....EVRK....K.YPYPMDIPRYVVIGIG....TII.DF.L..M....VPNWK....LFEIKASPWLPDSV..G.IN..ER........YERLK.TM.LRYIFT.....EKDIVNVQFD.........................................
A0A235B1N6_9BACL/9-80 ......lvl---KKNARGEKGSFIYFLHERNRFDEKSYREYFNSVI....NIVN....K.RA-DKPLDRDISTMLVksysYIL.RS.F..-....-----....--------------..-.--..--........-----.--.------.....----------iflli....................................
A0A1H9BEQ0_9FIRM/8-118 ........k-VLSDNYECTGESFFYYLYEESIFSVEKFWEYYDCIV....AFVG....Q.RDKDPEITKEIDYTYQ....KIL.KE.F..I....YHFDPn..dLTELKNFPE-----..N.YT..QY........IERIE.FA.QAAYY-.....----------rnnlaliddsifd............................
A0A235B4J0_9BACL/9-118 ....lvlkk-----NVRGEKGSFIYFLHERNRFDEKSYREYFNSVI....NIVN....KrEPLDRDISTMLVKSYS....YIL.RS.F..I....FHLSPn..dLSEIDKYP---QES..S.-S..DY........IENLN.IV.IESYFR.....GTKV------drrif....................................
A0A0C2RFW1_9BACL/6-119 .......av--IYNNSILREGSFLCSLVEEATFDEHLFWRYYNSVI....TLTE....E.NL-NKDYDWELVKQVIwthnRII.KC.F..L....WHHDEk..dVYEM---ENFPQER..E.M-..DF........LERLD.FM.FDGFIG.....K---------raysekgfgd...............................
Q5F6G8_NEIG1/9-120 .........RNVPYFEGYDENSFIGKWYDDGVWDDEEYWKLENDLI....EVRR....K.YPYPMDIPRDIVIGIG....TII.EF.L..M....VPNWK....LFEIKASPWLPDSV..G.IN..ER........YERLK.TM.LRYIFT.....EKDIVNVQFD.........................................
A0A318JAF4_9BURK/13-125 rnlpehpnw----------EGSFYEQLTEYGTWNKKEFWLLHRDLVlaahELKD....A.ETVDKQLAEAIVRLQA....NVD.RL.L..M....AHFDQn..dVFTI-----LDLSA..D.ET..YA.......fKERFE.MA.VAGVFS.....GKVIAE----dafe.....................................
A0A1D7XW03_9FLAO/8-110 .....kiln----DNAATENDSYLYFIHEEGCFDEFSFWEFYNAIK....VLGH....E.FKDEKKLSRELMKKII....KSY.EW.Y..L....I----....--------------..-.--..--........-----.--.------.....----------ligfhfdpndksridhlpenysqyslrlrnaitsfid....
A0A1H2G214_9FLAO/8-111 .......ni--INDNAESENNSYMDFMHERGLFDKHSFWKFYNSIR....LLGY....E.FRNDESLPRELTKKIL....KSY.EW.-..-....-----....--------------..-.--..--........-----.--.------.....----------hliligfhfdenddssidnlpkdfsqyslrlrcavnafieg
Q9K123_NEIMB/9-120 .........RNIPCFKEYDENSFIGKWYDDGVWDDEEYWKLENDLI....EVRK....K.YPYPMDIPRDIVIGIG....TII.DF.L..M....VQNWK....LFEIKASTWLPKSV..K.IN..ER........YERFR.VM.LRYIFT.....DLDVEDWKFF.........................................
A0A427DMK8_9PSED/9-124 ....rnfvg-----GEAFEDASFIGRLHEAEIWDHDEYWLLEWALY....QLAT....E.ASFSLTLFQRVFEIFS....YSF.LL.F..G....CHFDHk..dGFKIR----NLKRN..Q.IY..DF........RERFK.MV.FEGFFA.....GK--------mpaparfdeanpwl...........................
C8PLA1_9PROT/8-128 ........r-NTAFDDRYDANSFIGMILDYNLWSDDEYWKLEADLK....KILQ....H.YK-NKELDPEIMQGII....SISnDI.F..L....NGSWR....DVDIDAKSECFKTY..E.YQ..EDtkpnifdrFRRIK.SL.LLAVAS....gDENFYKIKF-f........................................
A0A7W5FS17_9BACL/6-122 .....kvlf----NNFSCVENTFIHKLSEESLFDFPLFWELYNSVR....VVIK....E.TI-DQPLDREISRAISymhaKIL.EL.I..I....WEYSD....I-NVGQTENFP-FI..K.LN..LI........IERLS.FL.VDGYFK.....GYLIDESNF-deelk....................................
A0A1M5SGF6_9FIRM/6-123 .......qi--LFNNYKGKNDSFIYYLHEKNIFNENSFIEYCKAII....KITEenfkR.YN-HKNIDRKISKMINytygYIL.KS.F..I....NHLNKn..dLYKMSNYPV----K..N.LY..GY........ISILD.TV.INAYFA.....GK--------kldisidel................................
A0A2S0U6L7_9BACL/7-122 ....qvlld-----NFHGREGSFIYSLHERSEFSEPAFWDYYNSLI....ELTR....L.TKDHGALDRDLAEMVChtydYIL.KS.F..I....WNFHPt..dLYTISHLPIE----..-.--..--........-----.--.------.....----------dlslyierleyaykgfirghlfkeemfelk...........
A0A6N8F5V9_9GAMM/7-117 ........r-NIPGNLNW-EGSFYERLTEYGEWDSKSFWVLHLDLL....NIAK....Q.QISNKPVERELAYMLLqlqqKVL.NL.I..S....ANFAKd..dVFNI-SNITTEQLY..E.FQ..ER........FE---.--.------.....----------mailgaisgevlpess.........................
A0A2M8S4E0_9PAST/9-113 .........RNITFFEEYDENSFIGRWLDYSEWNDHEYFKLEKSLL....KIAR....I.YQENDELKQDILMGIM....RIV.EL.M..M....ISNWG....YFEV-------KSL..D.IY..DR........YDRFK.YL.LSKLFS.....KEEI------fldnfa...................................
A0A5D8Z0V2_9GAMM/9-119 ........r-NHPWSGEFDETSFRACLYEDATWSQDEYWKVEWALF....QLVG....A.VGSDPELRRRAFRLFS....ATF.SL.F..A....AHLDPn..dVYTIQ----NMEPE..K.LY..EA........KERFQ.LV.FEGFFA.....----------gempdlsagfd..............................
A0A5B7YJD1_9ALTE/6-118 ........r-NFVLSKEFSENSFISIFHESQTWNDVEYFKLENYLY....EECE....K.HLSVSVIPREVLWPAIriysYLS.NA.I..G....CHLDPn..dGFEI----IGISQK..Q.LY..QR........RERLQ.LV.FEGFFQ.....----------gempakkyi................................
A0A172TG07_9BACL/6-120 ........q-ILNNNYEIKEGSFIYSLSEEAVFNEQHFWDYYNAVI....EVVK....E.NL-NKQLDKEVTNIIHwtyrRIM.DC.F..L....WHLDTn..dAYLM---DNFP-SD..N.FI..YF........KERLD.LM.IEGYFG.....DFVMNEKQF-gds......................................
A0A5D0CX57_9BACL/7-124 ........k-VLEANSNGQKGSFIYYLHEEDLFHEASYWELYHAMV....DIIE....A.TKREPRLERGISAAIAkvfsFIY.RS.F..M....WNYCPn..dQYSI---QGLPGEE..H.FP..DM........VDRLD.EV.FGAYFH.....G---------isvkreaadsei.............................
A0A090ZPG5_PAEMA/6-118 .......qv--LMDNFHGAENSFLYRLSEEAFFDADLFGEYYQSLK....EIVR....Q.TL-GQPLDRELARAVSftqaKIL.EH.L..L....WEYADd..dAFQIGNFPF----G..R.LH..AF........IERLN.AA.VDGYFQ.....GY--------lvdeqsfg.................................
A0A345ZHP5_9GAMM/9-100 ........r-NHPWSGEFDETSFRACLYEDATWSQDEYWKVEWALF....QLVG....A.VGSDPELRRRAFRLFS....ATF.SL.L..A....AHLDPn..dVYTIKN--------..-.--..--........-----.--.------.....----------mepeklyeakerlq...........................
D3E9Z5_GEOS4/6-122 .........QVLTSNYQLKEGSFLYSLLEEASFNEIAFWNYYNAVI....EIID....Q.TK-DKQLDRELTKIIHwtykRVM.RS.F..L....CHFDPs..dVFKI---------S..D.FP..DDrf...iyfYERLD.FM.IDGYYEgfimsEKQF------gdnik....................................
A0A5B7Y8Q3_9ALTE/6-118 ........r-NFVLSKEFSENSFISIFHESQTWNDVEYFKLENYLY....EECE....K.HSSISAIPREVLLPAT....RIY.SY.L..SnaigCHLDPn..dGFEI----IGISQN..Q.LY..QR........RERLQ.LV.FEGFFQ.....----------gempakknl................................
A0A1B1U6I7_9HELI/17-126 ..kkllrln-----------DDFKYCLWNGGGWSDEEYWKLEKGVI....ELIE....L.NV-NGKYQKKINAILG....KII.DY.Y..F....AMNPS...yIIDFEKLNTQNQSE..N.INqyDR........IDRLQ.FLaLALMYN.....DTN-------litenq...................................
A0A839UTH0_9GAMM/8-121 .........RNFPWCDEYEDDSFTGTLNEKCAWSDEEYFKLDDELY....ELST....R.YKDADQLPRVLVWRLM....RIF.SY.V..MmtigCHSNPn..dGYKI----ENIDDE..Q.LF..DR........RERFQ.LV.FEGFFK.....----------gempktkyfe...............................
A0A1B1U6F5_9HELI/12-128 .snqhfedf--------LEDNNFRHCLWDERGWSDEEYWKLEKGVI....ELIE....L.NV-NGKYQKKINAILG....KII.EVyF..L....MQETHgcsiYFNDLNVDNQNGYI..G.IQ..ER........IDRFK.SLvLALLFN.....NT--------klikksfp.................................
A0A345ZHN9_9GAMM/9-119 ........r-NHPWSGEFDETSFRACLYEDATWSQDEYWKVEWALF....QLVG....A.VGSDPELRRRAFRLFS....ATF.SL.L..A....AHLDPn..dVYTIKNM----EPE..K.LY..EA........KERFQ.LV.FEGFFA.....----------gempdlsagfd..............................
A0A128EC93_9PROT/8-123 .........QNIKKIDKFNPHSFVGKFILQGVWSDIDYWGLDSDLV....KIYK....H.YK-NKELPKDIFAGIV....SIM.TD.IcgI....CEKSE....IY-IDNEYYLKNDD..GvIP..DLy.....srYERLK.VL.CECIVY.....KHEFECID--fw.......................................
#=GC seq_cons ...........h..stchcEsSFltpLaEcuhWs-ccYWclcsuLh....clsc....p.hh.stplsR-lsthls....pIh.ch.h..h....sphs.p...lapI.t.....t....p.l...-h........hERhp.hh.hphhFt.....t.........h........................................
//
