#=GF ID   Ntox28
#=GF AC   PF15605.10
#=GF DE   Bacterial toxin 28
#=GF PI   Toxin_52; Toxin_28;
#=GF AU   Zhang D;0000-0001-8535-7620
#=GF AU   de Souza RF;0000-0002-5284-4630
#=GF AU   Anantharaman V;0000-0001-8395-0009
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   [1]
#=GF GA   25.00 25.00;
#=GF TC   25.40 25.30;
#=GF NC   24.10 22.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   22731697
#=GF RT   Polymorphic toxin systems: comprehensive characterization of
#=GF RT   trafficking modes, processing, mechanisms of action, immunity
#=GF RT   and ecology using comparative genomics.
#=GF RA   Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL   Biol Direct. 2012;7:18.
#=GF RN   [2]
#=GF RM   22333533
#=GF RT   Identification of a target cell permissive factor required for
#=GF RT   contact-dependent        growth inhibition (CDI).
#=GF RA   Diner EJ, Beck CM, Webb JS, Low DA, Hayes CS;
#=GF RL   Genes Dev. 2012;26:515-525.
#=GF RN   [3]
#=GF RM   26305955
#=GF RT   Contact-dependent growth inhibition toxins exploit multiple
#=GF RT   independent cell-entry pathways.
#=GF RA   Willett JL, Gucinski GC, Fatherree JP, Low DA, Hayes CS;
#=GF RL   Proc Natl Acad Sci U S A. 2015;112:11341-11346.
#=GF DR   INTERPRO; IPR028948;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents the C-terminal RNase toxin domain found in
#=GF CC   bacterial polymorphic toxin systems. The toxin possesses an all
#=GF CC   alpha-helical fold and conserved aspartate and glutamate
#=GF CC   residues, and K[DE] and [DN]HxxE motifs. In bacterial
#=GF CC   polymorphic toxin systems, the toxin is exported by the type 2,
#=GF CC   type 5 or type 7 secretion system [1]. This C-terminal domain
#=GF CC   cleaves within tRNA anticodon loops, tRNase activity that is
#=GF CC   stimulated by CysK which stabilises this domain and allows its
#=GF CC   binding to the tRNA substrate [2,3].
#=GF SQ   60
#=GS A0A085AAB6_9ENTR/3203-3293  AC A0A085AAB6.1
#=GS A0A1D3TZD6_9FIRM/811-913    AC A0A1D3TZD6.1
#=GS A0A4U9QZZ0_HATHI/36-138     AC A0A4U9QZZ0.1
#=GS A0A0B5F249_STRA4/1-41       AC A0A0B5F249.1
#=GS A0A180EL25_9BACT/2131-2231  AC A0A180EL25.1
#=GS A0A0U3P9T2_9HYPH/467-562    AC A0A0U3P9T2.1
#=GS W6W510_RHIS8/136-239        AC W6W510.1
#=GS A0A8J3BZB1_9ACTN/288-387    AC A0A8J3BZB1.1
#=GS A0A3Q9I6U8_9BACL/623-725    AC A0A3Q9I6U8.1
#=GS A0A5C5BGI4_9MICO/325-417    AC A0A5C5BGI4.1
#=GS A0A7W9Q3N5_9ACTN/894-1006   AC A0A7W9Q3N5.1
#=GS A0A3A4K5D6_9NOCA/1-88       AC A0A3A4K5D6.1
#=GS A0A7Y0JLA7_9ACTN/287-387    AC A0A7Y0JLA7.1
#=GS A0A0Q4GIR4_9SPHI/1-81       AC A0A0Q4GIR4.1
#=GS A0A518B0H0_9BACT/268-365    AC A0A518B0H0.1
#=GS A0A3N4ZJH9_9MICO/1816-1917  AC A0A3N4ZJH9.1
#=GS A0A2D3UJT8_STRC0/1445-1557  AC A0A2D3UJT8.1
#=GS Q2K1C1_RHIEC/65-111         AC Q2K1C1.1
#=GS A0A6I2FZI5_9NOCA/37-104     AC A0A6I2FZI5.1
#=GS A0A0N1GKK7_9ACTN/1-82       AC A0A0N1GKK7.1
#=GS A0A2I0SGL6_9ACTN/2040-2143  AC A0A2I0SGL6.1
#=GS A0A7W9HDG9_9PSEU/847-959    AC A0A7W9HDG9.1
#=GS K0EYQ2_NOCBR/347-445        AC K0EYQ2.1
#=GS A0A4R2JTM3_9PSEU/1-88       AC A0A4R2JTM3.1
#=GS A0A1G6USC4_NIADE/308-416    AC A0A1G6USC4.1
#=GS A0A5J5G4T6_9BACL/1-59       AC A0A5J5G4T6.1
#=GS A0A370QHZ5_9GAMM/198-271    AC A0A370QHZ5.1
#=GS A0A081XIJ9_STRTO/1369-1481  AC A0A081XIJ9.1
#=GS A0A3S8RWE2_9BACL/65-177     AC A0A3S8RWE2.1
#=GS A0A852U526_9ACTN/378-479    AC A0A852U526.1
#=GS D3EGL4_GEOS4/240-342        AC D3EGL4.1
#=GS A0A285F082_9ACTN/287-387    AC A0A285F082.1
#=GS B5CLC2_9FIRM/168-270        AC B5CLC2.1
#=GS A0A2V3VQW6_9BACI/1-55       AC A0A2V3VQW6.1
#=GS A0A495XLK6_9PSEU/881-993    AC A0A495XLK6.1
#=GS Q97J44_CLOAB/1-71           AC Q97J44.1
#=GS A0A090IXP3_9BACI/271-373    AC A0A090IXP3.1
#=GS B5HEJ1_STRE2/135-247        AC B5HEJ1.1
#=GS A0A0K8MBJ2_9PROT/759-855    AC A0A0K8MBJ2.1
#=GS A0A6B3W739_9BACI/76-128     AC A0A6B3W739.1
#=GS A0A2H5B4G4_9ACTN/2281-2381  AC A0A2H5B4G4.1
#=GS A0A7L4Y9W4_9ACTN/1461-1573  AC A0A7L4Y9W4.1
#=GS A0A1H8B5D5_9BACL/89-191     AC A0A1H8B5D5.1
#=GS R4LG98_9ACTN/266-368        AC R4LG98.1
#=GS A0A6G9YVR9_9NOCA/1-29       AC A0A6G9YVR9.1
#=GS A0A1I0HRQ2_9BACL/403-512    AC A0A1I0HRQ2.1
#=GS A0A4Q7L5F9_9PSEU/628-732    AC A0A4Q7L5F9.1
#=GS A0A6B3W5E0_9BACI/7-109      AC A0A6B3W5E0.1
#=GS A0A269VX40_9BACL/83-192     AC A0A269VX40.1
#=GS A0A0G2ZFT4_9DELT/330-432    AC A0A0G2ZFT4.1
#=GS V6KEU4_STRRC/1345-1457      AC V6KEU4.1
#=GS A0A3N6HBT3_9ACTN/1433-1545  AC A0A3N6HBT3.1
#=GS A0A1H6CZW1_9ACTN/1113-1230  AC A0A1H6CZW1.1
#=GS A0A0C1HSF7_9BACT/152-262    AC A0A0C1HSF7.1
#=GS A0A1H3V490_9BACI/39-141     AC A0A1H3V490.1
#=GS S3XD07_9ACTN/317-413        AC S3XD07.1
#=GS A0A2N3XUK7_SACSN/290-404    AC A0A2N3XUK7.1
#=GS A0A2T0LZ59_9PSEU/2622-2723  AC A0A2T0LZ59.1
#=GS A0A660CGL1_9PSEU/1374-1473  AC A0A660CGL1.1
#=GS A0A5B1AZA2_9FLAO/39-147     AC A0A5B1AZA2.1
A0A085AAB6_9ENTR/3203-3293             .........................k-LNQKQESAIKKIDNT.......IKNALKDHDITGTLKDMDGNPVPK.E...-.....NGG..YWDHMQEMQNTLRGL.RNHADTLKN-VNNP-.---.......---......-----------------------eaqaaygratdainkiesa
A0A1D3TZD6_9FIRM/811-913               .........................t-LTDAQKSRLNSLENT.......INDHLTEGDFSGTLRDLQGNPVPN.G...-.....KGG..YFDHLAEMKDSYVGL.NKVRKGLEGSLKNPN.LSD.......IDR......TLLQEGLDNANSYISRIQDMFK-p..................
A0A4U9QZZ0_HATHI/36-138                ..........................ELTRTQSKYIERMNNV.......INDHLKESDFSGALRDLEGNPVL-.R...P.....DGS..AFNHKKEVEDAYVGL.KKITKGLGNSLKNPN.LSG.......ATR......KIIQENVDKGNYYLNRIEELFK-v..................
A0A0B5F249_STRA4/1-41                  ........................ms----------------.......------------------------.-...-.....---..---------------.-------EAELRNPP.ETL.......TDRe....kEALHRRRKQTVTELDQLNGFLHS...................
A0A180EL25_9BACT/2131-2231             .............diierytkkfnnq----------------.......-GDHLSESDLVGATKDLFGRGIKK.S...-.....DGT..YWDHIGEVRQALGGM.GKQLAKLRKQIDSGDfDGD.......SLEa....aESLYKEVQKRKDQVQKV------lkqae..............
A0A0U3P9T2_9HYPH/467-562               ..........................DLRRTQRNAIEKIDNV.......INNNAKPHDFEGVRNELSGR----.-...P.....--T..GWDHVTEMRNSVRAL.EGAIRSLEGSLRNPS.LSP.......AAR......SEINAALARGRATLGQMVD----vlg................
W6W510_RHIS8/136-239                   ........................al--TKTQQDVIQGIENR.......IANTLNEKHYDAVRAELEGNVVAT.K...P.....NGT..PYDHITEVREARAGQ.IDAAKNIQTALGSPS.LNP.......AAR......ETLEQALSKASKSIDEAT-----kalkg..............
A0A8J3BZB1_9ACTN/288-387               ..............rsepagptktdn----------------.......CKEHLTEKDLDAARRELDGEVVAT.K...S.....TRK..PWDHVDEVRNAQDGL.VNRLGQLKRLLGDSR.VSA.......ADR......AQYQSELSEASRLLDYSEQFVP-r..................
A0A3Q9I6U8_9BACL/623-725               ..........skittsqratlnqqer----------------.......TYSHLTEMDLKGAQRDLDGNPVPK.-...P.....GGG..FYDHVQEVSDAYRGL.VDLKRSWEGVLKNPN.LDT.......ELR......QLYTSKLNEINATMKKIEDMFA-p..................
A0A5C5BGI4_9MICO/325-417               ....................tptdrq----------------.......-KEHLTERDLDSARRERAGEVVAR.K...S.....DGT..PWDHVQEVRNAQQGL.WNRIAKLKRMLGDSR.LSP.......EAR......QAAQEELSEASRLFDHSKGYLP-w..................
A0A7W9Q3N5_9ACTN/894-1006              .........................g-LSPAAQRAIEKFENIkkdplgdVNSQPNHNHYNAARREANGEVVAR.K...A.....DGT..PFDHIAELKQARDGL.DRSRRVLEREIETPP.AGL.......TDRg....iKVLIAKRKELIGELDRLNGFLHS...................
A0A3A4K5D6_9NOCA/1-88                  .........................m----------------.......-KEHLTDRDLDAARRELNGEVMAR.K...P.....DGT..PWDHVNEVKDAQNGL.VKRIGQLNRKLSWPG.LSE.......AER......PLIEQELSEASRLLDYSEQFVP-r..................
A0A7Y0JLA7_9ACTN/287-387               .............ssparsvprktdr----------------.......LKEHLTEKDLDAASRELKGEVVAT.K...S.....TGQ..PWDHVDEVQNAQRGL.VKRIDQLKRLLGDAR.ASE.......AEK......AAYQEELSEASRLLDHSEQFVP-r..................
A0A0Q4GIR4_9SPHI/1-81                  ........................mt----------------.......-----------GAIRDIFKDPVII.N...-.....-GK..QYDHLGEVKDALKGL.GNQIEKLNKAIRDGS.FFQ.......DVL......EQAQKLRSSLQKEKDRIQDLLN-katka..............
A0A518B0H0_9BACT/268-365               ...............ygryvrrvdny----------------.......-KHSLDPRHVKSAAREKAGEVVSR.K...E.....SGV..PYDHLTETRNDMASA.KRHIVNIKKHLSDRN.LSK.......ANR......AIIEGELGELSNLLDNAENIL--ge.................
A0A3N4ZJH9_9MICO/1816-1917             ...............nagacsllggr------------IDN-.......ITEHLQYKDLDAARRELGGEVVAR.K...A.....DGT..PWDHVHEVRDAQNGL.LKVIREANGALGHPK.LEP.......QVR......AQMEGDLARASKLLDYSEQFVP-r..................
A0A2D3UJT8_STRC0/1445-1557             .........................g-LSDAAQRAIQKLTNViedpigkINSQPNHNHYSAARREASGEVVAW.K...A.....PGV..PYDHIEDLRQGRNAL.DNIRKVLDEEIRRLP.DTI.......TERg....lEVLIKKRQEVIYHLDRVNGFLHQ...................
Q2K1C1_RHIEC/65-111                    ......................gllp----TQRSAVERIDNR.......IEEALNEAHFDAVRRERMGQVVAM.N...P.....K--..---------------.---------------.---.......---......-----------------------tgkp...............
A0A6I2FZI5_9NOCA/37-104                ............vqhrrhlrtvtrlt----------------.......------------------------.-...-.....---..-----RRVRNSQRGL.QSRIESIKNRLGWPK.LDP.......AER......KGLEDELGEASRLLDKSKLYV--pn.................
A0A0N1GKK7_9ACTN/1-82                  ........................me----------------.......--------DLTGAARELKGEVVKR.K...A.....NGV..PWDHVNEVRETQNRL.VKIIGRINNKLGHPK.TGD.......AAR......ELLVADLGRARGMLDYSTHYVP-r..................
A0A2I0SGL6_9ACTN/2040-2143             ...............lakkavstpfs----------AKLDNL.......M-EHLKMDDLTGAARELKGEVVKW.K...S.....PGV..PWDHVHEVRDAQNSL.LKQIKAINKRLSHPN.TGG.......AER......ELLVADLGRASRMLDFSEQFVP-r..................
A0A7W9HDG9_9PSEU/847-959               .........................g-LRQEAVNAIAKLENLkrnpvgeINREPNHNHYSAARREARGEVVAR.R...S.....DGR..PFSHIRDLQEACDGL.FKVREALTREAHNPP.DTM.......TERg....mTVLLERLSEVNRLINRLAGFLN-e..................
K0EYQ2_NOCBR/347-445                   ..........................DQSSRPTKTDK-----.......IKEHLTDRDLDAARRELNGEVVAR.K...P.....DGT..PWDHVREVRDAQNGL.VNRIGQIQRKLGDSR.TSG.......TER......QELERELSEASRLLDYSEQFVP-r..................
A0A4R2JTM3_9PSEU/1-88                  .........................m----------------.......-KEHLTERDLDAAKRELNGEVVAR.K...P.....DGT..PWDHVDEVRNAQRGL.VNRINQLKRQLGDSR.LSD.......ADR......ATAQEELSEASRLLDHSEQYVP-r..................
A0A1G6USC4_NIADE/308-416               ..................lgaegtql------------LEKIaak.vgrISTALDEKHITAAVNDILGKPVVI.N...-.....-GK..VYDHLKEVDNALTGV.GNQLVELNKVIDSGD.LGK.......DAL......KAAQDMRSQLQKQKDSITDIL--nrareka............
A0A5J5G4T6_9BACL/1-59                  ........................mi----------------.......------------------------.-...-.....---..--DHAQEVSDAYRGL.VDLKRSWEGMLKNPN.LDA.......ELR......QIYTSKFNEVNSKMEKIETMFN-p..................
A0A370QHZ5_9GAMM/198-271               .........................k-LNQKQESSIKKIDNL.......IKNSIKDHDITGTLKDMDSNPIL-.K...P.....DGSgkYWNHMKEMQDTLNGL.RNHENTLR-------.---.......---......-----------------------nvnnp..............
A0A081XIJ9_STRTO/1369-1481             ........................gl--TPAAQRAIEKFENTradplgdINSQPNHNHYDAARREANGEVVAR.K...P.....DGT..PFDHIAELKQARSAL.DKVRRVLERELEALP.DGL.......TDRg....lEVLITKRKEVIDELDRLNGFLHS...................
A0A3S8RWE2_9BACL/65-177                svddlsdvakskittsqratlnqqer----------------.......TYSHLTEMDLKGAQRDLDGDPVPK.-...P.....SGG..YYDHAQEVSDAYRGL.VELKRSWEGMLKNPN.LDA.......ELR......QLYTSKLNEANATMEKIETMFN-p..................
A0A852U526_9ACTN/378-479               .............vhnssrrcptktd---------------R.......IKEHLTERDLDAARRELDGEVVAR.K...P.....DGT..PWDHVNEVREAQQGL.RNRIQQIQRRLGDSR.VTD.......AER......TELEEELSEASRLLDHSEGFVP-p..................
D3EGL4_GEOS4/240-342                   ..........................ELSRAQNRNLETLDNI.......VDKHLTEMDFSGTLRDLQGNPVPK.R...-.....DGG..YWNHLQEMQDSYKGL.SKIKRGLEGSLQNPN.LSD.......STR......KTLQDALNKANLNLRKIEDLFE-p..................
A0A285F082_9ACTN/287-387               .............sqpsrsvpsktdr----------------.......MKEHLTDRDLDAARRELNGEVVAR.K...P.....SGQ..PWDHVDEVRNAQRGL.TRRIDQLKRLLGDSR.TTE.......AER......AAYQSELSEASRLLDHSEQFVP-r..................
B5CLC2_9FIRM/168-270                   .........................t-LTDAQKSRLNALENT.......INDHLTDGDFSGTLRDLQGDPVPN.G...-.....RGG..YFDHLGEMQDSYKSL.RKIKKALEGSLKNPN.LSD.......VDR......ALLQEGLNKANSYINKIEELFD-p..................
A0A2V3VQW6_9BACI/1-55                  ..........................----------------.......------------------------.-...-.....---..----MQEMKDSYKGL.NKIKRGLEGSLKKPN.LNK.......FER......KLLKDGLDKANNNIKKIEDLFA-p..................
A0A495XLK6_9PSEU/881-993               .........................g-LRQEAVDAIAKLENLkknpvgeINREPNHNHYSAARREARGEVVAR.K...A.....NGR..PFSHIRDLQEACDGL.FNVRETLSREAHNPP.DTM.......TERg....mHVLLERLSEVNRLINRLAGFLN-e..................
Q97J44_CLOAB/1-71                      .........................m----------------.......-----------------QGNLAPK.Q...-.....SGG..YWNHLQEMKNSYVGL.KRAQSTLEGSLKNPN.LPS.......HTK......EFIQSKYETTTKYLQRIEELFK-a..................
A0A090IXP3_9BACI/271-373               .........................s-LSRAQQRNLETLENI.......VNNHLTDKDFSGTLRDLQGNPVPK.-...P.....GGG..FWNHLQEMKDSYKGL.VKIRKGLEGSLNNPN.LDV.......ETR......KVLQEASDKTNKYIKKIEDLFE-p..................
B5HEJ1_STRE2/135-247                   .........................g-LSDEAMNAINKLENIkadpigrINSEPNHNHYSAARREAAGEVVAR.R...P.....DGT..PYDHVKDLTQAQQGL.ENVRRILWKEMERLP.DGM.......TERg....lEVLLKKHDETVYHLDRVKGFLHQ...................
A0A0K8MBJ2_9PROT/759-855               ............ykrelfarekmpks----------------.......------KTTLKAAEQELKGKQIPLaE...Q.....RGR..IYDHVEKVKSSQNGL.VRLINDIKARLGYPE.LPQ.......IER......QALENQLSKTSKLLDHTEKFVP-r..................
A0A6B3W739_9BACI/76-128                ..........................ELTRAQKRNVEALNNV.......IANNLKDHDFSGTLRDLQGNPVPK.-...P.....SGG..FWDHKTEM-------.---------------.---.......---......-----------------------i..................
A0A2H5B4G4_9ACTN/2281-2381             .............hnsscgiptktdr----------------.......IAEHLTFRDLDAAKRELGGEVVAR.K...S.....DGT..PWDHVGEVRDAQAGL.LNRMHQIKVQMSKAG.VDD.......PIF......PSLQAELSQASKLLDYSEKYVP-r..................
A0A7L4Y9W4_9ACTN/1461-1573             .........................g-LSDDAMGAIQKLENIkedpigrINSEPNHNHYSAARREAAGEVVAR.K...A.....DGT..PFDHVKDLTQAQQGL.ENVRKILWKEMERLP.EGM.......TERg....lEVLLKKHDETVYHLDRVKGFLHQ...................
A0A1H8B5D5_9BACL/89-191                .........................h-LNDRQRAVVETIDNL.......INDHLKPHDFTGAERDLQGNPVPR.K...-.....GGG..YYNHLQEMVDTLIGL.KNARRKLSGALKNPN.LAP.......DVR......QTLQIYYDKSGDYIRQINELFS-k..................
R4LG98_9ACTN/266-368                   ...........rgsepvrsaprktdr----------------.......LKEHLTEKDLDGARRELNGEVVAR.K...S.....DGT..PWDHVDEVRNAQRGL.VNRIKQLKREIGDSR.SSE.......EQR......AAAQEELSEASRLLDHSEQYVP-r..................
A0A6G9YVR9_9NOCA/1-29                  .........................m----------------.......-KEHLTDGDLDAARRELNGEVVAA.K...P.....DG-..---------------.---------------.---.......---......-----------------------r..................
A0A1I0HRQ2_9BACL/403-512               ...dlsdasranittsqratlnqqer----------------.......TYSHLTEMDLKGAQRDLDGNPVPK.-...P.....GGG..YYDHAQEVSDAYRGL.SDMKKSWEGILKNPN.LDT.......ELR......QLYTSKLNEVNNTMKKVEDMFT-p..................
A0A4Q7L5F9_9PSEU/628-732               .........rknndktkgeptqtdkh----------------.......-KKHLKRSDLDGARRESGGEVVKR.K...A....kTGV..PYDHVDEVQNSQRGL.LNQIDWLNKKLDDSR.TSD.......ADK......KKMEAELGEASKLLDRSEGFLP-r..................
A0A6B3W5E0_9BACI/7-109                 ..........................ELTRAQKRNVEALNNV.......IENNLKDHDFSGTLRDLQGNPIPK.-...P.....SGG..FWDHKTEMIQSYDAL.QGVKKGLEGSLKNPN.LNS.......TVK......EFLEAEFAKANFYINKIEELFK-p..................
A0A269VX40_9BACL/83-192                ...dlsevakskittsqratlnqqer----------------.......TYSHLTEMDLKGAQRDLDGAPVPK.-...P.....GGG..YYDHAQEVSDAYRGL.VDLKRSWEGMLKNPN.LDD.......ELR......QLYTSKLNEVNATMEKVETMFS-p..................
A0A0G2ZFT4_9DELT/330-432               .......................all---ESQSKHIQKIDNI.......IRDHAKPSDFEGVAKELAGQKLPK.-...P.....GGG..YWDHRREMLQSIRDL.KRHVRALEGSLDNPA.HSF.......AVR......SYVQRAIDKARAMLSRMEDAL--sg.................
V6KEU4_STRRC/1345-1457                 .........................g-LRQAALDAIEKLENIkkdplkdINSQPKHNHYNAARREARGEVVAM.K...P.....DGT..PFDHIKDLTQARNGL.NNVREALEKELKNPP.DGI.......TERg....lEVLIRRRKETIDELDRLNGFLHS...................
A0A3N6HBT3_9ACTN/1433-1545             .........................g-LSRAAQLAFEKLENIkrdplgeINSQPNHNHYDAARREARGEVVAR.K...P.....DGT..PFDHISDLQQARNGL.DKIRKVIDLEIRSIP.DSL.......TDRg....lEVLLVKRSEVNKQLNELNGFLHS...................
A0A1H6CZW1_9ACTN/1113-1230             .........................g-LSERAKSALQKLKNVandplgsINRQTNKNHFAAARREANGEVIAR.K...P.....SGV..PFSHISDLQGARNALrNNIIPALNDEYAALS.RRM.......PDNlsyealDNLLRARSEANRLYNDVEGFLR-g..................
A0A0C1HSF7_9BACT/152-262               ........qevikdlnerlirltekg----------------.......---ALNRYHYTAYRKEAQGIVLLN.RegkPllnpkNGK..PYDHIKDVSDQQNGA.KKIIRDIRLRLRFDD.LTA.......DER......KELESILAKTSRILDDSYKF---ttk................
A0A1H3V490_9BACI/39-141                .........................n-LTRAQKRNLDTLDNI.......INKHLTEKDFSGTLRDLQGNPVPK.-...P.....GGG..HWNHLQEMQDSYKGL.IKIRKGLEGSLNNPQ.LNA.......ATR......EVLQDGLDKANKYIKEIEDLFE-p..................
S3XD07_9ACTN/317-413                   ................sgragrptdr----------------.......LKEHLTEKDLDAARRELDGEVVAR.K...P.....DGT..PWNHVHEVRDAQNGL.RNRIEVLKRRIGDTR.LTE.......AQR......NEAQAELSEASRLLDHSKGYV--p..................
A0A2N3XUK7_SACSN/290-404               .vnpidtsddvvesteplpaeqttkt--------------DR.......IKEHLTEKDLDAARRELNGEVVAR.K...P.....NGE..PWDHVDEVQNAQRGL.VNRIEQINRQLGDSR.TTP.......EQR......AGLESELSEASRLLDHSEGYVP-r..................
A0A2T0LZ59_9PSEU/2622-2723             .................gmrfadqls----------DKIDN-.......LSSHVTRKDLEAAARELQGEVVKR.R...R.....DGQ..SYDHIHEVRDAQNGL.LSIIDRANKVLSDPR.LPA.......AER......EAISAQLSRASRMLDFTEKYLP-r..................
A0A660CGL1_9PSEU/1374-1473             .............qchestrselgnl----------------.......-GEALDDRHLDAARREIGGEVVAR.K...A.....DGT..PYDHITEVANSQQGV.VNEIQAMERKLGHPG.LEE.......QTR......VDTTDRLSRYSRFLDYTEQWVP-h..................
A0A5B1AZA2_9FLAO/39-147                .............lsgtggdildgvi----------KK-TNN.......IGTHLSPNDLKGAVKDILGSPFTI.N...-.....-GK..TFDHIGEVTDALKGL.GKQITKLNKGIKNGS.FSDdvldaatSLR......TQLQNQKDQIQNVL---------nnarqea............
#=GC seq_cons                          .........................t.......................lpppLscpDhsuApRElpGcsVs+.+...s.....sGs...aDHlpElpsu.pGL.hphhctLctpLpsss.hs........spR......phlppclscssphlcchcthh.....................
//