KEGG   Pongo abelii (Sumatran orangutan): 100457536
Entry
100457536         CDS       T01416                                 
Symbol
MAP2K3
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 3 isoform X1
  KO
K04432  mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon04010  MAPK signaling pathway
pon04015  Rap1 signaling pathway
pon04218  Cellular senescence
pon04620  Toll-like receptor signaling pathway
pon04664  Fc epsilon RI signaling pathway
pon04668  TNF signaling pathway
pon04714  Thermogenesis
pon04750  Inflammatory mediator regulation of TRP channels
pon04912  GnRH signaling pathway
pon04935  Growth hormone synthesis, secretion and action
pon04936  Alcoholic liver disease
pon05014  Amyotrophic lateral sclerosis
pon05022  Pathways of neurodegeneration - multiple diseases
pon05132  Salmonella infection
pon05135  Yersinia infection
pon05145  Toxoplasmosis
pon05161  Hepatitis B
pon05169  Epstein-Barr virus infection
pon05170  Human immunodeficiency virus 1 infection
pon05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pon05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100457536 (MAP2K3)
   04015 Rap1 signaling pathway
    100457536 (MAP2K3)
   04668 TNF signaling pathway
    100457536 (MAP2K3)
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    100457536 (MAP2K3)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    100457536 (MAP2K3)
   04664 Fc epsilon RI signaling pathway
    100457536 (MAP2K3)
  09152 Endocrine system
   04912 GnRH signaling pathway
    100457536 (MAP2K3)
   04935 Growth hormone synthesis, secretion and action
    100457536 (MAP2K3)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100457536 (MAP2K3)
  09159 Environmental adaptation
   04714 Thermogenesis
    100457536 (MAP2K3)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100457536 (MAP2K3)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100457536 (MAP2K3)
   05161 Hepatitis B
    100457536 (MAP2K3)
   05169 Epstein-Barr virus infection
    100457536 (MAP2K3)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100457536 (MAP2K3)
   05135 Yersinia infection
    100457536 (MAP2K3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100457536 (MAP2K3)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    100457536 (MAP2K3)
   05022 Pathways of neurodegeneration - multiple diseases
    100457536 (MAP2K3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100457536 (MAP2K3)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    100457536 (MAP2K3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pon01001]
    100457536 (MAP2K3)
Enzymes [BR:pon01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     100457536 (MAP2K3)
Protein kinases [BR:pon01001]
 Serine/threonine kinases: STE group
  STE7 family
   100457536 (MAP2K3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like ABC1 Seadorna_VP7 Haspin_kinase Pkinase_fungal APH Choline_kinase RIO1 DUF4344
Other DBs
NCBI-GeneID: 100457536
NCBI-ProteinID: XP_002827186
Ensembl: ENSPPYG00000008073
UniProt: H2NT13
Position
17
AA seq 347 aa
MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVE
ADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDC
FYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL
HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPEL
NQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVD
FTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
NT seq 1044 nt   +upstreamnt  +downstreamnt
atggagtcgcccgcctcgagccagcccgccagcatgccccagtccaaaggaaaatccaag
aggaagaaggatctacggatatcctgtatgtccaagccacccgcacccaaccccacaccc
ccccggaacctggactcccggaccttcatcaccattggagacagaaactttgaggtggag
gctgatgacttggtgaccatctcggaactgggccgcggagcctatggggtggtagagaag
gtgcggcacgcccagagcggcaccatcatggccgtgaagcggatccgggccaccgtgaac
tcacaggagcagaagcggctgctcatggacctggacatcaacatgcgcacggtcgactgc
ttctacactgtcaccttctatggagcactattcagagagggagacgtgtggatctgcatg
gagctcatggacacatccttggacaagttctaccggaaggtgctggataaaaacatgaca
attccagaggacatccttggggagattgctgtgtctatcgtgcgggccctggagcatctg
cacagcaagctgtcggtgatccacagagatgtgaagccctccaatgtcctcatcaacaag
gagggccatgtgaagatgtgtgactttggcatcagtggctacttggtggactctgtggcc
aagacgatggatgccggctgcaagccctacatggcccctgagaggatcaacccggagctg
aaccagaagggctacaatgtcaagtcggacgtctggagcctgggcatcaccatgattgag
atggccatcctgcggttcccttacgagtcctgggggaccccgttccagcagctgaagcag
gtggtggaggagccgtccccccagctcccagccgaccgtttctcccccgagtttgtggac
ttcactgctcagtgcctgaggaagaaccccgcagagcgtatgagctacctggagctgatg
gagcaccccttcttcaccttgcacaaaaccaagaagacggacattgctgccttcgtgaag
gagatcctgggagaagactcatag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (21)   
   KEGG PATHWAY (21)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (5)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   RefSeq(pep) (4)   
DNA sequence (4)   
   RefSeq(nuc) (4)   
Protein domain (11)   
   Pfam (11)   
All databases (51)   

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