KEGG   Pongo abelii (Sumatran orangutan): 100445431
Entry
100445431         CDS       T01416                                 
Symbol
ADCY2
Name
(RefSeq) adenylate cyclase type 2
  KO
K08042  adenylate cyclase 2 [EC:4.6.1.1]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon00230  Purine metabolism
pon01100  Metabolic pathways
pon01522  Endocrine resistance
pon04015  Rap1 signaling pathway
pon04020  Calcium signaling pathway
pon04022  cGMP-PKG signaling pathway
pon04024  cAMP signaling pathway
pon04062  Chemokine signaling pathway
pon04072  Phospholipase D signaling pathway
pon04114  Oocyte meiosis
pon04211  Longevity regulating pathway
pon04213  Longevity regulating pathway - multiple species
pon04261  Adrenergic signaling in cardiomyocytes
pon04270  Vascular smooth muscle contraction
pon04371  Apelin signaling pathway
pon04540  Gap junction
pon04611  Platelet activation
pon04713  Circadian entrainment
pon04714  Thermogenesis
pon04723  Retrograde endocannabinoid signaling
pon04724  Glutamatergic synapse
pon04725  Cholinergic synapse
pon04727  GABAergic synapse
pon04750  Inflammatory mediator regulation of TRP channels
pon04911  Insulin secretion
pon04912  GnRH signaling pathway
pon04913  Ovarian steroidogenesis
pon04914  Progesterone-mediated oocyte maturation
pon04915  Estrogen signaling pathway
pon04916  Melanogenesis
pon04918  Thyroid hormone synthesis
pon04921  Oxytocin signaling pathway
pon04922  Glucagon signaling pathway
pon04923  Regulation of lipolysis in adipocytes
pon04925  Aldosterone synthesis and secretion
pon04926  Relaxin signaling pathway
pon04927  Cortisol synthesis and secretion
pon04928  Parathyroid hormone synthesis, secretion and action
pon04934  Cushing syndrome
pon04935  Growth hormone synthesis, secretion and action
pon04970  Salivary secretion
pon04971  Gastric acid secretion
pon04972  Pancreatic secretion
pon04976  Bile secretion
pon05032  Morphine addiction
pon05163  Human cytomegalovirus infection
pon05166  Human T-cell leukemia virus 1 infection
pon05200  Pathways in cancer
pon05207  Chemical carcinogenesis - receptor activation
pon05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:pon00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    100445431 (ADCY2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    100445431 (ADCY2)
   04371 Apelin signaling pathway
    100445431 (ADCY2)
   04020 Calcium signaling pathway
    100445431 (ADCY2)
   04072 Phospholipase D signaling pathway
    100445431 (ADCY2)
   04024 cAMP signaling pathway
    100445431 (ADCY2)
   04022 cGMP-PKG signaling pathway
    100445431 (ADCY2)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    100445431 (ADCY2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    100445431 (ADCY2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100445431 (ADCY2)
   04062 Chemokine signaling pathway
    100445431 (ADCY2)
  09152 Endocrine system
   04911 Insulin secretion
    100445431 (ADCY2)
   04922 Glucagon signaling pathway
    100445431 (ADCY2)
   04923 Regulation of lipolysis in adipocytes
    100445431 (ADCY2)
   04912 GnRH signaling pathway
    100445431 (ADCY2)
   04913 Ovarian steroidogenesis
    100445431 (ADCY2)
   04915 Estrogen signaling pathway
    100445431 (ADCY2)
   04914 Progesterone-mediated oocyte maturation
    100445431 (ADCY2)
   04921 Oxytocin signaling pathway
    100445431 (ADCY2)
   04926 Relaxin signaling pathway
    100445431 (ADCY2)
   04935 Growth hormone synthesis, secretion and action
    100445431 (ADCY2)
   04918 Thyroid hormone synthesis
    100445431 (ADCY2)
   04928 Parathyroid hormone synthesis, secretion and action
    100445431 (ADCY2)
   04916 Melanogenesis
    100445431 (ADCY2)
   04925 Aldosterone synthesis and secretion
    100445431 (ADCY2)
   04927 Cortisol synthesis and secretion
    100445431 (ADCY2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100445431 (ADCY2)
   04270 Vascular smooth muscle contraction
    100445431 (ADCY2)
  09154 Digestive system
   04970 Salivary secretion
    100445431 (ADCY2)
   04971 Gastric acid secretion
    100445431 (ADCY2)
   04972 Pancreatic secretion
    100445431 (ADCY2)
   04976 Bile secretion
    100445431 (ADCY2)
  09156 Nervous system
   04724 Glutamatergic synapse
    100445431 (ADCY2)
   04727 GABAergic synapse
    100445431 (ADCY2)
   04725 Cholinergic synapse
    100445431 (ADCY2)
   04723 Retrograde endocannabinoid signaling
    100445431 (ADCY2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100445431 (ADCY2)
  09149 Aging
   04211 Longevity regulating pathway
    100445431 (ADCY2)
   04213 Longevity regulating pathway - multiple species
    100445431 (ADCY2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    100445431 (ADCY2)
   04714 Thermogenesis
    100445431 (ADCY2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100445431 (ADCY2)
   05207 Chemical carcinogenesis - receptor activation
    100445431 (ADCY2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100445431 (ADCY2)
   05163 Human cytomegalovirus infection
    100445431 (ADCY2)
  09165 Substance dependence
   05032 Morphine addiction
    100445431 (ADCY2)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    100445431 (ADCY2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100445431 (ADCY2)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    100445431 (ADCY2)
Enzymes [BR:pon01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     100445431 (ADCY2)
SSDB
Motif
Pfam: Guanylate_cyc Adcy_cons_dom AC_N HNOBA
Other DBs
NCBI-GeneID: 100445431
NCBI-ProteinID: XP_024103376
Position
5:7325485..7755780
AA seq 1091 aa
MWQEAMRRRRYLRDRAEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLA
LLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAM
GYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSAT
PGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQ
ERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFT
RLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK
MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGG
VPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPR
HTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL
RTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAF
KYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFICFAGQLLQCSKKASP
LLVWLLKSSGIIANRPWPRISLTIITTAIILTMAVFNMFFLSDSEETIPPTANTTNTSFS
ASNNQLAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHT
HAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKK
EREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFY
TESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHS
QEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDI
WGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEM
SRSLSQSNVAS
NT seq 3276 nt   +upstreamnt  +downstreamnt
atgtggcaggaggcgatgcggcgccgccgctacctgcgggaccgcgccgaggaggcggcg
ggcggcggagacgggctgccgcggtcccgggactggctctacgagtcctactactgcatg
agccagcagcacccgctcatcgtcttcctgctgctcatcgtcatgggctcctgcctcgcc
ctgctcgccgtcttcttcgcgctcgggctggaagttgaagaccatgtggcgtttctaata
acagttccaactgccctggcgattttctttgcgatatttatcctggtctgcattgagtct
gtgtttaagaagctgctgcgcctcttctcgttggtgatatggatatgccttgttgccatg
ggatacctgttcatgtgttttggaggcactgtctctccctgggaccaggtatcgttcttc
ctcttcatcatcttcgtggtgtacaccatgctacccttcaacatgcgagacgccatcatt
gccagtgtcctcacctcctcctcccacaccatcgtgcttagcgtctgcctgtctgcaaca
ccgggaggcaaggagcacctggtctggcagatcttggccaatgtgatcattttcatctgc
gggaacctggcgggagcctaccataagcacctcatggaacttgctcttcagcaaacgtat
caggacacctgtaattgcatcaagtcccggatcaagttggaatttgaaaaacgtcaacag
gagcggcttctgctctccctgctgccggcccacattgccatggagatgaaagccgagatc
atccagaggctgcagggccccaaggcgggccagatggagaacacaaataacttccacaac
ctgtacgtgaagcggcataccaacgtgagcatcttatacgctgacatcgttggctttacc
cggctggcaagtgactgctccccgggagaactagtccacatgctgaatgagctcttcgga
aagtttgatcaaattgcaaaggagaatgaatgcatgagaattaaaattttaggagactgc
tactactgtgtatctggactccctatatctctccctaaccatgccaagaactgtgtgaaa
atggggctggacatgtgtgaagccataaagaaagtgagggatgctactggagttgatatc
aacatgcgtgtgggcgtgcattctgggaatgtcctgtgtggcgtgattggtctgcagaag
tggcagtatgatgtgtggtcacatgatgtgaccttggccaaccacatggaagctggaggg
gtccctggacgtgttcacatttcttccgtcaccctggagcacttgaatggcgcttataaa
gtggaggagggagatggtgacattagggacccatatttaaaacagcacctggtgaaaacc
tactttgtaatcaaccccaagggagaacgacggagcccccagcatctcttcagacctcgc
cacaccctcgacggagccaaaatgagggcctcggtccgcatgacccggtacttggagtcc
tggggggcggccaagccctttgcacacctacatcacagggacagcatgaccacagagaac
ggcaagatcagcaccacggatgtacccatgggtcagcataattttcaaaatcgcacctta
agaaccaagtcacaaaagaagagatttgaagaagaattgaatgaaaggatgattcaagca
attgatgggattaatgcacagaagcaatggctcaagtctgaagacattcagagaatctca
ctgcttttctataacaaagtactggaaaaagagtaccgggccacggcactgccagcgttc
aagtattatgtgacttgtgcctgtctcatattcttctgcatcttcattgtgcagattctc
gtgctgccaaaaacgtccgtcctgggcatctcctttggggctgcgtttctcttgctggcc
ttcatcctcttcatctgctttgctggacagcttctgcaatgcagcaaaaaagcctctccc
ctgctcgtgtggcttttgaagtcctcgggcatcattgccaaccgcccctggccacggatc
tctctcacgatcatcaccacagccatcatattaactatggccgtgttcaacatgtttttc
ctgagtgactcagaggaaacaatccctccaacggccaatacaacaaacacaagcttttca
gcctcaaataatcagttggcgattctgcgtgcgcaaaatttatttttcctcccgtacttt
atctacagctgcattctgggactgatatcctgttccgtgttcctgcgggtaaactacgag
ctgaagatgttgatcatgatggtggccttggtgggctacaacaccatcctactccacacc
cacgcccatgtcctgggcgactacagccaggtcttatttgagagaccaggcatttggaaa
gacctgaagaccatgggctctgtgtctctctctatattcttcatcacactgcttgttctg
ggcagacagaatgaatattactgtaggttagacttcttatggaagaacaagttcaaaaaa
gagcgggaggagatagaaaccatggagaacctgaaccgcgtgctgctggagaacgtgctt
cccgcacacgtggctgagcacttcctggccaggagcctgaagaatgaggagctataccac
cagtcctatgactgcgtctgcgtcatgtttgcctccattccggatttcaaagaattttat
acagaatccgacgtgaacaaggagggcttggaatgccttcggctcctgaacgagatcatc
gctgactttgatgatcttctttccaagccaaaattcagtggagttgaaaagattaagacc
attggcagcacatacatggcagcaacaggtctgagcgctgtgcccagccaggagcactcc
caggagcccgagcggcagtacatgcacattggcaccatggtggagtttgcttttgccctg
gtagggaagctggatgccatcaacaagcactccttcaacgacttcaaattgcgagtgggt
attaaccatggacctgtgatagctggtgtgattggagctcagaagccgcaatatgatatc
tggggcaacaccgtcaatgtggccagtaggatggacagcactggagtcctggacaaaata
caggttaccgaggagacgagcctcgtcctgcagaccctcggatacacgtgcacctgtcga
ggaataatcaatgtgaaaggaaagggggacctgaagacgtactttgtaaacacagaaatg
tcaaggtccctttcccagagcaacgtggcatcctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (50)   
   KEGG PATHWAY (50)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (4)   
   Pfam (4)   
All databases (75)   

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