KEGG   Panthera tigris altaica (Amur tiger): 102968217
Entry
102968217         CDS       T02988                                 
Symbol
PDHA2
Name
(RefSeq) pyruvate dehydrogenase (lipoamide) alpha 2
  KO
K00161  pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
Organism
ptg  Panthera tigris altaica (Amur tiger)
Pathway
ptg00010  Glycolysis / Gluconeogenesis
ptg00020  Citrate cycle (TCA cycle)
ptg00620  Pyruvate metabolism
ptg00785  Lipoic acid metabolism
ptg01100  Metabolic pathways
ptg01200  Carbon metabolism
ptg01210  2-Oxocarboxylic acid metabolism
ptg04066  HIF-1 signaling pathway
ptg04922  Glucagon signaling pathway
ptg05230  Central carbon metabolism in cancer
ptg05415  Diabetic cardiomyopathy
Module
ptg_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:ptg00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    102968217 (PDHA2)
   00020 Citrate cycle (TCA cycle)
    102968217 (PDHA2)
   00620 Pyruvate metabolism
    102968217 (PDHA2)
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    102968217 (PDHA2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    102968217 (PDHA2)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    102968217 (PDHA2)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    102968217 (PDHA2)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    102968217 (PDHA2)
Enzymes [BR:ptg01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.1  pyruvate dehydrogenase (acetyl-transferring)
     102968217 (PDHA2)
SSDB
Motif
Pfam: E1_dh DXP_synthase_N Chal_sti_synt_N
Other DBs
NCBI-GeneID: 102968217
NCBI-ProteinID: XP_015397859
Position
Un
AA seq 391 aa
MRKMLAAAVSRVLSGVTQKPASRVLVASCNYSNDAMFAIKKCDLYRLEEGPPVTTVLTRE
DGLKYYRMMQTVRRMELKADQLYKQKFIRGFCHLCDGQEACSVGLEAGINPTDHVITSYR
AHGLCYTRGLSVRSILAELTGRRGGCAKGKGGSMHMYVKNFYGGNGIVGAQGPLGAGIAL
ACKYKGNKEVCLTLYGDGAANQGQIAEAHNMAALWKLPCVFICENNLYGMGTPVERASAS
TDYYKRGNFIPGLRVDGMDVLGVREATKFVADYCRSGKGPIVMELQTYRYHGHSMSDPGI
SYRTREEVQNVRKKSDPIMLLKDRMVNSELATVEELKDIDVEVRKEVEDAAQFALTDPEP
PLEELAHHIYCNTPAFEVRGANQWIKFKSLS
NT seq 1176 nt   +upstreamnt  +downstreamnt
atgaggaagatgctcgctgccgctgtctcccgcgtgttgtccggggtcacgcagaagccc
gctagcagagtgctggtggcatcctgtaactattcaaatgatgcgatgtttgcaattaag
aaatgtgatctttatcgcttagaagagggtccccctgtcacaacagtgctcacccgggag
gatgggctcaaatactacaggatgatgcagactgttcgccgaatggagctgaaggcagat
cagctgtataaacaaaaatttatccgtgggttctgtcacttgtgcgatggtcaggaagct
tgttctgtgggcctggaggccgggataaatcccaccgaccatgtcatcacctcctatcgg
gctcatggcttgtgctatactcgtggactctctgtccgatcaattcttgcagagctgaca
ggacgaaggggaggctgtgctaaaggaaaaggaggatcgatgcatatgtatgtcaagaat
ttctatgggggcaatggcattgttggcgcacagggacccctgggagctggtattgctctg
gcctgtaaatacaagggaaacaaggaggtctgtttgactctttatggggatggtgctgcg
aatcagggtcagatagctgaagctcacaatatggcagctttgtggaaattaccctgtgtt
ttcatctgtgagaataacctctatggaatgggaacccctgttgagagagcatcagccagc
accgattactataagagaggaaattttatccctggactaagggtagacggaatggatgtt
ctaggtgttcgggaggcaactaagtttgtagctgactactgtagatctggaaaggggccc
atagtgatggagctgcagacctaccggtatcatggacacagtatgagtgaccctgggatc
agttatcgtacccgagaagaggttcagaatgtgagaaagaagagcgatcctattatgctt
ctcaaagacagaatggtgaacagtgagcttgccactgttgaggaactaaaggatattgat
gttgaagtgaggaaagaagtggaggatgcagcccagtttgctctgactgatcctgaacca
cctttggaagaattagctcatcacatctactgcaatactccagcttttgaagttcgtggt
gcaaaccagtggatcaagttcaagtccctcagttaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (12)   
   KEGG PATHWAY (11)   
   KEGG MODULE (1)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (3)   
   Pfam (3)   
All databases (40)   

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