{PDOC00307}
{PS00355; HMG14_17}
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* HMG14 and HMG17 signature *
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High mobility group (HMG) proteins are a family of relatively low molecular
weight non-histone components in chromatin. HMG14 and HMG17 [1], two related
proteins of about 100 amino acid residues, bind to the inner side of the
nucleosomal DNA thus altering the interaction between the DNA and the histone
octamer. These two proteins may be involved in the process which maintains
transcribable genes in a unique chromatin conformation.
The trout nonhistone chromosomal protein H6 (histone T) also belongs to this
family.
As a signature pattern we selected a conserved stretch of 10 residues located
in the N-terminal section of HMG14 and HMG17.
-Consensus pattern: [RQ]-R-S-A-[RS]-L-S-A-[RKM]-[PL]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Expert(s) to contact by email:
Landsman D.; landsman@ncbi.nlm.nih.gov
-Last update: December 2004 / Pattern and text revised.
[ 1] Bustin M., Reeves R.
"High-mobility-group chromosomal proteins: architectural components
that facilitate chromatin function."
Prog. Nucleic Acid Res. Mol. Biol. 54:35-100(1996).
PubMed=8768072
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