#=GF ID   Pox_A28
#=GF AC   PF04584.18
#=GF DE   Poxvirus A28 family
#=GF AU   Waterfield DI;0000-0003-2885-5126
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Pfam-B_4756 (release 7.5)
#=GF GA   27.00 27.00;
#=GF TC   37.20 74.30;
#=GF NC   23.30 20.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF DR   INTERPRO; IPR007664;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Family of conserved Poxvirus A28 family proteins. Conserved
#=GF CC   region spans entire protein in the majority of family members.
#=GF SQ   42
#=GS A28_VACCC/1-146         AC P68632.1
#=GS Q8V3I1_SWPV1/1-140      AC Q8V3I1.1
#=GS Q070A2_CPRVZ/1-139      AC Q070A2.1
#=GS A0A0H4XWP5_9POXV/1-136  AC A0A0H4XWP5.1
#=GS A0A2U9QHU4_9POXV/1-140  AC A0A2U9QHU4.1
#=GS H6TAA5_9POXV/1-140      AC H6TAA5.1
#=GS A28_MCV1/1-141          AC Q98300.1
#=GS A28_VAR67/1-146         AC P0DSX7.1
#=GS A0A223FMY1_9POXV/1-145  AC A0A223FMY1.1
#=GS A0A6B9R5T8_9POXV/1-142  AC A0A6B9R5T8.1
#=GS Q6TVL5_ORFSA/1-140      AC Q6TVL5.1
#=GS A28_CAMPS/1-146         AC P68558.1
#=GS D3IZQ3_9POXV/1-140      AC D3IZQ3.1
#=GS A28_RFVKA/1-140         AC Q9Q8W2.1
#=GS Q0GNT3_HSPV/1-146       AC Q0GNT3.1
#=GS A0A2C9DT98_9POXV/1-143  AC A0A2C9DT98.1
#=GS A28_YLDV/1-139          AC Q9DHJ5.1
#=GS A0A385H9X6_FOWPV/1-141  AC A0A385H9X6.1
#=GS Q0NP59_9POXV/1-146      AC Q0NP59.1
#=GS A0A223FNJ4_9POXV/1-146  AC A0A223FNJ4.1
#=GS Q08FM5_DPV83/1-140      AC Q08FM5.1
#=GS Q5GF33_9POXV/1-137      AC Q5GF33.1
#=GS Q9YVW0_MSEPV/1-139      AC Q9YVW0.1
#=GS A28_MYXVL/1-140         AC P68548.1
#=GS A28_FOWPN/1-141         AC Q9J541.1
#=GS A28_YMTV5/1-141         AC P60672.1
#=GS A0A1B1MRJ6_9POXV/1-140  AC A0A1B1MRJ6.1
#=GS Q1HTR8_9POXV/1-140      AC Q1HTR8.1
#=GS A0A220T6J2_9POXV/1-138  AC A0A220T6J2.1
#=GS A0A097IVZ5_9POXV/1-140  AC A0A097IVZ5.1
#=GS A0A1V0QGZ2_CNPV/1-140   AC A0A1V0QGZ2.1
#=GS B2CWM3_9POXV/1-140      AC B2CWM3.1
#=GS A28_AMEPV/1-139         AC P29816.1
#=GS Q6VZ81_CNPV/1-140       AC Q6VZ81.1
#=GS Q08F55_DPV84/1-140      AC Q08F55.1
#=GS A0A1L3IZP2_9POXV/1-140  AC A0A1L3IZP2.1
#=GS G3EI24_9POXV/1-145      AC G3EI24.1
#=GS A28_VACCW/1-146         AC P68633.1
#=GS A0A1B3B695_LSDV/1-140   AC A0A1B3B695.1
#=GS W6JLC6_9POXV/1-138      AC W6JLC6.1
#=GS A0A7H0DNC6_MONPV/1-146  AC A0A7H0DNC6.1
#=GS A0A0M3PB65_9POXV/1-140  AC A0A0M3PB65.1
A28_VACCC/1-146                    .....MNSLSIFFIVVATAAVCLLFIQGYSIYENYGNIKEFNATHAAFEYSKSIGG.TpALDRRVQDVNDTISDVKQKWRCVVYPgNGFVSASIFGFQAEVGPNntrsIRKFNTMQQCIDFTFSDVININIYNPCVVPN..INNAECQFLKSVL...........
Q8V3I1_SWPV1/1-140                 .....MDVITIFFIILATVAISIIIFQVYYIYQNYDNIKEFNEMHIPLEYSKTINV.L.SLDRSVEDPNDYIYDPKQKWRCVKFD.NDYVSVSRFGYKSNNGI-....IRKFNTINNCVDYTFSESTHSDIINPCISPN.tSKSKECIFLKSIL...........
Q070A2_CPRVZ/1-139                 .....MNALSAFLLVVATCAVCVFLFQLYTVYENYGNIVEFNDEYRSLEYAKTIGG.S.YVDRTVYDPNDSVLDPKEKWRCVIRN.GKYISVSKFGFKYDSVLG...rTLEFPTMEDCINFNYGSIFTGDIYNPCTDP-..-KSEECLFLKSVL...........
A0A0H4XWP5_9POXV/1-136             mrfsd------IFLIISVICVCFFLQQAWLMWSDWPKILEFVHAQKQNEYVQDSKH.E.YSDFAIYDPNDVSLEKKEKWRCVVSN.SLWYQINNHGAVSNPSGT....LKVFSTMSECKRNLFLYKGVRIYIDPCLSHG..DL-----------csqviyln...
A0A2U9QHU4_9POXV/1-140             .....MDVISIICIIIATVSVCVILIQSYSIYENYDNIKEFNLENAALEYSKSTGG.S.RTDRRVYDPNDNVYDVKQKWRCEKRN.QLYLSVSIFGFLSDDRNT....IKYFTSKDECILYTFTNRIFTDIFNPCLPPN..EGSDDCKFLKSIL...........
H6TAA5_9POXV/1-140                 .....MNILTVFIIIITTVAICMIMFQGYYIYNNYENIKEFNALHSSLEYTNTLNT.L.SIDRTVIDPNDDVYDVKQKWRCVKFN.NDYVSISAFGFKSDGKK-....IRKFNNIDDCIYYTFSISNNTNIINPCIYPN.dPKSKECIFLKSAL...........
A28_MCV1/1-141                     .....MDPLSVFFLVVAAAAVCTLLLQAYAVYENFDSILEFNDAHASLEYSKSLGG.S.YIDKHVFDPNDGVADVTQKWRCALYG.KVYVSASAFGFYAQPDGS....KRTFSTRDDCVDFTFGTADTSRVVNPCTDPN.gAQAEDCAFLKSVL...........
A28_VAR67/1-146                    .....MNSLSIFFIVVATAAVCLLFIQGYSIYENYGNIKEFNATHAAFEYSKSIGG.TpALDRRVQDVNDTISDVKQKWRCVAYPgNGFVSASIFGFQAEVGPNntrsIRKFNTMAQCIDFTFSDVINIDIYNPCVAPN..INNVECQFLKSVL...........
A0A223FMY1_9POXV/1-145             .....MNALSVFFIVMATAALCIIFIQLYSIYENYNNIKEFNSTHAAFEYSKSIGG.TpALDRRVTDVNDTIYDVKQKWRCVPYNgNVYVSASVFGFKAIGSNNt.ktIRKFNTLQQCIDFTFSNKDNVDIYNPCVAPN..MNTRDCDFLKSVL...........
A0A6B9R5T8_9POXV/1-142             .....MNAVYIFFIIIATAIICLLLLQAYIIYDNFDSIKEFNKMHAGLEFSKSVGG.T.SIDHRVTDYNDDIYDVKQKWRCVKYKdYYYVSLSIFGFRSNKDKS....IMSFQNIDECIYNNSTIFTDFNIYNPCLEPN.gNNKAECIFLKSVL...........
Q6TVL5_ORFSA/1-140                 .....MDAVSALCVALAAAAAMFVTLQLWAVYENYDNIREFNAANAALEFARTAGG.P.RVDRRVFDPNDEAFDVRKKWRCVLFK.GAAVAASEFGFRSHDGVS....PARFASVEACADEIFTAASDFRVFNPCLPPN..QGSEACLFLKSIL...........
A28_CAMPS/1-146                    .....MNSLSIFFIVVATAAVCLLFIQGYSIYENYGNIKEFNATHAALEYSKSIGG.TpALDRRVQDVNDTISDVKQKWRCVAYPgNGFVSASIFGFQAEVGPNntrsIRKFNTMAQCIDFTFSDVINIDIYNPCVAPN..INNVECQFLKSVL...........
D3IZQ3_9POXV/1-140                 .....MDAVSALCVACAAAAAMFVALQLWAVYENYDNIREFNAQNAALEFARTAGG.P.RVDRRVFDPNDEAFDVRKKWRCVLFK.GSAVAASEFGFRSHDGVS....PARFASVEACADEIFSNAIDFRVFNPCLPPN..QSSEACLFLKSIL...........
A28_RFVKA/1-140                    .....MNPVTVFFVVVVTVAACMILFQVYSIYLNYDNIKEFNAMHSPLEYSKMVNV.T.AIDRRIQDANDDIYDAKQKWRCVKLD.DSYVSLSMFGYKSDGIG-....IRRFRTLNSCIDYTFSTSTHSSILNPCISPN.dPKSRECTFLKSVL...........
Q0GNT3_HSPV/1-146                  .....MNSLSIFFIVVATAAVCLLFIQGYSIYENYGNIKEFNATHAAFEYSKSIGG.TpALDRRVQDVNDTISDVKQKWRCVVYPgNGFVSASIFGFQAEVGPNntrsIRKFNTMQQCIDFTFSDVINIDIYNPCVVPN..INNAECQFLKSVL...........
A0A2C9DT98_9POXV/1-143             .....MDALSVFFLVAATAAVCVFLMQVYAIYENFHHIQEFNEEYSGLEYARSVGGgS.YVDRKVQDPNDDESDVRAKWRCVLYE.RSYVTVSKFGFGTVKGRE....VRKFADLDECVEFNYLNGDLSNVWNPCIDNAegRNSSACSFLKSVL...........
A28_YLDV/1-139                     .....MNPSSVFLIVVATVAICLIVIQVYYIYENYDNIKEFNSTHSLLEYSKTINV.F.SLDRRIYDPNDHVHDVKQKWRCVNYD.NNYVSVSIFGFKSDSGKN....IKNFSTVDDCIDYTFSKSTHSNIFNPCINE-..DKSKDCNFLKSVL...........
A0A385H9X6_FOWPV/1-141             .....MDALFVFIIILATAVICLFLFQAYTIYDNYHNIIEFNEKYGGLEYSRSPGG.L.YIDKRVFDPNDSETDPKAKWRCVNYNnNQYASASKFGYLATSSRN....PVLFTNLEDCVYYNYTRGEIGTIWNPCAEYG..EGSAECSTLKSHL...........
Q0NP59_9POXV/1-146                 .....MNSLSIFFIVVATAAVCLLFIQGYSIYENYGNIKEFNATHAAFEYSKSIGG.TpALDKRVQDVNDTISDVKQKWRCVAYPgNGFVSASIFGFQAEVGPNntrsIRKFNTMAQCIDFTFSDVINIDIYNPCVAPN..INNVECQFLKSVL...........
A0A223FNJ4_9POXV/1-146             .....MNALSIFFVVIATAALCIIFIQLYSIYENYNNIKEFNSTHAAFEYSKSIGG.TpALDRRVTDVNDTIYDVKQKWRCVPYNgNVYVSASVFGFKANIGSNntktIRRFNTLQQCIDFTFSDKYNVDIYNPCVSPN..MNTRDCDFLKSIL...........
Q08FM5_DPV83/1-140                 .....MNVVTIFFIVVATVAVCLIFFQGYSIYKNYDNIKEFNNAHSVLEYSKTVNV.I.SLDRSVQDPNDQIYDVKQKWRCNKFE.NDYVSISIFGFKSDGNN-....IRKFRTLEDCINYTFSESTHSNIFNPCISPN.dPKSKECIFLKSIL...........
Q5GF33_9POXV/1-137                 ...ml------VILVIFIITLCFSLFQFYEFYKNYDYILEFNDRYKKYEYVTTPGF.N.FIDKSIFDPNDEAKTKEEKWRCIQSD.KVWSGISSRGFVNDGGH-....IAQWSNRETCLNYIFSHEIL-NYTNPCKTDG..KQSDN--------vlkkcnlfkaa
Q9YVW0_MSEPV/1-139                 .....MNIIQVFGIILITSALCFIIFQLWYYYENYDYIIKYNDAYGNLEYSQSANI.N.YQDSTVYDPNDTEYDVNKKWRCALNN.SIYYPVSEFGFMSTDSTK...iGLTYTYLNDCLLNLFDTQVKI-IYNPCSVS-..NTSNDCVLLNNL-l..........
A28_MYXVL/1-140                    .....MNPVTVFFVVVVTVAVCMILFQVYSIYLNYDNIKEFNAMHSPLEYSKMVNV.T.AIDRRVQDANDDIYDAKQKWRCVKFD.DSYVSLSMFGYKADGVG-....IRRFRTLNGCIDYTFSTSTHSSILNPCIPPN.dPKSRECTFLKSAL...........
A28_FOWPN/1-141                    .....MDALFVFIIILATAVICLFLFQAYTIYDNYHNIIEFNEKYGGLEYSRSPGG.L.YIDKRVFDPNDSETDPKAKWRCVNYNnNQYASASKFGYLATSSRN....PVLFTNLEDCVYYNYTRGEIGTIWNPCAEYG..EGSAECSTLKSHL...........
A28_YMTV5/1-141                    .....MNPTSIVLIVIATVAVCLIIMQIYYIYENYDNIKEFNSTHSTLEYSKTINV.F.SLDRRIYDPNDHIYDVKQKWRCVNYK.NNYVSVSVFGFKSNKDKN....IKMFTTINDCINYTFSKSTHSDIYNPCILDD.gFQNQDCIFLKSVI...........
A0A1B1MRJ6_9POXV/1-140             .....MDAITIMCIVIVTVAACVMMLQAYSIYENYENIKEFNSENASLEYAKSTGG.M.RVDYRVKDPNDTTHDVKQKWRCVIKQ.NVYVSASIFGFLSDNSKT....IKQFYTLDECILYTFMPKIDNNIYNPCVPPN..ERSEDCIFLKSIL...........
Q1HTR8_9POXV/1-140                 .....MDTVSVFVIVVATAAICVILMQAYAVYENYDNILEFNAAHAALEYASTVGG.P.QVDRRAFDPNDEATDAKAKWRCVLKG.SVYVSASLFGFRAEGGR-....VKLFPDEESCQDFTFTPGNAASIINPCAPPR.gPGDADCVFLKSVI...........
A0A220T6J2_9POXV/1-138             .....MGPLSIFFMILATVALCVILIQCYTIYENYDNIKEFNATHGALEYSKSTNV.I.SVDRREFDVNDQIYDVKEKWRCVKYN.DMFVSVSKFGFKANNGN-....IRKFSNFKDCLNYTFTTSTHSDIINPCIN-N..QADNDCIFLKSIL...........
A0A097IVZ5_9POXV/1-140             .....MNILTVFIIIITTVAICMIMFQGYYIYNNYENIKEFNALHSSLEYTNTLNT.L.SIDRTVIDPNDDVYDVKQKWRCVKFN.NDYVSISAFGFKSDGKK-....IRKFNNIDDCIYYTFSISNNTNIINPCIYPN.dPKSKECIFLKSAL...........
A0A1V0QGZ2_CNPV/1-140              .....MDALFVFIIIVATTVVCLFLFQAYTVYDNFHNILEFNEIYGGLEYARSPGG.L.YIDKRVFDPNDTETDPKAKWRCISYN.NNYVSASKFGYLATSNNN....PIIFTNLSDCIDYNYTKGEINTIWNPCTEYG..QSSVECNTLKSRL...........
B2CWM3_9POXV/1-140                 .....MNPVTVFFVVVVTVAVCMILFQVYSIYLNYDNIKEFNAMHSPLEYSKMVNV.T.AIDRRVQDANDDIYDAKQKWRCVKFD.DSYVSLSMFGYKADGVG-....IRRFRTLNGCIDYTFSTSTHSSILNPCIPPN.dPKSRECTFLKSAL...........
A28_AMEPV/1-139                    .....MNTVQILVVILITTALSFLVFQLWYYAENYEYILRYNDTYSNLQFARSANI.N.FDDLTVFDPNDNVFNVEEKWRCASTNnNIFYAVSTFGFLSTESTG...iNLTYTNSRDCIIDLFSRIIKI-VYDPCTV--..ETSNDCRLLR---llm........
Q6VZ81_CNPV/1-140                  .....MDALFVFIIILATTVICLFLFQAYTVYDNYHNILEFNDAYGGLEYARSPGG.L.YIDKRVFDPNDTETDPKAKWRCVDYN.NSYVSASKFGYLATSRNN....PMLFTNLTDCIDYNYTKGEINTIWNPCTEYG..EGSAECNTLKSRL...........
Q08F55_DPV84/1-140                 .....MNVVTIFFIVVATVAICLIFFQGYSIYKNYDNIKEFNNAHSVLEYSKTVNV.I.SLDRRVQDPNDQIYDVKQKWRCNKFE.NDYVSISIFGFKSDGNN-....IRKFRTLEDCINYTFSESTHSNIFNPCVSPN.dPKSKECIFLKSIL...........
A0A1L3IZP2_9POXV/1-140             .....MNILTVFFIIVATVAICMIMFQGYYIYQNYENIKEFNSMHSSLEYTKTLNT.L.SIDRTVTDPNDDIYDVKQKWRCVKFI.DAFVSISAFGFKSDGKK-....IRKFTNIEDCIYYTFSISNNTNMFNPCIYPN.dPKSKECIFLKFIL...........
G3EI24_9POXV/1-145                 .....MNSLSVFFIIIATATICIIFIQLYSIYENYNNIKEFNATHAAFEYSKSIGG.TpALDRRVTDVNDTIYDVKQKWRCVPYN.KMFVSASIFGFKANSSQNnetiIKKFNTLQECIDFTFSDIYNIDIYNPCIGLN..INTRDCDFLKSIL...........
A28_VACCW/1-146                    .....MNSLSIFFIVVATAAVCLLFIQGYSIYENYGNIKEFNATHAAFEYSKSIGG.TpALDRRVQDVNDTISDVKQKWRCVVYPgNGFVSASIFGFQAEVGPNntrsIRKFNTMQQCIDFTFSDVININIYNPCVVPN..INNAECQFLKSVL...........
A0A1B3B695_LSDV/1-140              .....MNAITIFFIILSTVAVCIIIFQLYSIYLNYDNIKEFNSAHSAFEFSKSVNT.L.SLDRTIKDPNDDIYDPKQKWRCVKLD.NDYVSVSMFGFKSNGSE-....IRKFKNLESCIDYTFSQSTHSDIKNPCILQN.gIKSKECIFLKSM-f..........
W6JLC6_9POXV/1-138                 .....MNIIQVFGIIFITASFCFIIFQLWYYAENYTYILKYNNAYSNLQFARSANI.N.YQDRTVNDPNDNEFNVDRKWRCAEEN.GIYYPVSSFGFMSTESTG...iNLTYTFIKDCILELFNTQLRI-VYNACSI--..SGSLDCQLLNRL-l..........
A0A7H0DNC6_MONPV/1-146             .....MNSLSIFFIVVATAAVCLLFIQSYSIYENYGNIKEFNATHAAFEYSKSIGG.TpALDRRVQDVNDTISDVKQKWRCVVYPgNGFVSASIFGFQAEVGPNntrsIRKFNTMRQCIDFTFSDVINIDIYNPCIAPN..INNTECQFLKSVL...........
A0A0M3PB65_9POXV/1-140             .....MDALFVFIVIVATVVICIFLFQLYIIYDNYHNILEFNDAYSSLEYSKSPGG.L.YIDKRVFDPNDSETDPKAKWRCIEYK.NQYVSASKFGFLSTSLGN....PILFNNLQDCIYYNYTRGEIGTIWNPCSESE..QSSDACITLKSNL...........
#=GC seq_cons                      .....MNslolFhIllATsAlCllhhQsYsIY-NYcNIKEFNstHuuLEYSKolss.h.tlDRRVhDPNDslhDVKQKWRCVtas.ssYVSsShFGFpussuss....I+pFsslpsCIsaTFopshpssIaNPClsPN...pSp-C.FLKSlL...........
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