#=GF ID B2-adapt-app_C
#=GF AC PF09066.14
#=GF DE Beta2-adaptin appendage, C-terminal sub-domain
#=GF AU Sammut SJ;0000-0003-4472-904X
#=GF SE pdb_1e42
#=GF GA 22.60 22.60;
#=GF TC 22.60 22.60;
#=GF NC 22.50 22.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF WK Beta2-adaptin_C-terminal_domain
#=GF CL CL0545
#=GF RN [1]
#=GF RM 10944104
#=GF RT The structure and function of the beta 2-adaptin appendage
#=GF RT domain.
#=GF RA Owen DJ, Vallis Y, Pearse BM, McMahon HT, Evans PR;
#=GF RL EMBO J. 2000;19:4216-4227.
#=GF DR INTERPRO; IPR015151;
#=GF DR SCOP; 1e42; fa;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Members of this family adopt a structure consisting of a 5
#=GF CC stranded beta-sheet, flanked by one alpha helix on the outer
#=GF CC side, and by two alpha helices on the inner side. This domain is
#=GF CC required for binding to clathrin, and its subsequent
#=GF CC polymerisation. Furthermore, a hydrophobic patch present in the
#=GF CC domain also binds to a subset of D-phi-F/W motif-containing
#=GF CC proteins that are bound by the alpha-adaptin appendage domain
#=GF CC (epsin, AP180, eps15) [1].
#=GF SQ 4263
#=GS A0A8C2VN43_CHILA/828-936 AC A0A8C2VN43.1
#=GS A0A7J7TVK8_PIPKU/546-656 AC A0A7J7TVK8.1
#=GS A0A1S3A6L4_ERIEU/621-733 AC A0A1S3A6L4.1
#=GS A0A067CQ20_SAPPC/797-906 AC A0A067CQ20.1
#=GS A0A6P6A6S8_DURZI/797-906 AC A0A6P6A6S8.1
#=GS A0A3Q7QXJ2_VULVU/836-944 AC A0A3Q7QXJ2.1
#=GS A0A1V4K2Y3_PATFA/827-935 AC A0A1V4K2Y3.1
#=GS A0A8C0IET1_BUBBB/415-488 AC A0A8C0IET1.1
#=GS A0A7L2MLX8_9PASS/839-947 AC A0A7L2MLX8.1
#=GS A0A7J8CVM6_MOLMO/718-826 AC A0A7J8CVM6.1
#=GS A0A6A5FGN4_PERFL/876-984 AC A0A6A5FGN4.1
#=GS A0A6P5XPF9_DURZI/722-835 AC A0A6P5XPF9.1
#=GS A0A0W8C226_PHYNI/473-584 AC A0A0W8C226.1
#=GS A0A8C7G9W1_ONCKI/742-847 AC A0A8C7G9W1.1
#=GS A0A8C8LU70_ONCTS/796-888 AC A0A8C8LU70.1
#=GS A0A6J0CBT1_NEOLC/812-920 AC A0A6J0CBT1.1
#=GS A0A2B4SRE9_STYPI/834-942 AC A0A2B4SRE9.1
#=GS A0A8J6LD66_TENMO/181-289 AC A0A8J6LD66.1
#=GS W4GZA0_APHAT/275-384 AC W4GZA0.1
#=GS A0A226P2E1_COLVI/627-737 AC A0A226P2E1.1
#=GS A0A6J0L408_RAPSA/788-897 AC A0A6J0L408.1
#=GS A0A485NCI6_LYNPA/827-935 AC A0A485NCI6.1
#=GS L1LEQ2_THEEQ/701-769 AC L1LEQ2.1
#=GS A0A2I3H8D8_NOMLE/546-656 AC A0A2I3H8D8.1
#=GS A0A4W4FR53_ELEEL/807-900 AC A0A4W4FR53.1
#=GS A0A2K5LS57_CERAT/849-957 AC A0A2K5LS57.1
#=GS A0A8B7IN55_9AVES/416-526 AC A0A8B7IN55.1
#=GS A0A452GR48_9SAUR/841-949 AC A0A452GR48.1
#=GS A0A8C5AU63_GADMO/834-929 AC A0A8C5AU63.1
#=GS A0A2I3LWD5_PAPAN/621-731 AC A0A2I3LWD5.2
#=GS A0A2K1K4N1_PHYPA/717-831 AC A0A2K1K4N1.1
#=GS A0A8B9VKQ9_9AVES/841-949 AC A0A8B9VKQ9.1
#=GS A0A087YEH0_POEFO/612-725 AC A0A087YEH0.2
#=GS A0A7L3YPJ5_FREGA/827-935 AC A0A7L3YPJ5.1
#=GS A0A7K7CHR2_APHCE/808-916 AC A0A7K7CHR2.1
#=GS A0A6J1REF5_9HYME/832-940 AC A0A6J1REF5.1
#=GS A0A2P5EA63_TREOI/172-227 AC A0A2P5EA63.1
#=GS A0A8D0D4B1_SANLU/792-900 AC A0A8D0D4B1.1
#=GS S9XJU5_CAMFR/845-953 AC S9XJU5.1
#=GS A0A1D3KXA6_9APIC/799-911 AC A0A1D3KXA6.1
#=GS A0A8C9B8A4_PHOSS/582-692 AC A0A8C9B8A4.1
#=GS M3YPP7_MUSPF/836-944 AC M3YPP7.1
#=GS A0A7L0T467_PODPO/827-934 AC A0A7L0T467.1
#=GS A0A8C8G3M9_ONCTS/815-923 AC A0A8C8G3M9.1
#=GS A0A3Q1LWC6_BOVIN/621-731 AC A0A3Q1LWC6.1
#=GS A0A2K5R259_CEBIM/380-488 AC A0A2K5R259.1
#=GS A0A8C0UAW4_CYACU/883-991 AC A0A8C0UAW4.1
#=GS A0A553NMQ6_9TELE/767-875 AC A0A553NMQ6.1
#=GS A0A1J4KUQ2_9EUKA/737-841 AC A0A1J4KUQ2.1
#=GS A0A5E4F4C8_PRUDU/35-144 AC A0A5E4F4C8.1
#=GS A0A6J0UG41_9SAUR/827-935 AC A0A6J0UG41.1
#=GS A0A8C3AHA1_CYCLU/824-923 AC A0A8C3AHA1.1
#=GS A0A673V9G5_SURSU/827-929 AC A0A673V9G5.1
#=GS A0A8K1CBH1_PYTOL/727-834 AC A0A8K1CBH1.1
#=GS A0A6P9B367_PANGU/100-210 AC A0A6P9B367.1
#=GS A0A672R2H6_SINGR/845-895 AC A0A672R2H6.1
#=GS A0A7N6AUE4_ANATE/795-903 AC A0A7N6AUE4.1
#=GS A0A8C8FZ00_ONCTS/862-970 AC A0A8C8FZ00.1
#=GS A0A6P8UGV9_GYMAC/838-946 AC A0A6P8UGV9.1
#=GS A0A8C6XX87_NAJNA/841-949 AC A0A8C6XX87.1
#=GS A0A1S3NMQ4_SALSA/856-964 AC A0A1S3NMQ4.1
#=GS A0A4S4E0Z1_CAMSI/785-894 AC A0A4S4E0Z1.1
#=GS A0A1U7ZJI2_NELNU/769-883 AC A0A1U7ZJI2.1
#=GS A0A498HMB0_MALDO/965-1078 AC A0A498HMB0.1
#=GS A0A3M7QXV7_BRAPC/510-620 AC A0A3M7QXV7.1
#=GS A0A6J2MUC2_9CHIR/836-947 AC A0A6J2MUC2.1
#=GS A0A2K5UI47_MACFA/453-563 AC A0A2K5UI47.1
#=GS A0A8D2KWV9_VARKO/835-943 AC A0A8D2KWV9.1
#=GS D0N317_PHYIT/319-427 AC D0N317.1
#=GS A0A3Q2E595_CYPVA/875-983 AC A0A3Q2E595.1
#=GS A0A5D6YFD6_9STRA/460-571 AC A0A5D6YFD6.1
#=GS A0A087GST7_ARAAL/787-896 AC A0A087GST7.1
#=GS A0A3B6FN84_WHEAT/707-820 AC A0A3B6FN84.1
#=GS A0A3Q3E8B4_9LABR/846-954 AC A0A3Q3E8B4.1
#=GS L5MAV6_MYODS/897-1005 AC L5MAV6.1
#=GS A0A4D9DX08_9SAUR/849-960 AC A0A4D9DX08.1
#=GS A0A453I3V7_AEGTS/759-868 AC A0A453I3V7.1
#=GS A0A8J5IYF9_9STRA/732-839 AC A0A8J5IYF9.1
#=GS A0A663E2Z2_AQUCH/841-949 AC A0A663E2Z2.1
#=GS A0A6P8PAT9_GEOSA/784-892 AC A0A6P8PAT9.1
#=GS A0A7L3JL87_THACH/835-943 AC A0A7L3JL87.1
#=GS A0A6J3DT67_AYTFU/829-937 AC A0A6J3DT67.1
#=GS A0A2U3VXF1_ODORO/809-917 AC A0A2U3VXF1.1
#=GS A0A1R0H469_9FUNG/1094-1204 AC A0A1R0H469.1
#=GS A0A7F8PUX3_LEPWE/528-638 AC A0A7F8PUX3.1
#=GS A0A8C5DT85_9TELE/617-742 AC A0A8C5DT85.1
#=GS A0A6J2KUH2_9CHIR/621-731 AC A0A6J2KUH2.2
#=GS A0A833T4B9_PHYIN/390-498 AC A0A833T4B9.1
#=GS A0A3Q1I5Q9_ANATE/830-938 AC A0A3Q1I5Q9.2
#=GS H2XZK4_CIOIN/31-144 AC H2XZK4.1
#=GS A0A7K6J7E1_9CORV/793-901 AC A0A7K6J7E1.1
#=GS A0A6Q2YGR4_ESOLU/826-868 AC A0A6Q2YGR4.1
#=GS A0A665VPR7_ECHNA/822-913 AC A0A665VPR7.1
#=GS A0A0L1IF22_PLAFA/813-922 AC A0A0L1IF22.1
#=GS R0H5G0_9BRAS/723-836 AC R0H5G0.1
#=GS U3CS25_CALJA/829-940 AC U3CS25.1
#=GS K2N028_TRYCR/669-778 AC K2N028.1
#=GS A0A8C0KJN6_CANLU/863-971 AC A0A8C0KJN6.1
#=GS A0A3B1JA01_ASTMX/798-906 AC A0A3B1JA01.1
#=GS A0A8C6GZB4_MUSSI/592-702 AC A0A8C6GZB4.1
#=GS A0A6G0XBX3_9STRA/583-700 AC A0A6G0XBX3.1
#=GS A0A6J0UG06_9SAUR/841-949 AC A0A6J0UG06.1
#=GS A0A7K9CQW5_9AVES/827-935 AC A0A7K9CQW5.1
#=GS A0A091F5U4_CORBR/839-947 AC A0A091F5U4.1
#=GS A0A7N4PSJ9_SARHA/841-949 AC A0A7N4PSJ9.1
#=GS A0A8D2I3K1_UROPR/802-910 AC A0A8D2I3K1.1
#=GS A0A8I6RTG7_CIMLE/844-952 AC A0A8I6RTG7.1
#=GS A0A8J8P1Z3_HALGN/878-994 AC A0A8J8P1Z3.1
#=GS A0A3L6QXZ0_PANMI/734-847 AC A0A3L6QXZ0.1
#=GS A0A5N4DUK0_CAMDR/631-741 AC A0A5N4DUK0.1
#=GS A0A7K9W2W2_9PASS/795-903 AC A0A7K9W2W2.1
#=GS A0A7K4R0G5_9TYRA/803-911 AC A0A7K4R0G5.1
#=GS A0A671NUM7_9TELE/790-880 AC A0A671NUM7.1
#=GS A0A553PWC5_9TELE/833-921 AC A0A553PWC5.1
#=GS A0A2I3GWU7_NOMLE/802-894 AC A0A2I3GWU7.1
#=GS A1L2H5_XENLA/836-944 AC A1L2H5.1
#=GS A0A7J0FRV3_9ERIC/789-898 AC A0A7J0FRV3.1
#=GS A0A7K8L6T5_9GRUI/827-935 AC A0A7K8L6T5.1
#=GS A2DLB3_TRIV3/702-806 AC A2DLB3.1
#=GS W7JX97_PLAFO/742-854 AC W7JX97.1
#=GS A0A852EFF1_VIDMA/839-947 AC A0A852EFF1.1
#=GS A0A671NCR5_9TELE/731-808 AC A0A671NCR5.1
#=GS A0A850WFR5_FREMA/827-935 AC A0A850WFR5.1
#=GS A0A8C5ZY22_MARMA/827-935 AC A0A8C5ZY22.1
#=GS D3BF27_POLPP/750-863 AC D3BF27.1
#=GS F6U640_ORNAN/621-731 AC F6U640.3
#=GS A0A6P7ZML0_9AMPH/841-949 AC A0A6P7ZML0.1
#=GS A0A443PE14_9MAGN/789-898 AC A0A443PE14.1
#=GS A0A851KTK1_VIDCH/784-892 AC A0A851KTK1.1
#=GS A0A3P9QDD5_POERE/829-926 AC A0A3P9QDD5.1
#=GS A0A7M7JDH0_VARDE/834-948 AC A0A7M7JDH0.1
#=GS T0Q1I8_SAPDV/814-923 AC T0Q1I8.1
#=GS A0A8U0N391_MUSPF/829-940 AC A0A8U0N391.1
#=GS L8HGQ2_ACACA/674-782 AC L8HGQ2.1
#=GS A2FAG5_TRIV3/724-828 AC A2FAG5.1
#=GS A0A813DYE8_POLGL/964-1074 AC A0A813DYE8.1
#=GS G3P172_GASAC/844-956 AC G3P172.1
#=GS A0A2K5F6E0_AOTNA/796-892 AC A0A2K5F6E0.1
#=GS A0A4W4EA24_ELEEL/821-929 AC A0A4W4EA24.1
#=GS A0A8C0YKI0_CYPCA/605-715 AC A0A8C0YKI0.1
#=GS A0A8C2YDT6_COTJA/828-936 AC A0A8C2YDT6.1
#=GS A0A7K7APX2_9AVES/839-947 AC A0A7K7APX2.1
#=GS A0A6J3S8H6_TURTR/841-949 AC A0A6J3S8H6.1
#=GS A0A7L1SF99_9PASS/784-892 AC A0A7L1SF99.1
#=GS A0A8D0D1W5_SANLU/843-951 AC A0A8D0D1W5.1
#=GS A0A340XQE6_LIPVE/836-944 AC A0A340XQE6.1
#=GS A0A8C9M3M1_PANTA/621-731 AC A0A8C9M3M1.1
#=GS A0A6P5SVA6_PRUAV/792-901 AC A0A6P5SVA6.1
#=GS A0A7K4XJE2_REGSA/799-907 AC A0A7K4XJE2.1
#=GS A0A3Q7S156_VULVU/841-949 AC A0A3Q7S156.1
#=GS A0A673UWG6_SURSU/841-943 AC A0A673UWG6.1
#=GS A0A2J8UUU3_PONAB/836-947 AC A0A2J8UUU3.1
#=GS A0A8B7RC88_HIPAR/836-944 AC A0A8B7RC88.1
#=GS A0A7K5H4V9_9AVES/830-938 AC A0A7K5H4V9.1
#=GS A0A3Q3MHS6_9TELE/880-988 AC A0A3Q3MHS6.1
#=GS A0A673W3Z8_SALTR/808-898 AC A0A673W3Z8.1
#=GS A0A0P1AGA1_PLAHL/790-880 AC A0A0P1AGA1.1
#=GS A0A1W0AA63_9STRA/1698-1803 AC A0A1W0AA63.1
#=GS A0A8C1B7S6_CYPCA/31-135 AC A0A8C1B7S6.1
#=GS A0A8C1ATG9_CYPCA/777-871 AC A0A8C1ATG9.1
#=GS A0A4X2KKP8_VOMUR/620-730 AC A0A4X2KKP8.1
#=GS A0A7K7CDY2_APHCE/839-947 AC A0A7K7CDY2.1
#=GS A0A3B6A128_WHEAT/32-128 AC A0A3B6A128.1
#=GS A0A7K8QSH1_9PASS/796-904 AC A0A7K8QSH1.1
#=GS A0A4U6T5P2_SETVI/788-897 AC A0A4U6T5P2.1
#=GS B6AJI5_CRYMR/752-862 AC B6AJI5.1
#=GS A0A663E3I2_AQUCH/836-944 AC A0A663E3I2.1
#=GS A0A1D6NI76_MAIZE/463-576 AC A0A1D6NI76.1
#=GS A0A3Q3WVN6_MOLML/778-886 AC A0A3Q3WVN6.1
#=GS A0A6J1JZ69_CUCMA/792-901 AC A0A6J1JZ69.1
#=GS A0A6H5GMP7_9HEMI/809-917 AC A0A6H5GMP7.1
#=GS A0A1S3U5V2_VIGRR/726-839 AC A0A1S3U5V2.1
#=GS A0A6J3PST6_TURTR/829-867 AC A0A6J3PST6.1
#=GS A0A7J8BX44_MOLMO/809-917 AC A0A7J8BX44.1
#=GS A0A4X2KKA2_VOMUR/452-562 AC A0A4X2KKA2.1
#=GS A0A667X8R3_9TELE/772-863 AC A0A667X8R3.1
#=GS A0A4U6T5S3_SETVI/746-855 AC A0A4U6T5S3.1
#=GS A0A067CL19_SAPPC/270-377 AC A0A067CL19.1
#=GS A0A6Q2X6R2_ESOLU/621-722 AC A0A6Q2X6R2.1
#=GS A0A4W3JPU4_CALMI/624-737 AC A0A4W3JPU4.1
#=GS A0A6P5LSW6_PHACI/841-949 AC A0A6P5LSW6.1
#=GS A0A3P7FQJ7_WUCBA/116-225 AC A0A3P7FQJ7.1
#=GS A0A397GFV6_9GLOM/639-736 AC A0A397GFV6.1
#=GS A0A8C5PQG1_9ANUR/792-900 AC A0A8C5PQG1.1
#=GS A0A8C3C6W9_CAIMO/829-937 AC A0A8C3C6W9.1
#=GS A0A6P5BNB7_BOSIN/621-731 AC A0A6P5BNB7.1
#=GS A0A8B7REM3_HIPAR/829-937 AC A0A8B7REM3.1
#=GS A0A2I0LZR5_COLLI/466-576 AC A0A2I0LZR5.1
#=GS A0A671P1B4_9TELE/841-949 AC A0A671P1B4.1
#=GS A0A1Y1XGY9_9FUNG/940-1049 AC A0A1Y1XGY9.1
#=GS A0A6Q2YPQ9_ESOLU/833-941 AC A0A6Q2YPQ9.1
#=GS A0A7L1LKN9_HIMHI/827-935 AC A0A7L1LKN9.1
#=GS M1B5K9_SOLTU/1-79 AC M1B5K9.1
#=GS A0A8D0GEV9_SPHPU/827-935 AC A0A8D0GEV9.1
#=GS A0A662WKU2_9STRA/96-176 AC A0A662WKU2.1
#=GS A0A7N6A9B6_ANATE/826-934 AC A0A7N6A9B6.1
#=GS A0A445HVW6_GLYSO/787-896 AC A0A445HVW6.1
#=GS A0A2P5DT77_PARAD/725-838 AC A0A2P5DT77.1
#=GS A0A7J7UFH2_PIPKU/829-937 AC A0A7J7UFH2.1
#=GS A0A851VK48_9PASS/839-941 AC A0A851VK48.1
#=GS A0A7L1B4N8_GYMTI/839-947 AC A0A7L1B4N8.1
#=GS A0A7L3AP44_9AVES/827-920 AC A0A7L3AP44.1
#=GS A0A7J8BWH7_MOLMO/747-855 AC A0A7J8BWH7.1
#=GS A0A1U7RF56_ALLSI/845-956 AC A0A1U7RF56.1
#=GS M3ZAF7_NOMLE/453-563 AC M3ZAF7.1
#=GS A0A3B6EH52_WHEAT/722-835 AC A0A3B6EH52.1
#=GS A0A1U8AIA1_NELNU/789-898 AC A0A1U8AIA1.1
#=GS A0A448ZAA6_9STRA/785-898 AC A0A448ZAA6.1
#=GS A0A8D2EJX2_THEGE/621-731 AC A0A8D2EJX2.1
#=GS A0A1U8MYC8_GOSHI/790-899 AC A0A1U8MYC8.1
#=GS A0DRP1_PARTE/662-769 AC A0DRP1.1
#=GS A0A7L1WCQ0_9PASS/839-947 AC A0A7L1WCQ0.1
#=GS A0A7L2ACZ7_9GRUI/833-942 AC A0A7L2ACZ7.1
#=GS A0A1Z5KH60_FISSO/750-864 AC A0A1Z5KH60.1
#=GS A0A3Q0E1P0_CARSF/453-563 AC A0A3Q0E1P0.1
#=GS A0A7K9DC27_9AVES/786-894 AC A0A7K9DC27.1
#=GS A0A8C8ZS36_PROSS/140-231 AC A0A8C8ZS36.1
#=GS A0A6A1UXL2_9ROSI/773-886 AC A0A6A1UXL2.1
#=GS A0A8C9MFQ3_SERCA/837-945 AC A0A8C9MFQ3.1
#=GS A0A835XUN9_9CHLO/353-411 AC A0A835XUN9.1
#=GS A0A669B621_ORENI/813-921 AC A0A669B621.1
#=GS A0A6P4AHG7_ZIZJJ/723-836 AC A0A6P4AHG7.1
#=GS A0A1S3PEV5_SALSA/856-964 AC A0A1S3PEV5.1
#=GS A0A7K5TS73_CEPOR/803-911 AC A0A7K5TS73.1
#=GS A0A8C9P395_SPEDA/587-697 AC A0A8C9P395.1
#=GS H0YTK5_TAEGU/638-748 AC H0YTK5.2
#=GS U3IGS4_ANAPP/841-875 AC U3IGS4.2
#=GS Q4DIK0_TRYCC/662-771 AC Q4DIK0.1
#=GS M4DS09_BRARP/769-878 AC M4DS09.1
#=GS A0A8V1A492_CHICK/416-526 AC A0A8V1A492.1
#=GS A0A819JU17_9BILA/847-955 AC A0A819JU17.1
#=GS A0A803Y213_MELGA/967-1075 AC A0A803Y213.1
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