#=GF ID MF_alpha_N
#=GF AC PF05436.6
#=GF DE Mating factor alpha precursor N-terminus
#=GF AU Moxon SJ
#=GF SE Pfam-B_12643 (release 8.0)
#=GF GA 21.90 21.90;
#=GF TC 25.30 25.50;
#=GF NC 20.00 18.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 6306574
#=GF RT Saccharomyces cerevisiae contains two discrete genes coding for
#=GF RT the alpha-factor pheromone.
#=GF RA Singh A, Chen EY, Lugovoy JM, Chang CN, Hitzeman RA, Seeburg PH;
#=GF RL Nucleic Acids Res 1983;11:4049-4063.
#=GF DR INTERPRO; IPR008675;
#=GF CC This family contains the N-terminal regions of the Saccharomyces
#=GF CC mating factor alpha precursor protein. All proteins in this
#=GF CC family contain one or more copies Pfam:PF04648 further toward
#=GF CC their C terminus.
#=GF SQ 57
#=GS G8ZYQ2_TORDC/1-79 AC G8ZYQ2.1
#=GS H0H1W1_9SACH/1-85 AC H0H1W1.1
#=GS C8ZIJ1_YEAS8/1-86 AC C8ZIJ1.1
#=GS Q6CMM5_KLULA/1-86 AC Q6CMM5.1
#=GS A7TJ28_VANPO/1-95 AC A7TJ28.1
#=GS Q874M4_CANGB/1-87 AC Q874M4.1
#=GS G2WE11_YEASK/1-81 AC G2WE11.1
#=GS G0WGY0_NAUDC/1-88 AC G0WGY0.1
#=GS G0XP55_9SACH/1-85 AC G0XP55.1
#=GS E7M106_YEASV/1-86 AC E7M106.1
#=GS A7TE98_VANPO/1-92 AC A7TE98.1
#=GS Q8J1Q5_SACPA/1-86 AC Q8J1Q5.1
#=GS G2WNZ7_YEASK/1-86 AC G2WNZ7.1
#=GS MFAP_LACKL/1-86 AC P06648.1
#=GS E9P9W0_YEASX/1-86 AC E9P9W0.1
#=GS Q8J094_SACPA/1-86 AC Q8J094.1
#=GS G0WCN5_NAUDC/1-93 AC G0WCN5.1
#=GS MFAL2_YEAST/1-81 AC P32435.1
#=GS H2ARH5_KAZAF/1-84 AC H2ARH5.1
#=GS Q8J1Q6_SACPA/1-86 AC Q8J1Q6.1
#=GS A6ZU91_YEAS7/1-81 AC A6ZU91.1
#=GS A3LXF9_PICST/1-83 AC A3LXF9.1
#=GS G0VEF5_NAUCC/1-90 AC G0VEF5.1
#=GS B3LHF4_YEAS1/1-81 AC B3LHF4.1
#=GS Q8J1Q7_SACPA/1-86 AC Q8J1Q7.1
#=GS G8BYV1_TETPH/1-85 AC G8BYV1.1
#=GS G8JR13_ERECY/1-85 AC G8JR13.1
#=GS C7GJD5_YEAS2/1-86 AC C7GJD5.1
#=GS E7NHM3_YEASO/1-81 AC E7NHM3.1
#=GS E7QEP9_YEASZ/1-81 AC E7QEP9.1
#=GS G0XP54_9SACH/1-86 AC G0XP54.1
#=GS F2Z659_CANGA/1-87 AC F2Z659.1
#=GS E7KCG9_YEASA/1-81 AC E7KCG9.1
#=GS G0VIT5_NAUCC/1-88 AC G0VIT5.1
#=GS Q874L5_KLUDE/1-85 AC Q874L5.1
#=GS E7KVD9_YEASL/1-86 AC E7KVD9.1
#=GS C5E2G9_LACTC/2-84 AC C5E2G9.1
#=GS G0WFY2_NAUDC/1-97 AC G0WFY2.1
#=GS G8JP74_ERECY/1-86 AC G8JP74.1
#=GS E7KJH1_YEASA/1-86 AC E7KJH1.1
#=GS Q8NK88_9SACH/1-86 AC Q8NK88.1
#=GS H0GG74_9SACH/1-81 AC H0GG74.1
#=GS MFAL1_YEAST/1-86 AC P01149.1
#=GS E7KNF1_YEASL/1-81 AC E7KNF1.1
#=GS E7QA67_YEASB/1-86 AC E7QA67.1
#=GS C7GW29_YEAS2/1-81 AC C7GW29.1
#=GS Q75ED2_ASHGO/1-85 AC Q75ED2.1
#=GS C8Z8F9_YEAS8/1-81 AC C8Z8F9.1
#=GS Q754X8_ASHGO/1-93 AC Q754X8.1
#=GS E7Q3T8_YEASB/1-81 AC E7Q3T8.1
#=GS H2AS56_KAZAF/1-88 AC H2AS56.1
#=GS E7LUC1_YEASV/1-81 AC E7LUC1.1
#=GS MFA1_SACBA/1-86 AC P25501.1
#=GS A6ZW67_YEAS7/1-86 AC A6ZW67.1
#=GS B3LKP2_YEAS1/1-86 AC B3LKP2.1
#=GS G0VKM8_NAUCC/1-86 AC G0VKM8.1
#=GS E7QLP5_YEASZ/1-86 AC E7QLP5.1
G8ZYQ2_TORDC/1-79 .........MKFFnTILST.TLFTYV.A.LAAP-.-.....-..--VES..DPV.....NIPSEAILGYMDFTEDQDVGVVAY..TNSTFSGLIFFNSSIIET-....--.-...--...-.------kdltkrdaea....
H0H1W1_9SACH/1-85 .........MRFS.SIITA.-VFAAS.S.ALAAP.V.....N..TTSES..ETV.....QIPAEAIIGYLDLEGDFDVAVLPF..ANSTNNGLLFINTTIANLA....TK.E...ES...V.PLSKRE..............
C8ZIJ1_YEAS8/1-86 .........MRFP.SIFTA.VLFAAS.S.ALAAP.V.....N..TTTED..ETA.....QIPAEAVIGYLDLEGDFDVAVLPF..SNSTNNGLLFINTTIASIA....AK.E...EG...V.SLDKRE..............
Q6CMM5_KLULA/1-86 .........MKFS.TILAA.STALIS.V.VMAAP.V.....S..TETDI..DDLp...iSVPEEALIGFIDLTGD-EVSLLPV..NNGTHTGILFLNTTIAEAA....FA.D...KD...-.DLKKRE..............
A7TJ28_VANPO/1-95 .........MKFS.TVLST.VALAAT.A.VSAAP.IsrasnE..TVESV..ESG....lNVPAEAVLGYLDFGEKDDVAMLPF..SNGTSNGLLFVNTTIYDAAf.adSD.D...ES...A.SLAKR-d.............
Q874M4_CANGB/1-87 .........MRFL.RFIST.VALLIT.G.LATAQ.P.....V..GEELG..ETV.....EVPSEAFIGYLDFGATNDVAILPI..SNKTNNGLLFVNTTLYNQA....TK.G...EK...-.------lsdftkrd......
G2WE11_YEASK/1-81 .........MKFI.STFLT.FILAAV.S.VTAS-.-.....-..--SDE..DIA.....QVPAEAIIGYLDFGGDHDIAFLPF..SNATASGLLFINTTIAEAA....EK.E...QN...T.TLAKRE..............
G0WGY0_NAUDC/1-88 .........MKFT.TILSA.ITLLSS.S.AFAE-.D.....I..STGDA..ELP.....QVPAEAVLGYLDFGSDNDIAMLPF..ANTTSNGLLFVNTTIVEQA....NE.KlenDP...S.SLTKRE..............
G0XP55_9SACH/1-85 .........MKLS.SLLPI.LA-AAT.T.AIAAP.V.....Q..TQGAE..SHL.....NIPQEAVLGFIDLGNGNDIQVTTI..LNGTQNGILLFNSTVANAA....AA.P...SD...S.TLAKRD..............
E7M106_YEASV/1-86 .........MRFP.SIFTA.VLFAAS.S.ALAAP.V.....N..TTTED..ETA.....QIPAEAVIGYLDLEGDFDVAVLPF..SNSTNNGLLFINTTIASIA....AK.E...EG...V.SLDKRE..............
A7TE98_VANPO/1-92 .........MKLT.NVLSA.VALAST.A.LAAPV.A.....KdaTNTTD..ASS....vQIPAEAVIGYLDLEQSNDVAMLQF..SNSTNNGILFVNSTILKAA....YA.E...ANansN.SNTKRE..............
Q8J1Q5_SACPA/1-86 .........MRFC.SVFTA.FSFAAS.S.ALAAP.V.....N..TTTED..EMA.....RIPAEAIIGYLDLEGDFDVAVLPF..SNSTNNGLLFINTTIANIA....AE.E...EG...V.TLNKRE..............
G2WNZ7_YEASK/1-86 .........MRFP.SIFTA.VLFAAS.S.ALAAP.V.....N..TTTED..ETA.....QIPAEAVIGYLDLEGDFDVAVLPF..SNSTNNGLLFINTTIASIA....AK.E...EG...V.SLDKRE..............
MFAP_LACKL/1-86 .........MKLF.TTLSA.SLIFIH.S.LGSTR.A.....A..PVTGD..ESS....vEIPEESLIGFLDLAGD-DISVFPV..SNETHYGLMLVNSTIVNLA....RS.E...SA...N.FKGKRE..............
E9P9W0_YEASX/1-86 .........MRFP.SIFTA.VLFAAS.S.ALAAP.V.....N..TTTED..ETA.....QIPAEAVIGYSDLEGDFDVAVLPF..SNSTNNGLLFINTTIASIA....AK.E...EG...V.SLDKR-f.............
Q8J094_SACPA/1-86 .........MRFC.SVFTA.FSFAAS.S.ALAAP.V.....N..TTTED..EMA.....QIPAEAIIGYLDLEGDFDVAVLPF..SNSTNNGLLFINTTIANIA....AE.E...EG...V.TLNKRE..............
G0WCN5_NAUDC/1-93 .........MKYS.HFFNS.LALLLS.S.ISLISaT.....Q..LIDDL..TNSd...gNIPTEAIIGYLDLGADSDVTLLPF..SNNTASGLLFVNATILDQAlassEK.S...DN...N.GLSKR-a.............
MFAL2_YEAST/1-81 .........MKFI.STFLT.FILAAV.S.VTAS-.-.....-..--SDE..DIA.....QVPAEAIIGYLDFGGDHDIAFLPF..SNATASGLLFINTTIAEAA....EK.E...QN...T.TLAKRE..............
H2ARH5_KAZAF/1-84 .........MKFT.GVLSA.LSLLSS.A.VLAET.-.....-..ESQST..EAI.....SVPSEAIIGYLDLDGANDVAIIPL..VNTTDSGLLFVNTTIYEQA....SN.E...DN...V.SLKKRE..............
Q8J1Q6_SACPA/1-86 .........MRFC.SVFTA.FSFAAS.S.ALAAP.V.....N..TTTED..EMA.....RIPAEAIIGYLDLEGDFDVAVLPF..SNSTNNGLLFINTTIANIA....AE.E...EG...V.TLNKRE..............
A6ZU91_YEAS7/1-81 .........MKFI.STFLT.FILAAV.S.VTAS-.-.....-..--SDE..DIA.....QVPAEAIIGYLDFGGDHDIAFLPF..SNATASGLLFINTTIAEAA....EK.E...QN...T.TLAKRE..............
A3LXF9_PICST/1-83 ....mhlrs---T.AILSA.VVFTSV.A.LSA--.-.....-..PTSGQ..NID....iDFPDESIAGAIPLSYD----LVPIigSYQGQNVILIVNSTIAAAS....EA.A...AS...E.GKSKR-d.............
G0VEF5_NAUCC/1-90 .........MKLS.ALLST.VALAST.S.FAAPI.D.....T..TASNEnlNST.....DIPAEAVIGYLDLGSDSDVAMLPF..QNSTSNGLLFVNTTIVQQA....AQ.E...NDd.sV.GLAKRE..............
B3LHF4_YEAS1/1-81 .........MKFI.STFLT.FILAAV.S.VTAS-.-.....-..--SDE..DIA.....QVPAEAIIGYLDFGGDHDIAFLPF..SNATASGLLFINTTIAEAA....EK.E...QN...T.TLAKRE..............
Q8J1Q7_SACPA/1-86 .........MRFC.SVFTA.FSFAAS.S.ALAAP.V.....N..TTTED..EMA.....QIPAEAIIGYLDLEGDFDVAVLPF..SNSTNNGLLFINTTIANIA....AE.E...EG...V.TLNKRE..............
G8BYV1_TETPH/1-85 .........MKLS.SVLST.LALTAT.S.AFAAP.V.....S..NESVD..N-A.....SVPAEAIIGYLNFDGANDIALLPF..SNSTTSGVMFINTTIAEQA....YE.E...AG...V.SLSKRE..............
G8JR13_ERECY/1-85 .........MKLS.SLLPI.LA-AAT.T.AIAAP.V.....Q..TQGAE..SHL.....NIPQEAVLGFIDLGNGNDIQVTTI..LNGTQNGILLFNSTVANAA....AA.P...SD...S.TLAKRD..............
C7GJD5_YEAS2/1-86 .........MRFP.SIFTA.VLFAAS.S.ALAAP.V.....N..TTTED..ETA.....QIPAEAVIGYLDLEGDFDVAVLPF..SNSTNNGLLFINTTIASIA....AK.E...EG...V.SLDKRE..............
E7NHM3_YEASO/1-81 .........MKFI.STFLT.FILAAV.S.VTAS-.-.....-..--SDE..DIA.....QVPAEAIIGYLDFGGDHDIAFLPF..SNATASGLLFINTTIAEAA....EK.E...QN...T.TLAKRE..............
E7QEP9_YEASZ/1-81 .........MKFI.STFLT.FILAAV.S.VTAS-.-.....-..--SDE..DIA.....QVPAEAIIGYLDFGGDHDIAFLPF..SNATASGLLFINTTIAEAA....EK.E...QN...T.TLAKRE..............
G0XP54_9SACH/1-86 .........MKFY.NILSV.ASIASL.V.FAAPV.S.....V..NDAKE..IAA.....TFPQEALLGFLDLTDAENIVILSL..VDEEKSGIALVNKTIWATA....RS.E...QA...A.GISKRD..............
F2Z659_CANGA/1-87 .........MRFL.RFIST.VALLIT.G.LATAQ.P.....V..GEELG..ETV.....EVPSEAFIGYLDFGATNDVAILPI..SNKTNNGLLFVNTTLYNQA....TK.G...EK...-.------lsdftkrd......
E7KCG9_YEASA/1-81 .........MKFI.STFLT.FILAAV.S.VTAS-.-.....-..--SDE..DIA.....QVPAEAIIGYLDFGGDHDIAFLPF..SNATASGLLFINTTIAEAA....EK.E...QN...T.TLAKRE..............
G0VIT5_NAUCC/1-88 .........MQLA.SIILA.FLIASFfS.IAVPI.Q.....L..SDNLA..NSR....qEIPKEAVIGYLDFGSQRDITLLPF..ANSTTSGLLFANSTLLEQA....SV.G...NN...R.TLLKRE..............
Q874L5_KLUDE/1-85 .........MKFS.KILIA.AASILT.A.VQAAP.V.....E..N--VD..DSA.....QVPEEAIIGYIDFEGASDVAILPF..SNSTDSGLMFVNTTIYNEA....TTaV...EG...E.SVEKRE..............
E7KVD9_YEASL/1-86 .........MRFP.SIFTA.VLFAAS.S.ALAAP.V.....N..TTTED..ETA.....QIPAEAVIGYLDLEGDFDVAVLPF..SNSTNNGLLFINTTIASIA....AK.E...EG...V.SLDKRE..............
C5E2G9_LACTC/2-84 ........l-KSF.SLFLA.FALTSI.T.VSAAP.I.....N..ITDSD..--P.....VIPRESICGFLDLTDAEDLALLPV..SNGTHSGILVVNTTILAQA....FG.-...--...-.------sddiltkrd.....
G0WFY2_NAUDC/1-97 .........MKFS.TLLSTaAALAST.S.LAAPI.N.....T..TETID..NSSaatsaDIPAEAILGYLDLDGDNDIALLPF..ANATSNGLLFVNTTIVEQA....TK.E...QQ...N.------gdgsvdltkre...
G8JP74_ERECY/1-86 .........MKFY.NILSV.ASIASL.V.FAAPV.S.....V..NDAKE..IAA.....TFPQEALLGFLDLTDAENIVILSL..VDEEKSGIALVNKTIWATA....RS.E...QA...A.GISKRD..............
E7KJH1_YEASA/1-86 .........MRFP.SIFTA.VLFAAS.S.ALAAP.V.....N..TTTED..ETA.....QIPAEAVIGYLDLEGDFDVAVLPF..SNSTNNGLLFINTTIASIA....AK.E...EG...V.SLDKRE..............
Q8NK88_9SACH/1-86 .........MKFS.TILSA.AALAAS.A.FAAPI.E.....Q..PEQDL..NST.....TIPAEAIISYLDLEGDKDIAVVPF..SNATDSGLLFVNTTILAQA....NK.E...AG...T.PLQKRE..............
H0GG74_9SACH/1-81 .........MKFI.STFLT.FILAAV.S.VTAS-.-.....-..--SDE..DIA.....QVPAEAIIGYLDFGGDHDIAFLPF..SNATASGLLFINTTIAEAA....EK.E...QN...T.TLAKRE..............
MFAL1_YEAST/1-86 .........MRFP.SIFTA.VLFAAS.S.ALAAP.V.....N..TTTED..ETA.....QIPAEAVIGYLDLEGDFDVAVLPF..SNSTNNGLLFINTTIASIA....AK.E...EG...V.SLDKRE..............
E7KNF1_YEASL/1-81 .........MKFI.STFLT.FILAAV.S.VTAS-.-.....-..--SDE..DIA.....QVPAEAIIGYLDFGGDHDIAFLPF..SNATASGLLFINTTIAEAA....EK.E...QN...T.TLAKRE..............
E7QA67_YEASB/1-86 .........MRFP.SIFTA.VLFAAS.S.ALAAP.V.....N..TTTED..ETA.....QIPAEAVIGYLDLEGDFDVAVLPF..SNSTNNGLLFINTTIASIA....AK.E...EG...V.SLDKRE..............
C7GW29_YEAS2/1-81 .........MKFI.STFLT.FILAAV.S.VTAS-.-.....-..--SDE..DIA.....QVPAEAIIGYLDFGGDHDIAFLPF..SNATASGLLFINTTIAEAA....EK.E...QN...T.TLAKRE..............
Q75ED2_ASHGO/1-85 .........MKTT.HILSL.ATLAAC.ApVQPAP.V.....Q..PTDLA..AAA.....NVPEKAVLGFFQLYNVGDVELLPV..DDGAHSGILFVNRTLADVD....YS.S...E-...-.------hvvqkw........
C8Z8F9_YEAS8/1-81 .........MKFI.STFLT.FILAAV.S.VTAS-.-.....-..--SDE..DIA.....QVPAEAIIGYLDFGGDHDIAFLPF..SNATASGLLFINTTIAEAA....EK.E...QN...T.TLAKRE..............
Q754X8_ASHGO/1-93 mkisllfsv----.SALLG.AVIAIP.-.VNGSR.P.....E..VTIDD..VRG.....NIPEDAVLGFLDLSDVEGLAVRPI..QTEERTGLLFVNRQLAEKG....T-.-...--...-.------eaassqgspklekd
E7Q3T8_YEASB/1-81 .........MKFI.STFLT.FILAAV.S.VTAS-.-.....-..--SDE..DIA.....QVPAEAIIGYLDFGGDHDIAFLPF..SNATASGLLFINTTIAEAA....EK.E...QN...T.TLAKRE..............
H2AS56_KAZAF/1-88 .........MKFS.TILST.AAFVSS.S.VMAAP.V.....N.vTETEQ..ENL.....AIPSEALIGYLDLKGDDDISILPV..SNSTNSGLLFLNSTILTQA....MN.E...NT..eA.ALSKRE..............
E7LUC1_YEASV/1-81 .........MKFI.STFLT.FILAAV.S.VTAS-.-.....-..--SDE..DIA.....QVPAEAIIGYLDFGGDHDIAFLPF..SNATASGLLFINTTIAEAA....EK.E...QN...T.TLAKRE..............
MFA1_SACBA/1-86 .........MRFP.SIFTA.VLFAAS.S.ALAAP.V.....N..TTTED..ETA.....QIPAEAVIGYLDLEGDFDVAVLPF..SNSTNNGLLFINTTIASIA....AK.E...EG...V.SLDKRE..............
A6ZW67_YEAS7/1-86 .........MRFP.SIFTA.VLFAAS.S.ALAAP.V.....N..TTTED..ETA.....QIPAEAVIGYLDLEGDFDVAVLPF..SNSTNNGLLFINTTIASIA....AK.E...EG...V.SLDKRE..............
B3LKP2_YEAS1/1-86 .........MRFP.SIFTA.VLFAAS.S.ALAAP.V.....N..TTTED..ETA.....QIPAEAVIGYLDLEGDFDVAVLPF..SNSTNNGLLFINTTIASIA....AK.E...EG...V.SLDKRE..............
G0VKM8_NAUCC/1-86 .........MKFS.SILST.IALFSA.S.TLAT-.-.....D..IETED..ATM....pQVPAEAVIGYLDFDGDNDIAMLPF..ANATSSGLLFVNTTLVEQA....NN.E...EG...SiSLAKRE..............
E7QLP5_YEASZ/1-86 .........MRFP.SIFTA.VLFAAS.S.ALAAP.V.....N..TTTED..ETA.....QIPAEAVIGYLDLEGDFDVAVLPF..SNSTNNGLLFINTTIAXIA....AK.E...EG...V.SLDKRE..............
#=GC seq_cons .........M+Fs.Slhos.hhhAAs.S.shAu..s.....t..spo--..-tA.....plPAEAlIGYLDLtGDpDlAlLPF..SNuTssGLLFlNTTIAptA....tc.E...ps...s.oLsKRE..............
//
