KEGG   Pongo abelii (Sumatran orangutan): 100434557
Entry
100434557         CDS       T01416                                 
Symbol
AKR1C4
Name
(RefSeq) aldo-keto reductase family 1 member C4 isoform X1
  KO
K00037  3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase [EC:1.1.1.50 1.1.1.357 1.1.1.225]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon00120  Primary bile acid biosynthesis
pon00140  Steroid hormone biosynthesis
pon01100  Metabolic pathways
pon05208  Chemical carcinogenesis - reactive oxygen species
Module
pon_M00104  Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
pon_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:pon00001]
 09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    100434557 (AKR1C4)
   00140 Steroid hormone biosynthesis
    100434557 (AKR1C4)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    100434557 (AKR1C4)
Enzymes [BR:pon01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.50  3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
     100434557 (AKR1C4)
    1.1.1.225  chlordecone reductase
     100434557 (AKR1C4)
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     100434557 (AKR1C4)
SSDB
Motif
Pfam: Aldo_ket_red
Other DBs
NCBI-GeneID: 100434557
NCBI-ProteinID: XP_002820533
Position
10:5246041..5272779
AA seq 323 aa
MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYDNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
ALKPGEMLLPKDENGKVIFDTVDLCATWEVMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIALVAYSALGTQRHELWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
RNYRYIVMDFLMDHPDYPFSDEY
NT seq 972 nt   +upstreamnt  +downstreamnt
atggatcccaaatatcagcgtgtggagctaaatgatggtcacttcatgcccgtattggga
tttggcacctatgcacctccagaggttccgaggaacagagctgtggaggtcaccaaatta
gcaatagaagctggcttccgccatattgattctgcttatttatacgataatgaggagcaa
gttggactggccatccgaagcaagattgcagatggcagtgtgaagagagaagacatattc
tacacttcaaagctttggtgcactttctttcaaccacagatggtccaaccagccttggaa
agctcactgaaaaaacttcaactggactatgttgacctctatcttcttcatttcccaatg
gctctcaagccaggtgagatgctactaccaaaagatgaaaatggaaaagtaatatttgac
acagtggatctctgtgccacatgggaggtcatggagaagtgtaaggatgcaggattggcc
aagtccatcggggtgtccaacttcaaccgcaggcagctggagatgatcctcaacaagcca
ggactcaagtacaagcctgtctgcaaccaggtggaatgccatccttacctcaaccagagc
aaactgctggatttctgcaagtcaaaagacattgctctggttgcctatagtgctctggga
acccaacgacatgaactatgggtagacccgaactccccagttcttttggaggacccagtt
ctttgtgccttagcaaagaagcacaaacgaaccccagccctgattgccctgcgctaccag
ctgcagcgtggggttgtggtcctggccaagagctacaatgagcagcggatcagagagaac
atccaggtttttgaattccagttgacatcagaggatatgaaagttctagatggcctaaac
agaaattatcgatatattgtcatggattttcttatggaccaccctgattatccattttca
gatgaatattag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (4)   
   KEGG MODULE (2)   
Chemical substance (29)   
   KEGG COMPOUND (29)   
Chemical reaction (26)   
   KEGG ENZYME (3)   
   KEGG REACTION (23)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (1)   
   Pfam (1)   
All databases (73)   

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